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Topic: Estrone

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	Estrone - Wikipedia, the free encyclopedia (Site not responding. Last check: 2007-10-22)
		Estrone is an estrogenic hormone secreted by the ovary.
		Estrone is synthesized from androstenedione, a derivative of progesterone.
		The conversion consists of the de-methylation of C-19 and the aromaticity of the 'A' ring.
	www.peekskill.us /project/wikipedia/index.php/Estrone (126 words)

	Estrone
		This multicenter, placebo-controlled study evaluated the lowest effective daily dose of estrone sulfate (0.3, 0.625, or 1.25 mg) combined with 1000 mg elemental calcium supplementation for preventing bone loss in the immediate supplementation for preventing bone loss in the immediate postmenopausal period.
		Estrone sulfate administration (0.625 and 1.25 mg) produced significant changes in various lipid measurements at both the 6- and 12-month observation points.
		Estrone sulfate 0.625 mg daily, combined with 1000 mg elemental calcium supplementation, was the minimum effective dosage to prevent loss of spinal bone mineral density in postmenopausal women over a 12-month period.
	www.salivatest.com /store/bhrt_esterone.html (224 words)

	Estrogens from Sewage in Coastal Marine Environments
		Estrone increased with proximity to sewage effluent, was low (nondetectable in some cases) in open-ocean seawater, and appears to be relatively stable in the marine environment, making it a useful indicator of the presence of sewage effluent.
		Experiments on uptake of estrone into communities of corals revealed that estrone is removed from water in proportion to its concentration, and the proportionality constant is close to the theoretical physical maximum (2).
		Adrenal glands alter the concentration of oestradiol-17ß and its receptor in the uterus of ovariectomized ewes.
	ehp.niehs.nih.gov /members/2003/5233/5233.html (3716 words)

	Hormone Replacement Therapy (Site not responding. Last check: 2007-10-22)
		Estrone, the primary estrogenic substance in post-menopausal women is made from conversion of androstenedione and estradiol primarily in the liver.
		Both estradiol and estrone are considered to be potent estrogens and may increase the risk of breast cancer.
		While the estrone and estradiol may be considered bio-identical, the are very strong hormones and are the estrogens implicated in breast cancer.
	www.montrealpharmacy.com /English/Natural_Hormone/Benefits/Contenu.html (1372 words)

	Estradiol, Estriol, Estrone, 17-a-Methyltestosterone, Progestrone, Testosterone - (Partially Validated Method #2001)
		progesterone, and testosterone, and 280 nm for estradiol, estrone, and estriol.
		Estradiol, estrone, progesterone, and testoterone are confirmed animal carcinogens with neoplastigenic, tumorigenic, and teratogenic effects.
		Estrone is a poison by intraperitoneal and subcutaneous routes.
	www.osha.gov /dts/sltc/methods/partial/pv2001/2001.html (3137 words)

	IBL ONLINE CATALOGUE
		Estrone (E1) is produced in the adrenal glands, the ovaries and the testes.
		The estrone concentration is fluctuating during the menstrual cycle with an increase during the luteal phase.
		The estrone level is a bit higher in the morning along with that of the adrenal androgens (which is regulated by ACTH).
	www.ibl-hamburg.com /prod/db_52051_m.htm (283 words)

	Radioimmunoassay of plasma equilin and estrone in postmenopausal women after the administration of premarin -- Bhavnani ...
		Radioimmunoassay of plasma equilin and estrone in postmenopausal women after the administration of premarin -- Bhavnani et al.
		estrone appeared in the blood gradually, and maximum levels of 560 and 1400
		manner similar to the conversion of circulating estrone sulfate to estrone.
	jcem.endojournals.org /cgi/content/abstract/52/4/741 (326 words)

	Estrone Sulfate (Site not responding. Last check: 2007-10-22)
		Estrone sulfate (E1S) is one of the most important and underutilized hormone measurements.
		Oral estradiol, conjugated equine estrogens or esterified estrogens are metabolized to estrone and E1S in the intestinal mucosa and in the liver, resulting in total serum estrone levels 3-6 times higher than estradiol.
		In fact the ratio of E1S to estrone is significantly higher in breast and endometrial cancer.
	www.antibodyassay.com /testinfo/estrone_sulfate.htm (465 words)

	Cancer Spectrum: CANCERLIT® Citation (Site not responding. Last check: 2007-10-22)
		The metabolism of estrone sulfate in the female rhesus monkey.
		Thus estrone sulfate is cleared slowly and is converted to both estrone and estradiol.
		The hydrolysis of estrone sulfate to estrone is not significantly different than the conversion of estrone to estrone sulfate.
	jncicancerspectrum.oxfordjournals.org /cgi/cancerlit/8079382 (251 words)

	Serum Estriol, Estradiol, and Estrone Estradiol, and Estrone (Site not responding. Last check: 2007-10-22)
		The timing of the cycle was chosen because estradiol and estrone are known to peak between the 10th and 14th day of the cycle and the date for the estriol peak is yet unknown.
		The serum of the 26 participants that met the study criteria was analyzed to determine the concentration of estriol, estrone, and estradiol.
		The estrone and estradiol were both very low which was to be expected (1 pg/mL and 7 pg/mL respectively), but interestingly the estriol remained fairly high at 303 pg/mL, yielding a very high EQ of 37.9.
	www.thorne.com /altmedrev/fulltext/estriol4-4.html (1213 words)

	Interpretation for the Estrone Sulfate Baseline Test (Site not responding. Last check: 2007-10-22)
		Estrone sulfate is a hormone produced by the fetoplacental unit of the horse.
		Estrone sulfate rises rapidly in blood 60 to 90 days after conception and persists until parturition.
		Estrone sulfate is also produced by a cryptorchid testicle.
	diaglab.vet.cornell.edu /Intreps/estron.htm (64 words)

	Women: Estriol, the Forgotten Estrogen?, by JALVIN H. FOLLINGSTAD, MD
		Estrone, E1, is an estrogen converted from androstenedione or estradiol by biosynthesis.
		Estrone has been thought to be more carcinogenic than the more natural estradiol.
		Moreover, it has been shown that orally administered estradiol, including the micronized form, is mainly converted to estrone in the small bowel, thus making all the usual orally administered estrogens, in effect, estrone.
	www.selfgrowth.com /articles/lee19.html (1449 words)

	The New Science of Estrogen Receptors - Lesson
		Estrone can also be produced in peripheral tissues through aromatization of androstenedione, an androgen precursor produced by both the ovaries and the adrenal glands.
		Estrone: Oral administration of estrone has been proposed as a safe form of estrogen therapy because it was believed to induce less stimulation of the endometrium.
		Esterified estrogen is a mixture of sodium salts of estrogenic substances consisting primary of estrone (75%–85%) and equilin (6%–15%).
	www.uspharmacist.com /newlook/Ce/er/lesson.htm (5354 words)

	Human Growth Hormone (HGH), Testosterone, Note to Physicians: Indole-3-Carbinol (Site not responding. Last check: 2007-10-22)
		It is the 16-alpha hydroxy estrone that has been shown to be carcinogenic, in animal studies and in invitro studies.
		The "weak:" or benign estrogen is the 2-hydroxy estrone.
		Therefore there is an increase in 2-hydroxy estrone and a decrease in 16-alpha hydroxy estrone, resulting in a commensurate lowering of the risk of breast cancer.
	www.cenegenics.com /abstracts/abs1007.html (1259 words)

	Estrogen: The Test
		Estrone tests may be done to aid in the diagnosis of an ovarian tumor, Turner’s syndrome, and hypopituitarism.
		Your doctor may order an estrone or estradiol (along with other tests) if you have symptoms such as pelvic heaviness, abnormal vaginal bleeding, abnormal menstrual cycles, or if your sex organs (men’s and women’s) are developing earlier or later than normally expected.
		Care must be used in the interpretation of estrone, estradiol, and estriol levels because their levels will vary on a day-to-day basis and throughout the menstrual cycle.
	www.labtestsonline.org /understanding/analytes/estrogen/test.html (673 words)

	Biotransformation and Bioconcentration of Steroid Estrogens by Chlorella vulgaris -- Lai et al. 68 (2): 859 -- Applied ...
		The average concentration factor for estrone was ca.
		estrone in the filtrate remained relatively constant and the
		Estradiol and/or estrone biotransformation by the algae was
	aem.asm.org /cgi/content/full/68/2/859 (3152 words)

	Developmental Synergism of Steroidal Estrogens in Sex Determination (Site not responding. Last check: 2007-10-22)
		Single treatments with estrone (10, 100, 250, 400, or 1,000 ng), estradiol (75, 200, 400, 1,000, or 5,000 ng), and estriol (10, 20, 30, 50, or 1,000 ng), and a series of combinations of these hormones were used to test for synergistic interactions among natural estrogens (see Table 1).
		In this study we demonstrate that estrone, estradiol, and estriol have different dosage effects when administered individually and that certain pairs of these estrogens produce a synergistic effect on sex reversal of turtle embryos incubated at a male-producing temperature.
		Thus, a portion of the difference in potency of estriol versus estrone and estradiol in the turtle may be related to cooperative binding in response to polar compounds: estriol is more polar than estradiol, which is more polar than estrone.
	ehp.niehs.nih.gov /members/1999/107p93-97bergeron/bergeron-full.html (4491 words)

	Estrogen: Estrogen Dominance, Estrogen Cream, Low Estrogen Level, Estrogen Replacement Therapy (Site not responding. Last check: 2007-10-22)
		There are three principle forms of estrogen found in the human body: estrone, estradiol, and estriol.
		There is also a group of compounds called phytoestrogens, generally found in food and herbs, which have been shown to have "estrogen like" effects in the body.
		Estrone, produced from androstenedione, is the predominant estrogen in a woman's body after menopause.
	www.womenshealth.com /estrogens.html (680 words)

	Estradiol - Wikipedia, the free encyclopedia
		After side chain cleavage and either utilizing the delta-5 pathway or the delta-4 pathway androstenedione is the key intermediary.
		Androstendione is either converted to testosterone which in turn undergoes aromatization to estradiol, or, alternatively, androstendione is aromatized to estrone which is converted to estradiol.
		During the reproductive years most estradiol in women is produced by the granulosa cells of the ovaries by aromatization of testosterone from the theca cells, or conversion of estrone to estradiol.
	en.wikipedia.org /wiki/Estradiol (556 words)

	Characterization of an organic anion transport system in a placental cell line -- Zhou et al. 285 (5): 1103 -- AJP - ...
		that the transport of estrone sulfate is a temperature-dependent
		A: inhibition of estrone sulfate uptake by unlabeled organic anions.
		the increase of the estrone sulfate uptake in the presence of
	ajpendo.physiology.org /cgi/content/full/285/5/E1103 (3165 words)

	Abstract: Abnormal Levels of Serum Dehydroepiandrosterone, Estrone, and Estradiol in Men with Rheumatoid Arthritis: ...
		We investigated serum levels of estradiol, estrone, and the adrenal androgen dehydroepiandrosterone (DHEAS) in men with RA and evaluated the association of various disease variables with these sex hormones.
		Estrone did not correlate with any disease variable, whereas estradiol correlated strongly and positively with all measured indices of inflammation.
		The low levels of estrone and DHEAS may depend on a shift in the adrenal steroidogenesis towards the glucocorticoid pathway, whereas increased conversion of estrone to estradiol seemed to be the cause of the high estradiol levels.
	www.jrheum.com /abstracts/abstracts03/2338.html (362 words)

	World Intellectual Property Organization (Site not responding. Last check: 2007-10-22)
		Effects that may be seen from contaminating estradiol, estrone, and 2- hydroxyestradiol include estrogenic effects such as feminization, endometrial proliferation, increased risk of uterine and breast cancer, developmental effects on sexual organs, inhibition of leukopoesis, and effects on hematopoetic cells.
		Figure 4 is an expanded view of the chromatogram in Figure 3 indicating the estrone impurity.
		On the contrary, it is to be clearly understood that resort may be had to various other embodiments, modifications, and equivalents thereof which, after reading the description herein, may suggest themselves to those skilled in the art without departing from the spirit of the present invention and/or the scope of the appended claims.
	www.wipo.int /ipdl/IPDL-CIMAGES/view/pct/getbykey5?KEY=01/14405.010301&ELEMENT_SET=DECL (4655 words)

	Reference #24: Inhibition of 17B-estradiol metabolism by grapefruit juice in ovariectomized women (Site not responding. Last check: 2007-10-22)
		In an open, randomized, cross-over study the concentrations of 17B-estradiol and estrone in serum were measured over 192 hours in 8 ovariectomized women after a single oral dose intake of 2 mg micronized 17B-estradiol.
		The relationship between the AUCs for 17B-estradiol and estrone was not altered by juice intake indicating that a metabolic step after estrone, i.e.
		This study demonstrates that grapefruit juice may alter the metabolic degradation of estrogens, and increase the bioavailable amounts of 17B-estradiol and its metabolite estrone, presumably by affecting the oxidative degradation of estrogens.
	www.powernetdesign.com /grapefruit/references/ref24abstract.html (249 words)

	DIALOG Dissertation Abstracts (Site not responding. Last check: 2007-10-22)
		Corals removed estrone from the water column in a recirculating flume (initial concentrations 1000 - 2500 pg l^-1, 3.7 - 9.2 pM) at a rate proportional to concentration (rate = S[estrone]); the estimated first-order rate constant (S) was 85 x 10-6 m s^-1 (95% confidence limit ± 24 x 10^-6 m s^-1).
		Tritiated estrone was taken up by live corals about twice as fast as estrone adsorbed to coral skeletons.
		Since concentrations of dissolved estrone are 50 - 1000 pg l^-1 (0.18 - 3.7 pM) over coral reefs, uptake rates of estrogen into coral communities from the water column are 0.37 -7.3 x 106 pg estrone m^-2 day^-1 (1400 - 27000 pmol m^-2 day^-1) with estimated turnover times of 6 - 115 days.
	aslo.org /phd/dialog/200208-19.html (390 words)

	CyberHealth Weekly #1: body fat, exercise, estrone and estradiol
		We know that estrone affects muscle formation (myoblasts have estrone receptors just as osteoblasts in the bone have them), and that muscle atrophy, in parallel with bone loss, accelerates after menopause, presumably due to hormone deficiencies.
		Thus it is likely that again it was the obese women, with their higher estrone and estradiol, who had superior grip strength, not the women who were the most physically active, and who in Cauley’s study were found to have the lowest estrogen levels.
		One of Cauley’s most interesting findings was that female smokers had significantly higher levels of androstenedione, the precursor of estrone and testosterone, and yet did not show the elevated levels of estrone and testosterone that the obese women did.
	www.antiaging.com /cyberhealth/CyberHealth_1_body_fat_exercise_estrone_estradiol.html (2998 words)

	Vallet and Christenson, November 1996 (Site not responding. Last check: 2007-10-22)
		To test this hypothesis, the effect of estrone and estradiol treatment from d 30 to 60 of pregnancy or pseudopregnancy on endometrial protein secretion was investigated.
		Pregnant (P; n = 16) and pseudopregnant (PP) gilts (n = 18) received either sham treatment or estrone or estradiol implants (5 mg/d release rate; 60 d release) on d 30 of P or PP.
		Blood samples were collected on d 30, 40, 50, and 60 to measure estrone and estradiol.
	www.asas.org /jas/papers/1996/nov/nov2765abs.html (196 words)

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