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Topic: Fibrosis

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	MSN Encarta - Cystic Fibrosis
		Cystic Fibrosis, incurable hereditary disorder that causes the body to secrete an abnormally thick, sticky mucus that clogs the pancreas and the lungs, leading to problems with breathing and digestion, infection, and ultimately, death.
		Cystic fibrosis is an autosomal recessive genetic disorder.
		Cystic fibrosis patients of all ages are prone to dehydration because they lose so much salt in their sweat.
	encarta.msn.com /encnet/refpages/RefArticle.aspx?refid=761567047 (1098 words)

	Cystic fibrosis - Wikipedia, the free encyclopedia
		Since cystic fibrosis is recessive, both copies of the gene have to be CF genes to cause the symptoms that occur in about 1 in every 2500 children.
		Cystic fibrosis is exclusively heritable as both parents must carry the recessive genes for a child to acquire the disease.
		In both cases, the low level of cystic fibrosis outside of Europe, in places where both cholera and typhoid fever are endemic, is not immediately explicable.
	en.wikipedia.org /wiki/Cystic_fibrosis (1739 words)

	Liver Fibrosis (Site not responding. Last check: 2007-10-21)
		Fibrosis is not only the result of necrosis, collapse and scar formation but also the result of derangements in the synthesis and degradation of matrix by injured mesenchymal cells that synthesize the various components of the matrix which in the liver are the following categories:
		Fibrosis develops after repeated and persistent injury that overcomes the degrading ability of matrix on the part of the liver that attempts to eliminate those formations through degrading enzymes which are produced by fibroblasts, neutrophils and macrophages.
		It is characterized by portal fibrosis with marked ductular proliferation extending to porto-portal septa and transformation of the liver parenchyma into sharp "garland" shaped nodules.
	www.meddean.luc.edu /lumen/MedEd/orfpath/fibrosis.htm (876 words)

	THE MERCK MANUAL, Sec. 4, Ch. 41, Chronic Liver Disease
		Fibrosis is a common response to hepatocellular necrosis or injury, which may be induced by a wide variety of agents, eg, any process disturbing hepatic homeostasis (especially inflammation, toxic injury, or altered hepatic blood flow) and infections of the liver (viral, bacterial, fungal, and parasitic).
		Lastly, congenital hepatic fibrosis is an autosomal recessive malformation.
		The development of fibrosis from active deposition of collagen is a consequence of liver cell injury, particularly necrosis, and inflammatory cells.
	www.merck.com /mrkshared/mmanual/section4/chapter41/41a.jsp (646 words)

	Information about Cystic Fibrosis
		Cystic fibrosis affects tissues that produce mucus secretions, such as the airway, the gastrointestinal tract, the ducts of the pancreas, the bile ducts of the liver and the male urogenital tract.
		Men with cystic fibrosis may become infertile because the tubules, called the vas deferens, that transport sperm from the testes are absent or undeveloped.
		Cystic Fibrosis is the #1 genetic killer of children and young adults in the United States.
	www.mamashealth.com /cfibrosis.asp (431 words)

	Cystic fibrosis - Genetics Home Reference
		Cystic fibrosis is an inherited disease of the mucus glands that affects many of the body's organs.
		The inability to conceive a child (infertility) is common in men with cystic fibrosis because the tubes that carry sperm (the vas deferens) often fail to develop properly.
		Mutations in the CFTR gene cause cystic fibrosis.
	ghr.nlm.nih.gov /condition=cysticfibrosis (724 words)

	Cystic fibrosis (Site not responding. Last check: 2007-10-21)
		Cystic fibrosis is an inherited disease that affects sodium channels in the body and causes respiratory and digestive problems.
		Cystic fibrosis affects the mucus and sweat glands of the body and is caused by a defective gene.
		Screening of family members of a cystic fibrosis patient may detect the cystic fibrosis gene in between 60 and 90% of carriers, depending on the test used.
	www.shands.org /health/information/article/000107.htm (591 words)

	Fibrosis
		Fibrosis is scarring of the liver that occurs in hepatitis infection.
		Fibrosis stage on the second biopsy was predicted by baseline fibrosis alone.
		Fibrosis was less advanced, on average, in women who had previously used oral contraceptives, as well.
	janis7hepc.com /fibrosis1.htm (4034 words)

	Cystic Fibrosis (Site not responding. Last check: 2007-10-21)
		Cystic fibrosis (CF) is the most common lethal autosomal recessive disease found in the Caucasian population, with a frequency of approximately one in 2,500 births.
		With a recent and unprecedented increase in the success of diagnosis and treatment modalities for the pulmonary component of cystic fibrosis, the estimated median survival age for those born in the 1990's is now 40 years.
		Cystic fibrosis heterozygote resistance to cholera toxin in the cystic fibrosis mouse.
	www.thorne.com /altmedrev/fulltext/cystic.html (5065 words)

	Cystic Fibrosis
		This protein is defective in cystic fibrosis, producing the thick, sticky mucus that causes problems for people with CF.
		Although someone with cystic fibrosis is born with it, it isn't always obvious at birth.
		Kids with cystic fibrosis have to work a little harder to breathe, and this burns more calories so it's important that they get enough to eat.
	www.kidshealth.org /kid/health_problems/heart/cystic_fibrosis.html (1069 words)

	Pulmozyme - Cystic Fibrosis information and disease education
		Disease Education Cystic fibrosis is a life-threatening disease involving a genetic mutation that disrupts the cystic fibrosis transmembrane regulator protein.
		According to the U.S. Cystic Fibrosis Foundation, the median average life expectancy for patients with cystic fibrosis is 31 years.
		Cystic fibrosis is an inherited, recessive disease which is more common in Caucasians.
	gene.com /gene/products/information/opportunistic/pulmozyme/index.jsp (291 words)

	Pulmonary Fibrosis Information
		In time, this fibrosis can build up to the point where the lungs are unable to provide oxygen to the tissues of the body.
		Often the immediate cause is respiratory failure due to hypoxemia, right-heart failure, a heart attack, blood clot (embolism) in the lungs, stroke, or lung infection brought on by the disease.
		Some people with idiopathic pulmonary fibrosis may be eligible to participate in an experimental clinical trial at the Warren Grant Magnuson Clinical Center of the National Institutes of Health in Bethesda, Maryland.
	www.california.com /~emile/Index.html (2139 words)

	CBBB Wise Giving Alliance (Site not responding. Last check: 2007-10-21)
		Cystic Fibrosis Foundation maintains a network of 10 research and development program centers, 8 therapeutic development centers (including drug and gene therapies), and over 110 care centers across the United States that are dedicated to the study, treatment, and cure of cystic fibrosis.
		Cystic Fibrosis Services, a CFF subsidiary, works with insurance companies and state health departments to give those with cystic fibrosis the latest pharmacological options, maximum benefits, and lowest costs.
		Cystic Fibrosis Services, Inc., a wholly-owned subsidiary of CFF, is a for profit taxable entity which provides pharmacy services for the benefit of CF patients.
	www.give.org /reports/care_dyn.asp?163 (708 words)

	Cystic Fibrosis / Family Village
		The Canadian Cystic Fibrosis Foundation has chapters help to promote public awareness of the CF cause through displays, speaking engagements, organize fundraising events, provide members with mutual self-help and support in coping with cystic fibrosis on a daily basis.
		The The Cystic Fibrosis Foundation (CFF) was established in 1955 to raise money for research to find a cure for Cystic Fibrosis (CF) and to improve the quality of life for the 30,000 children and young adults with the disease.
		Cystic Fibrosis, or CF as it is commonly called, is a disease caused by an inherited genetic defect.
	www.familyvillage.wisc.edu /lib_cysf.htm (552 words)

	Cystic Fibrosis - Pulmonologychannel
		Cystic fibrosis (CF) is the most common fatal, inherited disease in the United States (see Incidence).
		CF is a genetic disease resulting from the inheritance of a defective autosomal recessive gene (see Genetics of Cystic Fibrosis).
		The defective gene that is responsible for causing cystic fibrosis is on chromosome 7.
	www.pulmonologychannel.com /cf (1004 words)

	Cystic Fibrosis Information
		Cystic Fibrosis is not contagious, and therefore cannot be transmitted from person to person.
		Cystic Fibrosis Foundation:The Cystic Fibrosis Foundation (CFF) was established in 1955 to raise money for research to find a cure for cystic fibrosis (CF) and to improve the quality of life for the 30,000 children and young adults with CF.
		CFRI Research:CFRI's mission is to fund cystic fibrosis research and to offer educational and support programs for people with CF and their families.
	pw2.netcom.com /~yourman/webdoc1.htm (637 words)

	Cystic Fibrosis Disease Profile (Site not responding. Last check: 2007-10-21)
		Cystic fibrosis (CF) is a chronic, progressive, and frequently fatal genetic (inherited) disease of the body's mucus glands.
		caused by mutations in the CFTR (cystic fibrosis transmembrane conductance regulator) gene.
		This means that if both parents are CF carriers, their offspring would only express CF symptoms if they had inherited one defective copy of the CFTR gene from each parent.
	ornl.gov /sci/techresources/Human_Genome/posters/chromosome/cf.shtml (997 words)

	Cystic Fibrosis - Information and Support Resources (Site not responding. Last check: 2007-10-21)
		Cystic Fibrosis is an inherited disorder that causes problems with breathing and digestion.
		Both parents have to carry the Cystic Fibrosis gene for there to be a possibility of transmission to their child.
		There is a carrier screening test which requires a sample of blood that can determine whether or not a gene change is present in the gene for Cystic Fibrosis.
	www.mazornet.com /genetics/cystic_fibrosis.asp (570 words)

	Cystic Fibrosis Symptom.com - Cystic Fibrosis foundations, resources, symptoms, and information
		That median age is expected to grow as new treatments are developed, and it is estimated that a person born in 1998 with Cystic Fibrosis has a median expected life span of 40 years.
		Cystic Fibrosis affects approximately 30,000 children and young adults in the United States, and about 3,000 babies are born with Cystic Fibrosis every year.
		Visit our Cystic Fibrosis News page, and get the latest news on research, treatments and other cystic fibrosis news related stories.
	www.cystic-fibrosis-symptom.com (466 words)

	SixtyFiveRoses Cystic Fibrosis Resource Center (Site not responding. Last check: 2007-10-21)
		Mary G. Weiss became a volunteer for the Cystic Fibrosis Foundation in 1965 after learning that her three little boys had CF.
		Her duty was to call every civic club, social and service organization seeking financial support for CF research.
		After several calls, Richard came into the room and told his Mom, "I know what you are working for." Mary was dumbstruck because Richard did not know what she was doing, nor did he know that he had cystic fibrosis.
	www.65roses.com (219 words)

	UK Cystic Fibrosis Gene Therapy Consortium
		The UK Cystic Fibrosis Gene Therapy Consortium (UK CFGTC) is the unified research programme of the three leading gene therapy groups in the UK.
		The Consortium’s work is currently funded mainly by the Cystic Fibrosis Trust and the also the Medical Research Council.
		Health Minister Lord Warner announced on January 4th, 2005 that the Cystic Fibrosis Trust is one of two organisations benefiting from £2.5m to find a gene therapy cure for Cystic Fibrosis.
	www.cfgenetherapy.org.uk (425 words)

	Cystic Fibrosis Trust: Aiming to understand, treat and cure Cystic Fibrosis (Site not responding. Last check: 2007-10-21)
		The Cystic Fibrosis Trust is the UK's only national charity that funds research into treating and curing Cystic Fibrosis and to ensure appropriate clinical care and support for people with Cystic Fibrosis.
		The aim is to protect people, such as those with Cystic Fibrosis, who are more likely to develop complications from flu.
		To be held at The Manchester Conference Centre on Thursday 6 April 2006.
	www.cftrust.org.uk (311 words)

	Barnes-Jewish Hospital - Cystic Fibrosis
		Cystic Fibrosis is an inherited disease that affects the respiratory and digestive systems.
		That’s why Barnes-Jewish Hospital began the Adult Cystic Fibrosis program, as a complement to the excellent pediatric CF program at St. Louis Children’s Hospital, to treat patients with the latest therapies and improve their quality of life.
		If necessary, a patient can receive hospital care on a dedicated Cystic Fibrosis unit at Barnes-Jewish Hospital, or be referred for transplant services at Barnes-Jewish Hospital, one of the leading centers in the country for lung transplants in Cystic Fibrosis patients.
	www.barnesjewish.org /groups?NavID=338 (310 words)

	genome.gov \| Learning About Cystic Fibrosis
		Cystic fibrosis (CF) is the most common, fatal genetic disease in the United States.
		CF causes the body to produce thick, sticky mucus that clogs the lungs, leads to infection, and blocks the pancreas, which stops digestive enzymes from reaching the intestine where they are required in order to digest food.
		The first cystic fibrosis gene therapy experiments have involved lung cells because these cells are readily accessible and because lung damage is the most common, life-threatening problem in CF patients.
	www.genome.gov /10001213 (1015 words)

	Fibrosis - Wikipedia, the free encyclopedia
		Fibrosis is the formation or development of excess fibrous connective tissue in an organ or tissue as a reparative or reactive process, as opposed to formation of fibrous tissue as a normal constituent of an organ or tissue.
		progressive massive fibrosis, a complication of coal workers' pneumoconiosis
		This page was last modified 22:14, 6 October 2005.
	en.wikipedia.org /wiki/Fibrosis (81 words)

	MedlinePlus Medical Encyclopedia: Cystic fibrosis
		Cystic fibrosis is an inherited disease that causes thick, sticky mucus to build up in the lungs and digestive tract.
		Cystic fibrosis (CF) is caused by a defective gene which tells the body to produce abnormally thick and sticky fluid, called mucus.
		Disease registries now show that 40% of patients with cystic fibrosis are over age 18.
	www.nlm.nih.gov /medlineplus/ency/article/000107.htm (763 words)

	What is Pulmonary Fibrosis?, What are the symptoms, prevalence and treatments for the disease?
		The pharmacological agents designed to treat lung scarring are still in the experimental phase while the treatments intended to suppress inflammation have only limited success in reducing the fibrotic progress.
		Because the origin and development of the disease is not completely understood, misdiagnosis is common.
		Pulmonary Fibrosis is a very complex disease and the prediction of longevity of patients after diagnosis vary greatly.
	www.pulmonaryfibrosis.org /ipf.htm (359 words)

	Pulmonary Fibrosis symptoms, causes, and treatment by MedicineNet.com
		“Fibrosis” is a term used to refer to scarring, so pulmonary fibrosis means scarring throughout the lungs.
		In a condition known as hypersensitivity pneumonitis, fibrosis of the lung can develop following a heightened immune reaction to inhaled organic dusts or occupational chemicals.
		Most of these people have a condition called idiopathic pulmonary fibrosis (IPF) that does not respond to medical therapy, while some of the other types of fibrosis, such as nonspecific interstitial pneumonitis (NSIP), may respond to immune suppressive therapy.
	www.medicinenet.com /pulmonary_fibrosis/article.htm (355 words)

	Cystic Fibrosis News
		Michaela was born with cystic fibrosis, genetic disease affecting approximately 30,000 children and adults in the United States.
		The Cystic Fibrosis Foundation holds its sixth annual tailgate event, "Kickoff to a Cure," on Sunday in Terrace Suite of Alltel Stadium to cheer on the Jacksonville Jaguars and help raise funds and hopes toward...
		Cystic fibrosis is one of the most common genetically transmitted diseases...
	www.topix.net /health/cystic-fibrosis (1091 words)

	Biospace.com
		The Phase II study enrolled 125 patients who were treated at 26 CF centers in the U.S., and the Company believes that it represents the largest prospective, randomized, double blind, and dose-ranging trial conducted to evaluate the safety and efficacy of enzyme replacement therapy in the treatment of CF patients with pancreatic insufficiency.
		Cystic Fibrosis Foundation Therapeutics, Inc. (CFFT) the nonprofit drug discovery and development affiliate of the Cystic Fibrosis Foundation, is supporting this pivotal trial with study-specific funding of up to $2.35 million in milestone-driven, matching funds through a Therapeutics Development Award.
		PTC124 is a novel, orally administered drug that targets nonsense mutations and is being investigated initially as a treatment for CF and DMD, with the potential to treat a number of other genetic disorders.
	www.biospace.com /news_rxtarget.cfm?RxTargetID=63 (829 words)

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