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Topic: Fibroblast


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  BioMed Central | Full text | Fibroblast-derived MT1-MMP promotes tumor progression in vitro and in vivo
Fibroblasts were isolated from the dermis of late gestation embryos in mice deficient in MT1-MMP[8], MMP-2 [9] and MMP-9 [10].
Fibroblasts were used between passages 2–6 and maintained in DMEM supplemented with 10% (v/v) fetal bovine serum (Mediatech, Herdon, VA) and antibiotics (100 units/ml penicillin and 100 ug/ml streptomycin sulphate, Mediatech).
To compensate for the potential negative impact of this growth rate both a 1:2 ratio and a 1:3 ratio of tumor cells to fibroblasts was used for each fibroblast type to compensate for variations in primary culture growth rate [12].
www.biomedcentral.com /1471-2407/6/52   (4585 words)

  
 Fibroblast growth factor receptors from liver vary in three structural domains -- Hou et al. 251 (4994): 665 -- Science
Fibroblast growth factor receptors from liver vary in three structural domains -- Hou et al.
Changes in heparin-binding fibroblast growth factor gene expression and receptor phenotype occur during liver regeneration and in hepatoma cells.
Fibroblast growth factor receptor 1 is fused to FIM in stem-cell myeloproliferative disorder with t(8;13)(p12;q12).
www.sciencemag.org /cgi/content/abstract/251/4994/665   (1114 words)

  
  Molecular Cancer | Full text | Myb proteins inhibit fibroblast transformation by v-Rel
The actin stress fibers seen in control fibroblasts were replaced by a dense accumulation of cortical actin adjacent to the plasma membrane in the v-Rel-ER cells in the presence of estrogen.
Because neither v-Myb nor c-Myb are normally present in fibroblasts, one hypothesis is that v-Myb and c-Myb may act as tumor suppressors by dominantly inhibiting the function of B-Myb, a closely related protein which appears to be ubiquitously expressed in all vertebrate cells including in fibroblasts [21].
Moore BE, Bose HR Jr.: Expression of the v-rel oncogene in reticuloendotheliosis virus-transformed fibroblasts.
www.molecular-cancer.com /content/5/1/54   (3332 words)

  
 Heparin-induced Self-association of Fibroblast Growth Factor-2. EVIDENCE FOR TWO OLIGOMERIZATION PROCESSES -- Herr et ...
Fibroblast growth factor-2 (FGF-2), a potent angiogenic factor, requires heparin for dimerization and activation of the FGF
Fibroblast Growth Factor 2 Induced Proliferation in Osteoblasts and Bone Marrow Stromal Cells: A Whole Cell Model
Fibroblast growth factors 1 and 2 are distinct in oligomerization in the presence of heparin-like glycosaminoglycans
www.jbc.org /cgi/content/abstract/272/26/16382   (846 words)

  
 Arthritis Research & Therapy | Full text | Fibroblast activation protein is expressed by rheumatoid ...
Fibroblast activation protein (FAP), as described so far, is a type II cell surface serine protease expressed by fibroblastic cells in areas of active tissue remodelling such as tumour stroma or healing wounds.
Fibroblasts with myofibroblastic phenotype are a known source of proteolytic enzymes that are involved in ECM deposition.
Mattey DL: Interleukin-4 induces myofibroblast differentiation is synovial fibroblasts.
arthritis-research.com /content/8/6/R171   (4791 words)

  
 Ligand specificity and heparin dependence of fibroblast growth factor receptors 1 and 3 -- Ornitz and Leder 267 (23): ...
The myeloma-associated oncogene fibroblast growth factor receptor 3 is transforming in hematopoietic cells
Basic Fibroblast Growth Factor Binds Its Receptors, Is Internalized, and Stimulates DNA Synthesis in Balb/c3T3 Cells in the Absence of Heparan Sulfate
Isolation and developmental expression of the amphibian homolog of the fibroblast growth factor receptor 3
www.jbc.org /cgi/content/abstract/267/23/16305   (1854 words)

  
 Isolation of an Additional Member of the Fibroblast Growth Factor Receptor Family, FGFR-3 -- Keegan et al. 88 (4): 1095 ...
The fibroblast growth factors are a family of polypeptide growth factors involved in a variety of activities including mitogenesis, angiogenesis, and wound healing.
Fibroblast growth factor receptors (FGFRs) have previously been identified in chicken, mouse, and human and have been shown to contain an extracellular domain with either two or three immunoglobulin-like domains, a transmembrane domain, and a cytoplasmic tyrosine kinase domain.
Heterogeneity in the expression of fibroblast growth factor receptors during limb regeneration in newts (Notophthalmus viridescens)
www.pnas.org /cgi/lookup?vol=88&fp=1095&view=abstract   (1522 words)

  
 Differential Expression of Two Fibroblast Growth Factor-Receptor Genes is Associated with Malignant Progression in ...
Differential Expression of Two Fibroblast Growth Factor-Receptor Genes is Associated with Malignant Progression in Human Astrocytomas -- Yamaguchi et al.
Elevated expression of fibroblast growth factors (FGFs) in astrocytomas has implicated the FGF family of mitogens in the initiation and progression of astrocyte-derived tumors.
Activated fibroblast growth factor receptor 3 is an oncogene that contributes to tumor progression in multiple myeloma
www.pnas.org /cgi/content/abstract/91/2/484   (1643 words)

  
 Fibroblast growth factor receptor 2 definition - Medical Dictionary definitions of popular medical terms
Fibroblast growth factor receptor 2 definition - Medical Dictionary definitions of popular medical terms
Fibroblast growth factor receptor 2: A mutation (change) in the fibroblast growth factor receptor 2 (FGFR2) gene on chromosome 10 causes the best-known type of acrocephalosyndactyly, namely Apert syndrome which is characterized by abnormalities of the skull and face and the hands and feet.
There is premature closure of some of the sutures of the skull (craniosynostosis) resulting in an abnormally shaped head (which is unusually tall but short from front-to-back) and an abnormally shaped face with shallow eye sockets and underdevelopment of the midface.
www.medterms.com /script/main/art.asp?articlekey=6498   (260 words)

  
 Basic and acidic fibroblast growth factors have trophic effects on neurons from multiple CNS regions -- Walicke 8 (7): ...
Basic and acidic fibroblast growth factors have trophic effects on neurons from multiple CNS regions -- Walicke 8 (7): 2618 -- Journal of Neuroscience
Basic and acidic fibroblast growth factors have trophic effects on neurons from multiple CNS regions
The Neurotrophic Activity of Fibroblast Growth Factor 1 (FGF1) Depends on Endogenous FGF1 Expression and Is Independent of the Mitogen-activated Protein Kinase Cascade Pathway
www.jneurosci.org /cgi/content/abstract/8/7/2618   (921 words)

  
 Fibroblast definition - Medical Dictionary definitions of popular medical terms
Fibroblast definition - Medical Dictionary definitions of popular medical terms
Fibroblast: A cell ubiquitous in connective tissue that makes and secretes collagen.
Sarcoidosis - Learn more about sarcoidosis, a disease resulting from chronic inflammation.
www.medterms.com /script/main/art.asp?articlekey=24766   (137 words)

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