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Topic: Ethylmorphine

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	arthritis pain relief - Ethylmorphine
		Ethylmorphine is a drug in the class of both opiates (representing a minor synthetic change from morphine) and opioids (being effective in the CNS's opioid reception system).
		Ethylmorphine's metabolism is hindered by ethanol [1], which, being a CNS depressant, also boosts the drug's sedative effect on the central nervous system - creating a potentially dangerous combination as both drugs cause repression of the respiratory system that can be mutually amplified.
		Ethylmorphine is used as a antitussive to treat dry cough.
	www.painreliefchat.com /arthritis-pain-relief/Ethylmorphine (419 words)

	Effects of ethanol on ethylmorphine metabolism in isolated rat hepatocytes: characterization by means of a ...
		The present study was designed to characterise the acute effects of ethanol on the metabolism of ethylmorphine and to compare it with the effects on codeine in suspensions of freshly isolated rat hepatocytes.
		Ethylmorphine, codeine and their metabolites were quantified by HPLC with UV detection.
		The ratios between reaction rate constants in the ethylmorphine experiments at 100 and 0 mM ethanol were 0.65 for ethylmorphine-->norethylmorphine, 0.63 for norethylmorphine-->normorphine, 0.56 for ethylmorphine-->morphine, 0.49 for morphine-->normorphine, 0.31 for normorphine-->normorphine-3-glucuronide and 0.49 for morphine-->morphine-3-glucuronide.
	www.medscape.com /medline/abstract/9140136 (429 words)

	22-2/C. Popa.../Morphine Formation from Ethylmorphine: Implications for... (Site not responding. Last check: 2007-10-26)
		In drugs-of-abuse testing, opiates constitute a delicate and controversial task because morphine may occur in urine for several reasons.
		Ethylmorphine (EtM), which is used as an antitussive drug in many countries, is metabolically converted to morphine.
		The present study was performed in order to document intra- and interindividual differences in morphine formation after single-dose intake of EtM at two different doses (25 and 50 mg).
	www.jatox.com /abstracts/1998/mar-apr/becmiab.htm (341 words)

	Suchmaschine (Site not responding. Last check: 2007-10-26)
		Ethylmorphine (also known as ethyl morphine) is a drug in the class of both opiates (representing a minor synthetic change from morphine) and opioids (being effective in the CNS's opioid reception system).
		Ethylmorphine's metabolism is hindered by ethanol [1], which, being a CNS depressant, also boosts the drug's sedative effect on the central nervous system - creating a potentially dangerous combination as both drugs cause depression of the respiratory system that can be mutually amplified.
		Ethylmorphine is used as an antitussive to treat dry cough.
	www.dmoz.ch /lexikon.cgi?sprache=en&q=Ethyl_morphine (555 words)

	USGBC - LEED TSAC PVC Study Database (Site not responding. Last check: 2007-10-26)
		Age related response of di(2-ethylhexyl)phthalate (DEHP) was studied by administering the plasticizer (2000 mg/kg, orally) to 3, 6 and 10 week old wistar rats for 1, 7 or 15 days and determining the activity of hepatic P450 monooxygenases.
		Single administration of DEHP decreased the cytochrome P450 contents and activity of arylhydrocarbon hydroxylase, aniline hydroxylase and ethylmorphine N-demethylase at all the age groups while repeated exposure induced them with maximum alterations occurring in 3 week old rats.
		Repeated administration for 15 days, on the other hand, caused a decrease in the cytochrome P450 content and the activity of arylhydrocarbon hydroxylase, aniline hydroxylase and ethylmorphine N-demethylase only in the 3 week old rats.
	pvc.buildinggreen.com /source.php?id=384 (150 words)

	The kinetics of ethylmorphine N-demethylation in isolated hepatocytes: the effect of drug transport and oxygen ...
		The kinetics of ethylmorphine N-demethylation in isolated hepatocytes: the effect of drug transport and oxygen concentration -- Erickson et al.
		Articles by Erickson, R. Articles by Holtzman, J. The kinetics of ethylmorphine N-demethylation in isolated hepatocytes: the effect of drug transport and oxygen concentration
		In previous studies we have observed that the Km for ethylmorphine N- demethylase was only 50 to 100 microM in the isolated hepatocyte as opposed
	jpet.aspetjournals.org /cgi/content/abstract/220/1/35 (261 words)

	Simultaneous quantification of ethylmorphine O-deethylase and N-demethylase activity by high-performance liquid ...
		Simultaneous quantification of ethylmorphine O-deethylase and N-demethylase activity by high-performance liquid chromatography.
		Jarvi EJ; Stolzenbach JC; Larson RE The N-demethylation and O-deethylation of ethylmorphine by cytochrome P-450 are simultaneously measured using high-performance liquid chromatography.
		Assay of ethylmorphine N-demethylase and O-deethylase activities in rat liver microsomes revealed close agreement between this method and conventional ones.
	www.medscape.com /medline/abstract/3711216 (227 words)

	Legal Fusion Group Ethylmorphine
		After ingestion, ethylmorphine is converted to morphine in the human liver by the CYP450-isozyme
		Ethylmorphine is 'less potent than morphine' but 'more potent than codeine'.
		Antidepressants such as fluoxetine (prozac) inhibit the enzyme that metabolizes ethylmorphine.
	www.legalfusiongroup.com /articles/e/t/h/ethylmorphine/ethylmorphine.html (344 words)

	On Target - Weekly Journal, Issue February 18, 2001 (Site not responding. Last check: 2007-10-26)
		Joseph von Mering, a physician who was to become famous for his discovery of the hypnotic barbiturates, included the drug among 18 morphine derivatives that he tested for E Merck of Darmstadt.
		von Mering was particularly impressed with ethylmorphine, a compound synthesized by Grimaux in 1881,which he found to be efficacious in the alleviation of coughs, even in patients with pulmonary tuberculosis in whom codeine had proven ineffective.
		Ethylmorphine was the first semi-synthetic morphine derivative to be introduced into the clinic and probably influenced the subsequent decision of F Bayer and Co to introduce heroin for similar clinical purposes.
	www.targethealth.com /ontarget/2001/02182001.htm (1924 words)

	SVIBOR - Papers - project code: 3-03-287
		The inhibitory effect of vaccine against Gumborodesease on the microsomal enzyme activity may be a risk forbroilers treated with liposoluble drugs of a small therapeuticindex, e.g.
		On the otherhand, spiramycin did not significantly modulate their activity.The influence of sulphadimidine on broilers was diverse:inhibition of aniline hydroxylation and induction ofN-demethylation of ethylmorphine.
		P-450,activity of N-demethylation of ethylmorphine and hydroxylation ofanilene was measured.
	www.mzos.hr /svibor/3/03/287/rad_e.htm (2023 words)

	XXXV TIAFT Annual Meeting - Poster Abstracts
		A method using gas chromatograph with electron ionization detector (GCD) for simultaneous determination of morphine, codeine, dihydrocodeine, 6-monoacetylmorphine and ethylmorphine in blood after propionic acid anhydride derivatization is described.
		The initial temperature was 150° C for 1 min and was then increased with the rate of 15° C per min to 220° C and, finally, with the rate of 10° C/min to 320° C where it was held for 1 min.
		The ions followed were m/z 357 and 284 for dihydrocodeine (RT 9.9), m/z 282 and 355 for codeine (RT 10.2), m/z 296 and 369 for ethylmorphine (RT 10.4), m/z 327 and 268 for 6-acetylmorphine (RT 11.1) as well as m/z 341 and 324 for morphine (RT 11.7).
	www.tiaft.org /tiaft97/proceedings/abstract/posters/136.html (321 words)

	News \| TimesDaily.com \| TimesDaily \| Florence, AL (Site not responding. Last check: 2007-10-26)
		Approved indication for dihydrocodeine is the management of moderate to moderately severe pain as well as coughing and shortness of breath.
		For use against pain, dihydrocodeine is usually formulated as tablets containing a quarter grain (15 or 16 mg) and a half grain (30 or 32 mg) with or without other active ingredients such as aspirin, paracetamol, ibuprofen, or others.
		It results from the slowing of peristalsis in the gut and is a reason why dihydrocodeine, ethylmorphine, codeine, opium preparations, and morphine are used to stop diarrhoea and combat Irritable Bowel Syndrome (IBS) in its diarrhoeal and cyclical forms as well as other conditions causing hypermotility and/or intestinal cramping.
	www.timesdaily.com /apps/pbcs.dll/section?category=NEWS&template=wiki&text=Dihydrocodeine (1912 words)

	Medscape MEDLINE search: Ethylmorphine
		The aim of the present study was to investigate the influence of classic and atypical neuroleptics on the activity of rat CYP2D measured as a rate of ethylmorphine O-deethylation.
		The influence of two infectious bursal disease vaccines on the activities of hepatic microsomal enzymes aniline hydroxylase, ethylmorphine N-demethylase, NADPH-cytochrome c reductase, aryl sulphotransferase and p-nitrophenol UDP-glucuronyltransferase was investigated in chickens.
		The aim of this study was to investigate the influence of tricyclic antidepressants (imipramine, amitriptyline, clomipramine, desipramine), selective serotonin reuptake inhibitors (SSRIs: fluoxetine, sertraline) and novel antidepressant drugs (mirtazapine, nefazodone) on the activity of CYP2D, measured as a rate of ethylmorphine O-deethylation.
	search.medscape.com /uslclient/searchMedline.do?queryText=Ethylmorphine (1125 words)

	No. 77/1937: DANGEROUS DRUGS (METHYLMORPHINE AND ETHYLMORPHINE) REGULATIONS, 1937.
		Every import permit under section 18 of the Act in respect of a drug shall be in the Form set out in the First Schedule to these Regulations and shall contain the particulars indicated in such Form.
		Every export permit under section 19 of the Act in respect of a drug shall be in the Form set out in the Second Schedule to these Regulations and shall contain the particulars indicated in such Form.
		A person shall not manufacture, or carry on any process in the manufacture of a drug unless he is duly licensed so to do, and in so doing complies with the terms and conditions of his licence.
	www.irishstatutebook.ie /ZZSI77Y1937.html (2062 words)

	Accelerated Stability Studies of Widely Used Pharmaceutical Substances Under Simulated Tropical Conditions: 4. ...
		Results: The spots obtained from the solution of the sample subjected to procedure A1 and the spots obtained from the reference solution of ethylmorphine hydrochloride display the same chromatographic characteristics.
		After procedure B2 additional more or less mobile spots than the main spot are revealed, indicating degradation.
		Ethylmorphine hydrochloride is subject to decomposition under accelerated degradation conditions.
	www.who.int /medicinedocs/library.fcgi?e=d-0edmweb--00-1-0--010---4----0--0-10l--1fr-5000---50-about-0---01131-0011cbMB3ocm9ee80ca70000000044c8ab49-0utfZz-8-0-0&cl=CL2.1.1&d=Jh1808e.4.45&az=A>=0&gc=1&ihs=0&l=es&az=A&p=about (247 words)

	Hepatic Organelle Interaction: II. Effect of Tricarboxylic Acid Cycle Intermediates on N-Demethylation and ...
		the metabolism of aminopyrine and ethylmorphine about 2-3-fold;
		elevated the rates of aminopyrine and ethylmorphine N-demethylation
		and ethylmorphine oxidation; the combination of succinate and NADPH
	molpharm.aspetjournals.org /cgi/content/abstract/8/3/339 (279 words)

	Dihydromorphinones from Morphine and Analogs - [www.rhodium.ws]
		The first uses immense amounts of platinum or palladium in acid solution to affect the rearrangement, the second uses a lot less catalyst, and the last one uses alcohol as solvent, in which the reaction proceeds without any acid added.
		10 grams of ethylmorphine freebase was added to 50ml water, and HCl was added until the solution was slightly acidic and all ethylmorphine had dissolved.
		5 g ethylmorphine and 0.3g of palladium fl was dissolved in alcohol and the solution was refluxed.
	www.erowid.org /archive/rhodium/chemistry/dihydromorphinones.html (985 words)

	Infotrieve Online
		The aim of this study was to identify the effects of widely used laboratory anaesthetics on cytochrome (CYP) activity in male Sprague Dawley rats in vivo.
		7-Ethoxyresorufin (EROD), 7-pentoxyresorufin (PROD), aniline and ethylmorphine were used as substrates for CYP 1A, CYP 2B, CYP 2E1 and CYP 3A, respectively.
		Urethane increased EROD (CYP 1A) activity by 40 % (p < 0.01), and hydroxylation of aniline (CYP 2E1) by 14 % in the early phase of anaesthesia and by 60 % (p < 0.01) in the later one.
	www4.infotrieve.com /newmedline/detail.asp?NameID=10445403&Session=&searchQuery=Lorenzini&count=605 (227 words)

	ExactAntigen DIONINE
		(1998) Ethylmorphine N-demethylase activity as a marker for cytochrome P450 CYP3A activity in rat hepatic microsomes Toxicol Lett 94:115-25
		(1997) Effects of ethanol on ethylmorphine metabolism in isolated rat hepatocytes: characterization by means of a multicompartmental model Pharmacol Toxicol 80:171-81
		(1997) Evidence for CYP2D1-mediated primary and secondary O-dealkylation of ethylmorphine and codeine in rat liver microsomes Biochem Pharmacol 53:603-9
	chemical.exactantigen.com /d/dionine.html (93 words)

	Statutes & Constitution :View Statutes : flsenate.gov
		Not more than 1.8 grams of dihydrocodeine per 100 milliliters or not more than 90 milligrams per dosage unit, with recognized therapeutic amounts of one or more active ingredients which are not controlled substances.
		Not more than 300 milligrams of ethylmorphine per 100 milliliters or not more than 15 milligrams per dosage unit, with one or more active, nonnarcotic ingredients in recognized therapeutic amounts.
		Not more than 50 milligrams of morphine per 100 milliliters or per 100 grams, with recognized therapeutic amounts of one or more active ingredients which are not controlled substances.
	www.flsenate.gov /statutes/index.cfm?p=2&Mode=Statutes&SubMenu=1&App_mode=Display_Statute&url=ch0893/Sec03.htm&StatuteYear=1998 (1448 words)

	relations : terminologie CISMeF
		- MeSH en anglais : A drug-metabolizing enzyme of the hepatic microsomal oxidase system which catalyzes the oxidation of the N-methyl group of ethylmorphine with the formation of formaldehyde.
		Demethylase, Ethylmorphine N; Ethylmorphine N Demethylase; N Demethylase, Ethylmorphine
		Recherche des ressources pour le motcle : ethylmorphine-n-demethylase
	www.chu-rouen.fr /terminologiecismef/php/requete.php?motAChercher=relations&motCourant=ethylmorphine-n-demethylase&Choix=typeTous&motExact=of&compteur=1 (56 words)

	ISTC - PRA
		It was found that during incubation of separate alkaloids of chelidonium (berberine, chelidonine, chelerythrine, sanquinarine and protopine) with microsomal fraction of liver rats in the presence of oxygen and NADPH2 the formation of formaldehyde was noted, which presents evidence of O- and N-demethylation of alkaloids.
		A positive correlation was shown between the activity of sanquinarine-N-demethylase and the velocity of dealkylation of ethylmorphine (cytochrome P450 3A-dependent reaction), aminopyrine (cytochrome P450 2C11-dependent reaction) and total content of cytochrome P450 in liver microsomal fraction.
		The administration of alkaloids to rats (for 10 days at doses of 5, 10 and 20mg/kg/day) caused activation of cytochrome P450-dependent liver microsomal monooxygenases.
	www.istc.ru /ISTC/sc.nsf/html/pra.htm?open&id=6028 (294 words)

	Enzymatic Therapy Medical Abstracts
		Combined adenoma/carcinoma incidence was 8/38, 30/37, 21/38, 20/37, and 10/38 in groups control with no AFB1, control with AFB1, high methione with AFB1, high choline with AFB1, and high choline and high methionine with AFB1, respectively.
		Cytochrome P450, cytochrome B5, cytochrome C, and ethylmorphine N-demethylase activities were all increased over controls, with most marked increases in the cytochrome P450 and ethylmorphine N-demethylase activities.
		The data presented here document a protective effect of dietary methyl donors on AFB1-induced hepatocarcinogenesis in mice probably acting, in part, via activation/detoxification mechanisms favoring an increased balance in detoxification of AFB1.
	www.enzy.com /abstracts/display.asp?id=5045 (262 words)

	Re: codein question: ethylmorphine VS Methylmorphine (Site not responding. Last check: 2007-10-26)
		I > had took 80mg orally, I was working in a pharmacy and I stole some, > they were little pink pills containing 1mg or 2mg.
		> > In fact ethylmorphine IS codethyline > and methylmorphine IS codeine > > they're different but approximately the same effect and strenght, even > if I think ethylmorphine seems weaker as i said before.
		But if you have the > choice between the two substance I'd advice you to stick to codeine > which is more common and has less side effects.
	www.talkaboutdrugsnetwork.com /group/alt.drugs.morphine/messages/300.html (303 words)

	Definition of ethylmorphine - Merriam-Webster Online Dictionary (Site not responding. Last check: 2007-10-26)
		Learn more about "ethylmorphine " and related topics at Britannica.com
		Find more about "ethylmorphine " instantly with Live Search
		See a map of "ethylmorphine " in the Visual Thesaurus
	www.merriam-webster.com /dictionary/ethylmorphine (41 words)

	ethylmorphine HCL and codine phosphorus [Archive] - Bluelight (Site not responding. Last check: 2007-10-26)
		Oh oh, and you might start nodding which is always an added bonus.
		Is the bottle of ethylmorphine the cough syrup Cosylan from Parke-Davis in Europe?
		When you said you "took a shot", you didn't infer injecting, did you, if you ment like a shot of liquior, take two shots next time, and if you can handle that, maybe take three.
	www.bluelight.ru /vb/archive/index.php/t-105845.html (159 words)

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