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Topic: Finasteride

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	Finasteride - Wikipedia, the free encyclopedia
		Finasteride was approved initially in 1992 as Proscar, a treatment for prostate enlargement, but the sponsor had studied 1 mg of finasteride and demonstrated hair growth in male pattern hair loss.
		Finasteride is in the FDA pregnancy category X. This means that it is known to cause birth defects in an unborn baby.
		Finasteride is not intended for use by women and this medication should not be taken if you are breast-feeding a baby.
	en.wikipedia.org /wiki/Finasteride (560 words)

	Finasteride (androgen for prostate trt.) (Site not responding. Last check: 2007-10-29)
		Finasteride has been shown to increase and maintain maximum urine flow rate in men with BPH, although less than 50% of men show improvement despite a reduction in prostate size.
		Finasteride is a synthetic 4-aza analog of testosterone that acts as a competitive, specific inhibitor of 5-alpha-reductase, an intracellular enzyme responsible for converting testosterone to the potent androgen 5-alpha-dihydrotestosterone (DHT).
		Finasteride does not appear to affect circulating concentrations of cortisol, estradiol, prolactin, thyroid-stimulating hormone, thyroxine or cholesterol.
	www.rockford.uic.edu /jc/finasteride.htm (408 words)

	Direct To Consumer Advertising: Finasteride for male pattern hair loss
		When finasteride was compared to placebo using macrophotographs of 1-inch diameter circles, hair counts increased by 12% over baseline at l year (p < 0.00l).
		The patient questionnaire revealed that finasteride improved the appearance of the hair in 58% of patients as compared to placebo 35%, ABI* = 23% [95% CI* 18-28], NNT* = 4 for 1 year.
		Finasteride, 5 mg tablets, for symptoms of prostatic hypertrophy, average daily cost $1.70.
	www.ti.ubc.ca /pages/letter40.htm (1269 words)

	Propecia Side Effects, and Drug Interactions - Finasteride - RxList Monographs
		In a study of finasteride 1 mg daily in healthy men, a median decrease in ejaculate volume of 0.3 mL (-11%) compared with 0.2 mL (–8%) for placebo was observed after 48 weeks of treatment.
		Finasteride had no effect on circulating levels of cortisol, thyroid-stimulating hormone, or thyroxine, nor did it affect the plasma lipid profile (e.g., total cholesterol, low-density lipoproteins, high-density lipoproteins and triglycerides) or bone mineral density.
		In healthy volunteers, treatment with finasteride did not alter the response of LH and FSH to gonadotropin-releasing hormone indicating that the hypothalamic-pituitary-testicular axis was not affected.
	www.rxlist.com /cgi/generic3/propecia_ad.htm (1049 words)

	Prostate Cancer Research Institute - Does Finasteride Alter PCa Grading?
		Finasteride inhibits the type 2 receptors of the 5-alpha-reductase enzyme, thereby blocking conversion of testosterone to the more-potent dihydrotestosterone and reducing hormonal stimulation of the prostate.
		After finasteride treatment, prostatic volume is reduced by 20-30 percent, and there is a marked increase in the stroma/epithelial ratio when compared with untreated nodular hyperplasia; this was a near-constant finding in nine of ten published papers.
		Certainly, finasteride’s remarkable 24.8 percent improvement in chemoprevention of prostate cancer indicated in the PCPT study should not be withheld based on safety concerns about the emergence of aggressive prostate cancer when these concerns are based on available data that is quite likely to be attributable to grading bias.
	www.prostate-cancer.org /education/staging/Bostwick_DoesFinasterideAlter.html (1532 words)

	Revista do Hospital das Clínicas - Finasteride-associated male infertility (Site not responding. Last check: 2007-10-29)
		We hypothesize that finasteride may not dramatically change the spermatogenesis process in healthy men, but in patients with conditions related to infertility, an amplification of the negative influence of finasteride could occur.
		Finasteride was interrupted for 3 months, and a new seminal analysis showed a total concentration of 43 million spermatozoa/ml with 42% motility and 15% of normal shape.
		Finasteride treatment was interrupted, and after 3 months a seminal analysis showed a total concentration of 10 million spermatozoa/ml with 60% motility and 22% of normal shape.
	www.scielo.br /scielo.php?pid=S0041-87812004000400009&script=sci_arttext&tlng=en (1525 words)

	Facts about Propecia (Finasteride) FAQs and answers. (Site not responding. Last check: 2007-10-29)
		Finasteride (the active ingredient in Propecia) is a medical breakthrough — the first pill that effectively treats male pattern hair loss on the vertex (at top of head) and anterior mid-scalp area.
		Finasteride blocks the formation of DHT and, in this way, appears to interrupt a key factor in the development of inherited male pattern hair loss in men.
		Finasteride begins to block the formation of DHT almost immediately; however, because hair grows slowly, visible results from Propecia take some time.
	www.hair-loss-guide.com /propecia-FAQs.html (1133 words)

	Finasteride - Propecia - $0.72 cents a day.
		Men who took finasteride, a drug that affects male hormone levels, reduced their chances of getting prostate cancer by nearly 25 percent compared to men who took a placebo, according to results of a national study released today online by the New England Journal of Medicine.
		Another possible explanation being examined is whether finasteride truly causes more aggressive tumors to develop-either by preventing only low-grade tumors, or by making the prostate gland more favorable to aggressive tumors.
		Finasteride was approved in 1992 at a 5 milligram (mg) dose for treating benign prostatic hyperplasia (BPH), a noncancerous enlargement of the prostate that can cause problems with urine flow.
	www.propecia-generic.com /Prostate.html (1211 words)

	Using Propecia (Finasteride) for Hair Loss Treatment
		Finasteride is sometimes used alone or in combination with minoxidil (see Using Minoxidil (Rogaine)) to complement hair transplantation.
		Finasteride for treatment of hair loss should be prescribed only after examination by a physician hair restoration specialist.
		Finasteride is not approved the use in women, and particularly in women who are pregnant or who become pregnant.
	www.ishrs.org /nonsurgical/options-propecia.htm (698 words)

	Finasteride, Propecia®. DermNet NZ
		Finasteride is indicated for the treatment of men with male pattern hair loss (androgenetic alopecia) to prevent further hair loss and increase hair growth.
		Finasteride is contraindicated in women when they are or may potentially be pregnant, because it may cause abnormalities of the external genitalia of a male fetus.
		Finasteride is a specific inhibitor of type II 5-alpha reductase, which is found primarily in scalp hair follicles.
	www.dermnetnz.org /treatments/finasteride.html (1056 words)

	Minoxidil and Finasteride hair loss treatment, hair loss products, U.K
		Finasteride is without doubt the most exciting advance in the treatment and prevention of male pattern baldness available today.
		Finasteride is a pill, taken daily and is proven to be over 86% effective for most men.
		Finasteride and Minoxidil work in different ways; by using both products in combination, maximum regrowth and retention is ensured.
	www.mxclub.co.uk (751 words)

	[No title]
		In controlled clinical trials for finasteride of 12-month duration, 1.4% of the patients were discontinued due to adverse experiences that were considered to be possibly, probably or definitely drug-related (1.6% for placebo); 1.2% of patients on finasteride and 0.9% of patients on placebo discontinued therapy because of a drug-related sexual adverse experience.
		Two other studies showed that finasteride at 5 times the dosage of finasteride (5 mg daily) produced significant median decreases of approximately 0.5 mL (-25%) compared to placebo in ejaculate volume but this was reversible after discontinuation of treatment.
		In the clinical studies with finasteride, the incidences for breast tenderness and enlargement, and for hypersensitivity reactions in finasteride-treated patients were not different from those in patients treated with placebo.
	www.best-meds.com /druginfo/propecia_sideeffects.htm (592 words)

	MedlinePlus Drug Information: Finasteride (Systemic) (Site not responding. Last check: 2007-10-29)
		Finasteride blocks an enzyme called 5-alpha-reductase, which is necessary to change testosterone to another hormone that causes the prostate to grow.
		If hair growth is going to occur with the use of finasteride, it usually occurs after the medicine has been used for about 3 months and lasts only as long as the medicine continues to be used.
		Finasteride tablets may be crushed to make them easier to swallow.
	www.nlm.nih.gov /medlineplus/druginfo/uspdi/202649.html (1102 words)

	News - Propecia (Finasteride) Demonstrates Reduced Hair Loss/Increased Hair Growth in Male Pattern Hair Loss
		The hair count change measured in the finasteride 1 mg group was significantly superior to the change measured in the placebo group (p<0.05).
		Responses to questions related to satisfaction and effectiveness of treatment were significantly higher among the participants in the finasteride 1 mg group compared to the non-treated group.
		Finasteride 1 mg - available as a tablet to be taken once a day by prescription - is indicated for the treatment of MPHL in men.
	www.docguide.com /news/content.nsf/news/8525697700573E1885256B090065B448 (613 words)

	Benefit and harm with finasteride [April 1998; 50-4]
		Bandolier has reported on finasteride treatment for benign prostatic hyperplasia before, notably on the result of a meta-analysis showing that finasteride is effective in men with prostate volumes of more than 40 mL (Bandolier 46).
		Finasteride did its usual job of reducing symptom scores (an average fall of 3 points from a baseline of 15), prostate volume (by 18% on average over four years, compared with a 10% increase with placebo), and increasing urinary flow (by 2 mL/sec from a baseline of 11 mL/sec).
		Finasteride reduced the number of men with acute retention, either spontaneous or precipitated by previous surgery or urinary tract infection, with an NNT of 26.
	www.jr2.ox.ac.uk /bandolier/band50/b50-4.html (577 words)

	Hair Loss & Restoration: About Finasteride (Propecia)
		Finasteride is sometimes used alone or in combination with minoxidil (see About Minoxidil (Rogaine)) to complement hair transplantation.
		Men with extensive hair loss are unlikely to experience much regrowth with finasteride; these men are better candidates for hair transplantation or other surgical approach to hair restoration.
		Finasteride acts by inhibiting the action of 5-alpha-reductase and thus inhibiting the conversion of testosterone into DHT.
	www.ishrs.org /articles/about-propecia.htm (698 words)

	Buy Proscar - Order Proscar Finasteride Online
		Finasteride is used to treat benign prostatic hyperplasia (enlarged prostate).
		Finasteride is also used to reduce hair loss due to male pattern baldness.
		Finasteride is known to cause birth defects in a developing male baby.
	www.1000med.com /proscar.htm (437 words)

	Finasteride - Drugs & Vitamins - Drug Library - DrugDigest
		Finasteride can help to reduce symptoms caused by BPH such as a weak or interrupted urine flow; a feeling that the bladder is not completely empty; a need to pass urine more often, especially at night; an urgent feeling that you must pass urine right away; a delay or hesitation when you start to urinate.
		Finasteride is also used for the treatment of certain types of male hair loss.
		If a pregnant woman comes into contact with broken or crushed finasteride tablets she should check with her prescriber or health care professional.
	www.drugdigest.org /DD/DVH/Uses/0,3915,262\|Finasteride,00.html (673 words)

	Proscar Online, Description, Chemistry, Ingredients - Finasteride - RxList Monographs
		PROSCAR (finasteride), a synthetic 4-azasteroid compound, is a specific inhibitor of steroid Type II 5-reductase, an intracellular enzyme that converts the androgen testosterone into 5 -dihydrotestosterone (DHT).
		Finasteride is a white crystalline powder with a melting point near 250°C. It is freely soluble in chloroform and in lower alcohol solvents, but is practically insoluble in water.
		PROSCAR (finasteride) tablets for oral administration are film-coated tablets that contain 5 mg of finasteride and the following inactive ingredients: hydrous lactose, microcrystalline cellulose, pregelatinized starch, sodium starch glycolate, hydroxypropyl cellulose LF, hydroxypropylmethyl cellulose, titanium dioxide, magnesium stearate, talc, docusate sodium, FDandC Blue 2 aluminum lake and yellow iron oxide.
	www.rxlist.com /cgi/generic/finas.htm (148 words)

	Generic Propecia Finasteride from 64 cents a pill. The only Hair loss treatment pill.
		Rogaine or minoxidil is not thought to prevent the formation or concentration of DHT but concentrates on a nourishment effect of the hair follicle through its properties as a vasodialator.
		There is not sufficient clinical evidence to prove (or claim) that finasteride works to stop a receding hairline in front of the temples (recession at the temporal areas).
		If you have not seen acceptable results after 12 months of using finasteride either in terms of hair regrowth or in the prevention of further hair loss, then continued treatment is unlikely to be of any further benefit.
	www.propecia-generic.com (525 words)

	BPH, haematuria, and finasteride [May 2003; 111-3]
		The risk of recurrence of haematuria was reduced by 75% with finasteride (Table 2), and the number needed to treat (NNT) was 2 (1.6 to 2.7) to prevent recurrence.
		The risk of prostate surgery was reduced by 78% with finasteride (Table 2), and the number needed to treat (NNT) was 6 (3.7 to 17) to prevent surgery.
		Finasteride was given to 120 men, and 19 (16%) of those had recurrence of haematuria.
	www.jr2.ox.ac.uk /bandolier/band111/b111-3.html (956 words)

	hirsutism / hypertrichosis - finasteride for hirsutism
		Finasteride may be better known by the brand names Propecia or Proscar which are promoted for use in treating pattern baldness and benign prostate hyperplasia respectively.
		Finasteride is a type II 5alpha reductase inhibitor.
		When finasteride was tested on postmenopausal women with pattern baldness there was little or no response.
	www.keratin.com /ah/ah019.shtml (752 words)

	Buy Finasteride propecia : Generic propecia
		Finasteride propecia also is used by some balding men to stimulate hair growth.
		If hair growth is going to occur with the use of Finasteride propecia, it usually occurs after the Propecia Tablet has been used for about 3 months and lasts only as long as you continues to be use Propecia Tablet.
		Finasteride propecia blocks an enzyme called 5-alpha-reductase, which is necessary to change testosterone to another hormone that causes the prostate to grow.
	www.diet-online-pharmacy.com /finasteride_propecia.html (931 words)

	PROPECIA (FINASTERIDE) IN THE TREATMENT OF ALOPECIA ANDROGENETICA
		Finasteride, manufactured and marketed by Merck Pharmaceutical as Proscar, has been shown to be effective in the treatment of benign prostatic hyperplasia.
		The increased hair growth achieved with 1mg finasteride was evaluated by the patients as well as by clinical investigators and by review of patient photographs by a panel of dermatologists with expertise in hair loss.
		If you want to discontinue finasteride in favor of proven and safe topical medications or if you are not currently taking finasteride and wish to decrease the amount and/or activity of DHT in the scalp, use a topical medication such as azelaic acid, topical spironolactone or ketoconazole shampoo.
	www.minoxidil.com /Propecia.htm (2652 words)

	Product Review - Propecia (Finasteride)
		Finasteride was shown to inhibit the formation of DHT, one of the biggest culprits in the formation of Prostate Cancer, and conveniently enough, hair loss as well.
		Merck Pharmaceuticals sought to find the smallest effective quantity of finasteride and test its long term effects on 1,553 men between ages 18 and 41 with mild to moderate thinning of hair.
		Finasteride (Proscar) 5mg was split into fifths and bottled as a 1mg daily treatment for hair loss called Propecia.
	www.hairlosstalk.com /productreviews/men/propecia (1514 words)

	News - Finasteride Cuts Risk of Further Visible Hair Loss in Men: Presented at WCD
		The analysis included 713 patients who received finasteride 1 mg/day (645 patients) or placebo (68 patients) continuously from randomisation to study completion or discontinuation.
		Finasteride treatment led to a 93 percent reduction in the risk of developing further visible hair loss from baseline to end point, relative to placebo.
		Regardless of the subgroup examined, treatment with finasteride reduced the risk of further visible hair loss relative to placebo, confirming the key role of dihydrotestosterone produced by type II 5 alpha-reductase in mediating hair loss in men with androgenetic alopecia, he added.
	www.docguide.com /news/content.nsf/news/8525697700573E1885256BE90060F056 (404 words)

	Generic Proscar: Getting a better deal on Finasteride (Site not responding. Last check: 2007-10-29)
		If you went into a typical pharmacy and asked for finasteride, chances are the pharmacist would hand you a box of Merck product unless you specifically asked for a generic.
		Like most generics of 5mg finasteride Prosmin tablets are round and are easy to divide into smaller doses.
		Apeplus® 1mg finasteride, made in Chile by Labotatorios Recalcine in Santiago for Medidderm S.A. Argentine Propecia cones on blister packs with 30 tablets per box.
	www.rxtrust.com /generic_proscar.html (478 words)

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