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	Thrombocytopenia (reduced platelet count)
		Platelets are essential in the formation of blood clots to prevent haemorrhage – bleeding from a ruptured blood vessel.
		Thrombocytopenia may be due to a build up of platelets outside the normal blood 'pool', eg in a patient with a very large spleen.
		However, in the condition known as thrombotic thrombocytopenia purpura the use of platelet concentrates is in fact particularly hazardous.
	www.netdoctor.co.uk /diseases/facts/thrombocytopenia.htm (1778 words)

	Thrombocytopenia
		Thrombocytopenia is a disorder in which the number of blood cell platelets is abnormally low, sometimes associated with abnormal bleeding.
		Thrombocytopenia may be a result from a failure of platelet production and/or an increased rate of removal from blood.
		Thrombocytopenia often occurs in patients with cancers of the blood.
	www.mamashealth.com /blood/thrombo.asp (223 words)

	Inherited thrombocytopenia: when a low platelet count does not mean ITP -- Drachman 103 (2): 390 -- Blood
		c-mpl mutations are the cause of congenital amegakaryocytic thrombocytopenia.
		Identification of mutations in the c-mpl gene in congenital amegakaryocytic thrombocytopenia.
		Existence of a differentiation blockage at the stage of a megakaryocyte precursor in the thrombocytopenia and absent radii (TAR) syndrome.
	www.bloodjournal.org /cgi/content/full/103/2/390 (5206 words)

	Researchers find an antibody that destroys the blood's platelets
		Thrombocytopenia is associated with a number of diseases and can also be caused by some drugs.
		People with early HIV infection often develop a form of the condition called immunologic thrombocytopenia, which appears to be caused by antibodies that attack platelets.
		Other types of thrombocytopenia are not caused by antibodies, although the cause of some forms remains unknown.
	www.eurekalert.org /pub_releases/2001-09/nyum-rfa090601.php (628 words)

	eMedicine - Thrombocytopenia in Pregnancy : Article by Richard Fischer, MD
		The commonly used classification of thrombocytopenia severity in pregnancy is arbitrary and not necessarily clinically relevant.
		TTP and HUS are characterized by thrombocytopenia, hemolytic anemia, and multiorgan failure.
		The thrombocytopenia from hypersplenism usually is not associated with bleeding disorders.
	www.emedicine.com /med/topic3480.htm (4879 words)

	Thrombopoietin in Patients With Congenital Thrombocytopenia and Absent Radii: Elevated Serum Levels, Normal Receptor ...
		The pathophysiology of thrombocytopenia in the syndrome of thrombocytopenia with absent radii (TAR) is not yet understood.
		THROMBOCYTOPENIA WITH absent radii (TAR) is a rare congenital defect with hypomegakaryocytic thrombocytopenia and bilateral radial aplasia.
		Signal transduction pathways downstream of c-Mpl should be essentially similar in platelets and their progenitors in the bone marrow, regardless of whether the signal transduction in platelets is a simple remnant from the megakaryocytes or whether there is a physiological role of TPO in platelet activation.
	www.bloodjournal.org /cgi/content/full/90/2/612 (5569 words)

	eMedicine - Thrombocytopenia in Pregnancy : Article Excerpt by: Richard Fischer, MD
		Platelets are nonnucleated cells derived from megakaryocytes in the bone marrow, which normally live in the peripheral circulation for as long as 10 days.
		The secondary hemostatic phase begins when the coagulation pathway is activated on the surface of the activated platelets to form a fibrin meshwork, which serves to reinforce the platelet plug.
		Thrombocytopenia is encountered in 7-8% of all pregnancies.
	www.emedicine.com /med/byname/thrombocytopenia-in-pregnancy.htm (265 words)

	Thrombocytopenia (Site not responding. Last check: 2007-11-04)
		In immune-mediated thrombocytopenia (IMT), the reduction happens because there is increased destruction of platelets by the body's own immune system, at a rate faster than they are produced in the bone marrow.
		Influx, efflux, and redistribution of platelets to and from the circulating...
		Thrombocytopenia (or -paenia, or thrombopenia in short) is the presence of relatively few platelets in blood.
	www.originalsales.com /Remedies/thrombocytopenia-.html (446 words)

	Idiopathic/Autoimmune Thrombocytopenia Purpura (ITP) and Pregnancy
		Thrombocytopenia is a condition in which your blood platelets are very low.
		Idiopathic/autoimmune thrombocytopenia purpura (ITP) is an autoimmune disease that causes the body to interpret the platelets as foreign and then sets out to destroy them.
		Your baby is also at risk for developing neonatal thrombocytopenia after delivery which means she will have very low platelets after birth.
	my.webmd.com /content/article/4/1680_51829.htm?... (1071 words)

	Article (Site not responding. Last check: 2007-11-04)
		Gestational thrombocytopenia, also termed essential thrombocytopenia or benign or incidental thrombocytopenia of pregnancy, is by far the most common cause of mild thrombocytopenia during pregnancy, affecting up to 8% of gestations (2).
		Neonatal alloimmune thrombocytopenia is the platelet equivalent of hemolytic (Rh) disease of the newborn, developing as a result of maternal alloimmunization to fetal platelet antigens.
		In typical cases of unanticipated neonatal alloimmune thrombocytopenia, the mother is healthy and has a normal platelet count, and her pregnancy, labor, and delivery are indistinguishable from those of other low-risk obstetric patients.
	www.obgyndocdan.yourmd.com /ypol/user/userMain.asp?siteid=1732821&content=userViewContentInFramework&bcx=My%20Doctor^TAB~Web%20Site^MNU~Dr%20D.%20Bahnmiller^PST^1732821~Home%20Page^CAT^1~Article^MAP^ZZZOOGDHGIC&cid=ZZZOOGDHGIC&secure=2&rndm=3.259081E-02 (2133 words)

	What the Heck is an Antibiotic? (Site not responding. Last check: 2007-11-04)
		Iron, which is essential for the production of hemoglobin, (the red pigment in cells), is not handled normally during inflammation and accumulates unused in the marrow tissue.
		There are many causes of thrombocytopenia, so examination of the bone marrow may be necessary to clarify the diagnosis.
		The essential is the frequent monitorization of the patient.
	homepage.ntlworld.com /jennifer.robinson3/blood.htm (2340 words)

	Hemangioma Thrombocytopenia Syndrome
		Thrombocytopenia may occur within the first month of life in association with a hemangioma of the outer layer of the placenta (placental chorioangioma) or large hemangiomas of the skin.
		It is thought that the thrombocytopenia may be a result of platelet destruction which occurs in relationship to growth of the hemangioma.
		Essential Thrombocytopenia is a rare blood disease affecting the platelets of the blood.
	hw.healthdialog.com /kbase/nord/nord992.htm (1227 words)

	Diagnostic Edge - February 2004
		Thrombocytopenia (decreased platelet count) is the most common cause of a bleeding disorder in veterinary medicine.
		Alloimmune thrombocytopenia occurs when maternal antibodies to paternal antigens are transferred across the placenta or in colostrum, and cause platelet destruction in the neonate.
		Microscopic examination of the smear is essential to confirm thrombocytopenia (‹10 platelets per 1000x field without significant clumping of platelets, particularly in the "feathered edge" of the smear).
	www.idexx.com /animalhealth/education/diagnosticedge/200402.jsp;jsessionid=8B624A3DA119BF3468B3827895E38CAD (2301 words)

	Essential Thrombocytopenia (Site not responding. Last check: 2007-11-04)
		Essential Thrombocytopenia is a rare blood disease affecting the clotting factor (platelets) of the blood.
		Secondly, immune Thrombocytopenia which may develop due to autoimmune destruction of blood platelets when the patients own blood production system attacks itself as if it were a foreign body.
		Thrombocytopenia is treated by transfusions of normal platelets to control bleeding.
	www.littledov.com /AngelsOfAffliction/Hematology/thrombocytopenia.htm (543 words)

	National Cancer Institute - Chronic Myeloproliferative Disorders Treatment
		Essential thrombocythemia is a disease in which too many platelets are made in the bone marrow.
		Essential thrombocythemia causes an abnormal increase in the number of platelets made in the blood and bone marrow.
		Essential thrombocythemia often does not cause early symptoms.
	www.nci.nih.gov /cancertopics/pdq/treatment/myeloproliferative/Patient/page5 (240 words)

	Myeloproliferative Disorders
		The chronic myeloproliferative disorders are polycythemia vera (PV), myelofibrosis (MF), essential thrombocythemia (ET), chronic myelogenous leukemia (CML), and chronic myelomonocytic leukemia (CMML).
		Splenic irradiation is typically associated with transient responses and should be considered in patients too ill for splenectomy or chemotherapy.
		Blastic transformation was 16.3% in this series, and the risk was increased in patients with splenomegaly and preoperative thrombocytopenia, suggesting that pre-splenectomy thrombocytopenia may be a surrogate marker of advanced disease.
	www.clevelandclinicmeded.com /diseasemanagement/hematology/mdisorders/mdisorders.htm (4298 words)

	Essential measures to stop the AIDS epidemic
		The chronic use of cocaine, heroin, and alcohol has also caused peripheral neuropathy, thrombocytopenia, renal problems, and other systemic illnesses, that are treated with high doses of corticosteroids and other immunosuppressent agents.
		Thrombocytopenia and peripheral neuropathy are classified by the CDC as AIDS indicator diseases, which are also treated with high doses of glucocorticoids that cause AIDS
		The common drugs that cause thrombocytopenia include: chemotherapeutic agents, alcohol, myelosuppressive drugs, thiazide diuretics, estrogens, antibiotics, sedative, hypnotics, anticonvulsants, aspirin, sulfa drug, digitoxin, phenytoin, gold salts, heparin, and sulfnamides and trimethoprim (the treatment for Pneumocyst carrinii).
	ourcivilisation.com /aids/stop (3990 words)

	May Hegglin Anomaly
		Essential Thrombocytopenia is a rare blood platelet disorder characterized by an abnormally small number of circulating platelets that survive for a shorter than normal period of time.
		The major symptom is excessive hemorrhaging, especially under the skin, in the eyes, and in the mucous membranes of the mouth.
		In severe cases of Essential Thrombocytopenia abnormal bleeding may occur in the brain (intracranial hemorrhage).
	hw.healthdialog.com /kbase/nord/nord160.htm (1715 words)

	Thrombocytopenia
		The patient with severe thrombocytopenia may benefit from prophylactic administration of platelets.
		With an expected pattern of bleeding, thrombocytopenia alone is not an indication for platelet transfusion.
		Severe thrombocytopenia may predispose patients to bleeding from routine mechanical oral hygiene procedures.
	www.websters-online-dictionary.org /definition/english/Th/Thrombocytopenia.html (463 words)

	ITP, is the most common acquired bleeding disorder... (Site not responding. Last check: 2007-11-04)
		The diagnosis of ITP is chiefly based upon the clinical history, physical examination along with evidence of thrombocytopenia with normal peripheral blood smear and exclusion of secondary causes of thrombocytopenia.
		Thus measurement of PAIgG for the diagnosis of ITP is not essential.
		At present the prognostic factors to predict the response to splenectomy have not been identified and larger studies are essential to determine the prognostic factors.
	www.indegene.com /Onc/FeatArt/indOncFeatArt8.html (4367 words)

	Directory - Health: Conditions and Diseases: Blood Disorders: Platelet
		Platelet is disc-shaped, small cellular element in the blood, essential for blood clotting.
		Thrombocytopenia - Overview Â Â·Â iweb Â Â·Â cached Â Â·Â Adam.com looks at this disorder and its causes, incidence and risk factors.
		Thrombocytopenia During Pregnancy Â Â·Â cached Â Â·Â An in depth look at gestational thrombocytopenia, idiopathic thrombocytopenic purpura, HELLP syndrome, toxemia of pregnancy, TTP and HUS, systemic lupus erythematosus and APA syndrome.
	www.incywincy.com /default?p=441437 (293 words)

	Idiopathic thrombocytopenic purpura (Site not responding. Last check: 2007-11-04)
		Thrombocytopenia is another word for a decreased number of blood platelets.
		The acute form is most common in children between the ages of two and six years; the chronic form is most common in adult females between 20 and 40.
		The most important features that the doctor will be looking for during the physical examination are the condition of the patient's spleen and the presence of fever.
	www.chclibrary.org /micromed/00052550.html (1616 words)

	Dorlands Medical Dictionary
		essential thrombocythemia, hemorrhagic thrombocythemia, a myeloproliferative disorder characterized by a sharp increase in the number of circulating platelets, with repeated spontaneous hemorrhages either externally or into the tissues.
		infectious cyclic thrombocytopenia, &#160; thrombocytopenia in dogs recurring every one to two weeks, caused by infection with Ehrlichia platys ; it usually resolves spontaneously in time.
		neonatal thrombocytopenia, neonatal alloimmune thrombocytopenia, immune thrombocytopenia that results when platelets of the fetus express an antigen that is lacking on maternal platelets; fetal platelets enter the maternal circulation and stimulate the production of antibodies, which in turn cross the placenta and destroy fetal platelets.
	www.mercksource.com /pp/us/cns/cns_hl_dorlands.jspzQzpgzEzzSzppdocszSzuszSzcommonzSzdorlandszSzdorlandzSzdmd_t_10zPzhtm (3172 words)

	Throbocytopenia (Site not responding. Last check: 2007-11-04)
		Drug-induced thrombocytopenia can be caused by any medication commercially available, but somewhat frequently by valproic acid (Depakote), gold salts, heparin (Calciparine, Liquaemin) and several other medications.
		Autoimmune thrombocytopenia associated with the first cycle of fludarabine therapy in the treatment of relapsed non-Hodgkin's lymphoma - PubMed
		B-cell depletion with rituximab as treatment for immune hemolytic anemia and chronic thrombocytopenia.
	www.lymphomation.org /side-effect-throbocytopenia.htm (709 words)

	ITP
		Examination of the blood smear is essential to
		if the thrombocytopenia is severe, even if the bleeding is negligible.
		Drug-induced thrombocytopenia: a systematic review of published case reports.
	www.medical-journals.com /r03288b.htm (1153 words)

	Thrombocytopenia - Overview (Site not responding. Last check: 2007-11-04)
		Any of the bleeding disorders that result from a lack of functional platelets.
		Platelets are cells in the blood that are essential to blood clotting.
		Thrombocytopenia includes disorders where there are not enough platelets, and disorders where the platelets do not function properly.
	www.humed.com /humc_ency/ency/article/000586.htm (150 words)

	Markedly Reduced Expression of Platelet c-mpl Receptor in Essential Thrombocythemia -- Horikawa et al. 90 (10): 4031 -- ...
		In an effort to determine the pathophysiological role of TPO-c-Mpl system in essential thrombocythemia (ET), we have examined the levels of serum TPO and the expression and function of platelet c-Mpl in 17 patients with ET.
		These results suggested that the TPO-c-Mpl system may not be directly linked to pathogenesis of ET, and that gene(s) mutated in ET may be important in regulating the levels of c- mpl gene expression in addition to the growth and differentiation of multipotential hematopoietic stem cells.
		ESSENTIAL THROMBOCYTHEMIA (ET) is a chronic myeloproliferative disorder characterized by a persistent increase in circulating platelet count and by the bone marrow hyperplasia with excessive proliferation of megakaryocytes.
	www.bloodjournal.org /cgi/content/full/90/10/4031 (6013 words)

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