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Topic: FAS ligand

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	FAS ligand - Wikipedia, the free encyclopedia
		The FAS ligand is a type II transmembrane protein that belongs to the tumor necrosis factor (TNF) family.
		FAS is a protein which may bind to the surface of a cell possibly leading to apoptosis, or cell death.
		Germline mutation of Fas is asociated with Autoimmune Lymphoproliferative Syndrome (ALPS) (OMIM #601859), a childhood disorder of apoptosis.
	en.wikipedia.org /wiki/FAS_ligand (121 words)

	Prognostic significance of Fas and Fas ligand expressions in human esophageal cancer.
		Strong Fas expression was correlated with depth of invasion (40.3% in pT1,T2 versus 20.5% in pT3,T4; P = 0.0308), histological differentiation (45.7% in well versus 25.4% in nonwell; P = 0.0347), and lymph node metastasis (22.6% in positive versus 45.5% in negative; P = 0.0129).
		Fas expression was one of the independent favorable prognosticators for patients' survival (risk ratio, 3.26; P = 0.0103) in esophageal SCC.
		Fas expression was an independent prognosticator for recurrence-free survival, whereas FasL expression did not influence the survival in esophageal squamous cell carcinoma.
	www.aegis.com /aidsline/2000/jan/A0010902.html (520 words)

	The status of Fas and Fas ligand expression can predict recurrence of hepatocellular carcinoma (Site not responding. Last check: 2007-11-02)
		The status of Fas and Fas ligand (Fas L) expression was investigated in this study for 103 hepatocellular carcinomas (HCC).
		Fas L expression in carcinoma cells was observed exclusively in moderately or poorly differentiated cases.
		These results suggest that the evaluation of Fas and Fas ligand expression potentially has a significant prognostic value for DFS of HCC patients, in addition to the clinical stage, and can be regarded as a new prognostic marker.
	www.nature.com /bjc/journal/v82/n6/abs/6691065a.html (268 words)

	CD95 (FAS) & FAS-L antibodies from RDI Divison of Fitzgerald Industries Intl
		Fas appears to be a cell surface apotosis signalling molecule which is expressed in a number of different cell types.
		Activity: Reacts with Fas Ligand (FAS-L), a 40 KD type II integral membrane protein, homologous with tumor necrosis factor (TNF) and expressed on activated T and NK cells.HUman FASL is released from a 40Kd molecule as a 26KD soluble protein from transfectant cells or activated T cells by matrix metalloproteinases (MMPs).
		Fas L is a tyep II transmembrane protein which binds to its counter- receptor CD95 (FAS) and is speculated to participate in regulation of a variety of immunological responses and lymphocyte development.
	www.researchd.com /rdicdabs/cd95.htm (1819 words)

	Gastric cancer cell lines lack Fas ligand (FasL) expression but kill T cells via a FasL independent pathway • Reply -- ...
		The Fas counterattack in vivo: apoptotic depletion of tumor-infiltrating lymphocytes associated with Fas ligand expression by human esophageal carcinoma.
		Fas ligand is expressed by human gastric adenocarcinomas: a potential mechanism of immune escape in stomach cancer.
		Fas ligand expression in primary colon adenocarcinomas: evidence that the Fas counterattack is a prevalent mechanism of immune evasion in human colon cancer.
	gut.bmjjournals.com /cgi/content/full/46/5/738 (1857 words)

	Fas Ligand peptide (ab2441) datasheet
		If Fas Ligand peptide (ab2441) does not perform as described on this datasheet, notify us within 90 days of delivery using this form, so that we can help you or offer you a replacement or a refund.
		Fas gene mutations have been suggested to have a role in testicular germ cell tumours.
		Fas and Fas ligand: expression and soluble circulating levels in cutaneous malignant melanoma.
	www.abcam.com /?datasheet=2441 (487 words)

	Fas and Fas ligand expression in cystic fibrosis airway epithelium -- Durieu et al. 54 (12): 1093 -- Thorax
		Fas and Fas ligand expression in cystic fibrosis airway epithelium -- Durieu et al.
		Apoptosis, proliferation, and expression of Bcl-2, Fas and Fas ligand in bronchial biopsies from asthmatics.
		Involvement of Fas and Fas-ligand in cystic fibrosis.
	thorax.bmjjournals.com /cgi/content/full/54/12/1093 (3322 words)

	Fas and Fas Ligand Expression in Maternal Blood and in Umbilical Cord Blood in Preeclampsia -- KUNTZ et al. 50 (6): 743 ... (Site not responding. Last check: 2007-11-02)
		The Fas-Fas ligand (FasL) pathway of apoptosis is abnormally
		Hunt JS, Vassmer D, Ferguson TA, Miller L 1997 Fas ligand is positioned in mouse uterus and placenta to prevent trafficking of activated leukocytes between the mother and the conceptus.
		Kauma SW, Huff TF, Hayes N, Nilkaeo A 1999 Placental Fas ligand expression is a mechanism for maternal immune tolerance to the fetus.
	www.pedresearch.org /cgi/content/full/50/6/743 (4577 words)

	Fas and Fas ligand in gut and liver -- Pinkoski et al. 278 (3): 354 -- AJP - Gastrointestinal and Liver Physiology
		Fas and Fas ligand in embryos and adult mice: ligand expression in several immune-privileged tissues and coexpression in adult tissues characterized by apoptotic cell turnover.
		Fas ligand is constitutively secreted by prostate cancer cells in vitro.
		Fas ligand is present in tumors of the Ewing's sarcoma family and is cleaved into a soluble form by a metalloproteinase.
	ajpgi.physiology.org /cgi/content/full/278/3/G354 (7295 words)

	Macular degeneration: Researchers find Fas ligand is important in blinding disease
		The interaction between Fas and FasL is involved in preventing growth of blood vessels that interfere with vision in the "wet" form of age-related macular degeneration.
		When Fas molecules encounter FasL on the surface of cells in the eye, the activated immune cells are destroyed through programmed cell death.
		Already understood as key to immune system responses, the interaction of Fas and FasL in new vessel formation could be important in understanding other diseases where blood vessel formation is a problem.
	record.wustl.edu /archive/1999/03-11-99/articles/fas.html (993 words)

	Expression of Fas/Fas Ligand by Decidual Leukocytes in Hydatidiform Mole -- Wongweragiat et al. 64 (3): 784 -- Biology ...
		Expression of Fas/Fas Ligand by Decidual Leukocytes in Hydatidiform Mole
		Fas and FasL expression remains to be established.
		Kauma SW, Huff TF, Hayes N, Nikaeo A. Placental Fas ligand expression is a mechanism for maternal immune tolerance to the fetus.
	www.biolreprod.org /cgi/content/full/64/3/784 (3170 words)

	Fas and Fas Ligand Are Up-Regulated in Pulmonary Edema Fluid and Lung Tissue of Patients with Acute Lung Injury and the ...
		Fas and Fas Ligand Are Up-Regulated in Pulmonary Edema Fluid and Lung Tissue of Patients with Acute Lung Injury and the Acute Respiratory Distress Syndrome -- Albertine et al.
		Fas and Fas Ligand Are Up-Regulated in Pulmonary Edema Fluid and Lung Tissue of Patients with Acute Lung Injury and the Acute Respiratory Distress Syndrome
		Immunofluorescence co-localization of Fas or FasL protein (both are green) with epithelial cell markers (red) in lung tissue sections from patients.
	ajp.amjpathol.org /cgi/content/full/161/5/1783 (8005 words)

	Soluble Fas and Fas ligand in human tear fluid after photorefractive keratectomy -- Tuominen et al. 83 (12): 1360 -- ... (Site not responding. Last check: 2007-11-02)
		Tumour necrosis factor ligand superfamily: involvement in the pathology of malignant lymphomas.
		Molecular cloning and expression of the Fas ligand, a novel member of the tumour necrosis factor family.
		Expression of the Fas ligand in cells of T cell lineage.
	bjo.bmjjournals.com /cgi/content/full/83/12/1360 (2464 words)

	Functional Fas-ligand expression on T cells from HIV-1-infected patients is unrelated to CD4+ lymphopenia.
		Recent studies have demonstrated that the expression of Fas by peripheral T cells from HIV-1+ patients is deregulated and increases the susceptibility of these cells to undergo apoptosis.
		Since CD4+ cells of Th1 phenotype are impaired during HIV-1 infection and show high cellular expression of Fas-L, it is conceivable that excess Fas-L during the early or non-lymphopenic phase of the disease increases the extent of apoptosis in these cells by the Fas/Fas-L pathway.
		The defective expression of the ligand in severely lymphopenic stages could be explained by exhaustion of this mechanism as the disease progresses.
	www.aegis.com /aidsline/1999/may/A9950393.html (533 words)

	Membrane Fas Ligand Kills Human Peripheral Blood T Lymphocytes, and Soluble Fas Ligand Blocks the Killing -- Suda et ...
		Oligomerization of Soluble Fas Antigen Induces Its Cytotoxicity
		Expression and Regulation of Fas and Fas Ligand on Thyrocytes and Infiltrating Cells During Induction and Resolution of Granulomatous Experimental Autoimmune Thyroiditis
		Fas and Fas ligand in gut and liver
	www.jem.org /cgi/content/abstract/186/12/2045 (2767 words)

	Accelerated Rejection of FAS Ligand-Expressing Heart Grafts -- Takeuchi et al. 162 (1): 518 -- The Journal of Immunology
		Fas is a type I membrane protein, a member of the TNF receptor
		Fas and Fas ligand: lpr and gld mutations.
		Endothelial Overexpression of Fas Ligand Decreases Atherosclerosis in Apolipoprotein E-Deficient Mice
	www.jimmunol.org /cgi/content/full/162/1/518 (2968 words)

	Involvement of the Fas/Fas Ligand Pathway in Activation-Induced Cell Death of Mycobacteria-Reactive Human ...
		Involvement of the Fas/Fas Ligand Pathway in Activation-Induced Cell Death of Mycobacteria-Reactive Human {gamma}{delta} T Cells: A Mechanism for the Loss of {gamma}{delta} T Cells in Patients with Pulmonary Tuberculosis -- Li et al.
		Percentages of cell populations are calculated from the total viable lymphocytes by gating according to size (forward scatter) and granularity (side scatter) and from the level of staining with isotype-matched control Abs (open plots on histograms).
		Fas ligand mediates activation-induced cell death in human T lymphocytes.
	www.jimmunol.org /cgi/content/full/161/3/1558 (6010 words)

	Fas ligand is targeted to secretory lysosomes via a proline-rich domain in its cytoplasmic tail -- Blott et al. 114 ...
		Fas ligand is targeted to secretory lysosomes via a proline-rich domain in its cytoplasmic tail -- Blott et al.
		Fas ligand is targeted to secretory lysosomes via a proline-rich domain in its cytoplasmic tail
		Fas ligand is localized to membrane rafts, where it displays increased cell death-inducing activity
	jcs.biologists.org /cgi/content/abstract/114/13/2405 (605 words)

	PREVENTION OF ALLOGRAFT REJECTION
		Testis grafts from mice that expressed functional CD95 ligand survived indefinitely when transplanted under the kidney capsule of allogeneic animals, whereas testis grafts derived from mutant gld mice, which express non-functional ligand, were rejected.
		For gaining additional proof that Fas-Fas ligand interaction is involved in the rejection, the authors conducted further experimentation.
		Fas ligand-induced apoptosis as a mechanism of immune privilege.
	bioscience.org /news/scientis/diabete1.htm (482 words)

	The Cardiac Fas (APO-1/CD95) Receptor/Fas Ligand System : Relation to Diastolic Wall Stress in Volume-Overload ...
		Fas (APO-1/CD95) is a transmembrane receptor belonging to
		Fas was used as the primary antibody (FAS-M20, Santa Cruz).
		Fas mRNA expression normalized to 18S in LV myocardium from control rats and rats with volume-overload hypertrophy (A).
	circ.ahajournals.org /cgi/content/full/101/10/1172 (4624 words)

	Prognostic Significance of Fas and Fas Ligand Expressions in Human Esophageal Cancer -- Shibakita et al. 5 (9): 2464 -- ...
		Fas expression was observed in the outer layers in superficial tumors (C) and was located near the center of the tumor nest in more advanced tumors (D).
		Fas expression was predominant in the outer layers of the superficial
		One- and 5-year survival rates for patients with strong Fas expression were 91.1 and 81.2%, respectively, whereas those with weak Fas expression were 62.1 and 38.1%, respectively (log-rank test, P = 0.0001).
	clincancerres.aacrjournals.org /cgi/content/full/5/9/2464 (3481 words)

	Opposing Effects of Transmembrane and Soluble Fas Ligand Expression on Inflammation and Tumor Cell Survival -- Hohlbaum ...
		Opposing Effects of Transmembrane and Soluble Fas Ligand Expression on Inflammation and Tumor Cell Survival -- Hohlbaum et al.
		Opposing Effects of Transmembrane and Soluble Fas Ligand Expression on Inflammation and Tumor Cell Survival
		BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth.
	www.jem.org /cgi/content/full/191/7/1209 (6876 words)

	SBH Sciences - Fas Ligand (Site not responding. Last check: 2007-11-02)
		Our soluble Fas Ligand (sFasL) corresponding to the entire extracellular domain of Fas Ligand (FasL) was found to induce significant levels of apoptosis in the absence of any cross-linking.
		Initial clinical evidence suggests the importance of soluble Fas Ligand as a novel biological predictor of the following diseases.
		SBH Sciences is looking for partners to investigate SBH Sciences fully functional soluble Fas Ligand as therapeutic agent as well as diagnostic tool.
	www.sbhsciences.com /fasligand.asp (387 words)

	Cloning and Expression of a Short Fas Ligand: A New Alternatively Spliced Product of the Mouse Fas Ligand Gene -- ...
		Lynch DH, Ramsdell F, Alderson MR: Fas and FasL in the homeostatic regulation of immune responses.
		Gruss HJ, Dower SK: Tumor necrosis factor ligand superfamily: Involvement in the pathology of malignant lymphomas.
		Yang Y, Mercep M, Ware CF, Ashwell JD: Fas and activation-induced Fas ligand mediate apoptosis of T cell hybridomas: Inhibition of Fas ligand expression by retinoic acid and glucocorticoids.
	www.bloodjournal.org /cgi/content/full/94/10/3456 (5759 words)

	SBH Sciences - Fas Ligand Scientific Background
		Fas Ligand (FasL) has been shown to mediate both apoptotic and inflammatory reactions.
		When FasL binds to Fas, it oligomerizes the trimeric receptor that results in the recruitment of the death-inducing signal complex.
		Considerable confusion exists in the literature as to the relative importance of the membrane and soluble form of FasL on the proinflammatory effects of this molecule.
	www.sbhsciences.com /fasligand_background.asp (271 words)

	CHEST: Soluble Form of Fas and Fas Ligand in BAL Fluid From Patients With Pulmonary Fibrosis and Bronchiolitis ... (Site not responding. Last check: 2007-11-02)
		In this study, we hypothesized that soluble form of Fas (sFas) and FasL (sFasL) may also be associated with this disorder.
		Molecular cloning and nucleotide sequence analysis have revealed a human Fas messenger RNA variant that encodes a soluble Fas (sFas) molecule lacking the transmembrane domain because of the deletion of an exon encoding this region.[10] sFas blocks apoptosis in cells by inhibiting the binding of FasL to Fas on the cell membrane.[10,11]
		We previously demonstrated that the expression of Fas was upregulated in bronchiolar and alveolar epithelial cells and that FasL protein was upregulated mainly in infiltrating T lymphocytes in lung tissues from patients with IPF.[14] Therefore, we hypothesized that Fas-FasL pathway may be involved in the pathogenesis of IPF.
	www.findarticles.com /p/articles/mi_m0984/is_2_118/ai_65013870 (942 words)

	Role of Fas Ligand and Receptor in the Mechanism of T-Cell Depletion in Acquired Immunodeficiency Syndrome: Effect on ...
		A number of investigators have recently reported increased expression of the Fas receptor in individuals with HIV infection, along with increased sensitivity of their lymphocytes to anti-Fas antibody mimicking Fas ligand.
		Expression of the Fas ligand is also needed to induce apoptotic cell death in lymphocytes via the Fas pathway.
		We observed that the Fas ligand was produced in much greater quantities in lymphocytes from HIV-1-infected patients than in normal controls.
	www.bloodjournal.org /cgi/content/full/89/4/1357 (6054 words)

	The Cardiac Fas (APO-1/CD95) Receptor/Fas Ligand System : Relation to Diastolic Wall Stress in Volume-Overload ...
		Fas was expressed on the sarcolemma of cardiomyocytes in left ventricular
		of Fas and the presence of FasL in the myocardium.
		Fas pathway is a critical mediator of cardiac myocyte death and MI during ischemia-reperfusion in vivo
	circ.ahajournals.org /cgi/content/abstract/101/10/1172 (1167 words)

	Gene transfer of Fas ligand induces tumor regression vivo -- Arai et al. 94 (25): 13862 -- Proceedings of the National ...
		Gene transfer of Fas ligand induces tumor regression vivo -- Arai et al.
		Fas Ligand on Tumor Cells Mediates Inactivation of Neutrophils
		Expression of Fas ligand by human gastric adenocarcinomas: a potential mechanism of immune escape in stomach cancer
	www.pnas.org /cgi/content/abstract/94/25/13862 (1714 words)

	Fas Ligand (FASL) Antibodies and Positive Control,
		Apoptosis occurs not only during programmed cell death, but also during the death process induced by some cytotoxic T cells.
		A protein ligand, FASL, was identified that triggers cell death by binding to the cell surface receptor variously known as FAS or APT1 family of receptors that includes the 2 tumor necrosis factor (TNF) receptors.
		The FAS antigen is expressed not only in the cells of the immune system but also in the liver, lung, ovary, and heart, where its function is unclear.
	www.4adi.com /data/apoptosis/fasl11.html (607 words)

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