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| | 1.2.1 Fluid exudate |
 | | In the interstitial area, high-molecular proteins may be split into smaller fragments that participate in the raising of osmotic pressure of interstitial fluid. |
 | | In the fluid exudate, all components of plasma, including fibrinogen, kinins, complement, immunoglobulins etc., are present. |
 | | Actually, the pain is observed before the occurrence of greater edema, since also other factors such as the acidic pH of exudate, the accumulation of potassium ions and the presence of bradykinin, serotonin or other mediators take part in this process. |
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