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Topic: Eszopiclone

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	Eszopiclone (Lunesta): a new nonbenzodiazepine hypnotic agent
		Eszopiclone is indicated for the treatment of insomnia in patients ≥18 years of age.
		Eszopiclone is a nonbenzodiazepine hypnotic that is structurally unrelated to pyrazolopyrimidines, imidazopyridines, benzodiazepines, barbiturates, or other drugs with known hypnotic properties (6).
		Eszopiclone is not highly bound to plasma proteins; therefore, the disposition of eszopiclone is not expected to be sensitive to alterations in protein binding.
	www.sleepdex.org /eszopiclone.htm (3615 words)

	NursingCenter - Library - Journal Issue - Article
		Eszopiclone is indicated for the treatment of insomnia and has been studied in clinical trials with patients experiencing both chronic and transient insomnia.
		Eszopiclone is metabolized by oxidation and demethylation, primarily by plasma metabolites, although some metabolism occurs in the liver via CYP 3A4 and CYP 2E1 enzymes.
		Eszopiclone has not been studied in pregnant women and the drug is classified as a Pregnancy Category C. It is also unknown whether the drug is excreted in human milk.
	www.nursingcenter.com /library/JournalArticle.asp?Article_ID=601245 (1234 words)

	RemedyFind: patient ratings of Lunesta (Eszopiclone) for Depression
		Lunesta (Eszopiclone) is a sleeping medication from a newer group of non-benzodiazepine sleep aid drugs (officially a âpyrrolopyrazine derivative of the cyclopyrrolone classâ).
		Eszopiclone was approved by the U.S. FDA in December 2004 and is indicated for the treatment of patients who experience difficulty falling asleep as well as for the treatment of patients who are unable to sleep through the night (sleep maintenance difficulty).
		Eszopiclone has a longer half-life (the amount of time that it takes for one-half of the dose to be metabolized and cleared from the body) than the other non-benzo sleep aids.
	www.remedyfind.com /treatments/9/294 (675 words)

	Eszopiclone (Lunesta)
		Eszopiclone is a unique hypnotic medication approved by the FDA on December 15, 2004 for the treatment of insomnia to induce sleep and for sleep maintenance.
		Eszopiclone’s indication distinguishes it from other hypnotics, including benzodiazepines, which are indicated for short-term treatment of insomnia.
		Eszopiclone is absorbed from the intestinal tract, with peak plasma concentrations occurring one hour after administration.
	uuhsc.utah.edu /pharmacy/bulletins/eszopiclone.html (393 words)

	Eszopiclone - Wikipedia, the free encyclopedia
		Eszopiclone, available under the brand-name Lunesta, is a nonbenzodiazepine hypnotic agent, is a cyclopyrrone, which is used as a medication in treatment of insomnia.
		Eszopiclone is a nonbenzodiazepine hypnotic that is a pyrrolopyrazine derivative of the cyclopyrrolone class with a chemical structure unrelated to pyrazolopyrimidines, imidazopyridines, benzodiazepines, barbiturates, or other drugs with known hypnotic properties.
		Eszopiclone is rapidly absorbed, with a time to peak concentration (tmax) of approximately 1 hour and a terminal-phase elimination half-life (t½) of approximately 6 hours.
	en.wikipedia.org /wiki/Eszopiclone (679 words)

	eszopiclone - [Medication]
		Since eszopiclone is typically taken just prior to falling asleep for the night, this is generally not a problem.
		Eszopiclone should only be taken if you are able to get a full night's sleep (8 or more hours) before you must be active again.
		Eszopiclone is in the FDA pregnancy category C. This means that it is unknown whether eszopiclone will harm an unborn baby.
	www.peacehealth.org /kbase/multum/d05421a1.htm (1367 words)

	Lunesta Online, Description, Chemistry, Ingredients - Eszopiclone - RxList Monographs
		LUNESTA (eszopiclone) is a nonbenzodiazepine hypnotic agent that is a pyrrolopyrazine derivative of the cyclopyrrolone class.
		Eszopiclone is very slightly soluble in water, slightly soluble in ethanol, and soluble in phosphate buffer (pH 3.2).
		Eszopiclone is formulated as film-coated tablets for oral administration.
	www.rxlist.com /cgi/generic3/lunesta.htm (195 words)

	MedlinePlus Drug Information: Eszopiclone
		Eszopiclone is used to treat insomnia (difficulty falling asleep or staying asleep).
		These changes may be caused by eszopiclone or if they may be caused by physical or mental illnesses that you already have or that you develop during your treatment.
		If you did not take eszopiclone before you went to bed and you are unable to fall asleep, you may take eszopiclone if you will be able to stay in bed for at least 8 hours afterward.
	www.nlm.nih.gov /medlineplus/druginfo/medmaster/a605009.html (1014 words)

	Eszopiclone
		Eszopiclone is a nonbenzodiazepine hypnotic, pyrrolopyrazine derivative of the cyclopyrrolone class and is indicated for the short-term treatment of insomnia.
		Eszopiclone is not highly bound to plasma proteins (52-59% bound); therefore, the disposition of eszopiclone is not expected to be sensitive to alterations in protein binding.
		Administration of eszopiclone 3 mg to a patient taking another drug that is highly protein-bound would not be expected to cause an alteration in the free concentration of either drug.
	www.mongabay.com /health/medications/Eszopiclone.html (835 words)

	Eszopiclone for treatment of transient and chronic insomnia American Family Physician - Find Articles
		Eszopiclone (Lunesta), a nonbenzodiazepine hypnotic agent, is indicated for the treatment of transient and chronic insomnia.
		One study (3) analyzed the use of eszopiclone for six months in 791 adult patients with chronic insomnia (age = 21 to 69 years; 63 per-cent were women).
		Although labeled for this use, long-term, continuous use of eszopiclone should be reserved for those few patients who require nightly therapy and who are able to afford the drug and tolerate the side effects.
	www.findarticles.com /p/articles/mi_m3225/is_12_71/ai_n14730413 (761 words)

	Eszopiclone (Estorra) - Lunesta - New Drug's A Sleeper
		The pharmacology of eszopiclone is not well understood.
		Chemically, eszopiclone is a short-acting hypnotic agent that is a stereoselective isomer of the agent zopiclone.
		Lunesta is indicated for the treatment of patients who experience difficulty falling asleep as well as for the treatment of patients who are unable to sleep through the night (sleep maintenance difficulty).
	www.sleepdex.org /estorra.htm (718 words)

	Eszopiclone significantly improves sleep in elderly people with chronic insomnia (Site not responding. Last check: 2007-11-02)
		He said eszopiclone significantly reduced wakefulness after sleep had begun, wake time during the sleep period and daytime napping.
		The study compared eszopiclone with an inert placebo in patients 64 to 86 years old over a two-week period and used both measurements made in sleep laboratories and patients' own reports of their sleep activity during the study.
		The 136 patients in the eszopiclone group reported greater quality of sleep and greater depth of sleep than the 128 patients in the control group, he said.
	www.news-medical.net /?id=19061 (431 words)

	Eszopiclone Effective at Treating Menopause-Associated Insomnia: Presented at NAMS (Site not responding. Last check: 2007-11-02)
		"We found that eszopiclone was associated with significant improvement in sleep and daytime function, and we saw no evidence of rebound insomnia," he said.
		Soares and his co-investigators were interested in eszopiclone's potential because of the high prevalence of insomnia reported by women during this transitional phase.
		The investigators randomized 201 women to receive 3 mg of eszopiclone per night and 209 to placebo for the double-blind period.
	www.pslgroup.com /dg/25380e.htm (725 words)

	Eszopiclone(Systemic) - [Medication] (Site not responding. Last check: 2007-11-02)
		However, eszopiclone is not recommended during breast-feeding, because it may cause unwanted effects in nursing infants.
		Even though eszopiclone is taken at bedtime, it may cause some people to feel drowsy or less alert on arising.
		Make sure you know how you react to eszopiclone before you drive, use machines, or do anything else that could be dangerous if you are dizzy, or are not alert or able to see well.
	www.luhs.org /health/kbase/htm/mdx-/drde/5005/89/mdx-drde500589.htm (1329 words)

	Healthcare Sales & Marketing Network News: ESTORRA(TM) Data Presented at American Psychiatric Association Meeting
		An analysis of patients treated with eszopiclone 3 mg in a six-month, placebo-controlled study was performed to assess the impact of eszopiclone on wake-time after sleep onset (WASO).
		Notably, the relative reduction from baseline was similar in both subgroups, demonstrating the therapeutic effect of eszopiclone on sleep improvement parameters irrespective of the degree of baseline impairment.
		In this study, eszopiclone 2 mg and 3 mg were administered nightly and both objective PSG measures and patient-reported assessments were captured.
	salesandmarketingnetwork.com /news_release.php?ID=15567 (1433 words)

	Newly Approved Drug Therapies (877): Lunesta (eszopiclone), Sepracor
		Lunesta (eszopiclone formerly referred to as Estorra) is a nonbenzodiazepine hypnotic agent approved for the long term treatment of insomnia and sleep maintenance.
		Eszopiclone was designated as a Schedule IV controlled substance in April 2005 by the Federal Register.
		A 6-period cross-over PSG study evaluated eszopiclone doses of 1 to 3 mg, each given over a 2-day period, demonstrated effectiveness of all doses on LPS, and of 3 mg on WASO.
	www.centerwatch.com /patient/drugs/dru877.html (878 words)

	Experimental sleep drug eszopiclone helps elderly to sleep better
		The study showed the drug, called eszopiclone, significantly reduced both the amount of time it took to fall asleep and the tendency to wake up repeatedly once sleep had begun.
		When the code was broken to determine which patients were on placebo and who got the actual drug, patients treated with eszopiclone showed improvement in all measures of insomnia including falling asleep, staying asleep and total sleep time, as well as a reduction in frequency and duration of napping, he said.
		Eszopiclone is made by Sepracor Inc., a pharmaceutical company, which paid for the study.
	www.news-medical.net /?id=1281 (507 words)

	Circadiana: Lunesta
		Eszopiclone is unique in that it is the only drug used for insomnia that has been shown to be safe and effective for up to six months.
		Eszopiclone was approved by the FDA in December, 2004.
		Eszopiclone should be taken immediately before going to bed since the onset of sedation may occur as rapidly as 10 minutes.
	circadiana.blogspot.com /2005/03/lunesta.html (3934 words)

	Eszopiclone - Drugs & Vitamins - Drug Library - DrugDigest
		ESZOPICLONE (Lunesta™) is a sedative-type drug that helps to relieve insomnia (sleeplessness).
		Eszopiclone should only be taken immediately before going to sleep.
		This type of memory loss is usually not a problem since eszopiclone is taken right before bedtime.
	www.drugdigest.org /DD/DVH/Uses/0,3915,8400\|Eszopiclone,00.html (795 words)

	Sepracor - Products & Pipeline (Site not responding. Last check: 2007-11-02)
		Efficacy and safety of six-months of nightly eszopiclone in patients with primary insomnia: a second long-term placebo-controlled study (Abstract).
		Eszopiclone co-administered with fluoxetine for insomnia co-existing with Major Depressive Disorder (MDD): analysis by severity of insomnia (Abstract).
		Evaluation of eszopiclone 3 mg in the treatment of insomnia associated with the menopausal transition.
	www.sepracor.com /products/eszopiclone-abstracts.html (3090 words)

	Biocompare News - ESTORRA(TM) Phase III Data Presented At American Psychiatric Association Meeting
		The eszopiclone data presented at the APA meeting showcased the first long-term (six-month), double-blind, placebo-controlled, efficacy and safety study ever performed in patients with insomnia.
		"Eszopiclone is a promising candidate for the treatment of insomnia and the first compound to successfully complete a six-month, large-scale, double- blind, placebo-controlled, efficacy and safety study in chronic insomnia sufferers," said Andrew Krystal, M.D., Duke University Medical Center.
		"Eszopiclone led to improvement in sleep maintenance without next-day sedation, suggesting that there is potential to address the need for treatments that safely help people stay asleep throughout the night.
	news.biocompare.com /newsstory.asp?id=10693 (778 words)

	Lunesta Data Presented at 2005 American Psychiatric Association Meeting Poster Session
		Adjunctive Eszopiclone With Fluoxetine for MDD and Insomnia: Depression Effects The Phase IIIB/IV, 545-patient, double-blind, placebo-controlled, ten-week study evaluating the efficacy and safety of eszopiclone in patients with MDD and insomnia also assessed antidepressant efficacy, and the results were presented separately in the poster session.
		The effect of eszopiclone 2 mg on improvements in next-day function in this elderly population was largely explained by improvements in nighttime sleep.
		All eszopiclone doses and zolpidem were effective in reducing time to sleep onset and improving sleep efficiency when compared to those patients treated with placebo.
	www.medicalnewstoday.com /medicalnews.php?newsid=25237 (1257 words)

	Sepracor - Products & Pipeline (Site not responding. Last check: 2007-11-02)
		Eszopiclone co-administered with fluoxetine for insomnia co-existing with Major Depressive Disorder (MDD): analysis by severity of depression.
		Krystal A, Roach J. Efficacy of eszopiclone in the treatment of sleep-maintenance insomnia.
		McCall WV, Rosenberg R, Caron J. Polysomnographic evaluation of the efficacy and safety of eszopiclone in elderly patients with chronic insomnia.
	www.sepracor.com /products/eszopiclone-journals.html (681 words)

	Eszopiclone (Systemic) - MayoClinic.com
		Eszopiclone (ess-ZOP-i-klone) belongs to the group of medicines called central nervous system (CNS) depressants (medicines that make you drowsy or less alert).
		It is not known whether eszopiclone passes into human milk.
		Studies on this medicine have been done only in adult patients, and there is no specific information comparing use of eszopiclone in children with use in other age groups.
	www.mayoclinic.com /health/drug-information/DR500589 (1382 words)

	View topic - Zopiclone/Lunesta relationship
		Eszopiclone will be marketed as a prescription drug product for the short-term treatment of insomnia.
		Eszopiclone is the most active component of the racemic (R,S) zopiclone.
		In healthy human subjects, eszopiclone is rapidly absorbed with a time to peak concentration (tmax) of approximately 1 hour following oral ingestion (1-7.5 mg) and has an elimination half-life (t[frac1s2]) of approximately 6 hours.
	www.talkaboutsleep.com /message-boards/viewtopic.php?t=12373 (438 words)

	Stay Free! Daily: Medication vs. Meditation
		Eszopiclone, zaleplon, and zolpidem could also be called nonbenzodiazepine-benzodiazepines — they affect the body in a manner similar to benzodiazepines but have different chemical structures.
		Since eszopiclone and zopiclone are, for all practical purposes, the same drug, it is clear that eszopiclone is nothing special compared to sleeping pills already on the market.
		Eszopiclone will sell and taxpayers and patients will waste millions of dollars when equally effective, less expensive alternatives such generic oxazepam are available.
	blog.stayfreemagazine.org /2005/10/medication_vs_m.html (2266 words)

	Eszopiclone safe and effective in elderly patients : Epilepsy.com
		"The eszopiclone 1-mg group was not significantly different from placebo on total sleep time or any other secondary efficacy endpoint," according to the report.
		"Nightly treatment with eszopiclone 1 mg effectively induced sleep, while the 2-mg dose was effective in inducing and maintaining sleep," the researchers concluded.
		"Eszopiclone was well tolerated in elderly patients with primary insomnia, and the sleep efficacy was accompanied by significantly less napping and significantly higher ratings of daytime alertness, sense of physical well-being, and several quality-of-life parameters at the higher dose."
	www.epilepsy.com /newsfeed/pr_1123594219.html (435 words)

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