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Topic: Erythermalgia

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	[No title] (Site not responding. Last check: 2007-10-31)
		Symptoms of primary erythermalgia can be precipitated by standing, slight exercise such as walking, and exposure to heat; relief can be obtained by elevating the affected extremities and cooling them.
		The distinction between hereditary erythermalgia and acquired erythromelalgia was emphasized by van Genderen et al.
		The burning pain in the feet occurred episodically especially during the spring and summer months, was precipitated by heat, and was associated with redness or purplish discoloration, warmth, and slight swelling of the feet.
	zeta.embl-heidelberg.de:8000 /srs5bin/cgi-bin/wgetz?-e+[omim-id:133020] (1429 words)

	eMedicine - Erythromelalgia : Article Excerpt by: Robert J Nardino, MD
		This is the major reason that Drenth and Michiels distinguish primary erythromelalgia (erythermalgia) from secondary erythromelalgia.
		Several factors postulated to contribute to primary erythromelalgia are postganglionic sympathetic dysfunction; hypersensitivity of C-fibers; and maldistribution of skin perfusion resulting from arteriovenous shunting, which leads to an imbalance between thermoregulatory and nutritive perfusion.
		Early-onset erythromelalgia (or primary erythermalgia by the Drenth-Michiels classification) is rare, with fewer than 30 cases reported in the literature.
	www.emedicine.com /med/byname/erythromelalgia.htm (549 words)

	IngentaConnect Genetic heterogeneity and exclusion of a modifying locus at 2q in... (Site not responding. Last check: 2007-10-31)
		Primary erythermalgia is a rare disorder characterized by recurrent attacks of red, warm and painful hands and/or feet.
		To describe the clinical characteristics of a large three-generation family with primary erythermalgia and to test for genetic linkage to chromosome 2q.
		In this family with autosomal dominant primary erythermalgia, exclusion of linkage to chromosome 2q is strongly suggestive for genetic heterogeneity.
	www.ingentaconnect.com /content/bsc/bjd/2005/00000153/00000001/art00029 (277 words)

	Dr. Pribut on Erythromelalgia
		Drenth and Michiels (1994, 1995) proposed using the terms erythromelalgia for a platelet-mediated form that is responsive to aspirin and use the terms primary and secondary erythermalgia for non-aspirin sensitive forms of the disorder.
		Michiels JJ, Abels J, Steketee J: Erythromelalgia caused by platelet-mediated arteriolar inflammation and thrombosis in thrombocythemia.
		Michiels JJ, Drenth JP, Van Genderen PJ: Classification and diagnosis of erythromelalgia and erythermalgia.
	www.drpribut.com /sports/erythromelalgia.htm (459 words)

	Erythermalgia - Erythermalgia
		The attacks come and go, and tend to be worse in summer.
		Erythermalgia Erythromelalgia is often associated with vascular diseases such as polycythaemia vera, thrombocytosis or with heavy metal poisoning.
		It has been linked to a mutation of the SCN9A (a sodium channel), the gene of which is located on the long arm of the second chromosome (2q24).
	www.medicalgeo.com /Med-Diseases-E/Erythermalgia.html (209 words)

	[No title] (Site not responding. Last check: 2007-10-31)
		In affected members of a Chinese family with primary erythermalgia (133020) linked to chromosome 2q and in a sporadic patient, Yang et al.
		In all affected members of a Chinese family with autosomal dominant primary erythermalgia (133020), Yang et al.
		In a sporadic patient with primary erythermalgia (133020), Yang et al.
	zeta.embl-heidelberg.de:8000 /srs5bin/cgi-bin/wgetz?-e+[omim-id:603415] (557 words)

	Erythermalgia (Site not responding. Last check: 2007-10-31)
		Erythermalgia is a disorder characterised by episodic attacks of reddening of the skin, due to vasodilation of the dermis.
		Raised red lesions form which create a painful burning sensation.
		The precise cause of this disorder is unknown although it is believed to be associated with an abnormal immune response.
	www.yourskin.co.uk /skin-problems/erythermalgia.htm (49 words)

	Mutations in SCN9A, encoding a sodium channel alpha subunit, in patients with primary erythermalgia -- Yang et al. 41 ...
		Mutations in SCN9A, encoding a sodium channel alpha subunit, in patients with primary erythermalgia -- Yang et al.
		Primary erythermalgia is a rare autosomal dominant disease characterised
		primary erythermalgia to a 7.94 cM interval on chromosome 2q.
	jmg.bmjjournals.com /cgi/content/full/41/3/171 (2145 words)

	primary erythermalgia (Site not responding. Last check: 2007-10-31)
		Inherited erythermalgia (also termed erythromelalgia) is characterized by severe pain in the limbs in response to mild thermal stimuli or exercise.
		Shifts in activation and deactivation, and enhanced responses to small stimuli in SCN9A mutant channels, decrease the threshold for single impulses and high-frequency trains of impulses in pain-sensing neurons.
		Waxman SG, Dib-Hajj S. Erythermalgia: molecular basis for an inherited pain syndrome.
	www.humpath.com /article-printable.php3?id_article=8066 (93 words)

	Zebra Card EX-002: hot weather limb pains, sort of
		primary erythermalgia -- a rare disorder beginning in childhood or adolescence.
		secondary erythermalgia -- associated with gout, cryoglobulinemia, systemic lupus erythematosis, diabetes, vasoactive drugs, and more.
		Platelets seem not to play a role here, aspirin has no effect, and relief is best obtained by treating the underlying disorder.
	www.acponline.org /zebra/references/ex/EX-002.html (238 words)

	Electrophysiological Properties of Mutant Nav1.7 Sodium Channels in a Painful Inherited Neuropathy -- Cummins et al. 24 ...
		erythermalgia is a rare, dominantly inherited painful neuropathy
		the abnormal pain sensations in patients with inherited erythermalgia.
		in the symptoms of primary erythermalgia in patients with the
	www.jneurosci.org /cgi/content/full/24/38/8232 (3718 words)

	eMedicine - Erythromelalgia : Article by Robert J Nardino, MD
		Synonyms and related keywords: primary erythromelalgia, secondary erythromelalgia, erythermalgia, myeloproliferative disorder, arteriolar fibrosis, idiopathic erythromelalgia, platelet-mediated erythromelalgia, aspirin-sensitive erythromelalgia, primary erythermalgia, secondary erythermalgia, polycythemia vera, essential thrombocytosis
		Michiels JJ, Abels J, Steketee J, et al: Erythromelalgia caused by platelet-mediated arteriolar inflammation and thrombosis in thrombocythemia.
		Michiels JJ, te Morsche RH, Jansen JB, Drenth JP: Autosomal dominant erythermalgia associated with a novel mutation in the voltage-gated sodium channel alpha subunit Nav1.7.
	www.emedicine.com /med/topic730.htm (2570 words)

	[No title] (Site not responding. Last check: 2007-10-31)
		The suggestion of a localized scarletiniform eruption was interesting, and reaction to bacterial exotoxin similar to that seen with TSS and SSSS should have been considered.
		What I learned: 1) It's erythermalgia not erythromalgia 2) There's primary erythromelalgia, secondary erythromelalgia and erythermalgia.
		"The erythermalgia patient experiences the same redness and burning pain of the extremities brought on by heat or exercise, but by contrast finds: no response to aspirin no progression to necrosis" The conclusion: "Watch your vowels or you'll get the diagnosis wrong.
	matrix.ucdavis.edu /rxderm-archives/erythromelalgia (1037 words)

	Erythromelalgia Help (Site not responding. Last check: 2007-10-31)
		The diagnosis of any neuropathy or syndrome that is considered a rare disorder is very difficult to diagnose, and as EM has no test or conclusive evidence that facilitates a diagnosis, many doctors may never have heard of EM or seen a case to compare with yours.
		Yes, this disorder is very real, the ICD-9 billing code for erythromelalgia or erythermalgia is 443.82.
		Try visiting with a specialist in neuropathies, pain disorders, dermatology, etc. Most major medical centers should be able to help you locate a doctor with experience in diagnosing and treating EM.
	www.erythromelalgia.org /Help.asp (189 words)

	Erythermalgia
		Mutations in SCN9A, encoding a sodium channel alpha subunit, in...
		Mutations in SCN9A, encoding a sodium channel alpha subunit, in patients with primary erythermalgia Y Yang1,, Y Wang1,, S Li1,*, Z Xu2...
		We hope that this diseases directory has been of use in finding information regarding our illness or disease.
	www.medicality.org.uk /diseases/erythermalgia.php (129 words)

	Medical Dictionary: Primary erythermalgia - WrongDiagnosis.com
		Primary erythermalgia is listed as a "rare disease" by the Office of Rare Diseases (ORD) of the National Institutes of Health (NIH).
		This means that Primary erythermalgia, or a subtype of Primary erythermalgia, affects less than 200,000 people in the US population.
		Terms that may be interchangeable with Primary erythermalgia:
	www.wrongdiagnosis.com /medical/primary_erythermalgia.htm (163 words)

	Arch Neurol -- Abstract: Autosomal Dominant Erythermalgia Associated With a Novel Mutation in the Voltage-Gated Sodium ...
		Arch Neurol -- Abstract: Autosomal Dominant Erythermalgia Associated With a Novel Mutation in the Voltage-Gated Sodium Channel {alpha} Subunit Nav1.7, October 2005, Michiels et al.
		Autosomal Dominant Erythermalgia Associated With a Novel Mutation in the Voltage-Gated Sodium Channel
		Potent Modulation of the Voltage-Gated Sodium Channel Nav1.7 by OD1, a Toxin from the Scorpion Odonthobuthus doriae
	archneur.ama-assn.org /cgi/content/abstract/62/10/1587 (228 words)

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