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Topic: Etanercept

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Infliximab

Monoclonal antibody

Rheumatoid arthritis

Rheumatology

	Etanercept - British Association of Dermatologists
		Etanercept is a powerful drug that has been specially designed to mimic normal human molecules, and for this reason it is classed as a “biological” drug.
		Etanercept is reserved for patients with severe psoriasis who cannot take drugs such as methotrexate, cyclosporin, or use phototherapy (see separate British Association of Dermatologists’ leaflets on these drugs, and on severe psoriasis), or who have failed to respond to those treatments.
		Etanercept has not been studied in pregnant women or nursing mothers, so we don’t know what its effects are on pregnant women or babies who are being breast fed. You should tell your doctor if you are pregnant, become pregnant, or are thinking about becoming pregnant.
	www.bad.org.uk /public/leaflets/etanercept.asp (1694 words)

	etanercept (injectable) - [Medication]
		Etanercept reduces the actions of chemicals in the body that are involved in inflammatory and immune responses.
		Etanercept is used to treat the symptoms of moderate to severe rheumatoid arthritis, polyarticular-course juvenile rheumatoid arthritis (JRA), psoriatic arthritis, ankylosing spondylitis, and psoriasis.
		Etanercept is in the FDA pregnancy category B. This means that it is not expected to be harmful to an unborn baby.
	www.peacehealth.org /kbase/multum/d04365a1.htm (1567 words)

	etanercept (Enbrel) - drug class, medical uses, medication side effects, and drug interactions by MedicineNet.com
		Etanercept reduces the signs and symptoms of rheumatoid arthritis, the arthritis of psoriasis, and ankylosing spondylitis. It prevents the progressive destruction of the joints in patients with rheumatoid arthritis and the arthritis of psoriasis.
		Etanercept also is used to reduce the signs and symptoms of moderately to severely active, polyarticular-course, juvenile rheumatoid arthritis in patients who have had an inadequate response to one or more disease-modifying medicines.
		Etanercept is not recommended for persons with preexisting disease of the central nervous system (brain and/or spinal cord) or for those with multiple sclerosis, myelitis, or optic neuritis.
	www.medicinenet.com /etanercept/article.htm (919 words)

	Howstuffworks "Etanercept: A Profile of an Arthritis Drug"
		Etanercept is used to treat the symptoms of rheumatoid arthritis, such as pain and swelling of the joints, in both adults and children.
		Etanercept is also used for a condition known as ankylosing spondylitis (a form of arthritis of the spine).
		Etanercept is given by injection under the skin (subcutaneously), twice a week.
	health.howstuffworks.com /define-etanercept.htm (1075 words)

	ACR: Enbrel (Etanercept) Effective for Psoriatic Arthritis (Site not responding. Last check: 2007-10-20)
		Psoriasis activity was measured by improvement in target lesion score, and, in a subset of patients (n=62 for placebo; n=66 for etanercept), by using the psoriasis area and severity index (PASI).
		Patients receiving etanercept demonstrated significantly greater responses in each of the parameters of disease activity compared to placebo, regardless of concomitant methotrexate use.
		Etanercept was well tolerated, with no increase in the number of serious adverse events occurring in patients receiving Enbrel as compared with those receiving placebo.
	www.pslgroup.com /dg/20D6E6.htm (551 words)

	Etanercept for rheumatoid arthritis - [Medication] - Quest Diagnostics Patient Health Library (Site not responding. Last check: 2007-10-20)
		Etanercept is given as a shot under the skin (subcutaneous injection).
		Etanercept blocks the action of TNF and reduces symptoms and slows the progression of rheumatoid arthritis.
		Etanercept should not be used by pregnant women or women of childbearing age who are not using reliable birth control.
	www.questdiagnostics.com /kbase/topic/detail/drug/aa18665/detail.htm (616 words)

	Etanercept for juvenile rheumatoid arthritis - Information and Resources
		Etanercept is used to treat moderate to severe rheumatoid arthritis symptoms and to prevent joint damage, particularly in people who have had side effects or poor results from methotrexate treatment.
		Etanercept has shown positive preliminary results as a treatment for JRA-related inflammatory eye disease when combined with methotrexate and corticosteroid eyedrops.
		Etanercept is not used to treat people with lupus or multiple sclerosis, based on rare reports of etanercept worsening these diseases.
	www.kaiserpermanente.org /kpweb/healthency.do?hwid=tn8083 (557 words)

	Clinical Trial: Etanercept for Treatment of Hidradenitis
		Etanercept has been approved by the U.S. Food and Drug Administration (FDA) for the treatment of chronic moderate to severe plaque psoriasis (PsO), for use in reducing the signs and symptoms of moderately to severely active rheumatoid arthritis (RA) in adults and children, and psoriatic arthritis (PsA) and ankylosing spondylitis (AS) in adults.
		Etanercept is approved for injection under the skin at a dose of 50 mg per week in patients with psoriasis.
		Purpose: The primary objective of this study is to determine the safety and estimate the efficacy of etanercept for the treatment of hidradenitis suppurativa.
	www.clinicaltrials.gov /ct/gui/show/NCT00107991 (1545 words)

	Benefits of Etanercept Use for Rheumatoid Arthritis - May 1, 2001 - American Academy of Family Physicians
		Etanercept is a receptor fusion protein that binds and inactivates tumor necrosis factor.
		Etanercept has been shown to reduce disease activity in children and adults with chronic rheumatoid arthritis.
		During the first six months, the number of patients in the 25-mg etanercept group who had ACR 20, 50 and 70 percent responses was significantly greater than the number in the methotrexate group.
	www.aafp.org /afp/20010501/tips/5.html (792 words)

	Etanercept effective for moderate to severe psoriasis American Family Physician - Find Articles
		Leonardi and colleagues report on the use of etanercept, a synthetic protein that binds an inflammatory signal protein, in the treatment of psoriasis.
		An improvement of at least 75 percent in a psoriasis area-and-severity index was noted in 4 percent of control patients, 14 percent of patients who received low-dosage etanercept, 34 percent of patients who received medium-dosage treatment, and 49 percent of patients who received high-dosage treatment.
		The authors conclude that etanercept is well tolerated and useful, in a dosage-responsive fashion, in the treatment of moderate to severe psoriasis.
	www.findarticles.com /p/articles/mi_m3225/is_11_69/ai_n6077881 (562 words)

	Etanercept for ankylosing spondylitis - [Medication] - Quest Diagnostics Patient Health Library (Site not responding. Last check: 2007-10-20)
		Etanercept is given as an injection under the skin.
		Etanercept is a man-made protein that blocks the action of tumor necrosis factor (TNF).
		Etanercept decreases the activity of your body's immune system, which increases the risk of a serious bacterial infection.
	www.questdiagnostics.com /kbase/topic/detail/drug/ty6853/detail.htm (435 words)

	Etanercept - Wikipedia, the free encyclopedia
		Etanercept is a recombinant human soluble tumor necrosis factor-alpha (TNFα) receptor.
		Etanercept was developed by researchers at biotechnology company Immunex, which was subsequently purchased by Amgen.
		Etanercept is made from the combination of two naturally occurring soluble human 75-kilodalton TNF receptors linked to an Fc portion of an IgG1.
	en.wikipedia.org /wiki/Etanercept (479 words)

	Etanercept for the treatment of rheumatoid arthritis.
		Etanercept (Enbrel) is a "biologic" that is prescribed to decrease pain and swelling and slow the progress of rheumatoid arthritis.
		Etanercept is a soluble tumour necrosis factor alpha-receptor DMARD for the treatment of rheumatoid arthritis (RA).
		Etanercept 25 mg SC twice weekly was more efficacious than control treatment for ACR 20, 50 and 70 at 6 months, and over 12 months it slowed joint damage.
	www.cochrane.org /reviews/en/ab004525.html (889 words)

	Etanercept - Drugs & Vitamins - Drug Library - DrugDigest
		ETANERCEPT (Enbrel®) is used for the treatment of rheumatoid arthritis in adults and children.
		Etanercept is given by injection under the skin once weekly (as a single injection or 2 injections on the same day) or twice weekly (with each injection given at least 3—4 days apart).
		Etanercept is often given in combination with other agents to treat rheumatoid arthritis such as corticosteroids, anti-inflammatory drugs, methotrexate, and others.
	www.drugdigest.org /DD/DVH/Uses/0,3915,6100\|Etanercept,00.html (807 words)

	FDA approves etanercept for treating ankylosing spondylitis (Site not responding. Last check: 2007-10-20)
		Etanercept had previously been approved for treating rheumatoid arthritis, juvenile rheumatoid arthritis, and psoriatic arthritis.
		The major efficacy trial of etanercept for AS was a randomized, double-blind, placebo-controlled study of 277 patients.
		Etanercept should not be given to patients with any active infection.
	www.pharmacist.com /articles/h_ts_0337.cfm (212 words)

	Etanercept (Enbrel®) — An Update
		Etanercept (Enbrel®, Amgen) is a recombinant human protein with anti-inflammatory properties that was the first approved treatment for psoriatic arthritis by the US FDA in January 2002.
		Etanercept is supplied as a lyophilized powder (25mg to a vial) which requires reconstitution with sterile bacteriostatic water, which is also included.
		Etanercept is well tolerated by both adult and pediatric patient populations, and long-term data on the use of etanercept have demonstrated an excellent safety profile.
	www.skintherapyletter.com /2004/9.10/1.html (2379 words)

	Etanercept (Systemic)
		Etanercept (ee-tan-NER-cept) is injected under the skin to reduce signs and symptoms of rheumatoid arthritis, such as joint swelling, pain, tiredness, and duration of morning stiffness.
		Etanercept has been tested in elderly patients and has not been found to cause different side effects or problems in older people than it does in younger adults.
		Your body's ability to fight infection may be reduced while you are being treated with etanercept, it is very important that you call your doctor at the first signs of any infection (for example, if you get a fever or chills).
	allnutritionals.com /drugs/e/etanercept-systemic.shtml (987 words)

	Arthritis Research Campaign \| Drugs for Arthritis: Etanercept (Site not responding. Last check: 2007-10-20)
		Etanercept is also used for the treatment of children with juvenile idiopathic arthritis (also known as JIA or JCA) who have not responded to methotrexate.
		Etanercept has to be given by subcutaneous injection (an injection under the skin, like insulin injections for diabetes) once or twice a week.
		As yet, the long-term side-effects of etanercept are not known because it is a relatively new drug.
	www.arc.org.uk /about_arth/infosheets/6259/6259.htm (1097 words)

	Etanercept for the Treatment of Psoriasis (Site not responding. Last check: 2007-10-20)
		Etanercept (Enbrel®, Amgen/Wyeth Pharmaceuticals) is a fusion protein with affinity for soluble tumor necrosis factor alpha (TNF-a) and has been US FDA approved for the treatment of rheumatoid arthritis (RA) since 1998.
		Etanercept has also been shown to reduce the signs and symptoms of psoriatic arthritis and has been approved in the US since June 2002 and in Canada since Jan 2004 for this indication.
		Etanercept should be considered as a treatment option in patients with both plaque psoriasis and active psoriatic arthritis.
	www.skintherapyletter.com /2006/11.1/1.html (2301 words)

	Arthritis (juvenile idiopathic) - etanercept
		Etanercept is recommended for children aged 4 to 17 years who have active JIA in at least five joints and whose condition has not responded adequately to methotrexate or who have been unable to tolerate treatment with methotrexate.
		Etanercept should be prescribed in accordance with relevant sections of the protocol that has been produced by the British Paediatric Rheumatology Group (BPRG).
		It also sets out the criteria for withdrawal of etanercept treatment, which include withdrawal of treatment if severe side effects occur, or if there is no response to treatment after 6 months.
	www.nice.org.uk /page.aspx?o=29662 (422 words)

	Etanercept (Enbrel): update on therapeutic use -- Spencer-Green 59 (Supplement 1): 46 -- Annals of the Rheumatic ...
		Improvement in the etanercept 25 mg group was seen early in the study, as shown by improvement in the DAS (fig 1).
		Improvement in the etanercept 25 mg group was significantly better than the methotrexate group over both the six and 12 month time periods (p = 0.002 and p = 0.031, respectively).
		A trial of etanercept, a recombinant tumor necrosis factor receptor:Fc fusion protein, in patients with rheumatoid arthritis receiving methotrexate.
	ard.bmj.com /cgi/content/full/59/suppl_1/i46 (2555 words)

	CLINICAL TRIAL OF ETANERCEPT FOR WEGENER’S DISEASE SHOWS NO BENEFIT AGAINST THE AUTOIMMUNE CONDITION
		Etanercept, also called Enbrel, is a common treatment for rheumatoid arthritis and other types of joint inflammation.
		Etanercept, the first of a class of drugs called tumor necrosis factor inhibitors approved by the U.S. Food and Drug Administration for the treatment of rheumatoid arthritis, is also known to be effective in psoriasis, psoriatic arthritis, and juvenile rheumatoid arthritis.
		Twenty-three patients in the etanercept group suffered severe flares during the trial, for example, compared with 25 in the comparison group.
	www.hopkinsmedicine.org /Press_releases/2005/01_27_05.html (696 words)

	Johns Hopkins Arthritis Provides Treatment Information for Rheumatoid Arthritis
		Etanercept (Enbrel™) Etanercept is a human fusion protein that combines two extracellular binding domains of the p75 form of the TNF receptor to the Fc portion of a human IgG1 antibody molecule.
		In a series of clinical trials, etanercept proved to be safe and effective in reducing the signs and symptoms of RA, as well as in slowing or halting radiographic damage, when used either as monotherapy or in combination with methotrexate.
		Etanercept is also FDA approved for the treatment of psoriatic arthritis and for ankylosing spondylitis.
	www.hopkins-arthritis.org /rheumatoid/rheum_treat.html (5948 words)

	etanercept, Primary Sclerosing Cholangitis Literature (Site not responding. Last check: 2007-10-20)
		Goldenberg G, Jorizzo JL 2005 Use of etanercept in treatment of pyoderma gangrenosum in a patient with autoimmune hepatitis.
		Ritchlin CT 2004 The efficacy of etanercept in ankylosing spondylitis.
		Weinberg JM 2003 An overview of infliximab, etanercept, efalizumab, and alefacept as biologic therapy for psoriasis.
	home.insightbb.com /~rhodesdavid/etan.htm (6868 words)

	Etanercept for rheumatoid arthritis
		TNF is produced by your body in times of inflammation and attaches to the joint surface, causing inflammation and joint damage.
		Etanercept is effective in relieving joint pain and swelling in rheumatoid arthritis that have not improved with methotrexate or other DMARDs.
		Etanercept should not be used by pregnant women or women of childbearing age who are not using reliable contraception.
	www.webmd.com /hw/rheumatoid_arthritis/aa18665.asp (544 words)

	Etanercept Injection
		Etanercept is used alone or in combination with other medications to reduce the pain and swelling associated with rheumatoid arthritis, juvenile rheumatoid arthritis, and psoriatic arthritis.
		Etanercept is in a class of medications called tumor-necrosis factor (TNF) inhibitors.
		Etanercept comes as a solution to inject subcutaneously (under the skin).
	www.safemedication.com /displaydrug.cfm?id=602013 (1213 words)

	MedlinePlus Drug Information: Etanercept Injection
		Before you use etanercept for the first time, read the manufacturer's information for the patient that comes with it.
		If it is hard for you to prepare a dose because of arthritis of the hand, you may use another method to prepare etanercept.
		Etanercept is also used sometimes to treat psoriasis and ankylosing spondylitis.
	www.nlm.nih.gov /medlineplus/druginfo/medmaster/a602013.html (1371 words)

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