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Topic: Fibrinolysis

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	fibrinolysis inhibitor-thrombin topical - [Medication]
		Fibrinolysis inhibitor and thrombin are agents that are involved in blood clotting.
		Fibrinolysis inhibitor-thrombin topical is used to cause blood clotting during surgery or due to trauma when natural blood clotting processes are deficient.
		Fibrinolysis inhibitor-thrombin topical is in the FDA pregnancy category C. This means that it is not known whether it will be harmful to an unborn baby.
	www.peacehealth.org /kbase/multum/d04841a1.htm (963 words)

	Primary Or Secondary Fibrinolysis - Health Centers
		Secondary fibrinolysis is the breakdown of blood clots due to a medical disorder,?medicine, or other cause.
		The breakdown of fibrin (fibrinolysis) can increase under certain conditions (such as intense exercise, inadequate oxygenation of tissues, low blood sugar, or bacterial infections).
		For example, when an abnormal clot forms in the blood vessels of the heart and results in a heart attack, man-made fibrinolytic substances (such as tPA, streptokinase, or Retavase) may be given to break up the culprit clot.
	www.channel3000.com /encyclopedia/6860360/detail.html (288 words)

	Fibrinolysis
		Fibrinolysis occurs after coagulation, and is the process where a fibrin clot is broken down.
		This is released into the blood by the cells of the healthy endothelium[?] neighbouring the clot.
		It is important to know if fibrinolysis has recently happened, as this can indicate deep vein thrombosis[?] or a pulmonary embolism.
	www.ebroadcast.com.au /lookup/encyclopedia/fi/Fibrinolysis.html (297 words)

	Fibrinolysis or Angioplasty in Acute Myocardial Infarction - March 15, 2004 - American Family Physician
		Rapid angioplasty has been demonstrated to be superior to fibrinolysis in the treatment of patients with acute myocardial infarction; however, immediate angioplasty is available in only a limited number of specialized centers.
		Exclusion criteria included any contraindication to fibrinolysis, fibrinolytic therapy in the past 30 days, left bundle branch block, nonischemic heart disease, acute myocardial infarction, pulseless femoral arteries, renal failure, and nonischemic heart disease associated with a life expectancy of less than 12 months.
		At presentation to the local hospital, patients were assigned randomly to fibrinolysis with alteplase or transport to a catheterization laboratory for angioplasty.
	www.aafp.org /afp/20040315/tips/12.html (755 words)

	ECP
		The decision to admit patients to the CCU was made by either the physician or nursing supervisor on duty on the basis of a cursory examination of the patient, findings on electrocardiography performed at admission, or information obtained by ambulance paramedics en route to the hospital.
		Although the overall proportion of patients receiving fibrinolysis did not change, there was a trend toward greater use of fibrinolysis among higher-risk patients (who are potentially more likely to benefit from the therapy) after DSCP implementation.
		The fact that the DSCP did not change the proportion of appropriate patients receiving fibrinolysis is not unexpected, as it is now standard care to use fibrinolytics in patients with marked ST-segment elevation who present within a few hours of symptom onset.
	www.acponline.org /journals/ecp/janfeb01/kellett.htm (3339 words)

	BioCarta - Charting Pathways of Life
		Clot formation and fibrinolysis is a balance of plasmin activation/inhibition and thrombin-thrombomodulin activity that regulates fibrin polymer formation and degradation.
		Active thrombin is produced by the cleavage of prothrombin in the intrinsic thrombin activation pathway or the extrinsic thrombin activation pathway.
		Thrombin activatable fibrinolysis inhibitor (TAFI) is a carboxy-peptidase B-like proenzyme activated by the thrombin-thrombomodulin dimer.
	www.biocarta.com /pathfiles/h_fibrinolysisPathway.asp (304 words)

	Bylaws of the International Society for Fibrinolysis and Proteolysis
		Specifically, the objectives include the furtherance of scientific research relating to fundamental and medical aspects of Fibrinolysis, Proteolysis and Thrombolysis, the futherance of resarch in related disciplines, the interchange of ideas through the organization of scientific conferences (cf.
		The Chairman of the Subcommittee on Fibrinolysis of the Scientific and Standardization Committee of the International Society on Thrombosis and Haemostasis (ISTH), and the liaison officer with the International Fibrinogen Research Society (IFRS) are - ex officio - members of the Council of the ISFP.
		On the occasion of the International Congress on Fibrinolysis and Proteolysis a prize will be awarded for outstanding contributions to the field of fibrinolysis, proteolysis and thrombolysis.
	www.fibrinolysis.org /pages/Bylaws_of_ISFP.htm (2480 words)

	Dissertations from Karolinska Institutet - Published by Karolinska Institutet Karolinska Institutet - ki.se (Site not responding. Last check: 2007-10-14)
		Accounts of a fibrinolysis inhibitor that is generated by thrombin shed more light on this field and changed the concept by giving thrombin, the pivotal enzyme in hemostasis, another important role in the down-regulation of fibrinolysis.
		Thrombin Activatable Fibrinolysis Inhibitor (TAFI), also known as procarboxypeptidase B and procarboxypeptidase U, is a relatively recently described inhibitor of fibrinolysis that can be converted into its activated form which is a carboxypeptidase B- like enzyme, by the thrombin/thrombomodulin complex.
		Since this "inhibitor" of fibrinolysis is functional only in its active form, we reserve the term TAFI for the active form of the enzyme and suggest the term TAFli for the inactive form.
	diss.kib.ki.se /2003/91-7349-540-9 (978 words)

	Fibrinolysis or angioplasty in acute myocardial infarction - Tips from Other Journals American Family Physician - Find ...
		Fibrinolysis or angioplasty in acute myocardial infarction - Tips from Other Journals
		EDITOR'S NOTE: An accompanying editorial (1) notes that several other studies have demonstrated that transport for angioplasty is better than locally administered fibrinolysis, in terms of reduced rates of reinfarction and improvements in overall death rates and incidence of stroke.
		A combined review (2) of 23 trials comparing fibrinolytic therapy with angioplasty within the same referral center showed death rates decreasing from 9 to 7 percent, reinfarction dropping from 7 to 3 percent, and a slight decrease in stroke from 2 to 1 percent.
	www.findarticles.com /p/articles/mi_m3225/is_6_69/ai_114608444 (749 words)

	Coagulation and fibrinolysis in sepsis
		Thrombin, itself, is an activator of inflammation and inhibitor of fibrinolysis.
		The latter is achieved by the activation of TAFI (thrombin-activatable fibrinolysis inhibitor).
		The function of this compound is to activate protein C. Activated protein C modifies the inflammatory and coagulant response at several different levels; a deficiency occurs due to inhibition of thrombomodulin in sepsis.
	www.ccmtutorials.com /infection/sepsis/page8.htm (314 words)

	Euglobulin lysis time
		This is one of the best tests to differentiate primary fibrinolysis from DIC (disseminated intravascular coagulation).
		The euglobulin lysis test evaluates fibrinolysis (that is, the dissolution of a blood clot).
		In primary fibrinolysis (for example, caused by streptokinase administration, cancer of the prostate, shock), the euglobulin lysis time is shorter than normal.
	www.pennhealth.com /ency/article/003654.htm (574 words)

	Selective Intra-Arterial Fibrinolysis of Acute Central Retinal Artery Occlusion -- Weber et al. 29 (10): 2076 -- Stroke
		Improvement of vision in the control (n=15) and fibrinolysis (n=17) groups, ie, vision at outcome minus vision before treatment.
		Approximately one third of the patients undergoing fibrinolysis improved markedly or recovered completely, one third showed slight improvement, and the other third had no improvement at all.
		Local intra-arterial fibrinolysis for acute occlusion of the central retinal artery: a meta-analysis of the published data
	stroke.ahajournals.org /cgi/content/full/29/10/2076 (2085 words)

	Inhibition of fibrinolysis by recombinant factor VIIa in plasma from patients with severe hemophilia A -- Lisman et al. ...
		Inhibition of fibrinolysis by recombinant factor VIIa in plasma from patients with severe hemophilia A -- Lisman et al.
		Thrombin-activatable fibrinolysis inhibitor deficiency in cirrhosis is not associated with increased plasma fibrinolysis.
		Regulation of fibrinolysis in plasma by TAFI and protein C is dependent on the concentration of thrombomodulin.
	www.bloodjournal.org /cgi/content/full/99/1/175 (4021 words)

	Hyperprothrombinemia associated with prothrombin G20210A mutation inhibits plasma fibrinolysis through a TAFI-mediated ...
		Fibrinolysis was studied by a turbidimetric assay using a tissue factor–induced plasma clot exposed to 25 ng/mL exogenous t-PA. NP was also tested in the presence of CPI (50 µg/mL,
		Thrombin activatable fibrinolysis inhibitor deficiency in cirrhosis is not associated with increased plasma fibrinolysis.
		Inhibition of fibrinolysis by recombinant factor VIIa in plasma from patients with severe hemophilia A. Blood.
	www.bloodjournal.org /cgi/content/full/103/6/2157 (3262 words)

	Factor VLeiden Inhibits Fibrinolysis In Vivo -- Parker et al. 110 (23): 3594 -- Circulation
		Coagulation-dependent inhibition of fibrinolysis: role of carboxypeptidase-U and the premature lysis of clots from hemophilic plasma.
		Antovic JP, Blomback M. Thrombin-activatable fibrinolysis inhibitor antigen and TAFI activity in patients with APC resistance caused by factor V Leiden mutation.
		Regulation of Fibrinolysis by Thrombin Activatable Fibrinolysis Inhibitor, an Unstable Carboxypeptidase B That Unites the Pathways of Coagulation and Fibrinolysis
	circ.ahajournals.org /cgi/content/full/110/23/3594 (2177 words)

	Thrombin and Fibrinolysis -- Nesheim 124 (3 Supplement): 33 -- Chest
		Bajzar, L Thrombin activatable fibrinolysis inhibitor and an antifibrinolytic pathway.
		Marx, PF, Bouma, BN, Meijers, JC Role of zinc ions in activation and inactivation of thrombin-activatable fibrinolysis inhibitor.
		Broze, GJ, Jr, Higuchi, DA Coagulation-dependent inhibition of fibrinolysis: role of carboxypeptidase-U and the premature lysis of clots from hemophilic plasma.
	www.chestjournal.org /cgi/content/full/124/3_suppl/33S (4519 words)

	Intrapleural Fibrinolysis for Parapneumonic Effusion and Empyema in Children -- Wells and Havens 228 (2): 370 -- ...
		fibrinolysis was obtained from the parents or legal guardian.
		After intrapleural fibrinolysis with alteplase, 205 mL of fluid drained within 2 hours.
		fibrinolysis is safe and effective for children with pneumonia
	radiology.rsnajnls.org /cgi/content/full/228/2/370 (4986 words)

	Superselective Ophthalmic Arterial Fibrinolysis with Urokinase for Recent Severe Central Retinal Venous Occlusion: ...
		fibrinolysis; 12 were examined at 6 months; and 10 were examined
		Arteriovenous transit time is 4.8 seconds, as shown with the early appearance of venous laminar flow (arrow), which indicates an improvement in retinal circulation time.
		(c) Retinal photograph obtained 1 month after fibrinolysis shows the normalization of the venous caliber (short straight solid arrow) and the disappearance of retinal hemorrhages (long straight solid arrows) and of papillary edema (arrowheads), cotton-wool spots (open arrows) and areas of inner retinal ischemia in the posterior pole (curved arrow).
	radiology.rsnajnls.org /cgi/content/full/216/1/47 (4803 words)

	Enhancement of Fibrinolysis With 40-kHz Ultrasound -- Suchkova et al. 98 (10): 1030 -- Circulation
		Amount of fibrinolysis was determined as percentage of radiolabel that was solubilized.
		Amount of fibrinolysis at 1 hour was determined as percentage of radiolabel that was solubilized.
		Acceleration of fibrinolysis by ultrasound in a rabbit ear model of small vessel injury.
	circ.ahajournals.org /cgi/content/full/98/10/1030 (3494 words)

	Functional hierarchy of plasminogen kringles 1 and 4 in fibrinolysis and plasmin-induced cell detachment and apoptosis ... (Site not responding. Last check: 2007-10-14)
		Functional hierarchy of plasminogen kringles 1 and 4 in fibrinolysis and plasmin-induced cell detachment and apoptosis -- Ho-Tin-Noé et al.
		Functional hierarchy of plasminogen kringles 1 and 4 in fibrinolysis and plasmin-induced cell detachment and apoptosis
		-Val-Phe-Lys-CH Cl in Tris/HCl pH 5 and the degree of fibrinolysis was estimated by detecting the plasmin-generated fibrin fragment E with mAb FDP-14 and an HRP-conjugated goat anti-mouse IgG.
	content.febsjournal.org /cgi/content/full/272/13/3387 (6182 words)

	IngentaConnect A new functional assay of thrombin activatable fibrinolysis inhib... (Site not responding. Last check: 2007-10-14)
		IngentaConnect A new functional assay of thrombin activatable fibrinolysis inhib...
		New thrombin activatable fibrinolysis inhibitor (TAFI) assays are necessary for studying the role of this fibrinolysis inhibitor in cardiovascular disease.
		Keywords: fibrinolysis inhibitor; functional assay; polymorphisms; procarboxypeptidase B; thrombin activatable fibrinolysis inhibitor; thrombin activatable fibrinolysis inhibitor isofor
	www.ingentaconnect.com /content/bsc/jth/2005/00000003/00000006/art00030 (341 words)

	NEJM -- Enoxaparin versus Unfractionated Heparin with Fibrinolysis for ST-Elevation Myocardial Infarction
		NEJM -- Enoxaparin versus Unfractionated Heparin with Fibrinolysis for ST-Elevation Myocardial Infarction
		Enoxaparin vs. UFH as Adjunct to Fibrinolysis in STEMI.
		Unfractionated or LMW Heparin in Conjunction with Fibrinolysis?.
	content.nejm.org /cgi/content/abstract/NEJMoa060898 (556 words)

	Is primary angioplasty more effective than prehospital fibrinolysis in diabetics with acute myocardial infarction? Data ...
		Clinical outcomes of patients with diabetes mellitus and acute myocardial infarction treated with primary angioplasty or fibrinolysis.
		Primary angioplasty versus prehospital fibrinolysis in acute myocardial infarction: a randomised study.
		Impact of time to treatment on mortality after prehospital fibrinolysis or primary angioplasty: data from the CAPTIM randomized clinical trial.
	eurheartj.oxfordjournals.org /cgi/content/full/26/17/1712 (3307 words)

	Reviews, Notes, and Listings: Fibrinolysis, Thrombosis, and Hemostasis: Concepts, Perspectives, and Clinical ...
		Reviews, Notes, and Listings: Fibrinolysis, Thrombosis, and Hemostasis: Concepts, Perspectives, and Clinical Applications
		Fibrinolysis, Thrombosis, and Hemostasis: Concepts, Perspectives, and Clinical Applications
		of fibrinolysis, from the clinical investigator planning thrombolytic
	www.annals.org /cgi/content/full/118/5/399 (284 words)

	IngentaConnect Macromolecular Ensembles of Internal and External Fibrinolysis: t... (Site not responding. Last check: 2007-10-14)
		The action of fibrin-specific and fibrinnonspecific plasminogen activators in fibrinolysis has been evaluated.
		The necessity of the investigation of the regularities of internal and external fibrinolysis has been substantiated.
		The internal fibrinolysis became the resource for enhancement of thrombolysis efficacy.
	www.ingentaconnect.com /content/ben/cmc/2006/00000013/00000014/art00003 (219 words)

	Thrombin Activatable Fibrinolysis Inhibitor and an Antifibrinolytic Pathway -- Bajzar 20 (12): 2511 -- ...
		Thrombin Activatable Fibrinolysis Inhibitor and an Antifibrinolytic Pathway -- Bajzar 20 (12): 2511 -- Arteriosclerosis, Thrombosis, and Vascular Biology
		Thrombin Activatable Fibrinolysis Inhibitor and an Antifibrinolytic Pathway
		Plasma Thrombin-Activatable Fibrinolysis Inhibitor Antigen Concentration and Genotype in Relation to Myocardial Infarction in the North and South of Europe
	atvb.ahajournals.org /cgi/content/abstract/20/12/2511 (1254 words)

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