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Topic: Extracellular matrix

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In the News (Tue 23 Jul 19)

  Matrix - Wikipedia, the free encyclopedia
Extracellular matrix, any material part of a tissue that is not part of any cell.
Matrix (geology), the outer material of a rock consisting of larger grains embedded in a material consisting of smaller ones.
Matrix (IT), a group of data which forms the "essence" of an application.
en.wikipedia.org /wiki/Matrix   (275 words)

 Extracellular matrix - Wikipedia, the free encyclopedia
In biology, extracellular matrix (ECM) is any material part of a tissue that is not part of any cell.
Extracellular matrix is the defining feature of connective tissue.
The integrins transmit mechanical stimuli from the ECM to the cytoskeleton.
en.wikipedia.org /wiki/Extracellular_matrix   (159 words)

 Connective tissue article - Connective tissue biological tissue extracellular matrix Bone proteinaceous collagen - ...
Connective tissue is any type of biological tissue with an extensive extracellular matrix.
The extracellular matrix of cartilage is composed primarily of chondroitin sulfate.
The extracellular matrix of blood is the blood plasma, which transports dissolved nutrients, hormones, and carbon dioxide in the form of bicarbonate.
www.what-means.com /encyclopedia/Connective_tissue   (203 words)

 Rednova NEWS | Extracellular Matrix Protects Pancreatic [Beta]-Cells Against Apoptosis: Role of Short- and Long-Term ...   (Site not responding. Last check: 2007-10-08)
Disengagement from extracellular matrix (ECM) is known to prejudice islet cell survival, notably by inducing apoptosis and necrosis (4).
To determine whether the 804G matrix is able to serve as a survival ligand for primary rat pancreatic [beta]- cells, TUNEL and ELISA were performed on cells cultured on 804G matrix or on pLL (a nonspecific adhesive polymer)-coated Petri dishes.
Given that the 804G matrix stimulates the ERK cascade and that this signaling pathway is involved in the pro-survival effects of this matrix, we hypothesized that this cascade might mediate the effect of the matrix on I[kappa]B[alpha] gene expression.
www.rednova.com /modules/news/tools.php?tool=print&id=78182   (6179 words)

The extracellular matrix is involved in normal tissue function on a number of levels, including regulation of cell fate, growth and function within the tissue.
The matrix is a mediator of signals for cell proliferation and differentiation, and for apoptosis.
Thus, matrix influences on blood vessels and nerves in aging tissues of the musculoskeletal system and skin may be important to understand, as vascular and neural function change.
grants.nih.gov /grants/guide/pa-files/PA-03-167.html   (3694 words)

 Human protein: Q16610 - Extracellular matrix protein 1 precursor (Secretory component p85). EMBL Bioinformatic Harvester
This gene encodes an extracellular protein containing motifs with a cysteine pattern characteristic of the cysteine pattern of the ligand-binding "double-loop" domains of the albumin protein family.
Lipoid proteinosis maps to 1q21 and is caused by mutations in the extracellular matrix protein 1 gene (ECM1).
Extracellular matrix protein 1 gene (ECM1) mutations in lipoid proteinosis and genotype-phenotype correlation.
harvester.embl.de /harvester/Q166/Q16610.htm   (998 words)

 Extracellular matrix -- Facts, Info, and Encyclopedia article   (Site not responding. Last check: 2007-10-08)
In (The science that studies living organisms) biology, extracellular matrix (ECM) is any material part of a (A soft thin (usually translucent) paper) tissue that is not part of any cell.
Extracellular matrix is the defining feature of (Tissue of mesodermal origin consisting of e.g.
This cell-to-ECM (Abnormal union of bodily tissues; most common in the abdomen) adhesion is due to specific cell surface adhesion proteins.
www.absoluteastronomy.com /encyclopedia/e/ex/extracellular_matrix.htm   (161 words)

 Research and Reviews: Poultry and Swine, Special Circular 164-99, Skeletal Muscle Collagen Organization May Be ...
This definition implies that the extracellular matrix is a static structure with limited ability to influence tissue structure, function, development, or gene expression.
It is now known that the extracellular matrix is a dynamic structure which regulates cell behavior through the interaction of extracellular matrix molecules with each other, interaction with growth factors, and through cell-extracellular matrix signal transduction pathways.
In nanomelia, the aggrecan proteoglycan is absent from the cartilage extracellular matrix.
ohioline.osu.edu /sc164/sc164_3.html   (2382 words)

Observations of extracellular structures and intracellular events involved in their biogenesis are limited by relatively poor preservation with traditional TEM chemical fixation protocols, artifacts produced during fixation, dehydration and critical point drying (CPD) for SEM, and resolution limitations (Edgar and Pickett-Heaps 1982, Rosowski et al.
Wustman, B.A., Gretz, M.R. and Hoagland, K.D. Extracellular matrix assembly in diatoms (Bacillariophyceae).
Extracellular mucilage (arrowhead) appeared in the raphe (R) canal and was closely associated with the diatotepum (DL).
www.bio.mtu.edu /~mrgretz/www/publications/ecm_assy4.htm   (6091 words)

 Extracellular Matrix Components   (Site not responding. Last check: 2007-10-08)
The lateral matrix components are present on the lateral borders of cells, bind together homotypic cells, and consists of cell adhesion molecules (CAMs) and proteoglycans.
The basal matrix is present on the basal surfaces of cells and binds together heterotypic cells such as epithelia to mesenchymal cells.
When it is not known which extracellular matrix component is needed for specific cells or functions, extracts enriched in extracellular matrix are prepared from the specified tissues.
www.med.unc.edu /~cgibd/Extracellular.html   (790 words)

 Encyclopedia: Extracellular matrix   (Site not responding. Last check: 2007-10-08)
Connective tissue is any type of biological tissue with an extensive extracellular matrix and often serves to support, bind together, and protect organs.
Schematic of cell adhesion The study of cell adhesion is part of cell biology.
Cell Adhesion Molecules (CAMs) are proteins located on the cell surface involved with the binding with other cells or with the extracellular matrix (ECM) in the process called cell adhesion.
www.nationmaster.com /encyclopedia/Extracellular-matrix   (406 words)

 ARS | Publication request: Melanin in the Extracellular Matrix of Germlings of Botrytis Cinerea
This paper reports that one component of the extracellular matrix (a sort of fungal glue) secreted by the fungus is a dark pigment called melanin.
We conclude that melanin is an important component of the extracellular matrix of germlings of B. cinerea.
This is the first report of a melanin present in the extracellular matrix of a plant pathogenic fungus.
ars.usda.gov /research/publications/Publications.htm?seq_no_115=152118   (269 words)

 GEArray Q Series Human Extracellular Matrix & Adhesion Molecules Gene Array
The GEArray Q Series Human Extracellular Matrix and Adhesion Molecules Gene Array contains 96 genes encoding proteins important for the attachment of cells to their surroundings.
These proteins play key roles in mediating cell-cell, cell-tissue and cell-extracellular matrix interactions and are involved in the normal processes of cell growth, division, differentiation, migration, as well as apoptosis.
Matrix Metalloproteinases: ADAMTS1 (Meth 1), ADAMTS8 (Meth 2), MMP1 (collagenase-1), MMP2 (gelatinase A), MMP3 (stromelysin-1), MMP7 (matrilysin), MMP8 (neutrophil collagenase), MMP9 (gelatinase B), MMP10 (stromelysin-2), MMP11 (stromelysin-3), MMP12 (macrophage elastase), MMP13 (collagenase-3), MMP14 (MT1-MMP), MMP15, MMP16, MMP17, MMP20 (enamelysin), MMP24, MMP26.
www.superarray.com /gene_array_product/HTML/HS-010.html   (523 words)

The extracellular matrix (ECM) is a complex structural entity surrounding and supporting cells that are found within mammalian tissues.
Following completion of processing the procollagens are secreted into the extracellular space where extracellular enzymes remove the pro-domains.
fibrillin, which is an integral constituent of the non-collagenous microfibrils of the extracellular matrix.
web.indstate.edu /thcme/mwking/extracellularmatrix.html   (782 words)

 Developmental Biology Online: Building the Egg's Extracellular Matrix
Fertilization not only activates the egg and provides a new assortment of genes for the developing organism, it also provides the embryo with an extracellular matrix that is extremely important in coordinating cell stability and migration during cleavage and gastrulation.
This extracellular matrix is sometimes called the hyaline layer.
The sea urchin extracellular matrix is not a simple structure, either.
www.devbio.com /article.php?ch=7&id=73   (515 words)

 Developmental Biology Online: The Specificity of the Extracellular Matrix
Before the molecular analysis of the migratory pathway of the neural crest cells was possible, a series of ingenious experiments demonstrated that the extracellular matrix regulated neural crest cell migration.Some of the best evidence for the importance of extracellular matrices in directing neural crest cell migration comes from studies of mutant salamanders.
Microcarriers containing extracellular matrix material from mutant embryos likewise did not stimulate neural crest cell migration in either mutant or wild-type embryos (Figure 2C, D).
The microcarriers containing wild-type extracellular matrix, however, were able to stimulate neural crest migration from both the mutant and wild-type crests (Figure 2E, F), demonstrating the importance of the extracellular matrix in neural crest cell migration.
www.devbio.com /article.php?ch=13&id=132   (440 words)

 Basic Sciences - Extracellular Matrix Pathology
The research goal of the Extracellular Matrix Pathology Section, LP, CCR, NCI is to further our understanding of the mechanisms of cell-extracellular matrix interactions which regulate cell behavior during tumor progression and angiogenesis.
These processes require remodeling of the extracellular matrix that occurs in a spatially and temporally controlled fashion.
All TIMP family members are secreted into the extracellular milieu and have a similar size core protein of 182-194 amino acids with 12 cysteine residues that form six intramolecular disulfides.
home.ncifcrf.gov /ccr/lop/Research/extracellular   (1566 words)

 Hydrogel thin film containing extracellular matrix components (US20020086423A1)
The thin film of the invention comprises a hydrate of a vitrified gel containing an extracellular matrix components, which can be integrated with a retainer as required.
A hydrogel thin film containing an extracellular matrix components such as thin-film collagen hydrogel thin film, which is useful for a cell culture substratum and for preventing organ adhesion, can be easily prepared, and is excellent in expediency.
A hydrogel thin film containing an extracellular matrix components, which is a thin film comprising a hydrate of a vitrified matrix gel containing an extracellular matrix components.
www.delphion.com /details?pn=US22086423A1   (154 words)

 Extracellular matrix
So, selection of the appropriate matrix for experiments using cultured cells is crucial, as it can profoundly affect the cellular response.
Matrix metalloproteinases: a tail of a frog that became a prince.
Wight, T.N. Versican: a versatile extracellular matrix proteoglycan in cell biology.
ipmc.epfl.ch /page53083.html   (369 words)

 [No title]
Studies on the components of the extracellular matrix have expanded recently and greatly increased our understanding of their biological functions and roles in development and in disease.
The description of extracellular matrix component receptors is far from complete, but worthy of a progress report since much is already known.
Extracellular Matrix and Bone Morphogenetic Proteins in Cartilage and Bone Development and Repair (S.Vukicevic, W.M. Paralkar, and A.H. Reddi).
www.shop.com /op/aprod-p20748940   (365 words)

 Comparison of IgG diffusion and extracellular matrix composition in rhabdomyosarcomas grown in mice versus in vitro as ...
The tumour extracellular matrix acts as a barrier to the delivery of therapeutic agents.
To test the hypothesis that extracellular matrix composition governs the penetration rate of macromolecules in tumour tissue, we measured the diffusion coefficient of nonspecific IgG in three rhabdomyosarcoma subclones growing as multicellular spheroids in vitro or as subcutaneous tumours in dorsal windows in vivo.
Penetration of therapeutic macromolecules through tumour extracellular matrix might thus be largely determined by the host organ.
www.nature.com /bjc/journal/v86/n10/abs/6600270a.html   (268 words)

 ASIP Symposium: Extracellular Matrix and Signalling   (Site not responding. Last check: 2007-10-08)
Description: Extracellular matrix exerts profound effects on tissue homeostasis and regulates the ability of cells to migrate, proliferate and generate an angiogenic response.
Dr. Bissell will discuss the central role of extracellular matrix and integrins in the control of cell proliferation, apoptosis and cancer.
These three renowned experts will address important biological questions related to novel aspects of extracellular matrix and to the molecular mechanisms regulating how cells respond to changes in the outside environment.
asip.uthscsa.edu /EB99/TUE_AM.html   (170 words)

 Stimulation of extracellular matrix remodeling by the first type III repeat in fibronectin -- Klein et al. 116 (22): ...
Stimulation of extracellular matrix remodeling by the first type III repeat in fibronectin -- Klein et al.
Stimulation of extracellular matrix remodeling by the first type III repeat in fibronectin
the matrix was not dependent on heparan sulfate proteoglycans.
jcs.biologists.org /cgi/content/abstract/116/22/4663   (394 words)

 The Extracellular Matrix
Fibrous and binding connective tissue is derived from cells called fibroblasts, which secrete the extracellular matrix.
The extracellular matrix of cartilage and bone is secreted by specialized cells derived from fibroblasts:
Most normal vertebrate cells cannot survive unless they are anchored to the extracellular matrix.
users.rcn.com /jkimball.ma.ultranet/BiologyPages/E/ECM.html   (752 words)

 Pseudomonas aeruginosa Binds to Extracellular Matrix Deposited by Human Corneal Epithelial Cells -- Esco et al. 43 ...
Pseudomonas aeruginosa Binds to Extracellular Matrix Deposited by Human Corneal Epithelial Cells -- Esco et al.
To measure the effect of extracellular matrix substrate,
of strain 19660 bacteria bound to extracellular matrix substrates
www.iovs.org /cgi/content/abstract/43/12/3654   (321 words)

 Extracellular Matrix (BIOE464)
There will be an emphasis on cells and cell-matrix interactions, matrix distributions in connective tissues and organs, techniques for measurement and modeling, changes with growth and aging, and tissue/matrix degradation including enzyme kinetics.
Extracellular matrix is barely covered in bioscience courses such as cell biology and biochemistry courses, although bioengineers may learn about it in their biomechanics and tissue engineering classes.
I also spent several days covering biochemical assays and techniques that can be used to quantify or identify extracellular matrix.
www.ruf.rice.edu /~bioewhit/courses/bioe464/home.html   (502 words)

 The Role of the Extracellular Matrix in Cancer
Normal breast cells organized in three dimension (left), breast tumor cells unable to form organized tissue-like structure (middle), reversion of tumor cells to near normal appearance by extracellular matrix (right).
The extracellular matrix (ECM), the network of proteins surrounding cells in the body, long was believed to function mainly as inert scaffolding for tissue.
Lelièvre, SA, V. M Weaver, J. Nickerson, C. Larabell, A. Bhaumik, O. Petersen and M. Bissell, "Tissue phenotype depends on reciprocal interactions between the extracellular matrix and the structural organization of the nucleus," Proc.
www.er.doe.gov /Sub/Accomplishments/Decades_Discovery/85.html   (489 words)

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