
	Where results make sense

Topic: FOXP3

In the News (Tue 2 Dec 08)

Damian Green

Sumner Redstone

Crimson Tide

Tommy Tuberville

Bill Clinton

Wayne Rooney

Vilasrao Deshmukh

Wake Forest

Grand Slam

Oklahoma State

	IPEX and the role of FOXP3 in the development and function of human Tregs -- Le Bras and Geha 116 (6): 1473 -- Journal ...
		Ectopic expression of Foxp3 in vitro and in vivo is sufficient
		Tregs are absent in Scurfy mice and in mice with disruption
		Allergic dysregulation and hyperimmunoglobulinemia E in Foxp3 mutant mice.
	www.jci.org /cgi/content/full/116/6/1473 (1554 words)

	FOXP3 - Wikipedia, the free encyclopedia
		Foxp3 is a member of the forkhead/winged-helix family of transcriptional regulators and functions as the master regulator in the development and function of regulatory T cells.
		FOXP3 gene is mutated in the X-linked syndrome of immunodysregulation, polyendocrinopathy, and enteropathy, (IPEX).
		In mice, a Foxp3 mutation (a frameshift mutation that result in protein lacking the forkhead domain) is responsible for 'Scurfy', an X-linked recessive mouse mutant that results in lethality in hemizygous males 16 to 25 days after birth.
	en.wikipedia.org /wiki/FOXP3 (250 words)

	Regulatory T cell - Wikipedia, the free encyclopedia
		Expression of FOXP3 is required for regulatory T cell development and appears to control a genetic program specifying this cell fate.
		Foxp3 is not expressed on activated T cells and the regulatory T cell population as more accurately defined by Foxp3 expression extends beyond the CD4
		The IPEX syndrome is characterized by the development of overwhelming systemic autoimmunity in the first year of life resulting in the commonly observed triad of watery diarrhea, eczematous dermatitis, and endocrinopathy seen most commonly as insulin-dependent diabetes mellitus.
	en.wikipedia.org /wiki/Regulatory_T_cell (1224 words)

	Inhibition of the Transcription Factor Foxp3 Converts Desmoglein 3-Specific Type 1 Regulatory T Cells into Th2-Like ...
		Foxp3 protein expression was measured in a resting Dsg3-reactive Tr1 clone (C7-17) and a resting Dsg3-reactive Th2 cell clone (C4-10) as a cytospin by fluorescence microscopy (D).
		Foxp3 antisense induces a proliferative response of Tr1 clones to Dsg3 and mitogens.
		Inhibition of Foxp3 mRNA in Tr1 by antisense
	www.jimmunol.org /cgi/content/full/176/5/3215 (4860 words)

	Messenger RNA for FOXP3 in the Urine of Renal-Allograft Recipients
		Levels of messenger RNA (mRNA) for FOXP3, a specification and functional factor for regulatory T lymphocytes, and mRNA for CD25, CD3{varepsilon}, perforin, and 18S ribosomal RNA (rRNA) were measured with a kinetic, quantitative polymerase-chain-reaction assay.
		FOXP3 mRNA levels were inversely correlated with serum creatinine levels measured at the time of biopsy in the acute-rejection group (Spearman's correlation coefficient = —0.38, P=0.02) but not in the group with chronic allograft nephropathy or the group with normal biopsy results.
		FOXP3 mRNA levels identified subjects at risk for graft failure within six months after the incident episode of acute rejection (relative risk for the lowest third of FOXP3 mRNA levels, 6; P=0.02).
	www.immunetolerance.org /news/articles/pub_alerts/article_996.html (310 words)

	BIO.COM: Biotechnology Pharmaceutical Therapeutics, Vaccines, Diagnostics, Discovery - Biotech, Pharma, Biomedical
		They say that when FOXP3 is reduced due to abnormalities in its expression, the suppressive activity of regulatory T-cells, or T-regs, also plummets.
		NeuroVax, a T-cell receptor peptide vaccine co-discovered by Vandenbark and colleagues at The Immune Response Corp., was shown in a separate study to increase FOXP3 expression levels among MS patients receiving injections of the drug for a year.
		FOXP3 has been shown in several studies to be an unequivocal marker for T-reg cell function - mice and humans lacking the gene are susceptible to a fatal autoimmune lymphoma.
	www.bio.com /newsfeatures/newsfeatures_research.jhtml;jsessionid=0SHNIUNBFKSABR3FQLMCFEWHUWBNSIV0?cid=11800032 (794 words)

	Transplantation Institute - Mount Sinai School of Medicine (Site not responding. Last check: 2007-11-01)
		These cells express the Foxp3 transcription factor, which is to date the most specific marker for cells that possess the Treg suppressive function.
		Foxp3 may be a "master switch" for the transcriptional program for Treg function.
		Importantly, TGFBeta induces de novo Foxp3 expression and Treg function in uncommitted naïve cells, and Foxp3 induction is blocked by CD28 co-stimulation in an IL-4 dependent fashion.
	www.mssm.edu /rmti/basic_sci_program.shtml (3388 words)

	Journal of Translational Medicine \| Full text \| In situ analysis of FOXP3+ regulatory T cells in human colorectal cancer
		It was shown for ovarian cancer that tumoral Tregs suppress tumor-specific T cell immunity and contribute to reduced survival [29].
		FOXP3 fulfills the criteria of a Treg-specific marker, which is, at least in differentiated Treg, not known to be substantially regulated and represents a good marker for quantifying Treg in tissues [31].
		Here, we used FOXP3 staining in CRC to analyze Treg infiltration of CRC in situ and to test whether there is a correlation to a disease stage, systemic TAA-specific T cell response, and survival of CRC patients.
	www.translational-medicine.com /content/4/1/52 (5611 words)

	FOXP3 antibody [mAbcam 450] (ab450) datasheet (Site not responding. Last check: 2007-11-01)
		FOXP3 (a 431 amino acid protein) is a member of the forkhead/winged-helix family of transcriptional regulators and is highly conserved across mammals.
		FOXP3 may be a master regulatory gene and a more specific marker of regulatory T cells than other T cells.
		Foxp3 interacts with nuclear factor of activated T cells and NF-kappa B to repress cytokine gene expression and effector functions of T helper cells.
	www.abcam.com /?datasheet=450 (795 words)

	Control of Regulatory T Cell Development by the Transcription Factor Foxp3 -- Hori et al. 299 (5609): 1057 -- Science (Site not responding. Last check: 2007-11-01)
		Foxp3+ CD25+ regulatory T cells specific for a neo-self-antigen develop at the double-positive thymic stage.
		Primary unexplained infertility is associated with reduced expression of the T-regulatory cell transcription factor Foxp3 in endometrial tissue.
		Mucosal FOXP3+ regulatory T cells are numerically deficient in acute and chronic GvHD.
	www.sciencemag.org /cgi/content/abstract/299/5609/1057 (2985 words)

	Novus Bio - FOXP3 antibody Goat polyclonal to FOXP3
		FOXP3 (a 381 amino acid protein) is a member of the forkhead/winged-helix family of transcriptional regulators and is highly conserved across mammals.
		FOXP3 is stably and constitutively expressed at a high level in CD25 + CD4 positive regulatory T cells, a low level in CD4-positive/CD25-negative cells, and is absent in CD4-negative/CD8-positive T cells.
		FOXP3 may be a master regulatory gene and a more specific marker of regulatory T cells than other T cells.
	www.novusbio.com /data_sheet/index/&prod_id=4741&prev_module=search (366 words)

	ScienceDaily: Gene Changes Linked To Deficient Immune Suppression In Multiple Sclerosis
		They say that when FOXP3 is reduced due to abnormalities in its expression, the suppressive activity of regulatory T-cells, or T-regs, also plummets.
		NeuroVax, a T-cell receptor peptide vaccine co-discovered by Vandenbark and colleagues at The Immune Response Corp., was shown in a separate study to increase FOXP3 expression levels among MS patients receiving injections of the drug for a year.
		FOXP3 has been shown in several studies to be an unequivocal marker for T-reg cell function -- mice and humans lacking the gene are susceptible to a fatal autoimmune lymphoma.
	www.sciencedaily.com /releases/2005/06/050627061854.htm (1069 words)

	Scientist Solutions - Human version of FOXp3
		A transcription factor called FOXp3 appears to be a prime player molecular basis of tolerance.
		Sakaguchi and colleagues showed that FOXp3 expression is confined predominantely to CD4+and CD25+Treg in the tymus.
		It has been even suggested that Foxp3 may be important to other subsets of T cells.
	www.scientistsolutions.com /index.php?a=topic&t=951 (491 words)

	Foxp3 interacts with nuclear factor of activated T cells and NF-{kappa}B to repress cytokine gene expression and ...
		Foxp3 interacts with nuclear factor of activated T cells and NF-{kappa}B to repress cytokine gene expression and effector functions of T helper cells -- Bettelli et al.
		disregulation syndrome, and the mouse Foxp3 mutation is responsible
		Foxp3 may mediate its inhibitory functions in T cells (18, 19).
	www.pnas.org /cgi/content/full/102/14/5138 (4503 words)

	Abstract
		Recently, the transcription factor Foxp3 has been identified to be a key regulatory gene for the development of Treg.
		We are currently using Foxp3 transfected T cells for the treatment of systemic autoimmunity in K14-CD40L transgenic mice in order to ameliorate disease.
		Furthermore, Foxp3 gene transfer may be useful to generate large numbers of Treg for immunotherapy of autoimmune disorders.
	www.blackwellpublishing.com /esdr2004/abstract.asp?id=18571 (297 words)

	The Immune Response Corporation (Site not responding. Last check: 2007-11-01)
		FOXP3, T-reg cells and IL-10 are known to play important roles in regulating the immune system and it is believed that affecting these cells may be one of the mechanisms of action of NeuroVax™, the Company’s investigational T-cell receptor (TCR) peptide vaccine for the treatment of MS.
		Previous research indicated that MS patients have abnormalities in FOXP3 message and protein expression levels in peripheral T-reg cells.
		This observation linked a defect in functional peripheral immunoregulation to an established genetic marker, FOXP3, previously shown to be associated with maintaining immune tolerance and preventing development of autoimmune diseases.
	www.imnr.com /news/2005/2005OCT03.htm (1014 words)

	FOXP3
		FOXP3 is playing an essential role for T regulatory cells (Treg) and is involved in the molecular mechanisms controlling immune tolerance.
		In our studies we describe the localization and structure of the human FOXP3 promoter, as well as elements, that are essential for its induction in T cells.
		The FOXP3 promoter is located -6221 bp upstream of the translation start site and the 5’UTR is interrupted by a 6000 bp intron, which contains a splice donor site at the 5’ end and a splice acceptor site at the 3’ end, 22 bp upstream of the translation start site.
	www.siaf.unizh.ch /Web-Site/FOXP3.html (169 words)

	The Scientist : Foxp3 targets revealed
		Expressed primarily in regulatory T-cells, Foxp3 is essential to both their development and normal function.
		Ethan Shevach of the National Institutes of Health in Bethesda, Md., who was not involved in either study, said he preferred the use of normal T-cells -- as in the Zheng et al.
		Some of the direct targets of Foxp3 identified in the two studies -- such as members of the irf family -- are transcription factors in their own right, indicating a second layer of regulation mediated by Foxp3.
	www.the-scientist.com /news/display/42904 (760 words)

	GTX14551-FOXP3 antibody-GeneTex Inc.
		All lanes : FOXP3 antibody (GTX14551) at 1 ug/ml
		FOXP3 (a 381 amino acid protein) is a member of the forkhead/winged-helix family of transcriptional regulators and is highly conserved across mammals.
		This antibody recognises a band at 50kd representing FOXP3 in HEK293 lysates overexpressing mouse FOXP3.
	www.genetex.com /ccp24948-foxp3-antibody-ab14551-gtx14551.htm (160 words)

	Transcriptional Control of Impaired Th1 Responses in Patent Lymphatic Filariasis by T-Box Expressed in T Cells and ...
		Expression of T-bet, GATA-3, and Foxp3 in filarial infections.
		Foxp3 induction in T cells correlates with IL-10 expression.
		The n-fold induction of Foxp3 by BmA in the cohort of INF and UN (n = 12) was measured and plotted against the n-fold induction of IL-10 mRNA expression by BmA.
	iai.asm.org /cgi/content/full/73/6/3394 (3477 words)

	Mutational Analysis of the FOXP3 Gene and Evidence for Genetic Heterogeneity in the Immunodysregulation, ...
		Mutational Analysis of the FOXP3 Gene and Evidence for Genetic Heterogeneity in the Immunodysregulation, Polyendocrinopathy, Enteropathy Syndrome -- Owen et al.
		FOXP3 mutation in family A leads to a frameshift and premature termination codon.
		Genetic association studies of the FOXP3 gene in Graves' disease and autoimmune Addison's disease in the United Kingdom population.
	jcem.endojournals.org /cgi/content/full/88/12/6034 (2945 words)

	BioMed Central \| Full text \| Delayed functional maturation of natural regulatory T cells in the medulla of postnatal ...
		It has been proposed that induction of FoxP3 and maturation of the Treg lineage represent a separate lineage in the thymus due to selection signals that fall between those of positive and negative selection [19-22].
		To investigate whether TSLP interacts directly with thymocytes to induce FoxP3 expression or indirectly via interactions with other cell types such as DCs in the thymus as reported in humans [26-28], we isolated thymocytes from 2 day old mice and treated them with TSLP in vitro for 2 days.
		Elucidating how FoxP3 expression is modulated during the development of natural Treg cells in the thymus will be of great importance both for understanding the ontogenic mechanism of their development, and for shedding light on how to modulate their generation and expansion for use in therapeutic applications.
	www.biomedcentral.com /1471-2172/7/6 (5744 words)

	Regulatory T Cells: Foxp3, GITR, CD127
		The anti-mouse Foxp3 antibodies, FJK-16s and NRRF-30 recognize different epitopes in the amino terminus, with the former recognizing the region corresponding to the human splice variant.
		The expanding panel of antibodies reactive with distinct epitopes of Foxp3 is useful for investigating the complete Foxp3 protein expression profile at the single-cell level in both human and mouse, particularly with regards to its relationship to functionally-defined Regulatory T cells.
		The expression of the regulatory T cell-specific forkhead box transcription factor FoxP3 is associated with poor prognosis in ovarian cancer.
	www.ebioscience.com /ebioscience/whatsnew/TregPage/Treg.htm (2396 words)

	FoxP3 mRNA Expression in Regulatory T Cells from Patients with Tuberculosis/From the Authors American Journal of ...
		FoxP3 mRNAin CD4+CD25+ T cells was compared between patients with TB and control subjects.
		The transcription factor FoxP3 is the most specific molecular marker for Tregs available to date, and its correct evaluation is crucial (2-4).
		When we compared FoxP3 mRNA expression in CD4+CD25+ T cells in patients and controls, we found no significant difference, suggesting that the increased FoxPS expression in tuberculosis reflects increased frequencies of Tregs rather than increased expression of FoxP3 per cell.
	www.findarticles.com /p/articles/mi_qa4085/is_200608/ai_n16717181 (983 words)

	CRISP - Computer Retrieval of Information on Scientific Projects, Abstract Display (Site not responding. Last check: 2007-11-01)
		Importantly, TGFbeta induces de novo Foxp3 expression and Treg function in uncommitted naive cells, and Foxp3 induction is blocked by CD28 co-stimulation in an IL-4 dependent fashion.
		Based on these findings, we hypothesize that TGFbeta is a key regulator of the signaling pathways that initiate and maintain Foxp3 expression and function of Treg.
		In the autoimmune model of colitis, the ability of these cells to regulate the homeostatic proliferation and autoimmune function of effector T cells will be determined, with attention to specific effector molecules, including IL-10 and TGFbeta, and costimulatory molecules.
	crisp.cit.nih.gov /crisp/CRISP_LIB.getdoc?textkey=6848244&p_grant_num=1R01AI062765-01&p_query=&ticket=12892963&p_audit_session_id=59966423&p_keywords= (514 words)

	Low FOXP3 linked to deficient immune suppression in MS (Site not responding. Last check: 2007-11-01)
		Low FOXP3 linked to deficient immune suppression in MS From rxpgnews.com
		Oregon Health and Science University researchers have measured genetic changes reflecting a drop in the body's ability to suppress inflammatory cells that attack nerve fibers and promote progression of multiple sclerosis.
		FOXP3 has been shown in several studies to be an unequivocal marker for T-reg cell function — mice and humans lacking the gene are susceptible to a fatal autoimmune lymphoma.
	www.rxpgnews.com /research/neurosciences/printer_1770.shtml (792 words)

	Foxp3 occupancy and regulation of key target genes during T-cell stimulation : Abstract : Nature
		Here we identify Foxp3 target genes and report that many of these are key modulators of T-cell activation and function.
		Remarkably, the predominant, although not exclusive, effect of Foxp3 occupancy is to suppress the activation of target genes on T-cell stimulation.
		Foxp3 suppression of its targets appears to be crucial for the normal function of T
	www.nature.com /doifinder/10.1038/nature05478 (376 words)

	CiteULike: Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+CD25- T cells. (Site not responding. Last check: 2007-11-01)
		Recently, the forkhead/winged helix transcription factor, FoxP3, has been shown to be important for the function of TR cells in mice.
		In this study, human TR cells were examined and, in results similar to those of studies done in mice, expression of FoxP3 was found exclusively in CD4+CD25+ T cells and correlated with the suppressive activity of these cells.
		Expression of FoxP3 in activated human CD4+CD25+ cells also correlated with suppression of proliferation by these cells in freshly isolated CD4+CD25- T cells from the same donor.
	www.citeulike.org /user/eisei/article/1233310 (462 words)

	The Immune Response Corporation's NeuroVax Demonstrates Increase in FOXP3 Gene Marker Levels and Treg Cell Functional ... (Site not responding. Last check: 2007-11-01)
		The new data, presented yesterday at the European Neurological Society (ENS) in Vienna, demonstrated that monthly NeuroVax(TM) injections during a one-year period increased the FOXP3 marker and Treg cell functional activity in MS patients to a level equivalent to that seen in healthy controls.
		Recently published research indicates that FOXP3, known to be associated with maintaining immune tolerance and regulation of autoimmune diseases, is significantly reduced in patients with MS compared to healthy controls.
		This observation linked a defect in functional peripheral immunoregulation to an established genetic marker, FOXP3, previously shown to be associated with maintaining immune tolerance and preventing development of autoimmune diseases.
	www.redorbit.com /news/display?id=157345&source=r_health (792 words)

Try your search on: Qwika (all wikis)