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Topic: Factor XI

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In the News (Mon 15 Apr 19)

  Factor XI - Wikipedia, the free encyclopedia
Factor XI or plasma thromboplastin antecent is one of the enzymes of the coagulation cascade.
Factor XI (FXI) is produced by the liver and circulates as a homo-dimer in its inactive form.
Deficiency of factor XI causes the rare Haemophilia C; this mainly occurs in Ashkenazi Jews and is believed to affect approximately 8% of that population.
en.wikipedia.org /wiki/Factor_XI   (381 words)

 OHC : Factor XI deficiency   (Site not responding. Last check: 2007-10-24)
Deficiency of factor XI is associated with a bleeding tendency, but the correlation between the plasma level and the severity of the haemorrhagic manifestations is poor.
Factor XI is a serine protease enzyme, encoded by a gene located on chromosome 4 and synthesized in the liver.
The principal inhibitor of activated factor XIa in the circulation is alpha 1-antitrypsin.
www.medicine.ox.ac.uk /ohc/fxidef.htm   (877 words)

 NHF | Bleeding Disorders Information Center | Factor XI Deficiency
Factor XI deficiency is a very rare bleeding disorder, occurring in an estimated one in 100,000 Americans.
Factor XI is a protein that helps blood clot and is activated by thrombin.
If you have factor XI deficiency, chances are your symptoms are milder than those of either hemophilia A or hemophilia B, and there may be no strong relationship between your factor XI levels and bleeding complications.
www.hemophilia.org /bdi/bdi_types9.htm   (848 words)

 Factor XI in Kerry Blue Terriers
Factor XI deficiency is a rare bleeding disorder in human beings and is characterized by mild bleeding
As in human beings, factor XI deficiency in Holstein cattle is inherited as an autosomal trait.
Prevalence and inheritance of factor XI (plasma thromboplastin antecedent) deficiency in cattle.
www.kerryblues.info /HEALTH/FACTORXI.HTML   (3237 words)

 Factor XI Activity
Factor XI is a 160,000 Dalton glycoprotein proenzyme that is produced by the liver and megakaryocytes.
Hereditary factor XI deficiency, referred to as Hemophilia C is transmitted as an autosomal recessive mutation.
The bleeding associated with factor XI deficiency is generally not as severe as that found with hemophilia A or B.
www.labcorp.com /datasets/labcorp/html/chapter/mono/cf001100.htm   (599 words)

 Haematologic Technologies - Human Factor XI
Factor XI is a plasma glycoprotein which circulates in a non-covalent complex with high molecular weight kininogen (1).
Factor XI circulates as a zymogen and requires proteolytic activation to acquire serine protease activity.
Factor XIa consists of two NH -terminal derived heavy chains, and two COOH-terminal derived light chains, all of which are held together by disulfide bonds.
www.haemtech.com /Zymogens/Factor_XI.htm   (529 words)

 Production and therapeutic use of a factor XI concentrate from plasma.
Factor XI deficiency is an uncommon bleeding disorder usually manifested by excessive bleeding after surgery or trauma.
We describe the efficacy and safety of a new factor XI concentrate produced from human donor plasma by a modification of the method used for antithrombin III concentrate.
The mean recovery of factor XI in the circulation measured on 62 occasions was approximately 91% of the injected dose, and the mean half-disappearance-time was 52 h.
www.aegis.com /aidsline/1992/nov/M92B0743.html   (445 words)

 Thrombin-mediated Activation of Factor XI Results in a Thrombin-activatable Fibrinolysis Inhibitor-dependent Inhibition ...
Factor XI and XII double-deficient plasma was preincubated with
Factor XI by thrombin in the intrinsic pathway (5).
Factor XI is activated by thrombin and factor XIa in the presence of negatively charged surfaces.
www.jci.org /cgi/content/full/99/10/2323   (4057 words)

 Illini DairyNet: Paper Display: Research Update on Bovine Factor XI...   (Site not responding. Last check: 2007-10-24)
Factor XI deficiency is an inherited bleeding disorder observed in Holstein-Friesian cattle worldwide.
As a result, little testing for Factor XI has occurred in the U. despite its presence here at a frequency that could be as high as the 7 percent currently estimated for Canadian Holsteins.
In the case of the human deficiency of Factor XI, which is found in a variety of ethnic groups around the world, at least 15 separate mutations have been identified as causes of the bleeding symptoms.
www.traill.uiuc.edu /dairynet/paperDisplay.cfm?ContentID=176   (891 words)

 Chicago Center for Jewish Genetics Disorders - Ashkenazi Disorders: Factor XI Deficiency
Individuals with this factor deficiency are prone to easy bruising, nosebleeds, or blood in their urine.
By a physician knowledgeable about the disorder, by measuring the Factor XI level in the blood, and by identifying a specific PTA gene mutation.
By measuring Factor XI level in blood or identifying a known mutation.
www.jewishgeneticscenter.org /what/ashkenazi/factor.asp   (170 words)

 Enhancement of rabbit jugular vein thrombolysis by neutralization of Factor XI . in vivo evidence for a role of factor ...
inhibition of factor XI and TAFI in an experimental thrombosis
Lysis of a thrombin induced clot in the presence or absence of anti-factor XI antibodies or PCI.
on clot lysis of inhibition of factor XI and TAFI.
www.jci.org /cgi/content/full/101/1/10   (3978 words)

 Prevalence, causes, and characterization of factor XI inhibitors in patients with inherited factor XI deficiency -- ...
Factor XI deficiency, an injury-related bleeding disorder, is
XIa on factor IX (the physiological substrate) was markedly
Factor XI deficiency in French Basques is caused predominantly by an ancestral Cys38Arg mutation in the factor XI gene.
www.bloodjournal.org /cgi/content/full/101/12/4783   (4832 words)

 Hemophilia: Factor XI Deficiency (Hemophilia C)
Factor XI (pronounced Factor 11) Deficiency is an inherited bleeding disorder.
In Factor XI Deficiency, the level of Factor XI in the blood is lower than normal.
For reasons that are not well understood, the use of Factor XI concentrate raises the risk of blood clots forming in the bloodstream where they are not wanted (thrombosis).
www.hemophilia.ca /en/2.3.7.php   (934 words)

 Thrombin Activates Factor XI on Activated Platelets in the Absence of Factor XII -- Oliver et al. 19 (1): 170 -- ...
PhosphorImager analysis revealed 40%, 15%, and 4% conversion of factor XI to heavy and light chains, respectively, in the lanes of the upper panel, and 16%, 8%, and 1% conversion in the lanes of the lower panel.
Factor XII-independent activation of factor XI in plasma: effects of sulfatides on tissue factor-induced coagulation.
Prothrombin is a cofactor for binding of factor XI to the platelet surface and for platelet-mediated factor XI activation by thrombin.
atvb.ahajournals.org /cgi/content/full/19/1/170   (5967 words)

 Coagualtion Factors: The Test
Sometimes factor testing may be done on a patient with a known deficiency to monitor the factor deficiency, and to evaluate the effectiveness of treatment.
Factor testing may be done if an inherited factor deficiency is suspected, especially when bleeding episodes begin early in life or when a close relative has an inherited factor deficiency.
Factors may be decreased because of: DIC, liver disease, uremia, some cancers, bone marrow disorders, exposure to snake venom, a Vitamin K deficiency, anticoagulation therapy, an accidental ingestion of the anticoagulant warfarin, or due to blood transfusions (stored units of blood lose some of their clotting factors).
www.labtestsonline.org /understanding/analytes/coagulation_factors/test.html   (910 words)

 Chicago Center for Jewish Genetics Disorders - Ashkenazi Disorders: Factor XI Deficiency
Gene: Factor XI deficiency in caused by mutations in the F11 gene, which is located at 4q35.
It encodes for the protein Factor XI or plasma thromboplastin antecendent (PTA), which is involved in blood coagulation.
Use of Plasma concentrate of Factor XI may be necessary for major surgery.
www.jewishgeneticscenter.org /what/ashkenazi/factor2.asp   (191 words)

 eMedicine - Factor XI Deficiency : Article Excerpt by: Jamie E Siegel, MD
Background: Factor XI (FXI) deficiency is an autosomal disorder that may be associated with bleeding.
FXI remains on the surface and activates factor IX in plasma.
This results in no measurable FXI in the homozygous state and a measurable factor XI level that is lower than the expected 50% in the heterozygous state.
www.emedicine.com /med/byname/factor-xi-deficiency.htm   (590 words)

 Factor XI Inhibitor Panel, Comprehensive   (Site not responding. Last check: 2007-10-24)
Factor inhibitors (also called circulating anticoagulants or inactivators) are endogenously produced antibodies that interfere with coagulation in vivo or in vitro
Factor inhibitors are not normally present in plasma.
Factor inhibitor assays are ordered in response to clinical impression, and are performed periodically on individuals who have inhibitors and are receiving therapy.
www.labcorp.com /datasets/labcorp/html/chapter/mono/nf10005950.htm   (728 words)

 Blood Coagulation on LookSmart Conditions   (Site not responding. Last check: 2007-10-24)
Factor V deficiency is an inherited abnormal blood coagulation disorder caused by a deficiency of the plasma protein Factor V. Parahemophilia; Owren's disease Normal blood coagulation is a...
Factor II deficiency is a disorder of blood clotting (coagulation) resulting from a deficiency of prothrombin.
Factor X deficiency is a disorder that causes abnormal blood clotting (coagulation), resulting from a shortage of a plasma protein called factor X. Stuart-Prower deficiency...
www.looksmartconditions.com /p/search?qt=Blood+Coagulation&tb=art&qf=f...   (398 words)

 What is Factor XI Deficiency (Hemophilia C)? -- Bleeding Disorders Association of Northeastern New York (BDANENY), Inc.
The incidence of factor XI deficiency is 1 in 100,000, though it occurs more frequently among members of some ethnic groups.
There are at least three different known genetic changes associated with factor XI deficiency; these vary in their effect on bleeding.
Factor XI deficiency is usually diagnosed after injury-related bleeding, and symptoms tend to be mild.
www.bdaneny.org /xi.htm   (216 words)

 eMedicine - Factor XI Deficiency : Article by Jamie E Siegel, MD
Factor XII deficiency, also a cause of a prolonged aPTT, is not associated with bleeding (and possibly associated with thrombosis) and therefore should not be treated with plasma or any other agent to prevent bleeding.
Dzik WH, Arkin CF, Jenkins RL: Transfer of congenital factor XI deficiency from a donor to a recipient by liver transplantation.
Zivelin A, Bauduer F, Ducout L, et al: Factor XI deficiency in French Basques is caused predominantly by an ancestral Cys38Arg mutation in the factor XI gene.
www.emedicine.com /med/topic3515.htm   (3893 words)

 FXI Mutation Database - References
Severe factor XI deficiency caused by compound heterozygosity for the type III mutation and a novel insertion in exon 9 (codons 324/325 +G) Brit J of Haem (2001) 114:875-877
Factor XI deficiency with a novel homozygous mutation Trp599Arg near the C-terminal region.
Factor XI (PTA) deficiency in an English-American kindred.
www.biochem.ucl.ac.uk /~becky/FXI/references.php   (1235 words)

 Illini DairyNet: Paper Display: Mutation that Causes Factor XI...   (Site not responding. Last check: 2007-10-24)
Mutation that Causes Factor XI Deficiency in Holstein Cattle
We have recently shown that Factor XI deficiency in Holstein cattle is caused by a mutation that leads to a shortened protein that lacks biological activity.
As a result, little testing for Factor XI has occurred in the U. where its frequency could be as high as the 7 percent currently estimated for Canadian Holsteins.
www.traill.uiuc.edu /dairynet/paperDisplay.cfm?ContentID=332   (753 words)

 ADHIS Web Site - ADHIS adopts codes for Factor XI   (Site not responding. Last check: 2007-10-24)
ADHIS adopts codes for Factor XI ADHIS recognised Factor XI as a single locus genetic defect that exists in Holstein cattle in 2003.
In the case of Factor XI, the carrier animal does sometimes exhibit signs of deficiency and furthermore is able to be identified by a blood test.
The genetics show that there is a simple but effective way of reducing the incidence of Factor XI deficiency in the national herd - that is to reduce the use of carrier bulls to a minimum, and eventually the number of carrier cows will be negligible.
www.adff.com.au /v2/sitev2.nsf/0/C7299DD37F90F2DFCA256E3100171FCC   (591 words)

Factor XI Although factor XI deficiency is a rare bleeding disorder with only 500 affected individuals identified nationally in the United Kingdom, it is very common in Ashkenazi Jewish people.
Not only would this provide better care for affected individuals, but in the process of screening, blood samples could be stored for genetic analyses and studies of the haemostatic process in relation to factor XI.
A research physician (£30,000 per annum), whose task would be to see individuals for screening, take a bleeding history, establish a bank of stored specimens and then provide individuals who had been identified with factor XI deficiency with advice about the management of the condition and register them as having a deficiency;
londonline.com /versions/haemappeal/factorxi.html   (395 words)

 Acquired factor XI deficiency in systemic lupus erythematosus.
The low factor XI levels were not due to a classical coagulation inhibitor, but to a plasma factor (probably an immunoglobulin) that selectively bound factor XI.
The factor XI deficiency improved after treatment with corticosteroids.
Thus it is possible that in SLE immune complexes may bind clotting factors making them unavailable for use in the coagulation cascade.
www.aegis.com /aidsline/1983/jun/M8360029.html   (311 words)

 Factor XI Deficiency : BPL (Bio Products Laboratory)
Factor XI deficiency is another inherited bleeding disorder, which affects both males and females, and which is rare except in some ethnic groups.
Many people with Factor XI deficiency do not experience bleeding problems, but some do, particularly after surgery or trauma.
When treatment is needed, the patient's Factor XI level can be raised by transfusion of fresh frozen plasma or Factor XI concentrate.
www.bpl.co.uk /public/therapy_areas/coagulation/factor_xi.asp   (160 words)

 ISTH: High Factor XI Levels Linked With Cardiovascular Disease In Women   (Site not responding. Last check: 2007-10-24)
PARIS, FRANCE -- July 9, 2001 -- Factor XI is increased in women with severe coronary artery disease (CAD), investigators reported at the Eighteenth Congress of the International Society on Thrombosis and Haemostasis (ISTH).
The study was designed to investigate the role of prothrombotic risk factors which are believed to be important in cardiovascular disease among women and to dissect the interaction of coagulation factor risk factors with those of other known risk factors.
Although one study has noted high factor XI levels in relation to deep-vein thrombosis, this is the first study to examine this association in arterial disease and particularly in women with CAD."
www.pslgroup.com /dg/2003B2.htm   (436 words)

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