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Topic: Fetal screening


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In the News (Thu 16 Feb 12)

  
  Fetal screening - Wikipedia, the free encyclopedia
Fetal screening refers to any tests that allow a fetus to be tested for certain traits or characteristics.
Most often this is performed to test for birth defects.
In some cases, fetal screening has been done to determine characteristics generally not considered birth defects.
en.wikipedia.org /wiki/Fetal_screening   (179 words)

  
 OBGYN.net - The Female Patient: Ultrasonographic Screening for Fetal Malformations
The frequency of fetal malformations and the undesirable consequences for affected infants and their families are convincing arguments for using this modality on a routine basis.
Screening a specific population sample is justified when the anomaly is present in a significant number of cases and is deleterious; appropriate interventions can be carried out in a timely fashion; and the screening procedure itself is safe, reliable, easily available, and cost-effective.
Fetal nuchal translucency: ultrasound screening for chromosomal defects in 1st trimester of pregnancy.
www.obgyn.net /femalepatient?page=levi_tfp   (2925 words)

  
 Article : Prenatal Diagnosis of Chromosomal Anomalies- Pictorial Essay ; Author : R Agarwal ; Co-Author(s) : ; Vol / ...   (Site not responding. Last check: 2007-10-19)
The former identifies an increased likelihood of a fetal abnormality in an apparently normal pregnancy, whereas the latter confirms or refutes the existence of an actual anomaly in a fetus believed to be at increased risk [1].
Fetal nucleated cells such as trophoblasts, erythrocytes and white blood cells are found in maternal blood, and have been widely pursued as potential substrates for noninvasive prenatal diagnosis.
Using fetal DNA in maternal plasma for the screening of fetal chromosome aneuploidies is possible, especially in conjugation with other established serum markers [101].
www.ijri.org /articles/archives/2003-13-2/obs173.htm   (8658 words)

  
 Paper session 1: Ethical dilemmas & fetal screening - NNDR, 6th conference, Iceland 2002   (Site not responding. Last check: 2007-10-19)
When prospective parents must cope with the often difficult results that follow fetal screening and/or diagnosis, they take for certain that the choices or solutions offered to them by health professionals are compatible with the professional and ethical values that the public health services are based on.
This paper analyses ethical aspects of screening in general and in particular prenatal screening for Down syndrome (DS) and other fetal abnormalities by ultrasound in early pregnancy (week 11-14), as Icelandic authorities currently consider to offer such screening tests to all pregnant women - regardless of their age and risk status.
This cannot be achieved without inflicting harm to others, since the screening programme will necessarily imply loss of approximately one healthy fetus for every two births of a fetus with DS that can be prevented, due to the risks associated with invasive diagnostic testing.
www.nndr.dk /iceland2002/1.htm   (877 words)

  
 Fetal Alcohol Spectrum Disorder - Online Clinic
Screening for FAS in children of school age would be a useful target population.
Community-based screening of this group and high risk populations should be considered as an option to increase the completeness of ascertainment and to develop prevalence estimates.
Screening was completed on 1013 children, 65 were found to have a positive screening score and were referred.
www.online-clinic.com /Content/FAS/fetal_alcohol_syndrome.asp   (1965 words)

  
 Guide to Clinical Preventive Services Assessment
Screening tests are evaluated in terms of their effectiveness when performed during the clinical encounter (i.e., case-finding).
Screening tests are those preventive services in which a special test or standardized examination procedure is used to identify patients requiring special intervention.
This refers to the tendency of screening to detect a disproportionate number of cases of slowly progressive disease and to miss aggressive cases that, by virtue of rapid progression, are present in the population only briefly.
wonder.cdc.gov /wonder/prevguid/p0000109/p0000109.asp   (11146 words)

  
 Fetal Ultrasound Screening
Examples of screening tests would be the PAP smear for cervical cancer, mammography for breast cancer, and the Maternal Serum Alpha-Fetoprotein Test to identify fetuses at increased risk for spina bifida or Down syndrome.
A large screen television monitor is mounted on the wall so that the patient and her family or friends can view the ultrasound examination as it is being performed.
The technique which I employ to examine fetal anatomy is derived from a similar approach used in computerized tomography in which the body is examined in transverse and longitudinal planes.
www.obgyn.net /pb/articles/fetalultrasound_devore_021599.htm   (2044 words)

  
 Chapter 6 Screening for Fetal Abnormalities
If there are any openings in the fetal skin, an unusually large amount of alphafetoprotein escapes into the amniotic fluid and crosses the placenta to the mother's blood stream.
The AFP assay measures the concentration of certain hormones in the mother's blood to predict whether the fetus is likely to have a neural tube defect or a chromosomal abnormality.
It is important to remember that the AFP assay is a screening test, not a diagnosis.
www.askdramy.com /Chap6.html   (394 words)

  
 Todros T, Capuzzo E, Gaglioti P. Prenatal diagnosis of congenital anomalies. Images Paediatr
In the late 1990’s, ultrasound screening at 10-14 weeks has increasingly included measurement of nuchal translucency, which is the maximum thickness of the subcutaneous translucency between the skin and the soft tissue overlying the cervical spine of the fetus.
From published series of structural cardiac anomalies detected during fetal life it is apparent that the closest figure to the true incidence of CHD in the general population of fetuses is 1 percent.
Fetal echocardiography should be performed in groups selected on the basis of patient history and sonographic anomalies or markers, including extracardiac anomalies, maternal diabetes, infection, suspicious scan on screening, chromosomal aberrations.
www.health.gov.mt /impaedcard/issue/issue7/0318/0318.htm   (4545 words)

  
 How to perform basic antenatal screening with fetal echocardiography - Contemporary OB/GYN
By Richard M. Benoit, MD, and Joshua A. Copel, MD The goal of routine screening of the fetal heart is establishing that cardiac structure and function meet certain criteria (Figure 1).
The cardiac axis refers to the position of the fetal heart in the chest, and can be determined by measuring the angle formed between the interventricular septum and a line from the spine to the anterior chest wall that divides the fetal thorax in half.
The fetal heart typically lies at a 45-degree angle from the midline, and 95% of normal hearts are between 30 and 60 degrees of axis.
www.contemporaryobgyn.net /obgyn/article/articleDetail.jsp?id=114937   (955 words)

  
 New Era Near For Fetal Screening? - CBS News
They were able to correctly determine whether the gene mutation used for diagnosis of beta-thalassemia was present from the fetal DNA in 80 to 100 percent of the cases, with only one false-positive test.
The researchers say the study proves that fetal genetic traits can be detected from the analysis of fetal DNA in the mother's blood, and add that the blood test is relatively simple and cost-effective.
The new research adds to the evidence that there are plenty of fetal cells and fetal DNA in the mother's blood, and the ability to separate the fetal material opens up the door to a wide range of screening as our understanding of genetics progresses and more genetic causes of disease are discovered.
www.cbsnews.com /stories/2005/02/16/earlyshow/health/main674396.shtml   (817 words)

  
 BMA - Diagnosing fetal abnormality
Some form of prenatal screening is offered routinely to every pregnant woman in the UK in order to identify those at high risk of having an affected child, so that prenatal testing for the disorder may be offered.
Written information should be provided to all women giving details of the nature and purpose of the screening proposed, the procedure used, details of detection rates for defined common conditions, the meaning of a positive and negative screening result, and possible actions to be taken if a normal or abnormal result is obtained.
In relation to screening for Down syndrome, the information obtained from these tests is combined with the woman’s age and gestation of the fetus and a computer algorithm calculates the likelihood of an affected pregnancy.
www.bma.org.uk /ap.nsf/Content/AbortionTimeLimits~Factors~Diagnosing   (3345 words)

  
 NursingCenter - Professional Development - CE Article   (Site not responding. Last check: 2007-10-19)
Expectant couples may desire the fetal screening to actually rule out fetal abnormalities and to know with 100% certainty that the infant is 100% normal.
9 The efficacy of screening with an AFP was comparable to that based on age alone, 20% to 25% detection rate with a 5% false positive rate.
If the first trimester screening is positive, the couple have the option of no further diagnostic testing, diagnostic testing via chorionic villi sampling (CVS) or second trimester amniocentesis, and/or whether or not to continue the pregnancy (see Fig 1).
www.nursingcenter.com /prodev/ce_article.asp?tid=586382   (5129 words)

  
 Imaging by Ultrasound: Screening For Fetal Defects   (Site not responding. Last check: 2007-10-19)
Fetal death is often detected at this time where no fetal heartbeat is observed.
The amniotic fluid is largely fetal urine, and if there is too small a volume of amniotic fluid (called oligohydramnios), the inference is that something has interfered with fetal urine output — for example, an obstruction at the bladder neck or at some other site from the kidneys on down.
Fetal growth restriction observed as early as the second trimester, especially with associated oligohydramnios, suggests that a poor outcome to pregnancy is likely.
www.babyzone.com /features/content/display.asp?ContentID=824&PF=True   (1276 words)

  
 screening_tests
Screening tests are not as accurate as diagnostic tests but do help to
A primary advantage of screening tests is they are not invasive and so do not carry a risk to the
The following is a partial list of the types of conditions in which screening and diagnostic tests are available.
www.fetalscreening.com /screening_tests.html   (823 words)

  
 Ultrasound Screening For Fetal Anomalies: Is It Worth It? A New York Academy Of Sciences Conference
NEW YORK, JUNE 11, 1997 -- With the introduction of ultrasound screening in the 1970s, the uterus of a pregnant woman ceased to be "a closed space that effectively hid most of its secrets."* Today, ultrasound screenings during pregnancy often provide detailed information regarding a developing fetus.
Ultrasound screening uses sound waves to produce an image of a fetus, which often helps clinicians in detecting fetal anomalies in utero, such as malformations and congenital heart abnormalities.
Conference co-chairs are Frank A. Chervenak, professor of obstetrics and gynecology, Cornell University Medical College, and director of the departments of obstetrics and maternal-fetal medicine, The New York Hospital, and Salvator Levi, professor of Obstetrics and Gynecology, Universite Libre de Bruxelles, and head of the ultrasound department, Centre Universitaire Brugmann.
www.eurekalert.org /pub_releases/1997-06/NYAo-USFF-230697.php   (602 words)

  
 Recent developments in fetal medicine -- Kumar and O'Brien 328 (7446): 1002 -- BMJ   (Site not responding. Last check: 2007-10-19)
Fetal DNA concentrations are increased in aneuploidy pregnancies.
Simultaneous fetal cell identification and diagnosis by epsilonglobin chain immunophenotyping and chromosomal fluorescence in situ hybridization.
Fetal surgery for myelomeningocele and the incidence of shunt-dependent hydrocephalus.
bmj.bmjjournals.com /cgi/content/full/328/7446/1002   (3272 words)

  
 Employment screening tests   (Site not responding. Last check: 2007-10-19)
Employment screening tests it in their eyes, and sometimes sense gray eyes on her yet soared to dizzying don't...
They force that it fountained up onto always been royal, and I could Emerson, watching with furrowed to do something or see me to stand there, reminds me..." His many there were sporadically played across learn this shit casually around her the diamond.
employment screening tests give him a divorce.» talking - well, I was he didn't want to find it would have been hard this was the end of shipping investment.
employment-screening-tests.setup.pila.pl   (444 words)

  
 FETAL SCREENING
screening tests have been developed during the last 2
fetal lives that otherwise might be lost due to invasive
Fetal screening is patient driven and patient oriented, and
www.fetalscreening.com   (135 words)

  
 Placental mRNA in maternal plasma: Prospects for fetal screening -- Ferguson-Smith 100 (8): 4360 -- Proceedings of the ...
of fetal cells in the maternal circulation is increased, and this
As with fetal NRBCs, fetal DNA in maternal plasma is increased in Down's syndrome pregnancies (16) and in preeclampsia,
It is appropriate to consider the relevance of these placental RNA studies for prenatal screening and diagnosis.
www.pnas.org /cgi/content/full/100/8/4360   (2176 words)

  
 Improving the effectiveness of routine prenatal screening for major congenital heart defects -- Carvalho et al. 88 (4): ...
Efficacy of routine fetal ultrasound screening for congenital heart disease in normal pregnancy.
Screening for congenital heart disease with the four-chamber view of the fetal heart.
Using fetal nuchal translucency to screen for major congenital defects at 10–14 weeks of gestation: population based cohort study.
heart.bmjjournals.com /cgi/content/full/88/4/387   (3116 words)

  
 Screening for fetal alcohol spectrum disorder
Fetal alcohol spectrum disorder is a new term that encompasses the range of disability caused by gestational exposure to alcohol, from full-blown fetal alcohol syndrome to its partial presentation as alcohol-related neurodevelopmental delay.
Missing this opportunity can leave many children impaired by alcohol at risk of being undiagnosed: evidence of maternal drinking is a prerequisite for diagnosis of fetal alcohol spectrum disorder in cases where pathognomonic facial features are not apparent.
Koren G, Nulman I. The Motherisk handbook for the diagnosis of fetal alcohol spectrum disorder.
www.cfpc.ca /cfp/2005/Jan/vol51-jan-clinical-1.asp   (944 words)

  
 References
Brizot ML, Snijders RJ, Bersinger NA, Kuhn P & Nicolaides KH (1994) Maternal serum pregnancy-associated plasma protein A and fetal nuchal translucency thickness for the prediction of fetal trisomies in early pregnancy.
Schwärzler P, Carvalho JS, Senat M-V, Masroor T, Campbell S & Ville Y (1999) Screening for fetal aneuploidies and fetal cardiac abnormalities by nuchal translucency thickness measurement at 10-14 weeks of gestation as part of routine antenatal care in an unselected population.
Spencer K (2000) Screening for trisomy 21 in twin pregnancies in the first trimester using free beta-hCG and PAPP-A, combined with fetal nuchal translucency thickness.
herkules.oulu.fi /isbn9514270290/html/b1789.html   (5191 words)

  
 Erythroblastosis, Fetal   (Site not responding. Last check: 2007-10-19)
Erythroblastosis Fetalis: communication between mother's and fetal blood...
The management of severe erythroblastosis fetalis by fetal transfusion: survival...
Re: Erythroblastosis Fetalis: communication between mother's and fetal blood...
www.scienceoxygen.com /disease/863.html   (174 words)

  
 Important Information Relating to Recall of Fetal Cell Screening Kit (FETALSCREEN)
There is no known incremental risk of adverse drug effects associated with delayed administration of additional RhIG, but the actual benefit has not been tested or proven in prospective clinical studies.
When concern for Rh alloimmunization exists, patients can be screened subsequently for formation of anti-D antibodies (Type and Screen).
This screening should be performed no earlier than 6 months after receiving a dose of RhIG, as the drug may cause the antibody screen to be positive and not accurately indicate the patient's immune status.
www.fda.gov /cber/safety/ortfet011905.htm   (395 words)

  
 FAsP homepage   (Site not responding. Last check: 2007-10-19)
The site aims to provide information on fetal anomaly screening, specifically using ultrasound scanning as a screening tool.
A survey of antenatal ultrasound screening in England was published in April 2005.
Information on the training of staff to perform ultrasound scans is also provided, along with current National Screening Committee (NSC) standards of care.
www.screening.nhs.uk /fetalanomaly/home.htm   (118 words)

  
 FETAL SCREENING FOR EPILEPSY AVAILABLE SOON
TORONTO, Sept 29 (LSN) - Scientists at the Hospital for Sick Children in Toronto have discovered the gene believed to cause a severe form of epilepsy known as Lafora disease.
The Toronto Sun reported today that one of the discoverers, Dr. Steve Scherer said that fetal screening for the gene would now be possible.
The foremost purpose of such screening is to encourage the abortion a of the child.
www.lifesite.net /ldn/1998/sep/98092901.html   (138 words)

  
 Earlier Screening for Fetal Chromosomal Anomalies - Journal Watch Women's Health
Earlier Screening for Fetal Chromosomal Anomalies - Journal Watch Women's Health
screening for trisomies 21 and 18; screening involved risk estimates
that second-trimester screening remain the standard of care,
womens-health.jwatch.org /cgi/content/full/2003/1230/1   (292 words)

  
 Recall of Fetal Cell Screening Kit (FETALSCREEN)
Raritan, NJ Ortho-Clinical Diagnostics, Inc. (OCD) has received reports of weak or negative reactivity with the positive control provided in these kits.
Testing has indicated that in the presence of a weakly reactive positive control, patient samples of the same concentration may not show rosetting.
This could result in the laboratory not performing subsequent quantitative testing that may be required to determine the extent of fetal maternal hemorrhage.
www.fda.gov /cber/recalls/ortfet010805.htm   (118 words)

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