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Topic: Etoperidone

	Patent 4132791: Use of etoperidone in parkinsonism and in other extrapyramidal syndromes characterized by tremors
		The drug etoperidone is presently being used in therapy as a psychotropic agent, the main field of application being primary or secondary depressive and anxious-depressive states.
		Clonidine-induced tremors are inhibited by trazodone and etoperidone.
		Etoperidone was studied as follows: a double blind placebo controlled cross-over clinical trial was performed on a group of 10 patients (7 males and 3 females) suffering from Parkinsonism and ranging in age from 60 to 72 years (average age: 64).
	www.freepatentsonline.com /4132791.html (2120 words)

	Patent 4131675: Use of combinations of L-DOPA with trazodone and L-DOPA with etoperidone in Parkinsonism
		A combination of trazodone or etoperidone with L-DOPA is used in the treatment of Parkinsonism by oral administration to a patient.
		The effects of trazodone and etoperidone on the signs of adrenergic stimulation produced by L-DOPA were studied by considering piloerection and mydriasis which represent the most typical expressions of adrenergic stimulation.
		Trazodone and etoperidone were administered at a fixed dose of 50 mg/kg.
	www.freepatentsonline.com /4131675.html (1831 words)

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		In vitro identification of metabolic pathways and cytochrome P450 enzymes involved in the metabolism of etoperidone.
		Ten in vitro metabolites were profiled, quantified and tentatively identified after incubation with human hepatic S9 fractions.
	www.hair-loss-stop.com /ref-testosterone/testosterone-research-abs4.85.html (1526 words)

	1-(3-CHLOROPHENYL)-4-(3-CHLOROPROPYL)PIPERAZINE HCl (Site not responding. Last check: 2007-11-05)
		The piperazine ring and piperazine derivatives are important cyclic components in industrial field as raw materials for hardener of epoxy resins, corrosion inhibitors, insecticides, accelerators for rubber, urethane catalysts and antioxidants.
		An Examples of target compound from 1-(3-Chlorophenyl)-4-(3-chloropropyl) piperazine are antidepressant agents (etoperidone, nefazodone, trazodone).
		We are pleased to receive your any questions or remarks.
	www.chemicalland21.com /specialtychem/NH/1-(3-CHLOROPHENYL)-4-(3-CHLOROPROPYL)PIPERAZINE%20HCl.htm (210 words)

	't)1991 Th" Insritur" of MinJ anJ &havior, Inc Th" Journal of MinJ anJ &havior
		Blind- ability takes on added importance, in the light of recent compelling reports which estimate that up 70% of patients affected with mild medical condi- tions respond very favorably to placebo (Goleman, 1993).
		White, Kando, Park, Waternaux, and Brown (1992) retrospectively assessed the "blindability" of a clinical drug trial of etoperidone, a putative antidepressant.
		An evaluator was provided with all the drug trial data minus the outcome results.
	www.academicarmageddon.co.uk /library/cohen2.htm (6098 words)

	Le Magazine, December 2001 - Report: Mutated Hormones That Cause Cancer (Site not responding. Last check: 2007-11-05)
		I3C's potential as a chemopreventive agent was confirmed in a study funded by the National Cancer Institute where 90 different cancer preventatives were put through six different tests of cancer prevention.
		I3C was one of 8 compounds proven effective in all six assays (the other 7 were ascorbic acid, bismuththiol, esculetin, etoperidone, folic acid, hydrocortisone and tocopherol succinate).
		Another potential action of I3C against chemical cancers is its potential to keep dioxin and other chlorine chemicals out of cells.
	www.lef.org /magazine/mag2001/dec2001_report_i3c_01.html (2406 words)

	Synergistic Action of 5-HT2A Antagonists and Selective Serotonin Reuptake Inhibitors in Neuropsychiatric Disorders (Site not responding. Last check: 2007-11-05)
		In addition to the well-known 'atypical' antidepressants listed above, there are double-blind studies demonstrating antidepressant activity of other potent 5-HT antagonists as well, such as ritanserin, pipamperone, pizotifen, danitracen, and etoperidone (Matussek et al, 1976; Ansoms et al, 1977; Standal, 1977; Kern and Richter, 1985; Bersani et al, 1990).
		In contrast to the preliminary evidence that blockade of 5-HT receptors may augment the therapeutic effects of SSRIs in OCD, evidence from monotherapy with potent 5-HT antagonists in this disorder is generally negative.
		Clinical comparison of etoperidone and amitriptyline in endogenous depressive patients.
	www.nature.com /cgi-taf/dynapage.taf?file=/npp/journal/v28/n2/full/1300057a.html (8023 words)

	Thioridazine for dementia (Cochrane Review) (Site not responding. Last check: 2007-11-05)
		Thioridazine was also associated with significantly more dizziness.
		No superiority for thioridazine was shown in comparisons with etoperidone, loxapine or zuclopenthixol, except to produce fewer side effects than loxapine.
		Reviewers' conclusions: Very limited data are available to support the use of thioridazine in the treatment of dementia.
	www.mediscope.ch /cochrane-abstracts/ab000464.htm (637 words)

	CDM Volume 1 Number 3 (Site not responding. Last check: 2007-11-05)
		In this review, publications from the metabolism studies of ten compounds, seven CNS and three cardiovascular agents, from the Johnson and Johnson Corp. were reviewed.
		The seven CNS compounds are: three antipsychotic agents, mazapertine (arypiperazine analog), RWJ-46344 (arypiperidine analog) and risperidone (aryisoxazole-piperidine analog), one antidepressant, etoperidone (arypiperazine analog), one anxiolytic agent, fenobam (aryimidazole urea analog), one muscle relaxant, xilobam (pyrrolidinylidene urea analog), and one antiepileptic agent, topiramate (fructopyranose sulfamate analog).
		The three cardiovascular agents are: two arylalkylamine calcium channel blockers, bepridil and RWJ-26240, and one thioindolaminidine antianginal agent, RWJ-34130.
	www.bentham.org /cdm/cdm1-3.htm (999 words)

	CNND Biosketch: David Folks (Site not responding. Last check: 2007-11-05)
		PI: Glenn Hughes, M.D. Etoperidone: Efficacy and Safety in Depressed Geriatric Outpatients
		PI: David G. Folks, M.D. Etoperidone Geriatric Outpatient Study of Major Depression: Double-Blind Placebo Controlled Study
		PI: David G. Folks, M.D. A Study of Alprazolam in Treatment of Anxiety and Depression Associated with Coronary Bypass Surgery and its Effects on Psychosocial Outcome
	www.unmc.edu /cnnd/biosketches/folks2.htm (2068 words)

	Critical approach to antidepressant trials: Blindness protection is necessary, feasible and measurable -- EVEN et al. ...
		White et al (1992) devised an original method for the retrospective
		trial that compared placebo and low and high dosages of etoperidone.
		For each patient the data record included the initial clinical
	bjp.rcpsych.org /cgi/content/full/177/1/47?ijkey=dAdqxJUcogwNI#REF14 (2820 words)

	PsiTri - search results (Site not responding. Last check: 2007-11-05)
		Intervention: Amitriptyline; Dosage of Drug +; Etoperidone +
		1) Muller N, Schmauss M, Scherer S, Spiess-Kiefer C, Ruther E. Double blind comparison of etoperidone and amitriptyline in endogenous depressed patients..
		1) Kern U, Richter W. Clinical comparison of etoperidone and amitriptyline in endogenous depressive patients..
	psitri.stakes.fi /search?search_query=hc%3D(DEPRESSION%20ENDOGENOUS) (1338 words)

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