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Topic: Fibrin

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Thrombin

Fibrinolysis

Coagulation

Protein C

Plasmin

Factor XI

Protein S

Fibronectin

Factor V

Factor VIII

Factor IX

Factor VII

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	Fibrin - LoveToKnow 1911
		FIBRIN, or Fibrine, a protein formed by the action of the so-called fibrin-ferment on fibrinogen, a constituent of the bloodplasma of all vertebrates.
		To obtain pure coagulated fibrin it is best to heat blood-plasma (preferably that of the horse) to 56° C. The usual method of beating a blood-clot with twigs and removing the filamentous fibrin which attaches itself to them yields a very impure product containing haemoglobin and much globulin; moreover, it is very difficult to purify.
		Fibrin is a very voluminous, tough, strongly elastic, jelly-like substance; when denaturalized by heat, alcohol or salts, it behaves as any other coagulated albumin.
	www.1911encyclopedia.org /Fibrin (132 words)

	eMedicine - Dysfibrinogenemia : Article Excerpt by: Wendy Brick, MD
		In normal fibrin clot formation, a fibrin monomer forms after thrombin cleaves fibrinopeptide A and B from the alpha and beta chains of the fibrinogen molecule.
		The impairment of the fibrinogen, which is manufactured in the liver, is due to a structural defect caused by an increased carbohydrate content impairing the polymerization of the fibrin, depending on the degree of abnormality of the fibrinogen molecule.
		One of the rarer disorders of coagulation is congenital dysfibrinogenemia, a qualitative abnormality of the fibrin molecule.
	www.emedicine.com /med/byname/dysfibrinogenemia.htm (582 words)

	Fibrin Sealants - Definition, Purpose, Description, Preparation, Normal results
		All fibrin sealants in use as of 2003 have two major ingredients, purified fibrinogen (a protein) and purified thrombin (an enzyme) derived from human or bovine (cattle) blood.
		The fibrin molecules arrange themselves into strands that are then cross-linked by a blood factor known as Factor XIII to form a lattice or net-like pattern that stabilizes the clot.
		Fibrin sealants are undergoing rapid refinement as the result of recent advances in tissue adhesives in general.
	www.surgeryencyclopedia.com /Ce-Fi/Fibrin-Sealants.html (903 words)

	Biologic bioadhesive compositions containing fibrin glue and liposomes, methods of preparation and use - Patent 5631019
		Fibrin glue of the invention comprises fibrinogen and thrombin which are mixed together in various modes with liposomes and applied to a site of injury, to a wound, or to a surgical or nonsurgical incision or opening.
		Fibrin glue has the potential to be prepared in virally sterilized form by treating the fibrinogen and thrombin by viral inactivation processes, such as the solvent-detergent or SD process.
		The final fibrin glue and liposome bioadhesive formulation may be achieved in a number of different ways, such as by premixing at least one of the fibrin glue components with liposomes prior to application or administration, and then adding the remaining component(s) to form in situ the final liposome-containing fibrin glue.
	www.freepatentsonline.com /5631019.html (12354 words)

	Fibrin - Article
		Fibrin is a protein involved in the clotting of blood.
		Fibrin is made from its zymogen fibrinogen, a soluble plasma glycoprotein that is synthesised by the liver.
		Conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B from alpha and beta chains, and thus exposes the N-terminal polymerization sites responsible for the formation of the soft clot.
	goldbamboo.com /topic-t4258-a1-6Fibrinogen.html (961 words)

	Fibrin sealant use for minimising peri-operative allogeneic blood transfusion
		Fibrin sealants have gained increasing popularity as interventions to improve peri-operative (intra/post-operative) haemostasis and diminish the need for allogeneic red cell transfusion (blood from an unrelated donor).
		Fibrin sealant treatment, on average, reduced the rate of exposure to allogeneic red cell transfusion by a relative 54% (relative risk [RR] = 0.46: 95%CI = 0.32 to 0.68).
		Overall the results suggest that fibrin sealants are efficacious in reducing both post-operative blood loss and peri-operative exposure to allogeneic RBC transfusion.
	www.cochrane.org /reviews/en/ab004171.html (555 words)

	Guidance for Industry - Efficacy Studies to Support Marketing of Fibrin Sealant Products Manufactured for Commercial Use
		These clinicians consider the use of locally-prepared fibrin sealant to be of such benefit in controlling bleeding in confined or nearly inaccessible areas that a placebo-controlled trial would put the control patients at significant and unnecessary risk.
		For fibrin sealant products containing multiple biologic components, the contribution of each component may be demonstrated in a non-clinical setting appropriate to the indication(s) sought, although the overall efficacy of multiple-component fibrin sealant products should be demonstrated in clinical trials.
		Fibrin sealant products should be tested in settings and under conditions where they would normally be expected to be used in clinical practice.
	www.fda.gov /Cber/gdlns/fibrinocc.htm (1105 words)

	Cerebral Microvascular Obstruction by Fibrin is Associated with Upregulation of PAI-1 Acutely after Onset of Focal ...
		Intravascular fibrin deposition in a relative large vessel causes the vessel to narrow and decreases plasma perfusion in capillaries (A, B).
		Parenchymal fibrin deposition was also observed in the ipsilateral caudate putamen (G) but not the homologous area of the contralateral hemisphere (J) from extensively perfused brain tissue at 4 hr of MCA occlusion.
		Shrunken neurons (arrowhead) with vacuoles were present in the striatum with extravascular fibrin deposition (E) compared with intact neurons (arrowhead) in the contralateral striatum with patent vessels (curved arrow) at 4 hr of embolic MCA occlusion (F).
	www.jneurosci.org /cgi/content/full/19/24/10898 (6617 words)

	APPLICATION OF AUTOLOGOUS FIBRIN GLUE IN DURAL CLOSURE (Site not responding. Last check: 2007-11-02)
		Fibrin glue was used to treat CSF leakage in 11 patients who had not responded to the conventional medical treatment.
		Fibrin glue was also found to be useful in enhancing bone repair, healing skin incisions, nerve grafting and for sealing mastoid and frontal cavities.
		Fibrin glue was developed in the operating room by mixing the previously prepared components, i.e., cryoprecipitate, bovine thrombin and calcium chloride.
	ijms.sums.ac.ir /9934/alibai9934.html (2302 words)

	fibrin
		When an injury occurs fibrin is deposited around the wound in the form of a mesh, which dries and hardens, so that bleeding stops.
		Fibrin is developed in the blood from a soluble protein, fibrinogen.
		The conversion of fibrinogen to fibrin is the final stage in blood clotting.
	www.tiscali.co.uk /reference/encyclopaedia/hutchinson/m0029762.html (272 words)

	Fibrin Sealant Demonstrates Reduced Complications From Breast Cancer Surgery (Site not responding. Last check: 2007-11-02)
		The trial demonstrated the use of Vitex’s fibrin sealant reduced the amount of fluid accumulating at the surgical site by approximately 50 percent and decreased the time the drain was in place by more than half.
		Fibrin sealants are tissue adhesives used during surgical procedures for hemostasis and sealing of tissues.
		Each component of the fibrin sealant is treated by the Solvent Detergent (SD) VI method and also by a second proprietary VI procedure, short wavelength ultraviolet light (UVC), which has been shown to eliminate infectious doses of both enveloped and non-enveloped viruses.
	www.pslgroup.com /dg/3df72.htm (547 words)

	The Analyst - Internet Health Report: Condition: Hypercoagulation (Thickened Blood)
		Fibrin formation is the last step in the clotting process that stops bleeding when blood vessels are cut.
		Normally, long strands of fibrin weave a mesh around platelets and blood cells to form a clot that plugs the break in the wall of a vessel.
		SFM is a sticky protein that increases blood viscosity (thickness) and results in the deposit of fibrin on the endothelial cells lining the blood vessels.
	www.digitalnaturopath.com /cond/C546009.html (1676 words)

	Fibrin Regulation of Interleukin-8 Gene Expression in Human Vascular Endothelial Cells -- Qi et al. 90 (9): 3595 -- ...
		In fact, fibrin may be particularly important in the development of the proinflammatory endothelium that controls the movement of cells and fluids during tissue trauma and inflammation.
		Fibrin was polymerized in situ using physiologic relevant concentrations of fibrinogen, and low concentrations of thrombin, to simulate in vivo conditions.
		This study indicated that the fibrin induced increases of IL-8 expression from vascular endothelial cells may be responsible for recruitment of neutrophils to the site of inflammation in vivo since fibrin deposition is a common finding in a variety of disease processes.
	www.bloodjournal.org /cgi/content/full/90/9/3595 (5800 words)

	Dorlands Medical Dictionary (Site not responding. Last check: 2007-11-02)
		(fi´brin) the insoluble protein formed from fibrinogen by the proteolytic action of thrombin during normal clotting of blood; it forms the essential portion of the blood clot.
		fibrin obtained from the stroma of blood cells.
		(fi”brĭ-nu´re-ə) the presence of fibrin in the urine.
	www.mercksource.com /pp/us/cns/cns_hl_dorlands.jspzQzpgzEzzSzppdocszSzuszSzcommonzSzdorlandszSzdorlandzSzdmd_f_06zPzhtm (3260 words)

	DNA and Proteins
		Furthermore, the manipulation depicted in (D) and (E) suggests that the deformation in the fibrin fiber is (at least partially) elastic.
		The image in (H) shows fibrin fibers that were deposited onto a silicon grid (1mm troughs and 2mm wide and 100nm tall ridges) and imaged in buffer (10mM CaCl2, 130mM NaCl, 20mM Hepes, pH 7.4).
		At left, a labeled fibrin fiber is imaged lying suspended in fluid, attached to the structured substrate “hills”.
	www.cs.unc.edu /Research/nano/cismm/fibrin/index.html (845 words)

	UCSD researchers determine fibrin depletion decreases multiple sclerosis symptoms
		Although fibrin is best known for its important role in blood clotting, recent studies have shown that fibrin accumulates in the damaged nerves of MS patients, followed by a break down of myelin.
		Fibrin’s role in excessive inflammation was shown in a follow-up experiment where transgenic mice were shown to experience high expression of pro-inflammatory molecules, followed by myelin loss, as compared to the fibrin-negative transgenic mice with no signs of inflammation or myelin destruction.
		In addition to the genetic deletion of fibrin, the researchers tested drug-induced fibrin depletion, which was accomplished by administering ancrod, a snake venom protein, to the transgenic mice.
	www.innovations-report.com /html/reports/medicine_health/report-28229.html (785 words)

	fibrin - Search Results - MSN Encarta
		Fibrin film and fibrin foam, plastics made from the blood protein fibrinogen, are extensively used in surgery.
		Fibrin foam is used in the form of a...
		Researchers use MAbs created to target a muscle protein called myosin to assess the extent of damage to the heart muscle after a heart attack.
	encarta.msn.com /fibrin.html (110 words)

	AllRefer Health - Fibrin Degradation Products (FDPs, Fibrin Breakdown Products, Fibrin Split Products, FSPs) - ...
		As a result of the coagulation process, fibrinogen is split into fibrin monomer and fibrin.
		Fibrin monomer polymerizes to form fibrin polymer (the clot).
		Coagulation factor inhibitors and plasmin (which eventually lyses the fibrin clot) are simultaneously activated by damaged tissue, but they function more slowly and over a longer period of time than the coagulation factors.
	health.allrefer.com /health/fibrin-degradation-products-info.html (560 words)

	[No title] (Site not responding. Last check: 2007-11-02)
		Fibrin is the natural provisional matrix for wound healing and tissue repair.
		Finally, fibrin clots are readily remodeled and resorbed through normal fibrinolytic processes as cells deposit the tissue-specific extracellular matrix components during the regeneration of functional tissues.
		Once hemostasis is achieved, the fibrin clot serves as the foundation of a complex provisional matrix to both initiate and support subsequent tissue repair.
	www.ipam.ucla.edu /abstract.aspx?tid=2056 (456 words)

	Fibrin Fibers: Numero Uno in Stretchability - Medgadget - www.medgadget.com
		This discovery, which makes these fibrin fibers the most stretchable known fibers existing in nature, will help medical researchers create more accurate blood clot models, provide new insights into the wound healing process and offer a deeper understanding of heart attacks and strokes...
		Because of its important function of stemming the flow of blood in the body, clots have to be both strong and pliable.
		Fibrin is currently the focus of some tissue engineering studies.
	www.medgadget.com /archives/2006/08/fibrin_superher_1.html (725 words)

	Fibrin Sealant in the United States
		Fibrin sealant is not a substitute for meticulous surgical technique and cannot reduce bleeding when traditional surgical methods such as a suture are required.
		The dangers associated with the use of fibrin sealant can be linked to the individual component producing the sealant, as well as the fibrin clot.
		Fibrin sealant or thrombin itself may be inadvertently injected into the arterial system and can cause dangerous embolization or intravascular coagulation.
	www.healthsystem.virginia.edu /internet/stac/research/spfsuseatuva.cfm (1164 words)

	Indications for Fibrin Sealing in Pancreatic Surgery
		Three to 5 ml fibrin sealant was injected into the main pancreatic duct, either through a blunt needle or a thin plastic catheter, beginning as deeply as possible in the remaining glandular tissue.
		As the needle or catheter is slowly withdrawn, fibrin sealant is continously injected until small fibrin thrombi appear on the resection surface.
		A fibrin sealant should be used for the following indications: (a) lesions of the tail, possibly perforating; (b) combined head and corpus lesions with intact main duct; and (c) management of all resection surfaces.
	www.ump.com /articles/marczell/Marczell.htm (1916 words)

	Blood Vessels, Platelets and Fibrin Work Together
		Thrombin is activated on the surface of platelets, and transforms a protein called fibrinogen into fibrin.
		The fibrin mesh is stronger and more stable than the temporary platelet plug.
		A protein called plasmin is formed that dissolves fibrin, and the blood clot is slowly removed.
	www.coagulation-factors.com /html/normal-blood-clotting.php3 (437 words)

	Aneurysms & Fibrin - Kosmix Topic Page
		Fibrin is a protein involved in the clotting of blood.
		It is a fibrillar protein that is polymerised to form a mesh that forms a hemostatic plug or clot over a wound site.Fibrin is made from its zymo...
		In conclusion, embolisation of iatrogenic aneurysms with fibrin adhesive is a safe and effective treatment.
	www.kosmix.com /search?q=Aneurysms&c=health.drugs3:Fibrin&o=t&t=vhealth.all (245 words)

	Fibrin Glue for Anal Fistula
		Fibrin tissue glue is a biological product that can stimulate wound healing.
		These investigators concluded that the use of fibrin tissue glue for low output (little amount of discharge from the fistula tract) entero-cutaneous (abnormal connection between intestine and skin) speeded healing and reduced hospital stay.
		It is not possible to use fibrin glue for high output (large amounts of discharge from fistula tract) fistulae.
	www.medhelp.org /forums/gastro/archive/1054.html (508 words)

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