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Topic: Familial Mediterranean fever

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Hyperimmunoglobinemia D with recurrent fever

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	Familial Mediterranean fever - Wikipedia, the free encyclopedia
		Familial Mediterranean fever (FMF) is a hereditary inflammatory disorder that affects groups of patients originating from around the Mediterranean Sea (hence its name).
		Mutations occur in exons 2, 3, 5 and 10.
		FMF patients who marry a carrier or another FMF patient have a 50% and 100% chance, respectively, in having a child with FMF.
	en.wikipedia.org /wiki/Familial_Mediterranean_fever (765 words)

	Familial Mediterranean fever - Genetics Home Reference
		Familial Mediterranean fever is an inherited condition characterized by recurrent episodes of painful inflammation in the abdomen, chest, or joints.
		Mutations in the MEFV gene cause familial Mediterranean fever.
		In rare cases, familial Mediterranean fever is inherited in an autosomal dominant pattern, which means one copy of the altered gene is sufficient to cause the disorder.
	ghr.nlm.nih.gov /condition=familialmediterraneanfever;jsessionid=1C3... (668 words)

	GeneDis Familial Mediterranean Fever (FMF) Mutations
		FMF disease is an autosomal recessive disease clinically characterized by recurrent short self-limited attacks of fever accompanied by peritonitis, pleurisy, and arthritis, due to mutations in the pyrin gene.
		Familial Mediterranean fever (FMF, MEF; OMIM 249100) is an autosomal recessive disease clinically characterized by recurrent short self-limited attacks of fever accompanied by peritonitis, pleurisy, and arthritis.
		Using extended pedigree data of 90 FMF probands, the FMF gene frequency in various ethnic groups in Israel was calculated by analyzing the frequency in a total of 2,312 first cousins (3).
	life2.tau.ac.il /GeneDis/Tables/FMF/fmf.html (987 words)

	Mediterranean Fever, Familial
		It is possible that the main title of the report Mediterranean Fever, Familial is not the name you expected.
		Familial Mediterranean fever (FMF) is a rare, inherited, inflammatory disease characterized by recurrent attacks of fever and acute inflammation of the membranes that line the abdominal cavity (peritonitis) and/or the lungs (pleuritis); pain and swelling of the joints (arthritis); and/or the heart (pericarditis) and, in some cases, skin rashes.
		FMF is inherited as an autosomal recessive trait.
	my.webmd.com /hw/arthritis/nord127.asp (473 words)

	Familial Mediterranean Fever differential diagnosis (Site not responding. Last check: 2007-10-21)
		Familial Mediterranean fever is the commonest periodic fever disorder, occurring mainly in people originating from the Mediterranean basin.1 In Israel alone over 5000 people are estimated to suffer from this disorder.
		Familial Mediterranean fever can be complicated by nephropathic amyloidosis of the AA type, but in most patients colchicine up to 1-2 mg/day prevents both the acute attacks and the development of amyloidosis.
		Familial Mediterranean fever, or recurrent polyserositis, is a recessively inherited disorder that affects Sephardic Jews, Turks, Armenians, and Arabs.
	www.fmfcommunity.org /diagnosis.html (3962 words)

	Familial Mediterranean Fever
		Familial Mediterranean fever associated pyrin mutations in Greece.
		Familial Mediterranean fever (FMF) mutations occur frequently in the Greek-Cypriot population of Cyprus.
		Diagnostic value of MEFV gene analysis in familial Mediterranean fever must still be assessed in non-classically affected populations (Letter to the Editor).
	www.nzma.org.nz /journal/117-1199/1007 (582 words)

	THE MERCK MANUAL, Sec. 21, Ch. 289, Familial Mediterranean Fever
		Familial mediterranean fever (familial paroxysmal peritonitis): An inherited disorder characterized by recurrent fever and peritonitis and less frequently by pleuritis, arthritis, skin lesions, and pericarditis.
		Fever as high as 40° C (104° F), usually accompanied by peritonitis, is the major manifestation; occasionally, serositis occurs with a low fever.
		Amyloidosis may develop (most frequently in patients in the Mediterranean region) due to perivascular deposition of serum amyloid A protein; it is much less common since the advent of colchicine.
	www.merck.com /mrkshared/mmanual/section21/chapter289/289a.jsp (651 words)

	Familial Mediterranean Fever
		Familial Mediterranean fever: clinical and genetic characterization in a mixed pediatric population of Jewish and Arab patients.
		Familial Mediterranean fever (FMF) is a recessive disorder characterized by episodes of fever and intense inflammation.
		Familial Mediterranean fever (FMF) is an autosomal recessive disease.
	www.thedoctorsdoctor.com /diseases/familial_med_fever.htm (3418 words)

	Armenian Disease
		However, continued fever, pleurisy, and radiographic changes suggested a diagnosis of pulmonary tuberculosis, which was confirmed bacteriologically. The patient's entire clinical course could be explained on the basis of tuberculosis infection and reactivation, whereas the clinical significance of his FMF mutation remains unclear.
		Familial Mediterranean fever is an autosomal recessive disease carried by one in seven Armenians.
		Familial Mediterranean fever in Armenians: autosomal recessive inheritance with high gene frequency.
	www.cilicia.com /armo24g.html (1342 words)

	genome.gov \| Learning About Familial Mediterranean Fever
		Familial Mediterranean Fever (FMF) is an inherited disease, characterized by recurrent attacks of fever, inflammation of the abdominal lining (peritonitis), inflammation of the lining surrounding the lungs (pleurisy), painful, swollen joints (arthralgia and occasionally arthritis), and a characteristic ankle rash.
		FMF is characterized by relatively short, usually 1- to 3-day, episodes of fever accompanied with serositis, synovitis or skin rash.
		Familial Mediterranean Fever (FMF) is an autosomal recessive inherited disease, which means it appears only in individuals who received two copies of the mutant (altered) gene that causes FMF, one from each parent.
	www.genome.gov /12510679 (1192 words)

	Scientists Identify Gene For Familial Mediterranean Fever (Site not responding. Last check: 2007-10-21)
		Out of the three FMF gene mutations identified so far in these families, the same two mutations are found in ethnic populations that have been geographically separated for over 2,000 years, suggesting that most individuals with the disease are descended from a small, ancient group of individuals.
		Kastner and colleagues found that the FMF gene is decoded to make the protein only in white blood cells called peripheral blood leukocytes, which are the first line of the body’s defense system in an infection or after certain other challenges to the body.
		In FMF, Kastner hypothesizes, "this switch is not working quite right, so that even if you get a small provocation you can end up getting a strong inflammatory response, whereas in normal people the protein would [eventually] shut down this response." This over-reaction leads to disease symptoms such as fever and excessive inflammation.
	pslgroup.com /dg/357da.htm (1258 words)

	FAMILIAL MEDITERRANEAN FEVER
		The gene, a variant of a gene that controls fever, has come to light because it causes an unusual disease called familial Mediterranean fever in people who inherit a copy from both parents.
		Since the gene is active only in a special class of white blood cells, its usual duty seems to be to control the cells' activity and rein them in when the threat of infection has passed.
		Familial Mediterranean fever is rare in the United States.
	www.saudades.org /familialmedit.html (905 words)

	eMedicine - Mediterranean Fever, Familial : Article by John Meyerhoff, MD
		Synonyms and related keywords: FMF, periodic disease, recurrent polyserositis, familial Mediterranean fever, amyloidosis, colchicine therapy, colchicine, appendicitis, peritonitis, amyloid nephropathy, MEFV gene, pyrin, marenostrin, amyloid A, serum amyloid A, nephrotic syndrome, paroxysm, renal vein thrombosis, proteinuria, vasculitis, arthritis, myalgia syndrome, peritonitis, pleuritis, peritoneum, seronegative spondyloarthropathy, chemotactic factor
		Pathophysiology: Nonsense or missense mutations in the MEFV (Mediterranean fever) gene appear to cause the disease.
		However, patients with FMF lack this ability, and this results in uninhibited activity of the chemotactic factor and episodes of inflammation (with associated fever) in the peritoneum, pleura, and joints.
	www.emedicine.com /med/topic1410.htm (2845 words)

	Hospital Practice: Familial Mediterranean Fever (Site not responding. Last check: 2007-10-21)
		Although the gene responsible for hyperimmunoglobulinemia D syndrome and the one responsible for familial Hibernian fever have not yet been identified, the absence of genetic linkage to the short arm of chromosome 16 shows that the genes are not MEFV.
		Familial Hibernian fever is the rarest of the three syndromes.
		When Israeli investigators compared 148 FMF carriers with 148 controls not known to be in an FMF family, the control group turned out to include six asthmatics, whereas the carrier group had three--a difference that did not reach statistical significance.
	www.hosppract.com /genetics/9804gen.htm (4848 words)

	Familial Mediterranean Fever and associated periodic fever diseases (Site not responding. Last check: 2007-10-21)
		The hyperIgD and periodic fever syndrome is characterized by febrile attacks every 4–8 weeks associated with an intense inflammatory reaction, accompanied by adenopathies, abdominal pain, diarrhea, joint pain, hepatosplenomegaly and cutaneous signs.
		It can be established by the detection of elevated excretions of mevalonic acid in urine during fever episodes or by dosage of level of mevalonate kinase in lymphocytes.
		Periodic fever is an uncommon condition defined by recurring bouts of fever in people who seem healthy except during their fever attacks.
	www.fmfcommunity.org /HIDS.html (1035 words)

	Familial Mediterranean Fever - Information and Support Resources (Site not responding. Last check: 2007-10-21)
		Familial Mediterranean Fever is an inherited rheumatic disease that occurs most commonly in people of non-Ashkenazi Jewish, Armenian, Arab and Turkish Background living in the United States and abroad.
		As many as one in 200 people in these populations have the disease and as many as one-in-five to one-in-seven carry the mutated Familial Mediterranean Fever gene.
		The only treatment for Familial Mediterranean Fever is a drug called Colchicines which patients have to take every day for their life.
	www.mazornet.com /genetics/familial_mediterranean_fever.asp (485 words)

	Melungeon Health (Site not responding. Last check: 2007-10-21)
		The gene for FMF is located on the short arm of chromosome 16, yet the exact nature of the disease remains unclear.
		The identification of FMF is based on clinical findings, family history, physical examination and laboratory results obtained from patients experiencing attacks.
		Fever, weight loss, joint pain, with liver involvement and enlarged lymph nodes are common.
	www.melungeonhealth.org (1682 words)

	Mediterranean Fever, Familial
		The symptoms of familial Mediterranean fever, which may be recurring, typically include fever, severe abdominal pain, and/or chest pain.
		For example, the researchers stressed that a particular FMF gene mutation (known as "Met694Val") is common in certain populations with more severe disease including earlier disease onset, increased frequency of inflammation of the joints (arthritis) and the membranes that line the lungs (pleuritis), and a high occurrence of amyloidosis.
		It has also been suggested that certain FMF gene mutations may be inherited as an autosomal dominant trait, meaning that only a single copy of the disease gene is needed to result in expression of the disorder.
	hw.healthdialog.com /kbase/nord/nord127.htm (2215 words)

	Chicago Center for Jewish Genetics Disorders - Sephardi Disorders: Familial Mediterranean Fever
		Familial Mediterranean Fever (FMF) is characterized by recurrent painful episodes of fever, peritonitis (abdominal pain), pleuritis (lung inflammation leading to painful breathing), and/or arthritis in the hip, knee, and/or ankle, lasting 2 - 3 days.
		The most severe complication is amyloidosis, a condition resulting from accumulation of a starch-like glycoprotein (amyloid) in tissues and organs, impairing their function.
		It is estimated to be as high as 1 in 5 for Ashkenazi Jews, in whom the disease is much milder.
	www.jewishgeneticscenter.org /what/sephardi/familial.asp (215 words)

	Disease - Familial Mediterranean fever - Hartford, Connecticut
		Familial Mediterranean fever is an inherited disorder characterized by recurrent fever and inflammation, often involving the abdomen or the lung.
		Risk factors include a family history of familial Mediterranean fever or being of Mediterranean ancestry.
		Amyloidosis (deposits of protein in different organs) is more common in patients with familial Mediterranean fever.
	www.saintfranciscare.com /12157.cfm (456 words)

	Diagnosis of Familial Mediterranean Fever by a Molecular Genetics Method -- Eisenberg et al. 129 (7): 539 -- Annals of ...
		mutations of MEFV are responsible for familial Mediterranean
		Genotypes ("normal" for homozygous normal, "affected" for homozygous familial Mediterranean fever [FMF], and "carrier" for heterozygous familial Mediterranean fever) were inferred from the combined results of both reactions.
		fever, a disease primarily diagnosed on a clinical basis [3-7].
	www.annals.org /cgi/content/full/129/7/539 (2291 words)

	Dr. Koop - Familial Mediterranean fever (Site not responding. Last check: 2007-10-21)
		The cause of familial Mediterranean fever is unknown.
		Inflammation in the lining of the abdominal cavity, chest cavity, skin, or joints occurs, along with high fevers that usually peak in 12 to 24 hours.
		Risk factors include a family history of familial Mediterranean fever or having Mediterranean ancestry.
	www.drkoop.com /ency/93/000363.html (243 words)

	Familial Mediterranean fever - MayoClinic.com (Site not responding. Last check: 2007-10-21)
		Familial Mediterranean fever is a rare, inherited disorder caused by a defect in chromosome 16.
		It's characterized by recurrent bouts of fever and inflammation, usually involving the abdomen, lungs and joints.
		Familial Mediterranean fever is inherited as an autosomal recessive trait.
	www.mayoclinic.com /invoke.cfm?id=AN00865 (301 words)

	Mediterranean Fever definition - Medical Dictionary definitions of popular medical terms
		Mediterranean Fever: A inherited disorder of unknown cause featuring short recurring bouts of fever together with pain in the joints, chest or abdomen.
		The gene for FMF (autosomal recessive, on chromosome 16) was reportedly identified in August, 1997.
		FMF is found in persons of Mediterranean ethnic background.
	www.medterms.com /script/main/art.asp?articlekey=4328 (185 words)

	Familial Mediterranean Fever (Site not responding. Last check: 2007-10-21)
		Familial Mediterranean fever is a disease of high prevalence around the Mediterranean countries with four ethnic groups being particularly affected, namely Non-Ashkenazi Jews, Armenians, Arabs and Turks.
		Typically it presents as acute episodes of fever accompanied by complaints of abdominal pain, chest pain, or joint pain.
		Except for those with protracted arthritis, most patients remain free from fever and inflammation between their episodes; rarely patients report a low level of baseline discomfort or fever.
	www.ucy.ac.cy /~deltas/cyprusgmd/diseases/FMF.htm (580 words)

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