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Topic: Fecal elastase

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	Fecal Elastase-1 Is Superior to Fecal Chymotrypsin in the Assessment of Pancreatic Involvement in Cystic Fibrosis -- ...
		Fecal Elastase-1 Is Superior to Fecal Chymotrypsin in the Assessment of Pancreatic Involvement in Cystic Fibrosis -- Walkowiak et al.
		Fecal Elastase-1 Is Superior to Fecal Chymotrypsin in the Assessment of Pancreatic Involvement in Cystic Fibrosis
		Fecal elastase-1 is decreased in villous atrophy regardless of underlying disease.
	pediatrics.aappublications.org /cgi/content/full/110/1/e7 (2485 words)

	Monoclonal versus Polyclonal ELISA for Assessment of Fecal Elastase Concentration: Pitfalls of a New Assay -- Schneider ...
		elastase 1 in stool specimens (Pancreatic Elastase 1; Schebo
		Comparison of fecal elastase concentrations measured with the pET and the mET in 27 patients with CF-associated severe exocrine pancreatic insufficiency who were receiving continuous oral pancreatic enzyme replacement therapy.
		In contrast to fecal chymotrypsin, the monoclonal elastase 1
	www.clinchem.org /cgi/content/full/51/6/1052 (1612 words)

	IngentaConnect Fecal Elastase-1 Determination: `Gold Standard' of Indirect Pancr... (Site not responding. Last check: )
		Fecal elastase-1 concentration of 200 and 100 µg/g stool and chymotrypsin activity of 6 and 3 U/g stool were used separately as cut-off levels for calculation.
		2) The correlation between fecal elastase-1 and chymotrypsin with duodenal enzyme outputs of amylase, lipase, trypsin, chymotrypsin and elastase-1 ranged between 33% and 55% and 25% and 38%, respectively.
		Conclusion: Determination of fecal elastase-1 is highly sensitive in the diagnosis of severe and moderate exocrine pancreatic insufficiency and is of significantly higher sensitivity than fecal chymotrypsin estimation.
	www.ingentaconnect.com /content/tandf/sgas/2001/00000036/00000010/art00016 (412 words)

	Monoclonal Versus Polyclonal ELISA for Assessment of Fecal Elastase Concentration: Pitfalls of a New Assay - Health - ...
		Elastase is excreted by the pancreas and passes through the intestine without significant degradation or inactivation.
		Although fecal elastase testing has a low sensitivity for the diagnosis of mild exocrine pancreatic insufficiency, the assay reliably predicts clinically relevant degrees of pancreatic insufficiency and is widely used in clinical medicine (7, 8).
		As a consequence, an explanation for the substantial difference between the elastase tests is that the polyclonal assay is influenced by the oral pancreatic supplement, which consists of capsules containing porcine pancreatin, lipase, amylase, and proteases.
	www.redorbit.com /news/display?id=155443&source=r_health (1804 words)

	The Turkish Journal of Gastroenterology (Site not responding. Last check: )
		Fecal elastase 1 measurement compared with endoscopic retrograde cholangio-pancreatography for the diagnosis of chronic pancreatitis.
		Fecal elastase- 1 test is superior to fecal lipase test in the assessment of exocrine pancreatic function in cystic fibrosis.
		Fecal elastase- 1 is superior to fecal chymotrypsin in the assessment of pancreatic involvement in cystic fibrosis.
	www.turkgastro.org /text.php?id=384 (2943 words)

	MEDICINA
		The fecal concentration of alpha-1-antitrypsin was measured by radial immunodiffusion and the activities of the enzymes were measured using specific substrates.
		We found an increase in fecal PA, alpha-1-antitrypsin and neutrophil elastase in patients with UC and the correlation between the severity of the disease and the PA was statistically significant (r = 0.62, P < 0.05).
		This study shows that fecal proteolytic activity was significantly higher in patients with ulcerative colitis than in healthy subjects and this PA had a significantly positive correlation with the severity of the disease.
	www.medicinabuenosaires.com /vol58-98/3/colonicproteinases.htm (1692 words)

	Fecal Incontinence
		Fecal incontinence - Fecal incontinence is the inability to control one's bowels.
		Fecal elastase - Fecal elastase refers to the testing of the concentration of the pancreatic elastase-1 enzyme found in fecal matter with an enzyme-linked immunosorbent assay (ELISA).
		Causes Fecal incontinence Fecal incontinence Fecal incontinence Fecal incontinence can have several causes: diarrhea pelvic floor dysfunction an extended period without defecation severe muscular strain in the abdominal area, particularly when giving birth damage to the anal sphincter muscles damage to the...
	di67.macblo.com /FecalIncontinence.html (909 words)

	CAT.INIST
		Diagnostic accuracy of fecal elastase 1 assay in patients with pancreatic maldigestion or intestinal malabsorption: A collaborative Study of the Italian Society of Pediatric Gastroenterology and Hepatology
		Several reports have indicated that fecal elastase-1 (EL-1) determination is a new, sensitive, and specific noninvasive pancreatic function test; however, very few patients with malabsorption due to small intestine diseases have been included in the previous studies.
		The aim of the study was to compare the diagnostic accuracy of fecal EL-1 and fecal chymotrypsin (FCT) in distinguishing between pancreatic maldigestion and intestinal malabsorption.
	cat.inist.fr /?aModele=afficheN&cpsidt=1002825 (574 words)

	INTER SCIENCE INSTITUTE
		Human pancreatic elastase (EL 1) is a glycoprotein synthesized by the acinar cells that differs from other pancreatic proteases in that, in addition to extending a protolytic activity, it combines with bile acids and neutral steroids in the intestinal lumen to transport cholesterol and its metabolites along the intestinal tract.
		Elastase (EL 1) concentration in stool is five times higher than pancreatic juice (1991, Ref. 2); therefore, fecal elastase (EL 1) concentration accurately reflects the amount of enzyme secreted from the pancreas.
		Fecal elastase (EL 1) is an ideal diagnostic test for pancreatic function in children with Cystic Fibrosis (reliable over the age of two weeks), since it remains intact during its intestinal transition and its concentration reflects the secretory capacity of the pancreas with 100% sensitivity.
	www.interscienceinstitute.com /book/e.html (4644 words)

	Genova Diagnostics
		Faecal elastase 1: a marker of exocrine pancreatic insufficiency in cystic fibrosis.
		Evaluation of fecal pancreatic elastase as a measure of pancreatic exocrine function in children with cystic fibrosis.
		12.Walkowiak J, Herzig KH, Strzykala K, Przyslawski J, Krawczynski M. Fecal elastase 1 is superior to fecal chymotrypsin in the assessment of pancreatic involvement in cystic fibrosis.
	www.gdx.net /ns/assessments/pe1 (559 words)

	Exocrine Pancreatic Insufficiency
		Fasting is not necessary and any fecal sample will do; however, 3 consecutive samples are needed to get a consistent result as there is tremendous variability in fecal enzyme activity over the day.
		The Fecal Elastase test (elastase being another digestive enzyme) is the newest test and it is only available for dogs.
		A single fecal sample is needed but the problem is that some times normal dogs will test negative for Elastase.
	www.marvistavet.com /html/body_exocrine_pancreatic_insufficie.html (951 words)

	IngentaConnect Diagnostic Accuracy of Fecal Elastase 1 Assay in Patients with Pa...
		IngentaConnect Diagnostic Accuracy of Fecal Elastase 1 Assay in Patients with Pa...
		Several reports have indicated that fecal elastase-1 (EL-1) determination is a new, sensitive, and specific noninvasive pancreatic function test; however, very few patients with malabsorption due to small intestine diseases have been included in the previous studies.
		The aim of the study was to compare the diagnostic accuracy of fecal EL-1 and fecal chymotrypsin (FCT) in distinguishing between pancreatic maldigestion and intestinal malabsorption.
	www.ingentaconnect.com /content/klu/ddas/2001/00000046/00000006/00340951 (501 words)

	Fecal elastase test: evaluation of a new noninvasive pancreatic function test.
		Fecal elastase test: evaluation of a new noninvasive pancreatic function test.
		METHODS: A total of 69 patients were included in the study, 20 of whom were diagnosed with CP according to the findings on ERP and CT; 13 patients had other pancreatic diseases, and the remaining 36 patients had gastrointestinal or hepatic disorders.
		RESULTS: Similar to PLT, fecal elastase concentration was significantly decreased in patients with moderate and severe CP (assessed by ERP) compared with patients with extrapancreatic disorders.
	www.medscape.com /medline/abstract/7572904 (345 words)

	Human pancreatic elastase ELISA from BIOSERV Diagnostics
		In-vitro test kit for the quantitative detection of human fecal pancreatic elastase in stool in order to diagnose and quantify pancreatic insufficiency.
		Pancreatic Elastase is enriched 5-6 fold in feces in comparison to the concentration in the duodenal juice
		The Bioserv Elastase ELISA for the detection of fecal pancreatic Elastase allows a highly sensitive and specific determination of faecal pancreatic Elastase, enabling the clinician to establish a prompt and reliable diagnosis of suspected cases of pancreatic insufficiency.
	www.bioserv-diagnostics.com /gastroenterology/pancreatic_elastase.htm (195 words)

	INTER SCIENCE INSTITUTE
		The following tests are also available from Inter Science Institute:
		Calprotectin, Chromogranin A (CgA), Elastase Fecal, Ghrelin, Inhibin A, and Inhibin B, Interleukins 10-18, Obestatin, Octreotide (Sandostatin®).
		Please contact ISI for the most up to date testing availability.
	www.interscienceinstitute.com (361 words)

	Cystic Fibrosis \| A Support Community for those dealing with Cystic Fibrosis (Site not responding. Last check: )
		In addition, protrusion of internal rectal membranes (rectal prolapse) is more common in CF because of increased fecal volume, malnutrition, and Valsalva maneuver intra–abdominal pressure due to coughing.
		Couples who are pregnant or who are planning a pregnancy can themselves be tested for CFTR gene mutations to determine the likelihood that their child will be born with cystic fibrosis.
		Consistently, neutrophil burden in CF airways was decreased upon treatment as was the number of airway neutrophils actively releasing elastase-rich granules, as measured by flow cytometry.
	wiki.cysticfibrosis.com /index.php?title=Main_Page (4834 words)

	Genova Diagnostics
		Faecal elastase 1: a marker of exocrine pancreatic insufficiency in cystic fibrosis.
		Evaluation of fecal pancreatic elastase as a measure of pancreatic exocrine function in children with cystic fibrosis.
		12.Walkowiak J, Herzig KH, Strzykala K, Przyslawski J, Krawczynski M. Fecal elastase 1 is superior to fecal chymotrypsin in the assessment of pancreatic involvement in cystic fibrosis.
	www.genovadx.com /products/pancreaticelastase1.jsp (559 words)

	Kanami Arita - English to Japanese translator. Translation services in Medical (general) ...
		Fecal elastase was normal (elastase >200 μg/g) in 47 (67%) patients, mildly decreased (100-200 μg/g) in 10 (14%) and severely decreased in 13 (19%).
		There was a significant association between elastase levels and time of evolution of diabetes (p=0.049) and between lower elastase levels and the presence of a positive steatocrit (p=0.042).
		Conclusions: One third of this group of diabetic patients had decreased levels of fecal elastase, that was associated with the time of evolution of diabetes.
	www.proz.com /?sp=profile&eid_s=113403&sp_mode=profile&sp_submode=&font_size_change=1 (441 words)

	Pathology Associates Of Lexington, P.A.
		Thus the quantification of pancreatic elastase 1 in serum allows diagnosis or exclusion of acute pancreatitis.
		Two ELISA test kits (as of 5/8/2002...based on monoclonal antibodies) are available for the determination of pancreatic elastase 1.
		The stool test quantifies E1 in stool, allowing the diagnosis or exclusion of pancreatic exocrine insufficiency, which can be caused by chronic pancreatitis, cystic fibrosis, pancreatic tumor, cholelithiasis or diabetes mellitus for example.
	www.palpath.com /MedicalTestPages/pancelas.htm (142 words)

	Ceni E, et al. Role of Fecal Elastase 1 in Pancreatic Cancer: A Pilot Study. JOP. J Pancreas (Online) 2004; 5(5 ... (Site not responding. Last check: )
		Aims 1) To evaluate fecal elastase levels in normal healthy subject in comparison to patients with pancreatic cancer; 2) to assess the relationship between fecal elastase 1 and tumor topography in patients with pancreatic cancer.
		The head-body group of patients was removed from the study when we analyzed the relationship between fecal elastase levels and pancreatic cancer topography.
		Conclusions Fecal elastase 1 is significantly decreased in patients with pancreatic cancer in comparison to normal healthy subject.
	www.joplink.net /prev/200409/59.html (363 words)

	Faecal elastase 1 in chronic pancreatitis • Reply -- GULLO and LANKISCH 44 (2): 290 -- Gut
		and concluded that the estimation of faecal elastase 1 is not
		Fecal elastase test: evaluation of a new noninvasive pancreatic function test.
		Fecal pancreatic elastase 1 is inaccurate in the diagnosis of chronic pancreatitis.
	gut.bmjjournals.com /cgi/content/full/44/2/290b (1057 words)

	Mutations in the CEL VNTR cause a syndrome of diabetes and pancreatic exocrine dysfunction - Nature Genetics
		Using fecal elastase deficiency as a marker of exocrine pancreatic dysfunction refined the critical chromosomal region to 1.16 Mb (maximal lod score 11.6).
		This was supported by the finding of increased fecal fat excretion in all ten diabetic subjects tested and lowered concentrations of fat-soluble vitamins in the mutation carriers (Supplementary Table 3).
		There seems to be complete penetrance of reduced fecal elastase in the mutation carriers, and the exocrine disturbance is clearly linked to an abnormal structure of the pancreas.
	www.nature.com /ng/journal/v38/n1/full/ng1708.html (6169 words)

	Pancreas Function Tests
		Secretin is administered and the contents of the duodenal secretions are aspirated (removed with suction) and analyzed over a period of about two hours.
		The fecal elastase test measures elastase, an enzyme found in fluids produced by the pancreas.
		During this test, a patient’s stool sample is analyzed for the presence of elastase.
	www.clevelandclinic.org /health/health-info/docs/3600/3646.asp?index=12029 (461 words)

	Abstracts - HomePage PK
		Fecal elastase 1 (FELA) was determined using monoclonal antibody (ScheboTech, Germany).
		The Faecal Elastase I occurring in the stool was correlated with the level of the damage of pancreatic tissue together with the control group of the patients with different diagnoses.
		Faecal Elastase I was determined by a microplate ELISA method using monoclonal antibody to human pancreatic protein.
	www1.lf1.cuni.cz /~kocna/abstr.htm (10951 words)

	Chapter and verse on next year's CPT code changes - College of American Pathologists (Site not responding. Last check: )
		This test is also known as cobalt albumin binding, based on the fact that the ability of albumin to bind cobalt is decreased in the setting of myocardial ischemia.
		The test uses an enzyme-linked immunosorbent assay (ELISA), and formerly would have been reported with the method-specific code 83516, since there were no analyte-specific codes to specifically report the fecal pancreatic elastase-1 analyte, nor were there codes to codify the specimen preparation that is required before the actual analysis can take place.
		Before the addition, similar to pancreatic elastase, there was no analyte-specific code in CPT to identify fecal lactoferrin or the stool preparatory steps in this analysis.
	www.cap.org /apps/docs/cap_today/feature_stories/1204cptchanges.html (1955 words)

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