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Loverine Taylor white anther: a petunia mutant that abolishes pollen flavonol accumulation, induces male sterility and is complemented by a chalcone synthase transgene. Flavanone 3-hydroxylase and flavonol accumulation are temporally coordinate in maize anthers. Chalcone synthase and flavonol accumulation in stigmas and anthers of Petunia hybrida. www.wsu.edu /~crb/3FacultyPages/Taylor.html   (560 words)

Positive Health Magazine   (Site not responding. Last check: 2007-10-23) The aim of the study was to investigate the association between flavonol and flavone intake and the risk of intermittent claudication, a condition often experiences by smokers, in smoking men. Dietary intake of flavonols and flavones was inversely associated with the risk of intermittent claudication when adjusted for cardiovascular risk factors (relative risk in the highest vs. lowest quintile of intake 0.86, p for trend 0.007). Flavonol and flavone intake was not independently associated with the risk of intermittent claudication. www.positivehealth.com /test/research.asp?i=3325   (257 words)

BBC News | HEALTH | GM tomato to fight disease Flavonols are powerful antioxidants, chemicals which fight disease by neutralising harmful oxygen molecules that circulate in the body, damaging tissues and accelerating the ageing process. Taste was not affected, and 65% of the flavonols were retained when the GM tomatoes were processed into paste. One type of flavonol, quercetin glycoside, was "significantly increased" in the peel of the modified tomatoes. news.bbc.co.uk /1/hi/health/1305121.stm   (437 words)

Grotewold Lab Projects   (Site not responding. Last check: 2007-10-23) Flavonols are one group of phytochemicals that have important bioactivities in plants, animals and microorganisms, which play central roles in plant biology. These tag-based flavonols should have biological activities and have the ability to form a photoaffinity-mediated covalent crosslink with both high- and low-affinity interaction proteins. Flavonol induced pollen germination or flavonol induced gravitropic response will be selected for functional analysis. www.biosci.ohio-state.edu /pcmb/osu_pcmb/people/Erich/metscreen.html   (464 words)

A new prenylated flavonol from the root of Petalostemon purpureus - Publication - RTI International   (Site not responding. Last check: 2007-10-23) A new prenylated flavonol from the root of Petalostemon purpureus - Publication - RTI International A new prenylated flavonol, petalopurpurenol (1), and a known dihydroflavonol, petalostemumol (2), have been isolated by DNA scission-guided fractionation of the organic portion of a 20% MeOH/CHCl3/H2O partition of a 50% MeOH/CHCl3 extract of the roots of Petalostemon purpureus. A new prenylated flavonol from the root of Petalostemon purpureus. www.rti.org /abstract.cfm?pubid=2168   (155 words)

BBC News | Health | Chemical key to health Flavonols are antioxidants which can protect against cancer, heart disease, degenerative illnesses and the effects of ageing. He added that the research showed that people could increase their flavonol levels and their health with a relatively simple change in diet. As well as flavonols, fruit and vegetables contain other antioxidants, including vitamins A, C and E. And tomatoes - particularly processed tomatoes - contain lycopene. news.bbc.co.uk /1/hi/health/272026.stm   (503 words)

ARS | Publication request: Structural Characterization and Improved Detection of Kale Flavonoids by Electrospray ... Flavonols are a subgroup of flavonoids that contain two compounds of interest, quercetin and kaempferol. This report will be especially useful to plant scientists studying flavonol production in plants, chemists measuring flavonols in plants or biological samples, and nutritionists and nutrition scientists considering the impact of blanching on flavonol content of vegetables. Recovery of flavonols from kale was ~60% based on spike and recovery trials with rutin, a glycoside of quercetin. www.ars.usda.gov /research/publications/publications.htm?SEQ_NO_115=151807&pf=1   (513 words)

Reach for the chocolate - it's healthy   (Site not responding. Last check: 2007-10-23) Researchers measured the level of flavonols in participants' blood, and found that the chocolate flavonols in the flavonol-rich chocolate were absorbed into the blood stream. Flavonols are a sub-class of flavonoids found naturally in a variety of plant-based foods, including certain cocoas, chocolates and red wine. While not all chocolate retains the naturally-occurring flavonols, which can be lost during processing of the cocoa, Mars claims to have developed proprietary methods of processing cocoa beans to retain many of the flavonols in their chocolate products. www.nutraingredients.com /news/printNewsBis.asp?id=36791   (515 words)

Chocolate May Help Smokers' Blood Vessels The benefit may stem from antioxidants called flavonols that are found in chocolate (and fruits and vegetables), write the researchers in the Journal of the American College of Cardiology. Besides chocolate, flavonols are "abundantly present in fruits and vegetables," write the researchers. Flavonols belong to a family of antioxidants called flavonoids. psychologytoday.webmd.com /content/article/112/110553?src=rss_psychtoday   (474 words)

Overexpression of petunia chalcone isomerase in tomato results in fruit containing increased levels of flavonols - ... Flavonols are very potent antioxidants, and an increasing body of epidemiological data suggests that high flavonoid intake is correlated with a decreased risk for cardiovascular disease. Whole-fruit flavonol levels in the best of these lines are similar to those found in onions, a crop with naturally high levels of flavonol compounds. Processing of high-flavonol tomatoes demonstrated that 65% of flavonols present in the fresh fruit were retained in the processed paste, supporting their potential as raw materials for tomato-based functional food products. www.nature.com /cgi-taf/DynaPage.taf?file=/nbt/journal/v19/n5/abs/nbt0501_470.html   (305 words)

IGZ EV Four flavonol glycosides were isolated from an extract of sea buckthorn pomace (Hippophaë rhamnoides) by Sephadex LH-20 gel chromatography and semipreparative HPLC. The characteristic MS-MS and MS3 fragmentation pattern of flavonol glcosides previously identified in sea buckthorn juice and of flavonol glycosides identified by NMR spectroscopy gave valuable indications for their identification. Finally, eight flavonol derivatives were identified that are acylated by hydroxybenzoic or hydoxycinnamic acids. www.igzev.de /pub-details.php?pubid=771   (215 words)

School of Molecular Biosciences - Faculty: Taylor We have synthesized highly active affinity-tagged flavonols to identify and isolate the proteins that interact with, and transduce the flavonol signal. We have identified several "flavonol-responsive" cDNA's that are transcriptionally activated in response to the flavonol signal. The use of a photoactivatible kaempferol analogue to probe the role of flavonol 3 O-galactosyltransferase in pollen germination, In: J. Manthey and B. Buslig, eds., Flavonoids in Cell Function, Advances in Experimental Medicine and Biology 505: 41-50. molecular.biosciences.wsu.edu /faculty/taylor.html   (452 words)

Effect of dietary advice to increase fruit and vegetable consumption on plasma flavonol concentrations: results from a ... Effect of dietary advice to increase fruit and vegetable consumption on plasma flavonol concentrations: results from a randomised controlled intervention trial -- Huxley et al. to be rich in flavonols, although tea would be a possible source. The relation between dietary flavonol intake and coronary heart disease mortality: a meta-analysis of prospective cohort studies. jech.bmjjournals.com /cgi/content/full/58/4/288   (1081 words)

High-performance liquid chromatographic determination of selected flavonols in Ginkgo biloba solid oral dosage forms. Recently, the flavonol glycosides have gained renewed interest and it has been suggested that absorption of flavonoids is not limited to the aglycone form (7,13). The limits of detection and quantitation were determined by means of serial dilution based on a signal to noise ratio of 3:1 for the limit of detection and 10:1 for the limit of quantitation. Although reference standards for all known flavonol glycosides are not available, relevant active markers amongst the flavonols could be chosen for analytical techniques to ensure comprehensive standardization. www.ualberta.ca /~csps/JPPS7(3)/I.Kanfer/ginkgo.htm   (3226 words)

Want a healthier skin? Drink hot cocoa : HindustanTimes.com   (Site not responding. Last check: 2007-10-23) Flavonols are a group of plant compounds found in tea, wine and a variety of fruits and vegetables, as well as cocoa beans. Flavonols are not drugs, Stahl pointed out, and any subjective effects on the skin would be expected to be small -- although they might accumulate over time, he noted. Although Stahl said he could not speculate on whether fruits and vegetables would have comparable skin effects, he noted that there are hints from other studies that such flavonol-containing foods also benefit the skin. hindustantimes.com /news/181_1712121,001100020006.htm   (405 words)

The Harvard Crimson :: News :: Cocoa Could Cut Blood Pressure Consuming flavonol, an antioxidant found naturally in cocoa, reduces blood pressure and improves circulation, according to a new study co-authored by Harvard Medical School (HMS) Professor of Radiology Norman K. Hollenberg. Flavonol stimulates the body’s production of nitric oxide, which relaxes blood vessels and leads to a reduction in blood pressure, according to the study released last month. HMS Assistant Professor of Medicine Naomi D. Fisher, who has published similar research on flavonol with Hollenberg in the past, said that while flavonol is good for the heart, it is not a preferable alternative to losing weight or quitting smoking. www.thecrimson.com /article.aspx?ref=511314   (382 words)

Plant Physiology The latter class includes flavonols, which are C15 aromatic molecules that are required for pollen germination and tube growth. My laboratory established the flavonol requirement for pollen germination by analyzing maize and petunia mutants that were unable to synthesize flavonols and were self-sterile due to a failure to produce a functional pollen tube. We have developed a scheme for the synthesis of highly active affinity-tagged flavonols to identify and isolate the proteins that interact with, and transduce the flavonol signal. plantphys.wsu.edu /research/taylor   (584 words)

[No title]   (Site not responding. Last check: 2007-10-23) A new flavonol, kaempferol rhamnosyl diglycoside, was isolated from leaf tissue of Amazonian field-grown coca Erythroxylum coca var. The structure of the flavonol has been determined as kaempferol 4'-O-(rhamnosyl)glucoside by spectral analyses. coca and the flavonol is useful as a chemotaxonomic marker for the taxon. www.elsevier.com /cdweb/journals/03051978/articles/31/1/S030519780200071.abstract.en   (72 words)

white anther: A Petunia Mutant That Abolishes Pollen Flavonol Accumulation, Induces Male Sterility, and Is Complemented ... kaempferol, a flavonol aglycone, to an in vitro suspension of Flavonol levels in the anthers of two of the complemented transgenotes (Chs8705.5 and Chs8705.6) were virtually the same as Deboo GB, Albertsen MC, Taylor LP (1995) Flavanone 3-hydroxylase and flavonol accumulation are temporally coordinate in maize anthers. www.plantphysiol.org /cgi/content/full/120/2/615   (4684 words)

Cancer Resources—Cancer News, Cancer Conferences, Cancer Causes, Cancer Prevention Experimental studies have linked dietary flavonols with a reduced risk of breast cancer, but data from epidemiologic studies are lacking. As mentioned, overall flavonol intake was not associated with breast cancer risk. Moreover, intake of individual flavonols, such as kaempferol or quercetin, was not protective either. www.oncolink.upenn.edu /resources/article.cfm?c=3&s=8&ss=23&Year=2005&Month=4&id=11743   (341 words)

ARS | Publication request: Flavonol Glycosides in the Seed Coat of Montcalm Dark Red Kidney Bean (Phaseolus Vulgaris, ...   (Site not responding. Last check: 2007-10-23) Technical Abstract: Three flavonol glycosides were isolated and identified from the commercial dark red kidney bean (Phaseolus vulgaris L.) cultivar, 'Montcalm'. Compound 1 is a flavonol glycoside that has not been reported before in P.vulgaris L. These three flavonol glycosides were yellow compounds that do not contribute to the garnet brown color of Montcalm seed coats. Previous work on the chemistry of the compounds produced from the multi-allelic seed coat gene series C-C**r-C**u indicated that neither anthocyanins nor flavonol glycosides were detected in the seed coat extracts in the presence of the c**u locus. www.ars.usda.gov /research/publications/publications.htm?SEQ_NO_115=103887&pf=1   (536 words)

Dietary flavonol quercetin induces chloride secretion in rat colon -- Cermak et al. 275 (5): 1166 -- AJP - ... The aim of this study was to investigate the possible effects of the flavonol quercetin, the most abundant dietary flavonoid, evoked by carbachol was diminished by the flavonol. Herrmann, K. Of the occurence of flavonol and flavone glycosides in vegetables. ajpgi.physiology.org /cgi/content/full/275/5/G1166   (3703 words)

Extra Rich Cocoa May Improve Heart Function in Smokers - CME Teaching Brief® - MedPage Today Circulating nitric oxide is thought to be a "storage pool" of this important molecule, which can compensate for local nitric oxide deficits and restore vascular function where needed. Previous research has suggested that the cardiovascular benefits of flavonols, which are also found in fruits and vegetables, are partly due to their ability to increase nitric oxide synthesis, the researchers noted. The flavonol-related improvement of endothelial function could be reversed by infusion of L-NG-monomethyl-arginine, an inhibitor of nitric acid synthase, consistent with the hypothesis that the mechanism of action of flavonol rich food involves an increase in nitric acid synthase activity. www.medpagetoday.com /PrimaryCare/Smoking/tb/1840   (593 words)

Flavonols may impact brain functioning Professor Ian MacDonald, professor of physiology at the University of Nottingham in the UK said yesterday that he had found cocoa flavonols could increase blood flow to key areas of the brain. “We found that high cocoa flavonol drink was associated with a higher blood flow response to selective areas of the brain,” he told NutraIngredients.com. He added that further research should look at whether the flavonols offered any benefit on occasions when people are tired or for people with mild cognitive difficulties. www.nutraingredients-usa.com /news/ng.asp?n=61525-flavonol-blood   (484 words)

References - flavonoid or flavonol - HORT640 - Metabolic Plant Physiology - Department of Horticulture and Landscape ... Deboo GB, Albertsen MC, Taylor LP 1995 Flavanone 3-hydroxylase transcripts and flavonol accumulation are temporally coordinate in maize anthers. Holton TA, Brugliera F, Tanaka Y 1993 Cloning and expression of flavonol synthase from Petunia hybrida. Pelletier MK, Murrell JR, Shirley BW 1997 Characterization of flavonol synthase and leucoanthocyanidin dioxygenase genes in Arabidopsis. www.hort.purdue.edu /rhodcv/hort640c/referen/flav.htm   (10383 words)

The multi-protein family of Arabidopsis sulphotransferases and their relatives in other plant species -- Klein and ... Marsolais F, Varin L. Identification of amino acid residues critical for catalysis and cosubstrate binding in the flavonol 3-sulphotransferase. Marsolais F, Varin L. Mutational analysis of domain II of flavonol 3-sulphotransferase. Marsolais F, Varin L. Recent developments in the study of the structure-function relationship of flavonol sulphotransferases. jxb.oxfordjournals.org /cgi/content/full/55/404/1809   (5161 words)

Therapeutic Aspects of Ginkgo biloba Extracts, Flavonoid and TerpenoidConstituents Ginkgo-flavonol glycosides are a mixture of biflavones and flavonol glycosides, while ginkgo terpenes are trilactones and a mixture of ginkgolides and bilobalide that constitutes about 0.1% in dry Ginkgo biloba leaves. Ginkgolides are further separated into several components A, B, C, J and M, respectively having differential levels of pharmacological activities. Flavonoids (ginkgo-flavonol glycosides, a mixture of biflavones and flavonol glycosides) ihumans.com /news_comments_archive/GinkgoCompoundActivity.html   (1525 words)

Some Chocolate a Treat for the Heart Davis, says it is a substance called flavonol that has heart researchers paying attention. Researchers think that flavonol works in two ways to protect the heart: First, it makes the blood less "sticky" and less likely to form clots; second, it relaxes the blood vessels so that they allow more blood flow. But flavonols have a slightly bitter taste, something that doesn't appeal to a sweet-tooth nation like America. www.webmd.com /content/article/53/61325.htm   (526 words)

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