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Topic: Felodipine

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	MedlinePlus Drug Information: Enalapril and Felodipine
		The combination of enalapril and felodipine is used to treat high blood pressure.
		Enalapril and felodipine controls high blood pressure but does not cure it.
		Enalapril and felodipine may pass into breast milk and harm infants.
	www.nlm.nih.gov /medlineplus/druginfo/medmaster/a601046.html (726 words)

	Everlight Chemical
		Felodipine is a dihydropyridine derivative and optically active described as (±)ethyl methyl 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5- pyridinedicarboxylate.
		Felodipine is a calcium channel blocker which is thought to prevent the flow of calcium in the walls of smooth muscle cells which line small arteries.
		The effect of felodipine on blood pressure is principally a consequence of a dose-related decrease of peripheral vascular resistance in man, with a modest reflex increase in heart rate.
	www.ecic.com /product/api/pro-api-felodipine-e.htm (353 words)

	Felodipine: a new dihydropyridine calcium-channel antagonist -- Yedinak and Lopez 25 (11): 1193 -- The Annals of ... (Site not responding. Last check: 2007-10-26)
		Felodipine: a new dihydropyridine calcium-channel antagonist -- Yedinak and Lopez 25 (11): 1193 -- The Annals of Pharmacotherapy
		Felodipine, a dihydropyridine calcium-channel antagonist, significantly reduces systolic and diastolic blood pressure (BP) in patients with hypertension and has been associated with beneficial hemodynamic effects in patients with chronic stable angina pectoris or congestive heart failure (CHF).
		Studies comparing felodipine with other agents as monotherapy in mild to moderate hypertension have demonstrated felodipine to be at least as efficacious as hydrochlorothiazide (HCTZ) and HCTZ plus amiloride hydrochloride in combination.
	www.theannals.com /cgi/content/abstract/25/11/1193 (349 words)

	Howstuffworks "Felodipine: A Profile of an Antihypertensive Drug"
		Felodipine is used to treat various types of angina (chest pain) and hypertension (high blood pressure).
		Felodipine can be taken either on an empty stomach or with a meal; however, you should avoid taking this medication with grapefruit juice.
		Felodipine does not cure high blood pressure, but it will help to control the condition as long as you continue to take it.
	health.howstuffworks.com /define-felodipine.htm (988 words)

	felodipine - [Medication]
		Felodipine relaxes (widens) your blood vessels (veins and arteries), which makes it easier for the heart to pump and reduces its workload.
		Felodipine is used to treat hypertension (high blood pressure).
		Felodipine is in the FDA pregnancy category C. This means that it is not known whether felodipine will be harmful to an unborn baby.
	www.peacehealth.org /kbase/multum/d00231a1.htm (1184 words)

	Retrospective Analysis of Formulary Transition at Large Metropolitan HMO: Nifedipine GITS to Felodipine ER
		Felodipine and nifedipine are both members of the dihydropyridine class of calcium-channel blockers, with demonstrated safety and efficacy for the treatment of essential hypertension.
		A recent prospective study, involving a similar formulary switch at a VA hospital showed felodipine ER treatment to be therapeutically equivalent to nifedipine GITS therapy in a group of 87 elderly patients, most of whom were Caucasian men.
		One of the primary justifications for choosing felodipine ER as a formulary alternative to nifedipine GITS was its strong safety profile.
	www.amcp.org /data/jmcp/vol2/num6/retrospective.html (2436 words)

	felodipine - High Blood Pressure (hypertension) and related information on MedicineNet.com
		Felodipine prevents calcium from being released within the muscle cells of the small arteries and thereby causes the muscles to relax and the arteries to dilate or expand.
		Felodipine was approved by the FDA in 1991.
		Felodipine also is used to treat patients with angina and is being studied in patients with congestive heart failure.
	www.medicinenet.com /felodipine/article.htm (472 words)

	CIGNA - felodipine (Site not responding. Last check: 2007-10-26)
		Felodipine relaxes (widens) your blood vessels (veins and arteries), which makes it easier for the heart to pump and reduces its workload.
		Felodipine is used to treat hypertension (high blood pressure).
		Felodipine is in the FDA pregnancy category C. This means that it is not known whether felodipine will be harmful to an unborn baby.
	www.cigna.com /healthinfo/d00231a1.html (1236 words)

	Felodipine - Patient UK
		Felodipine is used to treat hypertension (high blood pressure) and angina (chest pain).
		Felodipine should be swallowed whole, not crushed or chewed with a glass of water.
		Felodipine may cause some people's skin to become more sensitive to sunlight than it usually is, try to avoid bright sunlight and sunbeds or use a sun cream higher than factor 15 until you know how your skin reacts.
	www.patient.co.uk /showdoc/30002728 (843 words)

	Lexxel (Enalapril Maleate-Felodipine) drug description - prescription drugs and medications at RxList
		Felodipine, a calcium channel blocker, is a dihydropyridine derivative that is chemically described as ethyl methyl 4- (2,3-dichlorophenyl)-1, 4-dihydro-2,6-dimethyl-3, 5-pyridinedicarboxylate.
		Felodipine is a slightly yellowish, crystalline powder with a molecular weight of 384.26.
		LEXXEL is available for oral use in two tablet combinations of enalapril maleate with felodipine as an extended-release formulation: LEXXEL 5-2.5, containing 5 mg of enalapril maleate and 2.5 mg of felodipine ER and LEXXEL 5-5, containing 5 mg of enalapril maleate and 5 mg of felodipine ER.
	www.rxlist.com /cgi/generic2/lexxel.htm (346 words)

	Renedil - Renedil Side Effects - Renedil Information - Canada Pharmacy - Drugs from Canada
		Due to rapid biotransformation of felodipine during its first pass through the portal circulation the systemic availability is approximately 20% and is independent of the dose in the range of 5 to 20 mg/day.
		Felodipine is extensively metabolized in the liver, predominantly by cytochrome P450 CYP 3A4.
		Felodipine has been observed to have a mean blood clearance of 914 ± 355 mL/minute in hypertensive patients, 606 ± 245 mL/minute in elderly hypertensive patients and 1337 ± 413 mL/minute in young healthy volunteers.
	www.rxcarecanada.com /Renedil.asp?prodid=2203 (3058 words)

	[No title]
		Cyclosporine increases felodipine's serum concentration; avoid the combination or reduce dose of felodipine and monitor blood pressure.
		Erythromycin decreases felodipine's metabolism; coadministration results in a twofold increase in the AUC and half-life of felodipine; monitor for hypotension.
		Grapefruit juice increases the bioavailability of felodipine; coadministration increases the AUC of felodipine twofold and half-life remains unchanged.
	www.musc.edu /pharmacyservices/Drugs/F/Felodipine.doc (242 words)

	Felodipine
		Felodipine is used to treat high blood pressure, Raynaud’s syndrome, and congestive heart failure.
		A study of felodipine indicated that the drug caused increased excretion of calcium.
		For the convenience of the reader, the information in the summary is categorized as follows: “Depletion or interference” indicates the drug may deplete or interfere with the absorption or function of the supplement or herb.
	www.gianteagle.com /healthnotes/Drug/Felodipine.htm (683 words)

	FELODIPINE-HEXAL™ 5 (film-coated slow release tablet)
		Felodipine is a dihydropyridine Class A calcium antagonist which lowers the arterial blood pressure by decreasing vascular resistance.
		Felodipine produces an increase in heart rate which is counteracted when concurrent beta-receptor blockers are admini-stered.
		Felodipine does not appear to affect the unbound fraction of other extensively bound medicines, such as warfarin, due to its high degree of plasma protein binding.
	home.intekom.com /pharm/hexal/hx-felod.html (654 words)

	CiteULike: Effect of amlodipine versus felodipine extended release on 24-hour ambulatory blood pressure in hypertension. (Site not responding. Last check: 2007-10-26)
		To study whether the different elimination rates of the drugs were reflected in different duration of blood pressure (BP) control, we compared amlodipine and felodipine extended release (ER) by both conventional clinic BP 24 h after drug intake and 24 h ambulatory BP monitoring (ABPM), with special reference to nighttime and morning blood pressure.
		Two hundred and sixteen patients with primary hypertension (supine diastolic BP, 95 to 115 mm Hg) were randomized to receive amlodipine or felodipine ER in a multicenter study.
		Amlodipine seems to be more effective than felodipine when the drugs are compared in the same dose, with regard to the effect on clinic BP 24 h after dosing and to ambulatory BP during the night.
	www.citeulike.org /user/abelmagalhaes/article/758180 (640 words)

	Felodipine
		Felodipine is used to treat high blood pressure.
		Felodipine controls high blood pressure but does not cure it.
		Your blood pressure should be checked regularly to determine your response to felodipine.
	www.safemedication.com /displaydrug.cfm?id=692016 (552 words)

	Felodipine (Site not responding. Last check: 2007-10-26)
		People taking felodipine should eat a high-potassium diet and be checked regularly for low blood potassium by a doctor.
		Quercetin is a flavonoid found in grapefruit juice, tea, onions, and other foods; it is also available as a nutritional supplement.
		Therefore, it would be reasonable to expect that pomegranate juice might interact with felodipine in the same way that grapefruit juice does.
	www.deliciouslivingmag.com /healthnotes/healthnotes.cfm?org=nh&lang=EN&ContentID=1378000 (755 words)

	Enalapril and Felodipine
		Potential advantages for enalapril and felodipine combination therapy may include improved compliance and synergistic reductions in blood pressure with an accompanied reduction in side effects.
		Felodipine has neutral effects on mortality in this setting and therefore may be considered for the treatment of hypertension or angina in patients with heart failure.
		Key adverse event(s) related to dental treatment: Gingival hyperplasia (fewer reports with felodipine than with other CCBs); resolves upon discontinuation (consultation with physician is suggested).
	www.metagenics.com /ADAM/41/047519.html (425 words)

	Lexxel, Enalapril maleate, Felodipine, side effects, drug interactions, overdose, dosage
		The ACE inhibitor (enalapril) lowers blood pressure by preventing a chemical in your blood called angiotensin I from converting to a more potent form that narrows the blood vessels and increases salt and water retention.
		The calcium channel blocker (felodipine) also works to keep the blood vessels open, and eases the heart's workload by reducing the force and rate of your heartbeat.
		If this medication is essential to your health, your doctor may advise you to stop breastfeeding.
	www.pdrhealth.com /drug_info/rxdrugprofiles/drugs/lex1224.shtml (924 words)

	Inotens (felodipine-ramipril) - calcium channel blocker, ACE inhibitor - treats hypertension
		Unimax is a mixture of two medicines: the calcium channel blocker called felodipine and the ACE (angiotensin converting enzyme) inhibitor, ramipril.
		Felodipine prevents calcium from entering and being released within the muscle cells lining the small arteries of the heart and other blood vessels of the body.
		Calcium is necessary for muscle cells to contract and for blood vessels to become narrowed.
	www.patienthealthinternational.com /product/2363.aspx (322 words)

	Felodipine, Plendil
		Felodipine is used to treat high blood pressure, Raynaud’s syndrome, and
		Until more is known about this interaction, patients taking felodipine should avoid supplementing with quercetin.
		Those who combine alcoholic beverages with felodipine should be aware of possible adverse consequences, such as increased lightheadedness.
	www.truestarhealth.com /Notes/1378000.html (689 words)

	Felodipine.
		Felodipine interferes with the movement of calcium into heart muscle cells and the smooth muscle cells in the walls of the arteries.
		This action relaxes blood vessels (causing them to widen), which lowers blood pressure, increases the blood supply to the heart, and decreases the heart's overall workload.
		magnesium (particularly in high doses) may cause low blood pressure (not specifically reported for felodipine, but another medicament in the calcium channel-blocker class does this).
	www.herbs2000.com /medica/felodipine.htm (486 words)

	Healthopedia.com Drugs Information - Enalapril and Felodipine (Lexxel)
		Enalapril (e-NAL-a-pril) and felodipine (fe-LOE-di-peen) combination belongs to the class of medicines called high blood pressure medicines (antihypertensives).
		It blocks an enzyme in the body that is necessary in producing a substance that causes blood vessels to tighten.
		Felodipine is a type of medicine known as a calcium channel blocker.
	www.healthopedia.com /drugs/detailed/enalapril-and-felodipine (396 words)

	Enalapril and Felodipine (Systemic)
		It is not known if felodipine passes into breast milk; however, felodipine passes into the milk of lactating rats.
		Although this medicine has not been shown to cause different side effects or problems in older people than it does in younger adults, blood levels of the felodipine component may be increased in the elderly.
		If felodipine is taken with grapefruit juice, its effects may be increased.
	allnutritionals.com /drugs/e/enalaprilfelodipine-systemic.shtml (1601 words)

	WCN: Adding Felodipine to Ramipril Slows Progression in Nondiabetic Renal Disease (Site not responding. Last check: 2007-10-26)
		Although the renoprotective effect of ACE inhibition is well established in patients with chronic renal disease, research on the effects of a calcium antagonist on both the progression of renal disease and on proteinuria has yielded inconsistent results.
		Silan and a team of researchers therefore conducted a long-term, open-label, randomised study to compare the combination of ramipril and felodipine with either drug used alone in the treatment of nondiabetic renal disease.
		Average doses at last patient visit after an average treatment time of approximately 2 years were 5 mg of ramipril and 5 mg of felodipine in the combination group, 10 mg of ramipril in the ramipril group, and 9 mg of felodipine in the felodipine group.
	www.pslgroup.com /dg/234D36.htm (624 words)

	Logimat (felodipine/metoprolol) - calcium-channel blocker, beta blocker – treats hypertension
		Logimax combines two medicines that have different ways of working (modes of action) and which doctors know lead to a greater lowering of blood pressure in some people than with either medicine used alone.
		Felodipine (see Plendil) belongs to the group of medicines called calcium-channel blockers which stop calcium entering into cells through holes (channels) in the cell wall.
		Felodipine interferes with calcium movement in the muscle cells of the small arteries and thereby causes the muscles to relax and the arteries to expand, which in turn lowers the blood pressure.
	www.patienthealthinternational.com /product/32.aspx (335 words)

	Plendil - Drugs & Vitamins - Drug Library - DrugDigest
		Take felodipine tablets regularly either on an empty stomach or with a light meal.
		Ask your prescriber or health care professional what your blood pressure and pulse rate should be and when you should contact him or her.
		If you are going to have surgery, tell your prescriber or health care professional that you are taking felodipine.
	www.drugdigest.org /DD/DVH/Uses/0,3915,255\|Plendil,00.html (721 words)

	Felodipine patient advice including side effects
		If you are sensitive to or have ever had an allergic reaction to Plendil or other calcium channel blockers, such as Calan and Procardia, you should not take Felodipine.
		If Plendil is taken with certain other drugs, the effects of either could be increased, decreased, or altered.
		If Felodipine is essential to your health, your doctor may advise you to discontinue breastfeeding until your treatment is finished.
	www.drugs.com /pdr/FELODIPINE.html (832 words)

	One-Year Study of Felodipine or Placebo for Stage 1 Isolated Systolic Hypertension -- Black et al. 38 (5): 1118 -- ...
		Active treatment with felodipine ER was associated with significantly
		Mean trough SBP reduction (compared with baseline) in patients randomized to felodipine ER (hatched bars) or placebo (open bars) according to duration (in weeks) of treatment.
		to felodipine ER versus 5 (6%) assigned to placebo.
	hyper.ahajournals.org /cgi/content/full/38/5/1118 (3435 words)

	felodipine side effects (Site not responding. Last check: 2007-10-26)
		Each report summarizes felodipine interactions, felodipine side effects, dosing and more.
		It takes just minutes to learn what you need to know about felodipine: whether you are on a safe dose and what other hazards may exist like interactions, conflicts with other diseases you may have, duplication of therapy, reproductive hazards...all customized for you.
		Some other popular drug information and interaction topics this week have included: Combivent side effects as well as Tenormin side effects, docusate side effects, Stress 600 with Zinc side effects and Aquasol E side effects.
	www.medicationadvisor.com /side_effects/felodipine.htm (1448 words)

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