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Topic: Fibronectin

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	Innovative Research, Inc - "The researcher's source for biomedical products".
		Human fibronectin is an adhesive glycoprotein found in the extracellular matrix and in plasma (1).
		Fibronectin is composed of two nearly identical polypeptide chains linked by a pair of disulfide bonds.
		The human fibronectin provided is suitable to promote the adhesion and propagation of cells in vitro when used to coat cell culture surfaces, including plasticware, glassware and microcarrier beads.
	www.innov-research.com /fibronectin.htm (199 words)

	Haematologic Technologies - Human Fibronectin
		Fibronectin (cold-insoluble globulin) is a high molecular weight, adhesive, glycoprotein found in both plasma (1) and the extracellular matrix (2).
		Fibrin-fibronectin complexes are stabilized by the factor XIIIa-catalyzed covalent cross-linking of fibronectin to the a chain of fibrin (18).
		Fibronectin is isolated from human plasma by thermal precipitation, ion exchange, and gelatin-agarose affinity chromatography.
	www.haemtech.com /Cofactors/Fibronectin.htm (454 words)

	Fibronectin and Integrin
		The extension difference between native state and intermediate is in agreement with atomic force microscopy unfolding experiments; the intermediate structure predicted by the simulations is suprisingly close to the structure of anastellin, the 76 amino-acid N-terminual portion of FN-III1 obtained by cutting the A- and B-strands.
		Fibronectin is recognized by integrins alpha5beta1 and alphaVbeta3.
		The primary sequence motif of fibronectin for integrin binding is a tripeptide, Arg-Gly-Asp (RGD), located on the loop connecting the force-bearing G- and F-strands of FN-III10.
	www.ks.uiuc.edu /Research/fibronectin (1874 words)

	InterPro: IPR000562 Type II fibronectin, collagen-binding
		Fibronectin is a multi-domain glycoprotein, found in a soluble form in plasma, and in an insoluble form in loose connective tissue and basement membranes, that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin.
		Fibronectins are involved in a number of important functions e.g., wound healing; cell adhesion; blood coagulation; cell differentiation and migration; maintenance of the cellular cytoskeleton; and tumour metastasis [ 1 ].
		The major part of the sequence of fibronectin consists of the repetition of three types of domains, which are called type I, II, and III [ 2 ].
	www.ebi.ac.uk /interpro/IEntry?ac=IPR000562 (3511 words)

	Fibronectin Molecular Interactions - Introduction
		Fibronectin is a large multidomain glycoprotein found in connective tissue, on cell surfaces, and in plasma and other body fluids [1808].
		Although fibronectin ultimately proved ineffective as a clinical product, we became adept at purifying gram quantities of this interesting protein at a time when the number of papers being published each year was rising exponentially.
		The title of the conference was later expanded to "Fibronectin and Related Molecules" and subsequently to "Fibronectin, Integrins and Related Molecules".
	home.comcast.net /~kennethingham/newsite/intro (455 words)

	Chemicon - Product #AB2047 - Anti-Fibronectin
		Fibronectin (FN) is an extracellular adhesion molecule and it is involved in many cellular processes, including tissue repair, embryogenesis, blood clotting, and cell migration/adhesion.
		Fibronectin exists in two main forms: 1) as an insoluble glycoprotein dimer that serves as a linker in the ECM (extracellular matrix), and; 2) as a soluble disulphide linked dimer found in the plasma (plasma FN).
		Fibronectin sometimes serves as a general cell adhesion molecule by anchoring cells to collagen or proteoglycan substrates.
	www.chemicon.com /browse/productdetail.asp?ProductID=AB2047 (366 words)

	Enhancement of fibronectin expression in rat lung by ozone and an inflammatory stimulus -- Gupta et al. 275 (2): 330 -- ...
		Fibronectin from lung tissue was extracted by the method described by Bray et al.
		The fibronectin analyses in blood plasma, BALF, and lung tissue were performed as described by Gomez-Lechon and Castell (17).
		Fibronectin and hyaluronan in bronchoalveolar lavage fluid from young patients with chronic obstructive pulmonary diseases.
	ajplung.physiology.org /cgi/content/full/275/2/L330 (3539 words)

	A 49-Residue Peptide from Adhesin F1 of Streptococcus pyogenes Inhibits Fibronectin Matrix Assembly -- ...
		Fibronectin extracellular matrix is a substratum for cell adhesion, migration, and proliferation during physiological and
		Fibronectin Binding Regions of F1 Both Enhance and Inhibit Assembly of Fibronectin-- We studied the effects of His-tagged fusion proteins corresponding to FUD, FRD, RD5, and FF1 containing both FUD and RD5 (Fig.
		The rhodamine fluorescence of cells not exposed to plasma fibronectin was negative and is not shown.
	www.jbc.org /cgi/content/full/276/26/23430 (6020 words)

	Fibronectin matrix polymerization increases tensile strength of model tissue -- Gildner et al. 287 (1): H46 -- AJP - ...
		Fibronectin increases the mechanical properties of collagen biogels.
		Fibronectin dependence of the contraction of collagen lattices by human skin fibroblasts.
		Fibronectin polymerization regulates the composition and stability of extracellular matrix fibrils and cell-matrix adhesions.
	ajpheart.physiology.org /cgi/content/full/287/1/H46 (4081 words)

	Extracellular matrix fibronectin alters connexin43 expression by alveolar epithelial cells -- Alford and Rannels 280 ...
		The effect of FBS on the fibronectin content (36) of type II cell-derived ECM was examined by Western blot analysis.
		Fibronectin mediates adherence of rat alveolar type II epithelial cells via the fibroblastic cell-attachment domain.
		The effect of fibronectin on cytoskeleton structure and transepithelial resistance of alveolar type II cells in primary culture.
	ajplung.physiology.org /cgi/content/full/280/4/L680 (5995 words)

	Fetal fibronectin - Wikipedia, the free encyclopedia
		Fetal fibronectin (fFN) is a protein produced by fetal cells.
		Fetal fibronectin "leaks" into the vagina if a preterm delivery is likely to occur and can be measured in a diagnostic test.
		A systematic review of the medical literature found that fetal fibronectin is a good predictor of spontaneous preterm birth before cervical dilation.
	en.wikipedia.org /wiki/Fetal_Fibronectin (256 words)

	Center News - 12/06 - Finding fibronectin leads to "FullTerm" product birth
		Still investigating the cause of metastasis, he found that fibronectin in cancer cells is different than fibronectin in normal cells — a difference that gives scientists another potential way to target cancer cells for treatment.
		In the process of discovering that the fibronectin in cancer cells is different from normal cells, Hakomori discovered that fetal-cell fibronectin demonstrated the same difference as cancer-cell fibronectin (the shared term for this deviation is oncofetal fibronectin).
		That meant it would be possible to identify the presence of fetal fibronectin in a mother's system — a telltale sign of impending birth.
	www.fhcrc.org /about/pubs/center_news/2006/dec/art5.html (837 words)

	Homocysteine Binds to Human Plasma Fibronectin and Inhibits Its Interaction With Fibrin -- Majors et al. 22 (8): 1354 ...
		The radiolabeled fibronectin was precipitated with perchloric acid and resuspended in TES buffer, and the pH was adjusted to neutral.
		The fibronectin was subjected to limited trypsin digestion for 6 hours at room temperature with 0.1% trypsin, and the digestion was stopped with 0.1 mmol/L phenylmethylsulfonyl fluoride.
		in a deficiency of fibronectin in the provisional clot and subsequent
	atvb.ahajournals.org /cgi/content/full/22/8/1354 (3746 words)

	Chemicon - Product #ECM300 - QuantiMatrix™ Human Fibronectin ELISA
		Human fibronectin is pre-coated on the wells with the exception of row H, which serves as a reference.
		Free rabbit anti-human fibronectin binds to the fibronectin on the plate.
		This color is quantitated using an ELISA reader; the intensity of the color is inversely proportional to the amount of fibronectin in the original sample.
	www.chemicon.com /browse/productdetail.asp?ProductID=ECM300 (696 words)

	Adeza : About FullTerm : Fetal Fibronectin Studies (Site not responding. Last check: 2007-10-13)
		Relative contribution of oxidants and elastase to fibronectin release from amniotic membranes.
		Summary: Predicted recurrence risk is increased by twofold to fourfold in women with a positive compared with a negative fetal fibronectin, and it increases as cervical length shortens in both fetal fibronectin-positive and fetal fibronectin-negative women.
		Title: The value of fetal fibronectin in cervical and vaginal secretions and of ultrasonographic examination of the uterine cervix in predicting premature delivery for patients with preterm labor and intact membranes.
	www.adeza.com /html/HCP_US_FetalFibronectinStudies.htm (1540 words)

	Stimulation of Integrin-mediated Cell Contractility by Fibronectin Polymerization -- Hocking et al. 275 (14): 10673 -- ...
		Fibronectin is a high molecular mass, multidomain glycoprotein that circulates in a soluble form in the plasma and is also
		Fibronectin polymerization by fibronectin-null cells was determined by imbedding cells in collagen gels in the presence of
		Fibronectin was visualized by SDS-PAGE under nonreducing and reducing conditions followed by immunoblotting with a polyclonal anti-fibronectin antibody.
	www.jbc.org /cgi/content/full/275/14/10673 (6221 words)

	Medical References: Fetal Fibronectin (fFN): A Test for Preterm Delivery (Site not responding. Last check: 2007-10-13)
		Fetal fibronectin (fFN) is a protein produced during pregnancy and functions as a biological glue, attaching the fetal sac to the uterine lining.
		During the first trimester, and for about half of the second trimester (up to 22 weeks of gestation), fFN is normally present in the cervico-vaginal secretions of pregnant women.
		Elliott, J (1997) Fetal fibronectin testing in the management of triplets and quadruplets.
	www.marchofdimes.com /professionals/681_1149.asp (769 words)

	Quick Reference: Fetal Fibronectin (fFN): A Test for Preterm Delivery
		The American College of Obstetrics and Gynecology recommends that screening for the presence of fetal fibronectin (fFN) may be useful for some pregnant women with symptoms of preterm labor (1).
		According to ACOG, “Fetal fibronectin testing may be useful in women with symptoms of preterm labor to identify those with negative values and a reduced risk of preterm birth, thereby avoiding unnecessary intervention” (1)
		Vaginal Fetal Fibronectin Levels and Spontaneous Preterm Birth in Symptomatic Women.
	www.marchofdimes.com /professionals/14332_1149.asp (749 words)

	Adeza : About FullTerm (Site not responding. Last check: 2007-10-13)
		Elevated amounts of fetal fibronectin should not be detected in the vagina after 22 weeks gestation.
		Fetal fibronectin appearance before the normal onset of labor is a strong indicator of preterm birth risk.
		Fetal fibronectin as a predictor of preterm birth in patients with symptoms: A multicenter trial.
	www.adeza.com /html/HCP_US_FullTerm.htm (867 words)

	Fetal Fibronectin Enzyme Immunoassay
		Fetal fibronectin can be measured in cervicovaginal secretions early in pregnancy and at term, but is rarely detectable between 21 and 37 weeks gestation in normal pregnancies that are delivered at term.
		It has been hypothesized that cervicovaginal fetal fibronectin secretion in women with preeclampsia would be elevated compared to normotensive controls, and the level of fetal fibronectin may be correlated to the severity of the preeclampsia.
		Preliminary evidence, however, suggests that fetal fibronectin is not elevated in cervicovaginal secretions of women with preeclampsia.
	www.regence.com /trgmedpol/maternity/mat10.html (2299 words)

	Antiangiogenic proteins require plasma fibronectin or vitronectin for in vivo activity -- Yi et al. 100 (20): 11435 -- ...
		fibronectin genes; their plasma vitronectin levels were normal.
		Mice deficient in plasma fibronectin (pFN–), their littermate controls (pFN+), vitronectin-null mice (VN null), and same strain wild-type (wt) controls for the VN null mice were injected with matrigel plugs impregnated with bFGF.
		Results from mice treated with the two doses were pooled (16 mice in fibronectin experiments; 24 mice in vitronectin experiments).
	www.pnas.org /cgi/content/full/100/20/11435 (2445 words)

	Nitric oxide mediates LC-3-dependent regulation of fibronectin in ductus arteriosus intimal cushion formation -- MASON ...
		of nNOS, ecNOS and fibronectin staining was increased in the
		fibronectin up-regulation in the DA at the onset of intimal cushion
		in the DA, is the cause of increased fibronectin synthesis.
	www.fasebj.org /cgi/content/full/13/11/1423 (7254 words)

	Fibronectin in an Extracellular Matrix of Cultured Endothelial Cells Supports Platelet Adhesion via Its Ninth Type III ...
		Diagram of the fibronectin subunit illustrating the organization of type I (gray boxes), type II (cross-hatched boxes), and type III (white boxes, numbered 1 to 15) repeats and showing the location of the recombinant (fusion proteins FN1 up to FN7; 33- and 40-kDa fragment) and proteolytic (gelatin-, cell-, and heparin-binding domain) fragments.
		Inhibition of platelet adhesion to fibronectin or ECM by fragment FN4 or FN5.
		Characterization of regions of fibronectin besides the arginine-glycine-aspartic acid sequence required for adhesive function of the cell-binding domain using site-directed mutagenesis.
	atvb.ahajournals.org /cgi/content/full/20/4/e16 (5660 words)

	Fetal fibronectin and preterm labor
		Fetal fibronectin testing is occasionally done when preterm labor symptoms are present.
		For fetal fibronectin testing, a sample of fluid is collected from the vagina or the opening to the uterus (cervix).
		To reduce the risk of a false-positive result, it is important that a fetal fibronectin test be done before a manual pelvic exam.
	www.webmd.com /hw/health_guide_atoz/hw221557.asp?navbar=hw222240 (261 words)

	Fibronectin antibodies from RDI Divison of Fitzgerald Industries Intl
		Description: Fibronectin is a dimeric glycoprotein which is present in cells, extracellular matrix, and blood.1 It possesses at least four binding sites for collagen, glycosaminoglycans, transglutaminase, and a cell surface receptor.
		Description: Fibronectin is a dimeric glycoprotein which is present in cells, extracellular matrix, and blood.1 It is involved in cell adhesion, tissue organization, and wound healing.
		Fibronectin may precipitate in early steps of intracellular signal transduction by triggering responses to cell interactions with the extracellular matrix.
	www.researchd.com /miscabs/fibronab.htm (1219 words)

	InterPro: IPR000083 Fibronectin, type I
		Fibronectin type I repeats are one of the three repeats found in the fibronectin protein.
		Fibronectin is a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin.
		Smith B.O. Downing A.K. Driscoll P.C. Dudgeon T.J. Campbell I.D. The solution structure and backbone dynamics of the fibronectin type I and epidermal growth factor-like pair of modules of tissue-type plasminogen activator.
	www.ebi.ac.uk /interpro/IEntry?ac=IPR000083 (3348 words)

	Fibronectin Matrix Deposition and Cell Contractility: Implications for Airway Remodeling in Asthma -- Hocking 122 (6 ...
		Moreover, the disruption of caveolae inhibited the fibronectin-
		Little, CD, Chen, WT Masking of the extracellular collagen and the co-distribution of collagen and fibronectin during matrix formation of cultured embryonic fibroblasts.
		McDonald, JA, Kelley, DG, Broekelmann, TJ Role of fibronectin in collagen deposition: Fab' to the gelatin-binding domain of fibronectin inhibits both fibronectin and collagen organization in fibroblast extracellular matrix.
	www.chestjournal.org /cgi/content/full/122/6_suppl/275S (1894 words)

	Fibronectin (cellular) antibodies from RDI Divison of Fitzgerald Industries Intl
		CBL 248 does not recognize the soluble dimeric form of fibronectin (plasma fibronectin) but stains strongly matrix fibronectin in tissues.
		Fibronectin seems to play a key role in the tumor cell extracellular matrix during invasive tumor growth.
		Christensen L et al: The Distribution of Fibronectin, Laminin and Tetranectin in Human Breast Cancer with Special Attention to Extracellular Matrix.
	www.researchd.com /miscabs/cbl181.htm (604 words)

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