
	Where results make sense

Topic: Factor XII

In the News (Tue 2 Dec 08)

Damian Green

Sumner Redstone

Crimson Tide

Tommy Tuberville

Bill Clinton

Wayne Rooney

Vilasrao Deshmukh

Wake Forest

Grand Slam

Oklahoma State

	Factor XII Activity
		Factor XII is an 80 kilodalton single-chain proenzyme that is synthesized in the liver.
		Factor XII deficiency is usually inherited in an autosomal recessive manner and heterozygous deficiency is relatively common, affecting somewhere between 1.5% and 3.0% of the population.
		Factor XII levels are moderately diminished in heterozygous individuals with levels ranging between 20% and 60% of normal.
	www.labcorp.com /datasets/labcorp/html/chapter/mono/cf001200.htm (759 words)

	Haematologic Technologies - Human Factor XII
		Factor XII (XII) (Hageman Factor) is a single chain (Mr=78,000) glycoprotein zymogen that circulates in plasma at a concentration of 40 mg/ml (1-5).
		Reciprical activation of XII to the active serine protease factor XIIa (XIIa) by kallikrein is central to initiation of the intrinsic coagulation pathway.
		The ratio of C1-INH to XII has been implicated in the "cold activation" of factor VII and the conversion of prorenin to renin on storage of plasma (20,21).
	www.haemtech.com /Zymogens/Factor_XII.htm (564 words)

	Human Factor XII Binding to the Glycoprotein Ib-IX-V Complex Inhibits Thrombin-induced Platelet Aggregation -- Bradford ... (Site not responding. Last check: 2007-11-03)
		Factor XII fragment or factor XII zymogen could not block aggregation, indicating that this inhibition is due to the conformational exposure of the heavy chain of factor XIIa and that the catalytic domain is not sufficient.
		XII was observed in the absence of Zn Both HK and factor XII demonstrate Zn -dependent and specific binding to immobilized glycocalicin (Fig.
		Factor XII fragment does not bind to glycocalicin, indicating that the locus for factor XII binding resides in the heavy chain.
	www.jbc.org /cgi/content/full/275/30/22756 (5693 words)

	Factor XII Tenri, a Novel Cross-Reacting Material Negative Factor XII Deficiency, Occurs Through a Proteasome-Mediated ...
		Factor XII in plasmas of the proband (lane 1), his father (lane 2), mother (lane 3), sister (lane 4), and brother (lane 5) were immunoprecipitated by anti-factor XII antibody.
		Factor XII was immunoprecipitated from the pulse-labeled cell extracts (lane 1) and chased media (lanes 2 and 3), and then electrophoresed on an 8% SDS-polyacrylamide gel.
		Hereditary factor XII deficients in the factor XII Tenri
	www.bloodjournal.org /cgi/content/full/93/12/4300 (5068 words)

	Medical Dictionary: Factor XII deficiency - WrongDiagnosis.com
		Factor XII deficiency: An absence or reduced level of blood coagulation factor XII.
		Factor XII deficiency is listed as a "rare disease" by the Office of Rare Diseases (ORD) of the National Institutes of Health (NIH).
		This means that Factor XII deficiency, or a subtype of Factor XII deficiency, affects less than 200,000 people in the US population.
	www.wrongdiagnosis.com /medical/factor_xii_deficiency.htm (274 words)

	MedlinePlus Medical Encyclopedia: Factor XII assay
		Factor XII assay is a blood test to measure the activity of factor XII -- one of the substances involved in coagulation (blood clotting).
		Factor XII deficiency is not normally associated with clinical bleeding.
		In addition, factor XII does not appear to be necessary for the formation of clots for normal hemostasis (stopping of bleeding).
	www.nlm.nih.gov /medlineplus/ency/article/003681.htm (513 words)

	Factor XII - Wikipedia, the free encyclopedia
		The gene for factor XII is located on the tip of the long arm of the fifth chromosome (5q33-qter).
		Hageman factor deficiency is a rare hereditary disorder with a prevalence of about one in a million, although it is a little more common among Asians.
		Hageman factor was first discovered in 1955 when a routine preoperative blood sample of the 37-year-old railroad brakeman John Hageman was found to have prolonged clotting time in test tubes, even though he had no haemorrhagic symptoms.
	en.wikipedia.org /wiki/Factor_XII (293 words)

	Factor XII assay
		A test that measures the activity of factor XII (one of the substances used for coagulation) in the blood.
		Blood is drawn from a vein (venipuncture), usually from the inside of the elbow or the back of the hand.
		Factor XII deficiency is not normally associated with clinical bleeding and does not appear to be necessary for the formation of clots for normal hemostasis (stopping of bleeding).
	www.jrmc.org /adam/ency/article/003681.htm (519 words)

	NHF \| Bleeding Disorders Information Center \| Factor XII Deficiency
		First described in 1955, after routine blood tests before surgery on a man named John Hageman, factor XII deficiency is a very rare bleeding disorder.
		The hallmark of severe factor XII deficiency is prolonged APTT—usually more than 100 seconds—in a patient with no history of bleeding.
		It is an autosomal recessive disorder, which means if the clotting defect is inherited from a parent, the child will be a genetic carrier of the condition, but may or may not have symptoms.
	www.hemophilia.org /bdi/bdi_types10.htm (286 words)

	Thrombin Activates Factor XI on Activated Platelets in the Absence of Factor XII -- Oliver et al. 19 (1): 170 -- ... (Site not responding. Last check: 2007-11-03)
		Thrombin Activates Factor XI on Activated Platelets in the Absence of Factor XII -- Oliver et al.
		Thrombin Activates Factor XI on Activated Platelets in the Absence of Factor XII
		Factor XI deficiency in French Basques is caused predominantly by an ancestral Cys38Arg mutation in the factor XI gene
	atvb.ahajournals.org /cgi/content/abstract/19/1/170 (564 words)

	Factor XII light chain antibody [C6B7] (ab1008) datasheet (Site not responding. Last check: 2007-11-03)
		Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin.
		Factor XII, prekallikrein, and HMW kininogen form a complex bound to an anionic surface.
		Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then to beta-factor XIIa.
	www.abcam.com /index.html?datasheet=1008 (449 words)

	Rapid Factor XII (46C{->}T) Genotyping by Fluorescence Resonance Energy Transfer in Patients with Coronary Artery ... (Site not responding. Last check: 2007-11-03)
		Blood coagulation factor XII (FXII; Hageman factor) is a serine protease.
		Activated factor XII levels are dependent on factor XII 46C/T genotypes and factor XII zymogen levels, and are associated with vascular risk factors in patients and healthy subjects.
		A common genetic polymorphism (46 C to T substitution) in the 5'-untranslated region of the coagulation factor XII gene is associated with low translation efficiency and decrease in plasma factor XII level.
	www.clinchem.org /cgi/content/full/47/6/1117 (1896 words)

	Epidemiological and Genetic Associations of Activated Factor XII Concentration With Factor VII Activity, Fibrinopeptide ... (Site not responding. Last check: 2007-11-03)
		Inhibition of factor XII in septic baboons attenuates the activation of complement and fibrinolytic systems and reduces the release of interleukin 6 and neutrophil elastase.
		A common genetic polymorphism (46C to T substitution) in the 5'-untranslated region of the coagulation factor XII gene is associated with low translation efficiency and decrease in plasma factor XII level.
		Factor VII-deficient substrate plasmas depleted of protein C raise the sensitivity of the factor VII bioassay to activated factor VII: an international study.
	circ.ahajournals.org /cgi/content/full/102/17/2058 (3375 words)

	Hageman Factor Deficiency
		Hageman Factor Deficiency is a rare inherited blood disorder that causes prolonged clotting (coagulation) of blood in a test tube without the presence of prolonged clinical bleeding tendencies.
		It is caused by a deficiency of the Hageman factor (Factor XII), a plasma protein (glycoprotein).
		Although it is thought that Factor XII is needed for blood clotting, when it is deficient, other blood clotting factors tend to compensate for its absence.
	www.webmd.com /hw/raising_a_family/nord499.asp (442 words)

	Channel3000.com - Health Encyclopedia - Factor XII (Hageman Factor) Deficiency (Site not responding. Last check: 2007-11-03)
		Channel3000.com - Health Encyclopedia - Factor XII (Hageman Factor) Deficiency
		It?does not cause abnormal bleeding in the affected person, but the blood takes longer than normal to clot (coagulate) in a test tube.?It results from a deficiency of the plasma protein factor XII.
		Factor XII deficiency is a rare hereditary disorder that is usually found when clotting tests are done for routine screening.
	www.channel3000.com /encyclopedia/6860308/detail.html (282 words)

	Virginia Hospital Center - Factor Xii (hageman Factor) Deficiency
		Virginia Hospital Center - Factor Xii (hageman Factor) Deficiency
		This is an inherited disorder that causes prolonged clotting (coagulation) of blood in a test tube without a clinical bleeding tendency, and results from a deficiency of the plasma protein factor XII.
		Factor XII deficiency is a hrare ereditary disorder that is usually found when clotting tests are done for routine screening.
	www.virginiahospitalcenter.com /content/adam_000545.asp (211 words)

	Hemostasis Reference Laboratory \| Factor XII Activity
		A one-stage intrinsic system clotting assay is used to measure circulating factor XII levels.
		Clotting times of dilutions of patient plasma are compared to dilutions of a plasma pool from normal donors, when added to deficient plasma.
		[Levels are reduced in hereditary factor XI deficiency (which is sometimes associated with a clinical bleeding tendency), or in the presence of a factor XI inhibitor, liver disease, or disseminated intravascular coagulation (DIC).]
	www.psbc.org /lab_hemostasis/factor10.htm (94 words)

	Factor XII Deficiency - Hageman Trait - information page with HONselect
		Factor XII Deficiency - Hageman Trait - information page with HONselect
		Definition: An absence or reduced level of blood coagulation factor XII.
		Synonym(s): Hageman Trait / Deficiency, Factor XII / Deficiencies, Factor XII / Factor XII Deficiencies /
	www.hon.ch /HONselect/RareDiseases/EN/C15.378.100.141.330.html (199 words)

	Inhibition of ER{alpha}-Mediated Trans-Activation of Human Coagulation Factor XII Gene by Heteromeric Transcription ... (Site not responding. Last check: 2007-11-03)
		Inhibition of ER{alpha}-Mediated Trans-Activation of Human Coagulation Factor XII Gene by Heteromeric Transcription Factor NF-Y -- Farsetti et al.
		factors, which is abolished by deletion of the NF-YA carboxyl-terminus.
		Nuclear Factor Y and Steroidogenic Factor 1 Physically and Functionally Interact to Contribute to Cell-Specific Expression of the Mouse Follicle-Stimulating Hormone-{beta} Gene
	endo.endojournals.org /cgi/content/abstract/142/8/3380 (485 words)

	FACTOR V
		Applies To: Measures levels of factor/s that can be useful in diagnosing bleeding disorders and liver disease.
		Storage Instructions: Factor V: 4 hours at 2-8 C; Factor VIII: 2 hours at room temp, 4 hours at 2-8 C; Factor IX, XI, and XII: 3 hours at room temp.
		If time from draw to receipt in the laboratory is to be greater than 4 hours, centrifuge the specimen; remove the plasma from red cells and snap freeze (-70°C) plasma.
	www.utmb.edu /lsg/LabSurvivalGuide/hem/factor_v_viii_ix_xi_xii.htm (405 words)

Try your search on: Qwika (all wikis)