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	Factor V Leiden (Site not responding. Last check: 2007-10-07)
		Factor V Leiden is characterized by a phenomenon called APCR where a genetic mutation in the factor V gene causes a change in the factor V protein making it resistant to inactivation by protein C. A detailed description of the clotting process is found on the clotting information web page.
		The result is that factor V Leiden is inactivated by activated protein C at a much slower rate (see Figure 3), thus leading to a thrombophilic (propensity to clot) state by having increased activity of factor V in the blood.
		The factor V Leiden mutation is relatively uncommon in the native populations of Asia, Africa and North America.
	www-admin.med.uiuc.edu /hematology/PtFacV2.htm (893 words)

	Factor V Leiden - Wikipedia, the free encyclopedia
		Factor V Leiden is the most common hereditary hypercoagulability clotting disorder amongst Eurasians, possibly affecting up to 5% of the population of the U.S. It is named after the city Leiden (The Netherlands), where it was first identified in 1994 by Prof R. Bertina et al.
		It is an autosomal dominant condition in which the coagulation factor has a mutation and cannot be destroyed by activated protein C (aPC).
		Suspicion of Factor V Leiden being the cause for any thrombotic event should be considered in any white patient below the age of 45, or in any person with a family history of thrombosis.
	en.wikipedia.org /wiki/Factor_V_Leiden (347 words)

	Factor V Leiden thrombophilia - Genetics Home Reference
		Factor V Leiden thrombophilia is an inherited disorder of blood clotting.
		Factor V Leiden is the name of a specific mutation that results in thrombophilia, or an increased tendency to form abnormal blood clots in blood vessels.
		People who have the factor V Leiden mutation are at somewhat higher than average risk for a type of clot that forms in veins, such as the deep veins of the legs (deep venous thrombosis), or a clot that travels through the bloodstream and lodges in the lungs (pulmonary embolism).
	ghr.nlm.nih.gov /condition=factorvleidenthrombophilia (771 words)

	Factor V Leiden Mutation and the Risks for Thromboembolic Disease: A Clinical Perspective -- Price and Ridker 127 (10): ...
		the prevalence of the factor V Leiden mutation was 14% [24].
		V Leiden mutation (5 homozygotes and 16 heterozygotes) with
		Coexistence of hereditary homocystinuria and factor V Leiden-effect on thrombosis.
	www.annals.org /cgi/content/full/127/10/895 (6199 words)

	Factor V Leiden - MayoClinic.com (Site not responding. Last check: 2007-10-07)
		Factor V Leiden is an inherited blood clotting disorder that increases the risk of blood clots.
		Factor V is one of the clotting factors that are important for normal clotting to occur.
		An anti-clotting factor called protein C normally controls the activity of factor V. Factor V Leiden is caused by a gene mutation in factor V that causes it to respond more slowly to protein C. This increases the risk of blood clots (thrombophilia).
	www.mayoclinic.com /health/factor-v-leiden/AN00900 (389 words)

	MSRGSNet/Genetic Drift/Venous Thrombosis and the Factor V (Leiden) Mutation
		MSRGSNet/Genetic Drift/Venous Thrombosis and the Factor V (Leiden) Mutation
		Venous Thrombosis and the Factor V (Leiden) Mutation
		Factor V mutation testing should be performed before prescription of oral contraceptives if there is a personal or family history of thrombosis.
	www.mostgene.org /gd/gdvol14b.htm (1355 words)

	Factor V Leiden / Thrombophilia Support Page - living with thrombophilia
		Factor V Leiden is the most common hereditary blood coagualtion disorder in the United States.
		Factor V Leiden increases the risk of venous thrombosis 3-8 fold for heterozygous (one damaged gene inherited) and substantially more, 30-140 fold, for homozygous (two damaged genes inherited) individuals.
		It is only a mild risk factor for clots, but together with other risk factors (such as oral contraceptives, surgery, trauma, high blood pressure, obesity, smoking, etc) or combined with other clotting disorders (like Factor V Leiden), the risk of clotting increases dramatically.
	www.fvleiden.org (373 words)

	Factor V Leiden
		The presence of Factor V (Leiden) is the most common cause of inherited thrombophilia, accounting for 20% to 50% of cases.
		Factor V (Leiden) has traditionally been first detected by an APTT screening test, in which exogenous activated protein C is added to the patient plasma prolonging the clotting time for individuals with normal, but not mutant, Factor V protein.
		Factor V (Leiden) is associated with an increased risk of venous thrombosis and is estimated to occur in 20-50% of patients with family history of thrombosis.
	www.repromedix.com /documents/FactorVLeiden.htm (1018 words)

	Factor V Leiden
		Factor V Leiden is not a disease, it is the presence of a particular gene that is passed on from your parents.
		Factor V Leiden is a variant of the protein Factor V (5) which is needed for blood clotting.
		People with Factor V Leiden do not need treatment unless their blood starts to clot, in which case the doctor will prescribe blood-thinning (anticoagulant) medicines such as warfarin (eg Marevan) or heparin to prevent further clots.
	www.netdoctor.co.uk /diseases/facts/factorv.htm (897 words)

	Consensus Statement on Factor V Leiden Mutation Testing (Site not responding. Last check: 2007-10-07)
		Although factor V Leiden is detected in an appreciable percentage of patients, opinions differ as to the usefulness of identifying the mutation and the clinical criteria for testing.
		Factor V Leiden testing is well established in mainstream medicine and is used by physicians from numerous specialties including hematology, internal medicine, primary care, and obstetrics.
		Factor V Arg306→Thr (factor V Cambridge) and factor V Arg306→Gly mutations in venous thrombotic disease.
	www.acmg.net /resources/policies/pol-009.asp (6596 words)

	Factor V Leiden related Budd-Chiari syndrome -- Deltenre et al. 48 (2): 264 -- Gut
		The aim of this study was to ascertain the role of factor V Leiden in hepatic vein or inferior vena cava thrombosis and to
		Patient characteristics according to the presence or absence of factor V Leiden are presented in table 2.
		Gln mutation in the gene for factor V (factor V Leiden).
	gut.bmjjournals.com /cgi/content/full/48/2/264 (2789 words)

	Factor V Leiden Syndrome
		It is the result of a specific mutation in the gene for factor V which leads to increased risk for clots in the large veins of the legs (deep venous thrombosis), or clots that travel though the bloodstream and embed in the lungs (pulmonary embolism).
		Pregnancy: It is thought that Factor V Leiden increases the risk for recurrent fetal loss and has been associated with severe pre-eclampsia, unexplained intrauterine growth retardation, placental abruption, and stillbirth as well as maternal clotting during labor and in the postpartum period.
		Factor V. Leiden thrombophilia is characterized by a poor anticoagulant response to activated protein C (APC), and an increased risk of venous thromboembolish...
	www.ibis-birthdefects.org /start/f5fact.htm (521 words)

	Thrombophilia: genetic polymorphisms and their association with retinal vascular occlusive disease -- CHAK et al. 85 ...
		as a cofactor for factor Xa in the conversion of prothrombin to
		Factor V Leiden is undoubtedly a risk factor for thrombosis of large veins, but not for retinal vein occlusions.
		Factor V Leiden mutation is associated with ocular involvement in Behçet's disease.
	bjo.bmjjournals.com /cgi/content/full/85/7/883 (3475 words)

	News - Factor V Leiden and Prothrombin G20210A Mutations Increase Risk of Central Venous Catheter-Related Thrombosis
		In a large hospital population, Cornelis J. Van Rooden, MD, with the Department of General Internal Medicine, Leiden University Medical Center, the Netherlands, and colleagues assessed the incidence of CVC-related thrombosis and the contribution of factor V Leiden and the prothrombin G20210A mutation to this complication.
		Factor V Leiden and prothrombin G20210A mutation status and other potential risk factors were assessed in all patients.
		The relative risk of factor V Leiden or prothrombin G20210A mutation for thrombosis was 2.7 (CI95% 1.9 to 3.8).
	www.docguide.com /news/content.nsf/news/8525697700573E1885256E61007B6380 (583 words)

	August 1995 - The Factor V Leiden Mutation
		Recently, studies have clearly shown that a mutation of clotting factor V is highly associated with thrombosis and may account for as much as 25% of all cases of venous thrombosis of unknown cause.
		The factor V mutation, named factor V Leiden after the site of its discovery, is due to a point mutation in the normal factor V molecule.
		The newly described factor V Leiden mutation represents a major advance in the ability to diagnose and counsel patients with thrombosis.
	www.itxm.org /Archive/tmu8-95.htm (715 words)

	Kimball Genetics - Factor V Leiden DNA Test
		The factor V Leiden mutation is the most common genetic risk factor for venous thrombosis, a serious health problem affecting approximately 1 in 1000 people and leading to 50,000 deaths annually in this country.
		The Factor V Leiden DNA Test should be included in the evaluation of all patients with thrombosis or a family history of this condition.
		The Factor V Leiden mutation is also associated with multiple pregnancy loss and intrauterine fetal demise.
	www.kimballgenetics.com /tests-factor_v.html (360 words)

	Thrombophilia, polymorphisms, and vascular disease -- Sykes et al. 53 (6): 300 -- Molecular Pathology
		Factor V Leiden is not a risk factor for arterial vascular disease in the elderly: results from the cardiovascular health study.
		Factor V Leiden gene mutation and thrombin generation in relation to the development of acute stroke.
		Factor XIII Val34Leu is a genetic factor involved in the etiology of venous thrombosis.
	mp.bmjjournals.com /cgi/content/full/53/6/300 (5308 words)

	Factor V Leiden -- Ornstein and Cushman 107 (15): 94 -- Circulation
		heterozygous for the factor V Leiden gene mutation.
		The diagnosis of factor V Leiden is made by a blood test.
		Factor V Leiden, hormone replacement therapy and the risk of venous thromboembolic events in women with coronary disease.
	circ.ahajournals.org /cgi/content/full/107/15/e94 (2059 words)

	Factor V Leiden Mutation (Site not responding. Last check: 2007-10-07)
		Centrifuge blue-stopper tube within 1 hour of collection, separate plasma and test or quick-freeze at -70°C. If follow-up factor V Leiden mutation test is indicated, the lavender-stopper tube may be refrigerated up to 72 hours before shipping.
		APC resistance is a thrombotic risk factor* caused by the factor V Leiden mutation that is present in 3 to 8% of Caucasians.
		Factor V Leiden mutation confers a 2 to 8-fold increased risk of venous thrombosis.
	peir.path.uab.edu /coag/article_56.shtml (150 words)

	The effect of factor V Leiden carriage on maternal and fetal health -- Bloomenthal et al. 167 (1): 48 -- Canadian ...
		Factor V Leiden (FVL) is a mutation in the factor V molecule, rendering it resistant to cleavage by activated protein C. Factor V remains a procoagulant and thus predisposes the carrier to clot formation.
		Prothrombin and factor V mutations in women with a history of thrombosis during pregnancy and the puerperium.
		Factor V Leiden, C>T MTHFR polymorphism and genetic susceptibility to preeclampsia.
	www.cmaj.ca /cgi/content/full/167/1/48 (3632 words)

	Use of Selective Factor V Leiden Screening in Pregnancy to Identify Candidates for Anticoagulants -- Lindqvist et al. ...
		Use of Selective Factor V Leiden Screening in Pregnancy to Identify Candidates for Anticoagulants -- Lindqvist et al.
		with known factor V Leiden status was studied.
		V Leiden, and those with a resulting risk score of at least
	www.greenjournal.org /cgi/content/abstract/100/2/332 (320 words)

	Laboratory Investigation of Thrombophilia -- Tripodi and Mannucci 47 (9): 1597 -- Clinical Chemistry
		thrombosis (2) as a consequence of predisposing factors that
		Role of clotting factor VIII in effect of von Willebrand factor on occurrence of deep-vein thrombosis.
		Factor VIII activity as measured by an amidolytic assay compared with one-stage clotting assay.
	www.clinchem.org /cgi/content/full/47/9/1597 (6397 words)

	Genetic Testing for Cardiovascular Disease Susceptibility: A Useful Clinical Management Tool or Possible ...
		Factor V Leiden: The Copenhagen City Heart Study and 2 meta-analyses.
		De S, V, Martinelli I, Mannucci PM, Paciaroni K, Chiusolo P, Casorelli I, Rossi E, Leone G. The risk of recurrent deep venous thrombosis among heterozygous carriers of both factor V Leiden and the G20210A prothrombin mutation.
		A prospective study of asymptomatic carriers of the factor V Leiden mutation to determine the incidence of venous thromboembolism.
	www.atvbaha.org /cgi/content/full/24/4/628 (6356 words)

	Factor V Leiden and the Risk for Venous Thromboembolism in the Adult Danish Population -- Juul et al. 140 (5): 330 -- ...
		Factor V Leiden and the Risk for Venous Thromboembolism in the Adult Danish Population -- Juul et al.
		Factor V Leiden and the Risk for Venous Thromboembolism in the Adult Danish Population
		the adult Danish population according to factor V Leiden genotype.
	www.annals.org /cgi/content/abstract/140/5/330 (728 words)

	Hypercoagulability: Too Many Tests, Too Much Conflicting Data -- Bauer et al. 2002 (1): 353 -- Hematology (Site not responding. Last check: 2007-10-07)
		V Leiden mutation, the prothrombin G20210A mutation was not
		Combined effect of factor V Leiden and prothrombin 20210A on the risk of venous thromboembolism—pooled analysis of 8 case-control studies including 2310 cases and 3204 controls.
		Coexistence of factor V Leiden and factor II A20210 mutations and recurrent venous thromboembolism.
	www.asheducationbook.org /cgi/content/full/2002/1/353 (8763 words)

	Factor V Leiden Mutation and the Risks for Thromboembolic Disease: A Clinical Perspective -- Price and Ridker 127 (10): ...
		Conclusions: The presence of factor V Leiden mutation predisposes
		Factor V Leiden and Morbid Obesity in Fatal Postoperative Pulmonary Embolism
		Systemic-to-pulmonary artery shunt thrombosis in a neonate with factor V Leiden mutation
	www.annals.org /cgi/content/abstract/127/10/895 (876 words)

	First universal standard for genetic test approved by UN health agency (Site not responding. Last check: 2007-10-07)
		The test for Factor V Leiden is one of the most frequent genetic tests carried out in clinical laboratories, the agency said.
		WHO officials said researchers were currently investigating whether there was a link between air travel and deep vein thrombosis, adding that having information about their genetic make-up could allow travellers at risk to take additional precautions.
		The standard for Factor V Leiden was developed by WHO partner and the leading international laboratory for biological standards, the National Institute for Biological Standards and Control (NIBSC) in the United Kingdom, in collaboration with experts from other institutions.
	www.un.org /apps/news/story.asp?NewsID=12559&Cr=genetic&Cr1= (317 words)

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