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Topic: Famciclovir

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	famciclovir - Womens Health and Medical Information on MedicineNet.com
		Famciclovir reduces the pain and the number of sores with the first episode and decreases the frequency and severity of episodes in individuals with recurrent episodes.
		Famciclovir can be used to treat chicken pox to reduce healing time, limit the number of sores (pox), and reduce fever if used within the first 24 hours after the onset of the disease.
		Famciclovir should only be used during pregnancy when the benefits to the mother outweigh potential risks to the fetus.
	www.medicinenet.com /famciclovir/article.htm (539 words)

	Famciclovir patient advice including side effects
		Famciclovir tablets are used to treat herpes zoster, commonly referred to as "shingles," in adults.
		Famciclovir is also prescribed to treat attacks of genital herpes and to prevent future flare-ups.
		Famciclovir should be used during pregnancy only when the benefit to the mother clearly outweighs the potential risk to the baby.
	www.drugs.com /pdr/FAMCICLOVIR.html (830 words)

	Data Sheet
		Famciclovir should therefore not be used in children unless the potential benefits are considered to justify the potential risks associated with treatment.
		Famciclovir should therefore not be used during pregnancy or in nursing mothers unless the potential benefits are considered to outweigh the potential risks associated with treatment.
		Famciclovir was not found to be genotoxic in a comprehensive battery of in vivo and in vitro tests designed to detect gene mutation, chromosomal damage and repairable damage to DNA.
	www.medsafe.govt.nz /Profs/Datasheet/f/Famvirtab.htm (1848 words)

	FAMCICLOVIR Faq
		Famciclovir (fam-CY-clo-veer) is an antiviral agent used to treat infections such as genital herpes.
		Famciclovir is still a relatively new antiviral agent and is not currently approved for use in patients who are immunosuppressed (ie.
		Since famciclovir is removed from the body by your kidneys, it is important to inform your doctor if you have a history of kidney disease prior to taking this medicine.
	www.tthhivclinic.com /famcic.htm (627 words)

	Famciclovir (Systemic) - MayoClinic.com (Site not responding. Last check: 2007-10-17)
		Famciclovir (fam-SYE-kloe-veer) is used to treat the symptoms of herpes zoster (also known as shingles), a herpes virus infection of the skin.
		Famciclovir is not recommended during breast-feeding because it may cause unwanted effects in nursing babies.
		Famciclovir is best used within 48 hours after the symptoms of shingles (for example, pain, burning, blisters) begin to appear, or within 6 hours after the symptoms of recurrent genital herpes (for example, pain, blisters) begin to appear.
	www.mayoclinic.com /health/drug-information/DR202723 (956 words)

	Famciclovir - Drugs & Vitamins - Drug Library - DrugDigest
		Famciclovir relieves the symptoms of herpes zoster infection (shingles) or genital herpes infection.
		Famciclovir is also used to reduce the number of episodes of genital herpes infection.
		If famciclovir is used to treat (rather than prevent) an infection, it should be taken when you first notice symptoms of infection, such as tingling, itching, or pain in the affected area.
	www.drugdigest.org /DD/DVH/Uses/0,3915,251\|Famciclovir,00.html (603 words)

	FAMCICLOVIR
		You may take famciclovir with or without food. Swallow each tablet whole with water. Do not chew it. It is important to finish all the tablets you have been given even if you start to feel better.
		Since famciclovir is removed from the body by your kidneys, it is important to inform your doctor if you have kidney problems prior to taking this drug. Also tell your doctor if you have HIV, AIDS, or any kind of bone marrow disease.
		Famciclovir should be stored in a cool (15-30°C) dry place, protected from light and well out of the reach of children. Do not store in the bathroom or kitchen, as heat and moisture may cause the drug to be less active.
	www.tthhivclinic.com /FactSheets/html/FAMCICLOVIR.html (715 words)

	Famcyclovir for Herpes Simplex Virus Shedding in Women
		To determine whether famciclovir is effective in reducing asymptomatic shedding, women with frequent, recurrent genital outbreaks were enrolled in a randomized, double-blind, double-dummy, placebo-controlled, parallel-group, 112-day trial of suppressive treatment with famciclovir for anogenital viral shedding.
		Famciclovir is highly effective in the acute, episodic treatment of recurrent genital herpes, reducing the time to cessation of viral shedding and lesion symptoms and the time to lesion healing, compared with placebo.
		Because of that, I sought separately to confirm the efficacy of famciclovir twice daily in a small cohort of men with less frequent recurrences of genital herpes who were undergoing a 12-month, randomized, placebo-controlled treatment regimen of 250 mg of famciclovir twice daily designed to determine safety and effects on semenology parameters.
	www.natap.org /2004/HIV/051004_05.htm (2646 words)

	famciclovir Drug Information
		Treatment with famciclovir should be started as soon as possible after the first appearance of symptoms (such as tingling, burning, blisters).
		Famciclovir is used to treat infections caused by herpes viruses.
		If you are using probenecid, you may not be able to use famciclovir, or you may need dosage adjustments or special tests during treatment.
	www.drugs.com /mtm/famciclovir.html (1272 words)

	Welcome to Zellers Pharmacy Online
		Famciclovir belongs to the family of medications known as antivirals.
		Anyone allergic to famciclovir or to any of the ingredients of the medication should not use it.
		Transmission: Genital herpes is a sexually transmitted disease with an increased risk of passing it on to a sexual partner during acute episodes.
	www.mediresource.com /zellers/health/DrugInfo.asp?BrandNameID=1120&dowhat=accept_disclaimer (812 words)

	AEGiS-PRn: A Leading Antiviral, Famvir, is Safe and Effective Treatment for Hepatitis B
		In the famciclovir 500 mg three times daily treatment group, by the end of the study, there was significantly more seroconversion (loss of the antigen HBe Ag and appearance of antibodies to HBe Ag) compared to the placebo group (p=0.04).
		Seroconversion indicates that a person is mounting an immune response to the hepatitis B virus by producing antibodies to fight the infection.
		The safety profile of famciclovir was found to be comparable to placebo with no serious adverse events related to famciclovir treatment.
	www.aegis.com /news/pr/1996/PR961110.html (1137 words)

	Carilion - Famciclovir(Systemic) - [Medication]
		Although famciclovir will not cure genital herpes or herpes zoster, it does help relieve the pain and discomfort and helps the sores heal faster.
		However, famciclovir has not been shown to cause birth defects or other problems in animal studies.
		Famciclovir is not recommended during breast-feeding because it may cause unwanted effects in nursing babies.
	www.carilion.com /kbase/htm/mdx-/drde/2027/23/mdx-drde202723.htm (896 words)

	Howstuffworks "Famciclovir: A Profile of a Herpes Drug"
		Famciclovir is used to treat genital herpes and herpes zoster (shingles) infections of the skin.
		Be sure to tell your doctor about any unusual or allergic reactions you have had to famciclovir or to any other medication, including antiviral medications.
		Famciclovir is not considered safe to use during breast-feeding.
	health.howstuffworks.com /define-famciclovir.htm (675 words)

	Economic evaluation of famciclovir in reducing the duration of postherpetic neuralgia -- Huse et al. 54 (10): 1180 -- ...
		The economic impact of famciclovir therapy for postherpetic neuralgia (PHN) in patients with acute herpes zoster was studied.
		The effects of famciclovir on PHN in the model were based on the results of a randomized, double-blind trial in 419 adult outpatients.
		A model for the use of famciclovir to treat acute herpes zoster showed that the cost of such therapy was largely offset by savings in the cost of treating this complication.
	www.ajhp.org /cgi/content/abstract/54/10/1180 (398 words)

	ACS :: Cancer Drug Guide: famciclovir
		Famciclovir belongs to the general class of drugs called antivirals.
		Famciclovir is a tablet taken by mouth 2 to 3 times a day for 5 to 7 days as directed by your doctor.
		Famciclovir is very well tolerated with few side effects.
	www.cancer.org /docroot/CDG/content/CDG_famciclovir.asp (391 words)

	ICAR: Famciclovir More Effective Than Valaciclovir In Reducing Latent Herpes (Site not responding. Last check: 2007-10-17)
		Based on these compelling results, a world-wide clinical trial is underway to determine if a single 10-day treatment with famciclovir during a patient's primary genital herpes outbreak will prevent future outbreaks and eliminate the need for further medication.
		There is currently no cure for genital herpes, but recent preclinical research suggests that famciclovir may impact the genital herpes virus before it enters the latent stage of infection.
		Dr. Field presented studies that found through use of a co-cultivation laboratory assay, that treating initial herpes virus (HSV-1 or HSV-2) infections in mice with famciclovir appears to reduce the number of cells with latent HSV and in some cases prevent the virus from reactivating.
	www.pslgroup.com /dg/6A4DA.htm (563 words)

	Famvir Online, Description, Chemistry, Ingredients, Blackbox - Famciclovir - RxList Monographs
		Famciclovir is a white to pale yellow solid.
		C famciclovir is freely soluble (>25% w/v) in water initially, but rapidly precipitates as the sparingly soluble (2%-3% w/v) monohydrate.
		Mechanism of Antiviral Activity: Famciclovir undergoes rapid biotransformation to the active antiviral compound penciclovir, which has inhibitory activity against herpes simplex virus types 1 (HSV-1) and 2 (HSV-2) and varicella zoster virus (VZV).
	www.rxlist.com /cgi/generic/famciclovir.htm (494 words)

	Famciclovir for ophthalmic zoster: a randomised aciclovir controlled study -- Tyring et al. 85 (5): 576 -- British ...
		Iris atrophy was observed in 2% and 4% of famciclovir and aciclovir
		Famciclovir: confirmed efficacy of 250 mg tid for the treatment of herpes zoster infection.
		Famciclovir, a new oral antiherpes drug: results of the first controlled clinical study demonstrating its efficacy and safety in the treatment of uncomplicated herpes zoster in immunocompetent patients.
	bjo.bmjjournals.com /cgi/content/full/85/5/576 (3930 words)

	American Social Health Association - News
		For both recurrent genital herpes and cold sores, famciclovir therapy must be started as soon as possible after the first prodrome symptoms to be effective.
		The clinical studies of one-day therapy with famciclovir on people with recurrent genital herpes showed that the time for healing of the herpes sores and the time for symptoms such as pain, burning, and itching to resolve was significantly shortened by almost two days compared with placebo.
		The approved dosage of famciclovir for cold sores (recurrent oral herpes) is a single 1,500 mg dose.
	www.ashastd.org /news/news_pressreleases_Famvir.cfm (392 words)

	Famvir side effects (Site not responding. Last check: 2007-10-17)
		Famciclovir is used to treat infections caused by herpes viruses including shingles, genital herpes, and cold sores (in people with HIV).
		Famciclovir is in the FDA pregnancy category B. This means that it is unlikely to harm an unborn baby.
		A famciclovir overdose has no known symptoms, but an overdose of acyclovir (Zovirax), which is a similar drug, may cause seizures, hallucinations, and kidney damage (decreased urine production).
	www.medicationadvisor.com /side_effects/Famvir.htm (1231 words)

	Combination lamivudine-famciclovir needed to treat HBV in HIV-Infected patients
		NEW YORK (Reuters Health) - The addition of famciclovir (Famvir) to initial lamivudine (Epivir-HBV; 3TC) monotherapy is not an effective way to control hepatitis B virus (HBV) infection in HIV-infected patients, according to a recent report.
		Dr. Mark Nelson, from the Chelsea and Westminster Hospital in London, and colleagues assessed the outcomes of eight patients coinfected with HIV and HBV who were treated with lamivudine and famciclovir.
		A slight decrease in HBV viral load was noted 3 months after famciclovir was added to lamivudine therapy.
	www.hivandhepatitis.com /hiv_hbv_co_inf/011402b.html (239 words)

	Famciclovir for treatment of herpesvirus infections -- Luber and Flaherty JF 30 (9): 978 -- The Annals of ...
		In trials comparing famciclovir with acyclovir for the treatment of herpes zoster in immunocompetent individuals, comparable results were obtained.
		Famciclovir is also effective as therapy for recurrent episodes of genital herpes and may prove useful for chronic suppressive therapy.
		The dosage of famciclovir for herpes zoster in immunocompetent individuals is 500 mg po tid for 7 days; for recurrent genital herpes a dosage of 125 mg po bid for 5 days is recommended.
	www.theannals.com /cgi/content/abstract/30/9/978 (355 words)

	Famciclovir for the Treatment of Recurrent Genital and Labial Herpes Lesions
		dose of famciclovir had significant advantages over the placebo, reducing the time required to heal the lesions, preventing the development of lesions beyond the papule stage, and improving the time to resolution of all symptoms.
		Famciclovir was shown to stop the progression to a full outbreak or shorten the duration of a recurrent genital herpes outbreak.
		This study shows that a single dose (1,500mg) of famciclovir is effective in treating a herpes labialis outbreak, is well tolerated, and is convenient - a factor that may have the potential to improve patient compliance.
	www.skintherapyletter.com /2005/10.10/2.html (1350 words)

	News - Famciclovir (Famvir) Improves Time-to-Healing in Genital Herpes Outbeak: Presented at AAD (Site not responding. Last check: 2007-10-17)
		Famciclovir is FDA-approved for the treatment or suppression of recurrent genital herpes in immunocompetent patients, the treatment of recurrent mucocutaneous herpes simplex infections in HIV-infected patients and the treatment of acute herpes zoster (shingles).
		Famciclovir treatment also appeared to increase the proportion of patients with aborted lesions compared with the placebo group (23.3% vs. 12.7%;
		Famciclovir was faster than placebo in resolving all symptoms (median time for all comparisons, 3.3 vs. 5.4 days;
	www.docguide.com /news/content.nsf/news/852571020057CCF68525712B00644D57 (631 words)

	Famciclovir: Drug Information Provided by Lexi-Comp: Merck Manual Professional
		Famciclovir undergoes rapid biotransformation to the active compound, penciclovir, which is phosphorylated by viral thymidine kinase in HSV-1, HSV-2, and VZV-infected cells to a monophosphate form; this is then converted to penciclovir triphosphate and competes with deoxyguanosine triphosphate to inhibit HSV-2 polymerase (eg, herpes viral DNA synthesis/replication is selectively inhibited)
		For herpes zoster (shingles) infections, famciclovir should be started within 72 hours of the appearance of the rash to be effective.
		Famciclovir has been shown to accelerate healing, reduce the duration of viral shedding, and resolve posthepatic neuralgia faster than placebo.
	www.merck.com /mmpe/lexicomp/famciclovir.html (1228 words)

	News - Famciclovir Reduces Impact, Recurrence of Attacks of Genital Herpes: Presented at ICAAC
		In the multicenter, multinational, randomized, double-blind, placebo-controlled study of famciclovir, 163 patients took a 1-g dose of famciclovir twice in 1 day.
		Study subjects were told to begin treatment within 6 hours after they experienced the prodromal symptoms that accompany herpes outbreaks or when they first became aware of genital herpes lesions.
		All lesional symptoms resolved faster in famciclovir-treated than placebo-treated patients, he said, and noted that among famciclovir patients the mean time to clearance of symptoms was 3.3 days compared with 5.4 days for those on placebo.
	www.docguide.com /news/content.nsf/news/8525697700573E18852570DF0069F410 (544 words)

	Arch Fam Med -- Antiviral Therapy for Herpes Zoster: Randomized, Controlled Clinical Trial of Valacyclovir and ...
		Valacyclovir and famciclovir, as oral prodrugs of the acyclic
		Famciclovir for the treatment of acute herpes zoster: effects on acute disease and post-herpetic neuralgia.
		Degreef H. Famciclovir, a new oral antiherpes drug: results of the first controlled clinical study demonstrating its efficacy and safety in the treatment of uncomplicated herpes zoster in immunocompetent patients.
	archfami.ama-assn.org /cgi/content/full/9/9/863 (3403 words)

	Famciclovir - Wikipedia, the free encyclopedia
		Famciclovir (INN) (IPA: [pɛnˈsaɪklovir]) is a guanine analogue antiviral drug used for the treatment of various herpesvirus infections, most commonly for herpes zoster (shingles).
		It is a prodrug form of penciclovir with improved oral bioavailability.
		Famciclovir is marketed under the trade name Famvir (Novartis).
	en.wikipedia.org /wiki/Famciclovir (97 words)

	AEGiS-03CROI: Efficacy of famciclovir for suppressing HSV-2 infections among 13 HIV+ persons.
		In the intent to treat analysis of time prior to crossover, 4/21 (19%) on Famciclovir vs 13/21 (62%) on placebo reactivated HSV (p<.02), the overall shedding rate was 8/1035 (0.8%) days vs. 98/1090 (9.0%) days, respectively (p<.01).
		Among these 29 subjects, Famciclovir therapy was associated with significantly less overall HSV shedding, subclinical HSV shedding, and days of reported lesions.
		Suppressive therapy with Famciclovir at 500 mg PO BID x 8 weeks is safe, well tolerated and effective in significantly reducing clinical and subclinical HSV reactivation in HIV infected persons.
	ww2.aegis.org /conferences/CROI/1996/13.html (322 words)

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