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| | Insomnia, familial fatal (Site not responding. Last check: 2007-10-22) |
 | | Fatal Familial Insomnia (FFI) is a rare type of human transmissible spongiform encephalopathy (TSE) due to a defective gene encoding the prion protein (PRNP gene). |
 | | The disorder is characterized by refractory insomnia with dreams and hallucinations, vegetative disorders (abolition of circadian rythm, sympathic hyperactivity, sphincter disorders), motor impairment and dementia that may occur late in the disease course. |
 | | The EEG is abnormal but not periodic when the subject is awake, while it is marked by the progressive disappearance of delta activity, spindles, and «K complexes» when the subject is sleeping. |
| www.orpha.net /static/GB/insomnia.html (195 words) |
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