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Topic: Factor of adhesion


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In the News (Sat 26 Dec 09)

  
  Factor of adhesion - Wikipedia, the free encyclopedia
In railroad engineering, the factor of adhesion of a locomotive is the weight on the driving wheels divided by the starting tractive effort.
A common rule is that for a steam locomotive a good factor of adhesion equals or exceeds 4, but not by too much.
Diesel and electric locomotives can work with a much lower factor of adhesion than a reciprocating steam locomotive because their power is applied smoothly, unlike the latter's pulsed power delivery.
en.wikipedia.org /wiki/Factor_of_adhesion   (320 words)

  
 Endometriosis and adhesions
Whilst adhesions are more often than not spoken of as a postoperative complication then this does not necessarily hold entirely true for women with endometriosis, eventhough they, of course, are a group of people who often have had numerous surgeries and thereby, by that factor alone, increase their risk of developing further adhesions [2].
Adhesions may therefore form as a result of endometrial implants bleeding onto the area around them, causing inflammation, which again leads to the formation of scar tissue as - ironically - part of the healing process.
Yet, whilst the problem of adhesions in endometrisis is widely recognised, there is at the moment no way of preventing them, when caused by the disease alone, nor a fool proof profylactic which can be applied during surgery, though many companies are at present working on finding a product which prevents adhesions.
www.endometriosis.org /adhesions.html   (407 words)

  
 Granulocyte colony-stimulating factor promotes adhesion of neutrophils -- Chakraborty et al. 284 (1): C103 -- AJP - ...
Static adhesion was performed by using a static adhesion chamber, as described previously (44, 45).
in a moderate degree of adhesion of untreated neutrophils.
Leukocyte adhesion and transmigration in the liver vasculature.
ajpcell.physiology.org /cgi/content/full/284/1/C103   (5362 words)

  
 Hepatocyte Growth Factor/Scatter Factor Promotes Adhesion of Lymphoma Cells to Extracellular Matrix Molecules Via alpha ...   (Site not responding. Last check: 2007-11-01)
Hepatocyte growth factor (HGF)/scatter factor (SF) is the ligand for a tyrosine kinase cell surface receptor encoded by the MET protooncogene (c-MET).
Recently, hepatocyte growth factor (HGF), also known as scatter factor (SF), was identified as a chemoattractant for a subset of T cells.
Adhesion of BJAB cells to Matrigel coated on membranes of Boyden chambers in the presence (A) or absence (B) of HGF/SF (15 ng/mL) for 16 hours.
www.bloodjournal.org /cgi/content/full/89/3/990   (8639 words)

  
 Regulation of Neutrophil Adhesion by Pituitary Growth Hormone Accompanies Tyrosine Phosphorylation of Jak2, p125FAK, ...
Vascular endothelial growth factor stimulates tyrosine phosphorylation and recruitment to new focal adhesions of focal adhesion kinase and paxillin in endothelial cells.
focal adhesion kinase is a substrate for the insulin and insulin-like growth factor-I tyrosine kinase receptors.
Characterization of tyrosine phosphorylation of paxillin in vitro by focal adhesion kinase.
www.jimmunol.org /cgi/content/full/165/4/2116   (5341 words)

  
 Cell Migration, Adhesion, and Morphogenesis   (Site not responding. Last check: 2007-11-01)
One area of intense study is the role of focal adhesion kinase (FAK) in mediating signals from the extracellular matrix through the beta-integrin receptors.
Future studies will focus on the role of the cytoskeleton and associated regulatory proteins in orchestrating compartmentalized signaling in response to growth factor and adhesion signals during normal developmental processes and in cancer cells.
A role for focal adhesion kinase in phenylephrine-induced hypertrophy of rat ventricular cardiomyocytes.
www.healthsystem.virginia.edu /Internet/bims_cdb/areas/motadhesion.cfm?uva_id=jtp&hideintro=1   (435 words)

  
 LPS tolerance in human endothelial cells: reduced PMN adhesion, E-selectin expression, and NF-kappa B mobilization -- ...
of the adhesion molecules intercellular adhesion molecule-1 (ICAM-1)
Adhesion of human basophils, eosinophils, and neutrophils to interleukin 1-activated human vascular enodthelial cells: contributions of endothelial cell adhesion molecules.
Endotoxin tolerance: in vivo regulation of tumor necrosis factor and interleukin-1 synthesis is at the transcriptional level.
ajpheart.physiology.org /cgi/content/full/278/3/H853   (4691 words)

  
 artisan plating.com - factor 3 - adhesion of the goldplated layer
One of the things that is often overlooked during this phase is the microscopically imbedded contaminants in the watch's outermost surface layers.
By adhering to careful cleaning processes, your electroplater can overcome most adhesion issues by submerging the watch case in a light acid rinse to remove any oxide films and to activate it's surface area.
Lack of good adhesion is one factor in replating that can often lead to surface porosity or blistering in the goldplated layer.
www.artisanplating.com /articles/platingmyths7.html   (382 words)

  
 BCM Department of Medicine
Animal models of inflammation (e.g., intravital microscopy and myocardial ischemia) are studied in mice with targeted deletion or mutations of the specific adhesion molecules.
LFA-1 is sufficient in mediating neutrophil emigration in Mac-1-deficient mice.
Functions of Domain 1 and 4 of vascular cell adhesion molecule-1 in a4 integrin-dependent adhesion under static and flow conditions are differentially regulated.
www.bcm.edu /medicine/cwsmith.htm   (350 words)

  
 Cyclic AMP induces integrin-mediated cell adhesion through Epac and Rap1 upon stimulation of the {beta}2-adrenergic ...
Cells were treated with 8-Br-cAMP or 8CPT-2Me-cAMP, and adhesion to fibronectin (5 µg/ml) was determined and plotted relative to unstimulated, mock-transfected cells.
Adhesion of cells to fibronectin in the absence or presence of isoproterenol was quantified.
Rap1 is activated by erythropoietin or interleukin-3 and is involved in regulation of ß1 integrin-mediated hematopoietic cell adhesion.
www.jcb.org /cgi/content/full/jcb.200209105v1   (4451 words)

  
 Vascular Endothelial Growth Factor Expression of Intercellular Adhesion Molecule 1 (ICAM-1), Vascular Cell Adhesion ...
Vascular endothelial growth factor (VEGF) induces adhesion molecules on endothelial cells during inflammation.
RPA of adhesion molecule mRNAs in VEGF-stimulated HUVECs.
RPA of adhesion molecule mRNAs in VEGF-stimulated HUVECs cotreated with inhibitors.
www.jbc.org /cgi/content/full/276/10/7614   (4863 words)

  
 Insulin-like Growth Factor-1 Induces Adhesion and Migration in Human Multiple Myeloma Cells via Activation of ...
Adhesion was assessed in the presence or absence of IGF-I (100 ng/ml).
cell adhesion is a prerequisite for cell migration.
Casamassima A., Rozengurt E. Insulin-like growth factor I stimulates tyrosine phosphorylation of p130(Cas), focal adhesion kinase, and paxillin.
cancerres.aacrjournals.org /cgi/content/full/63/18/5850   (6400 words)

  
 R Kramer   (Site not responding. Last check: 2007-11-01)
The first project is concerned with the role of growth factors in regulating carcinoma motiltity and invasion.
We are studying the inductive effects of hepatocyte growth factor and epidermal growth factor in stimulating adhesion, migration, and invasion of the tumor cells and how cell-cell adhesion molecules like the cadherins may restrain such invasion.
The ligand specificity of these adhesion receptors as well as growth factor-induced modulation of their expression/function is under investigation.
anatomy.ucsf.edu /pages/kramer.html   (360 words)

  
 CCN2 (Connective Tissue Growth Factor) Promotes Fibroblast Adhesion to Fibronectin -- Chen et al. 15 (12): 5635 -- ...
Adhesion assays were repeated, but cells were incubated with or without heparinase (HEPase) or chondrotinase ABC (CHaseABC), or soluble chondrotinase A, B, or C, keratin sulfate, or heparin (50 µg/ml; 6 wells/data point; average [gray box] ± SEM [error bar] are shown).
Cell adhesion after 40 min was determined (N = 6; average ± SEM is shown) as described in Materials and Methods and in the legend to Figure 1B.
Gao, R., and Brigstock, D.R. Connective tissue growth factor (CCN2) induces adhesion of rat activated hepatic stellate cells by binding of its C-terminal domain to integrin alpha(v)beta(3) and heparan sulfate proteoglycan.
www.molbiolcell.org /cgi/content/full/15/12/5635   (6887 words)

  
 Interleukin-3, -5, and Granulocyte Macrophage Colony-Stimulating Factor-Induced Adhesion Molecule Expression on ...
intercellular adhesion molecule (ICAM)-1, and ICAM-3 on eosinophils.
mouse anti-human adhesion molecule monoclonal antibody or fluorescein-conjugated
and adhesion molecules (23), eosinophil degranulation, and chemotaxis
ajrcmb.atsjournals.org /cgi/content/full/29/1/133   (4428 words)

  
 Hepatocyte Growth Factor/Scatter Factor Promotes Adhesion of Lymphoma Cells to Extracellular Matrix Molecules Via alpha ...   (Site not responding. Last check: 2007-11-01)
Hepatocyte growth factor/scatter factor promotes adhesion of lymphoma cells to extracellular matrix molecules via alpha 4 beta 1 and alpha 5 beta 1 integrins
Hepatocyte growth factor (HGF)/scatter factor (SF) is the ligand for a
Adhesion to FN was mediated by beta 1-integrins
www.bloodjournal.org /cgi/content/abstract/89/3/990   (1028 words)

  
 ARS | Publication request: Granulocyte Colony-Stimulating Factor Promotes Adhesion of Neutrophils   (Site not responding. Last check: 2007-11-01)
G-CSF induced significant adherence to intercellular adhesion molecule (ICAM)-1 that was both macrophage antigen-1 (Mac-1) and leukocyte function-associated antigen-1 dependent.
This was in marked contrast to chemokines, in which peak activation of adhesion is seen within 1 min of stimulation.
In contrast to chemokine-induced adhesion, G-CSF stimulation was not inhibited by pertussis toxin.
ars.usda.gov /research/publications/publications.htm?SEQ_NO_115=147483   (259 words)

  
 UVA DB Faculty -- J. Thomas Parsons
The long term goal of our research is to understand how signal transduction cascades initiated by growth factors and extracellular matrix-integrin interactions regulate cell adhesion, cell motility, cell growth and differentiation.
Regulation of focal adhesion targeting and inhibitory functions of the FAK related protein FRNK using a novel estrogen receptor "switch".
The association of ASAP1, an ADP ribosylation Factor-GTPase Activating Protein, with focal adhesion kinase contributes to the process of focal adhesion assembly.
www.virginia.edu /biology/develbio/faculty/parsons.htm   (399 words)

  
 Regulation of nucleocytoplasmic trafficking by cell adhesion receptors and the cytoskeleton -- Aplin and Juliano 155 ...
Additionally, integrin-mediated adhesion and an intact actin cytoskeleton are important in controlling efficient ERK nucleocytoplasmic trafficking and phosphorylation of downstream transcription factors.
Integrin-mediated adhesion regulates ERK nuclear translocation and phosphorylation of Elk-1.
Cell adhesion and the integrin-linked kinase regulate the LEF-1 and beta-catenin signaling pathways.
www.jcb.org /cgi/content/full/155/2/187   (3318 words)

  
 Adhesion Aspects of Polymeric Coatings, Vol. 2
It contains 13 peer-reviewed and updated papers addressing a variety of topics, including adhesion improvement strategies, the formation and relevance of interphase in practical adhesion, imaging of polymer surfaces, surface treatment of metals and glass by silanes, measurement of internal stresses in polymeric coatings, and more.
From the Preface: “...Polymeric coatings are used for a variety of purposes, e.g., decorative, protective, functional (as dielectrics or insulators) and a special application of polymeric coatings is their use as lithographic materials for making integrated circuit elements.
So the need to understand the factors which influence adhesion of polymeric coatings and to control it to a desirable level is quite patent...”
www.polysurfacesbookstore.com /pages/3807.html   (333 words)

  
 Escherichia coli Cytotoxic Necrotizing Factor and Pasteurella multocida Toxin Induce Focal Adhesion Kinase ...
to the assembly of focal adhesions (22, 23).
Identification of p130Cas as a mediator of focal adhesion kinase-promoted cell migration.
Tyrosine phosphorylation of Crk-associated substrates by focal adhesion kinase.
iai.asm.org /cgi/content/full/69/9/5931   (3153 words)

  
 Carvedilol Inhibits Tumor Necrosis Factor-{alpha}-Induced Endothelial Transcription Factor Activation, Adhesion ...
Signal transduction and signal modulation by cell adhesion receptors: the role of integrins, cadherins, immunoglobulin-cell adhesion molecules, and selectins.
Antioxidants inhibit monocyte adhesion by suppressing nuclear factor-kappa B mobilization and induction of vascular cell adhesion molecule-1 in endothelial cells stimulated to generate radicals.
Vascular cell adhesion molecule-1 (VCAM-1) gene transcription and expression are regulated through an antioxidant-sensitive mechanism in human vascular endothelial cells.
atvb.ahajournals.org /cgi/content/full/24/11/2075   (3346 words)

  
 Modulation of Fibroblast Cell-Substratum Adhesion During Growth Factor-Induced Cell Motility Involves the MAP Kinase ...   (Site not responding. Last check: 2007-11-01)
UAB Department of Pathology, Birmingham, AL The biophysical process of cell adhesion impacts all stages of cell motility; adhesion and de-adhesion must be orchestrated both spatially and temporally for efficient movement.
Using a centrifugation assay to quantitate the adhesion forces involved, we discovered that EGF acutely decreases attachment of NR6 cells expressing either full-length (WT) receptors or truncated (c’973) receptors that fail to activate the PLC
We suggest that the change in adhesion requires an intact MAPK pathway and calpain activity and that talin may be one of the targets of EGF-induced calpain cleavage.
www.uchsc.edu /sm/mstp/aspen99/html/posterhtml/Chang_P.html   (255 words)

  
 Weill Cornell Research
We also hypothesize that host factors contribute to microbial transmission and disease.
On-going laboratory investigations focus on characterizing host or viral factors in innate immune recognition of HIV-1 and viral phenotypic changes that influence this process.
Patient cohorts, including long-term non-progressors in Haiti will be studied for factors identified in the laboratory.
www.med.cornell.edu /research/jho   (286 words)

  
 Factmonster Search: factor
factor, in arithmetic, any number that divides a given number evenly, i.e., without any remainder.
Rh factor, protein substance present in the red blood cells of most people, capable of inducing...
Factors Affecting Friction Friction depends partly on the smoothness of the contacting surfaces, a...
www.factmonster.com /search?fr=fmtn&x=0&y=0&query=factor   (74 words)

  
 Cytoplasmic interactions between decay-accelerating factor and intercellular adhesion molecule-1 are not required for ...   (Site not responding. Last check: 2007-11-01)
Cytoplasmic interactions between decay-accelerating factor and intercellular adhesion molecule-1 are not required for coxsackievirus A21 cell infection -- Shafren et al.
Cytoplasmic interactions between decay-accelerating factor and intercellular adhesion molecule-1 are not required for coxsackievirus A21 cell infection
Casasnovas, J. and Springer, T. Pathway of rhinovirus disruption by soluble intercellular adhesion molecule 1 (ICAM-1): an intermediator in which ICAM-1 is bound and RNA is released.
vir.sgmjournals.org /cgi/content/full/81/4/889   (3074 words)

  
 APStracts 8:0063F, 2001.   (Site not responding. Last check: 2007-11-01)
Murine inner medullary collecting duct-3 (mIMCD-3) cells subjected to 90% ATP depletion demonstrated a 55% decrease in adhesion, an effect that was completely reversed by the addition of HGF.
In contrast, HGF was unable to reverse the loss of adhesion of cells exposed to 99% ATP depletion.
Thus ATP-depleted cells demonstrate a marked decrease in cell adhesion that is reversible by the addition of HGF.
www.uth.tmc.edu /apstracts/2001/renal/May/63f.html   (249 words)

  
 Flavones & Cell Adhesion
Flavones have been classified as anti-atherogenic agents that inhibit monocyte adhesion to stimulated endothelium, possibly by blocking induction of cell adhesion molecules (CAM).
This study examined the effects of flavones on the induction of CAM and the translocation and DNA binding of nuclear factor-B (NF-B) in TNF--activated human umbilical vein endothelial cells (HUVEC).
The effects of flavones, luteolin and apigenin, on adhesion of THP-1 monocytes to the TNF--activated HUVEC, protein expression and mRNA levels of vascular cell adhesion molecule-1 (VCAM-1), intracellular cell adhesion molecule-1 (ICAM-1) and E-selectin, and nuclear appearance and DNA binding activity of NF-B were determined.
www.annieappleseedproject.org /flavcelad.html   (362 words)

  
 BCM Neonatology: Faculty Research Interests - C. Wayne Smith, MD   (Site not responding. Last check: 2007-11-01)
These investigations use in vitro models of leukocyte interactions with endothelial cells under conditions of flow at physiologic shear stresses in order to study in isolation the specific families of adhesion and signaling molecules that are necessary for the cascade of events that ultimately lead to transendothelial migration of leukocytes.
The contributions of neutrophils to injury and wound healing are analyzed in mice with targeted mutations in specific adhesion molecules.
Studies in collaboration with the Section of Cardiovascular Sciences, Department of Medicine, focus on ischemia reperfusion injury in the myocardium where we investigate the contributions of these adhesion molecule families to injury and healing.
www.neonate.net /faculty/research/smith.htm   (441 words)

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