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Functional Imaging of Mitochondria in Saponin-permeabilized Mice Muscle Fibers -- Kuznetsov et al. 140 (5): 1091 -- ... fluorescence and an increase in the flavoprotein fluorescence. flavoprotein fluorescence, and an increase of the NAD(P)H fluorescence Two-Photon Fluorescence Spectroscopy and Microscopy of NAD(P)H and Flavoprotein www.jcb.org /cgi/content/full/140/5/1091   (4385 words)

[No title]   (Site not responding. Last check: 2007-11-02) 101 : Q6L0C2 0.43 0.39 468 563 307 402 89 3 14 560 Q6L0C2 Succinate dehydrogenase flavoprotein subu 102 : Q7V8Z3 0.45 0.44 480 552 324 391 66 3 9 556 Q7V8Z3 L-aspartate oxidase (EC 1.4.3.16). 398 : Q67L22 0.36 0.44 483 563 335 409 74 2 8 573 Q67L22 Succinate dehydrogenase flavoprotein subu 399 : Q7P6K2 0.36 0.38 477 557 306 380 74 2 8 430 Q7P6K2 L-aspartate oxidase (EC 1.4.3.16). 603 : Q7VR93 0.32 0.33 468 563 313 434 96 3 26 602 Q7VR93 Succinate dehydrogenase flavoprotein subu 604 : Q62HM3 0.32 0.29 284 453 177 346 158 5 24 535 Q62HM3 L-aspartate oxidase (EC 1.4.3.16). www.infobiogen.fr /db/hssp/1d4e.hssp   (7913 words)

Significance of serum antibodies reactive with flavoprotein subunit of succinate dehydrogenase in thyroid associated ... Significance of serum antibodies reactive with flavoprotein subunit of succinate dehydrogenase in thyroid associated orbitopathy In conclusion, serum antibodies reactive with the flavoprotein subunit of succinate dehydrogenase are associated with extraocular The 64-kilodalton eye muscle protein is the flavoprotein subunit of mitochondrial succinate dehydrogenase: the corresponding serum antibodies are good markers of an immune-mediated damage to the eye muscle in patients with Graves' hyperthyroidism. bjo.bmjjournals.com /cgi/content/full/83/5/605   (2220 words)

Flavoprotein Autofluorescence Imaging of Neuronal Activation in the Cerebellar Cortex In Vivo -- Reinert et al. 92 (1): ... Flavoprotein Autofluorescence Imaging of Neuronal Activation in the Cerebellar Cortex In Vivo -- Reinert et al. metabolism, and are caused by the oxidation/reduction of flavoproteins It is the oxidation and reduction of flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN), the flavin moieties in respiratory complexes I and II, that generates the autofluorescence signal. jn.physiology.org /cgi/content/full/92/1/199   (7003 words)

Serum Antibodies against the Flavoprotein Subunit of Succinate Dehydrogenase Are Sensitive Markers of Eye Muscle ... Serum Antibodies against the Flavoprotein Subunit of Succinate Dehydrogenase Are Sensitive Markers of Eye Muscle Autoimmunity in Patients with Graves' Hyperthyroidism -- Gunji et al. Serum Antibodies against the Flavoprotein Subunit of Succinate Dehydrogenase Are Sensitive Markers of Eye Muscle Autoimmunity in Patients with Graves’ Hyperthyroidism to be the flavoprotein (Fp) subunit of mitochondrial succinate jcem.endojournals.org /cgi/content/full/84/4/1255   (4232 words)

The Flavoprotein MrsD Catalyzes the Oxidative Decarboxylation Reaction Involved in Formation of the Peptidoglycan ... The Flavoprotein MrsD Catalyzes the Oxidative Decarboxylation Reaction Involved in Formation of the Peptidoglycan Biosynthesis Inhibitor Mersacidin -- Majer et al. Mass spectroscopic analysis of a novel enzymatic reaction: oxidative decarboxylation of the lantibiotic precursor peptide EpiA catalyzed by the flavoprotein EpiD. Purification and characterization of EpiD, a flavoprotein involved in the biosynthesis of the lantibiotic epidermin. jb.asm.org /cgi/content/full/184/5/1234   (4936 words)

Sulfide Dehydrogenase Activity of the Monomeric Flavoprotein SoxF of Paracoccus pantotrophus, Flavocytochrome c-sulfide dehydrogenases (FCSDs) are complexes of a flavoprotein with a c-type cytochrome performing hydrogen sulfide-dependent cytochrome c reduction in vitro. The flavoprotein SoxF of Paracoccus pantotrophus is 29-67% identical to the flavoprotein subunit of FCSD of phototrophic sulfur-oxidizing bacteria. This is the first report of a monomeric flavoprotein with sulfide dehydrogenase activity. pubs.acs.org /cgi-bin/abstract.cgi/bichaw/2004/43/i46/abs/bi048568y.html   (338 words)

Activation of Mitochondrial ATP-Dependent Potassium Channels by Nitric Oxide -- Sasaki et al. 101 (4): 439 -- ...   (Site not responding. Last check: 2007-11-02) Changes in flavoprotein oxidation induced by coapplication of carboxy-PTIO (100 µmol/L) with SNAP (100 µmol/L) (A) and 1 mmol/L 8Br-cGMP (B) in a cell twice exposed to diazoxide. A pseudocolor palette was applied to visualize relative increase in mitochondrial flavoprotein, to yield images of cells at baseline (Control, A), after 7 minutes’ exposure to diazoxide (100 µmol/L, B), washing out diazoxide (Wash, C), after 12 minutes’ exposure to SNAP (200 µmol/L, D), and additional application of 1 mmol/L 5HD (SNAP+5HD, E). Dynamic range of flavoprotein fluorescence is indicated by exposures to cyanide (4 mmol/L, F) and DNP (100 µmol/L, G) as minimum and maximum, respectively. circ.ahajournals.org /cgi/content/full/101/4/439   (3957 words)

Crystallization and preliminary X-ray analysis of electron transfer flavoproteins from human and Paracoccus ... Crystallization and preliminary X-ray analysis of electron transfer flavoproteins from human and Paracoccus denitrificans -- ROBERTS et al. Crystallization and preliminary X-ray analysis of electron transfer flavoproteins from human and Paracoccus denitrificans flavoprotein responsible for the oxidation of at least nine primary matrix www.proteinscience.org /cgi/content/abstract/4/8/1654   (316 words)

Iron-Sulfur Flavoprotein (Isf) from Methanosarcina thermophila Is the Prototype of a Widely Distributed Family -- Zhao ... Iron-Sulfur Flavoprotein (Isf) from Methanosarcina thermophila Is the Prototype of a Widely Distributed Family -- Zhao et al. Fermentation of glucose, fructose, and xylose by Clostridium thermoaceticum: effect of metals on growth yield, enzyme, and the synthesis of acetate from CO Bacteriol. Site-specific mutational analysis of a novel cysteine motif proposed to ligate the 4Fe-4S cluster in the iron-sulfur flavoprotein of the thermophilic methanoarchaeon Methanosarcina thermophila. jb.asm.org /cgi/content/full/183/21/6225   (4725 words)

Amiodarone Inhibits Sarcolemmal but Not Mitochondrial KATP Channels in Guinea Pig Ventricular Cells -- Sato et al. 307 ... The flavoprotein fluorescence was calibrated by exposing the cells to DNP (100 µM) at the end of experiments. oxidized flavoprotein in guinea pig ventricular myocytes (Fig. Chance B, Salkovitz IA, and Kovach AG (1972) Kinetics of mitochondrial flavoprotein and pyridine nucleotide in perfused heart. jpet.aspetjournals.org /cgi/content/full/307/3/955   (3538 words)

E0215: Crystallographic Study of Electron Transfer Flavoprotein Ubiquinone Oxidoreductase   (Site not responding. Last check: 2007-11-02) Crystalllographic Study of Electron Transfer Flavoprotein Ubiquinone Oxidoreductase Jian Zhang, David L. Roberts, Frank E. Frerman* and Jung-Ja P. Kim; Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI 53226. Electron transfer flavoprotein ubiquinone oxidoreductase (ETF-QO) is a 69kDa membrane-associated protein containing an FAD and an iron-sulfur cluster[1]. ETF-QO and electron transfer flavoprotein (ETF) function as the primary links between acyl-CoA dehydrogenases, which are involved in the (-oxidation of fatty acids as well as degradation of certain amino acids, and the main mitochondrial respiratory chain. www.hwi.buffalo.edu /ACA/ACA98/abstracts/text/E0215.html   (315 words)

HMGP - Frank Frerman, Ph.D. We are investigating the catalytic mechanism of glutary-CoA dehydrogenase (GCD), a tetrameric flavoprotein dehydrogenase that catalyzes the oxidation of glutaryl-CoA, an intermediate in the oxidation of lysine. The electron acceptor for all nine dehydrogenases is electron transfer flavoprotein (ETF) which transfers electrons to a membrane-bound iron-sulfur flavoprotein, ETF-ubiquinone oxidoreductase (ETF-QO). The investigations are driven by the fact that inherited defects in these proteins cause metabolic diseases that are often fatal. www.uchsc.edu /genetics/bio/frerman.htm   (626 words)

Effects of the Flavoprotein Inhibitor, Diphenyleneiodonium Sulfate, on Ex Vivo Organic Nitrate Tolerance in the Rat -- ... Although all the possible flavoprotein targets of DPI in blood vessels have not been determined, several vascular and nonvascular McDonald BJ and Bennett BM (1993) Biotransformation of glyceryl trinitrate by rat aortic cytochrome P450. McGuire JJ, Anderson DJ and Bennett BM (1994) Inhibition of the biotransformation and pharmacological actions of glyceryl trinitrate by the flavoprotein inhibitor, diphenyleneiodonium sulfate. jpet.aspetjournals.org /cgi/content/full/293/2/569   (6226 words)

Azorhizobium caulinodans electron-transferring flavoprotein N electrochemically couples pyruvate dehydrogenase complex ... Azorhizobium caulinodans electron-transferring flavoprotein N electrochemically couples pyruvate dehydrogenase complex activity to N2 fixation -- Scott and Ludwig 150 (1): 117 -- Microbiology Abbreviations: ETF, electron-transferring flavoprotein; LpDH, dihydrolipoamide dehydrogenase; PDH, pyruvate dehydrogenase; Nif O'Neill, H., Mayhew, S. and Butler, G. Cloning and analysis of the genes for a novel electron-transferring flavoprotein from Megasphaera elsdenii. mic.sgmjournals.org /cgi/content/full/150/1/117   (4092 words)

LPDA - Flavoprotein Reductase Characterization of a new member of the flavoprotein disulfide reductase family of enzymes from Mycobacterium tuberculosis. The lpdA (Rv3303c) gene from Mycobacterium tuberculosis encoding a new member of the flavoprotein disulfide reductases was expressed in Escherichia coli, and the recombinant LpdA protein was purified to homogeneity. LpdA is a homotetramer and co-purifies with one molecule of tightly but noncovalently bound FAD and NADP+ per monomer. www.bioc.aecom.yu.edu /labs/blanlab/VETTING/LPDA.html   (211 words)

Frank Frerman, Ph.D., The Program in Biomolecular Structure, University of Colorado Health Sciences Center, Denver Four of these dehydrogenases are the chain length specific acyl-CoA dehydrogenases that catalyze the oxidation of acyl-CoA in the first reaction of each cycle of mitochondrial fatty acid b-oxidation. The intraflavin hydrogen bond in human electron transfer flavoprotein modulates redox potentials and may participate in electron transfer. Crystal structure of Paracoccus denitrificans electron transfer flavoprotein: structural and electrostatic analysis of a conserved flavin binding domain. biomol.uchsc.edu /faculty/ResearchPages/frermanResearch.html   (698 words)

Poor Recovery of Mitochondrial Redox State in CA1 After Transient Forebrain Ischemia in Gerbils • Editorial Comment -- ... The images are displayed in 16-grade gray scales; in each image fl represents the lowest fluorescence signal on flavoprotein and NADH images and lowest value (reduced state) on MRR images, and white represents the highest signal or value (oxidized state). Kunz WS, Kunz W. Contribution of different enzymes to flavoprotein fluorescence of isolated rat liver mitochondria. increases in NADH fluorescence and decreases in flavoprotein stroke.ahajournals.org /cgi/content/full/29/11/2421   (3134 words)

Chapter 3. Thiamin, riboflavin, niacin, vitamin B6, pantothenic acid and biotin Absorption of riboflavin is also affected in some other conditions, for example, tropical sprue, celiac disease, malignancy and resection of the small bowel, and decreased gastrointestinal passage time. In relatively rare cases the causes of deficiency are inborn errors in which the genetic defect is in the formation of a flavoprotein (e.g., acyl-co-enzyme A [co-A] dehydrogenases). Although some portions of the 8a-(amino acid)-riboflavins are released by proteolysis of these flavoproteins, they do not have vitamin activity (47). www.fao.org /DOCREP/004/Y2809E/y2809e09.htm   (8747 words)

GeneCard for ETFB Mutations and polymorphisms of the gene encoding the beta-subunit of the electron transfer flavoprotein in three patients with glutaric acidemia type II. Colombo I. Didonato S. cDNA cloning and mitochondrial import of the beta-subunit of the human electron-transfer flavoprotein. Stabilization of non-productive conformations underpins rapid electron transferto electron-transferring flavoprotein. www.genecards.org /cgi-bin/carddisp.pl?gene=ETFB   (804 words)

The Antituberculosis Drug Ethionamide Is Activated by a Flavoprotein Monooxygenase -- Vannelli et al. 277 (15): 12824 ... Rv3854c is more consistent with a flavoprotein (14, 15). The structures of analogues of ethionamide that are oxidized by the purified flavoprotein: thiobenzamide (7) with its observed metabolite thiobenzamide S-oxide (8), isothionicotinamide (9), and thiacetazone (10). compounds that are known to be substrates for the mammalian flavoprotein www.jbc.org /cgi/content/full/277/15/12824   (4546 words)

Three-dimensional structure of human electron transfer flavoprotein to 2.1-A resolution -- Roberts et al. 93 (25): ... Three-dimensional structure of human electron transfer flavoprotein to 2.1-A resolution -- Roberts et al. The structure of ETF provides a model for this unique family of flavoproteins. Cloning and Analysis of the Genes for a Novel Electron-transferring Flavoprotein from Megasphaera elsdenii. www.pnas.org /cgi/content/full/93/25/14355   (4038 words)

Human protein: Q53XN3 - Electron-transfer-flavoprotein, alpha polypeptide (Glutaric aciduria II) (Electron transfer ... It shuttles electrons between primary flavoprotein dehydrogenases and the membrane-bound electron transfer flavoprotein ubiquinone oxidoreductase. Defects in electron-transfer-flavoprotein have been implicated in type II glutaricaciduria in which multiple acyl-CoA dehydrogenase deficiencies result in large excretion of glutaric, lactic, ethylmalonic, butyric, isobutyric, 2-methyl-butyric, and isovaleric acids. the electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl- coa dehydrogenases, glutaryl-coa and sarcosine dehydrogenase. harvester.embl.de /harvester/Q53X/Q53XN3.htm   (736 words)

Properties of p-Cresol Methylhydroxylase Flavoprotein Overproduced by Escherichia coli Properties of p-Cresol Methylhydroxylase Flavoprotein Overproduced by Escherichia coli Molecular Biology Division, Department of Veterans Affairs Medical Center, San Francisco, California 94121, and Department of Biochemistry and Biophysics, University of California, San Francisco, California 94143 This is the first example of a "wild-type" flavoprotein, which normally has covalently bound flavin, to bind flavin noncovalently in a stable, redox-active manner. pubs.acs.org /cgi-bin/abstract.cgi/bichaw/1999/38/i50/abs/bi991273d.html   (319 words)

ETFA - Genetics Home Reference The ETFA gene provides instructions for making one part (the alpha subunit) of an enzyme called electron transfer flavoprotein. Electron transfer flavoprotein is involved in the process by which fats and proteins are broken down to produce energy. Other mutations result in the production of a defective enzyme that cannot fulfill its role in the series of reactions (metabolic pathways) that break down fats and proteins. ghr.nlm.nih.gov /gene=etfa   (470 words)

Formation of W3A1 Electron-transferring Flavoprotein (ETF) Hydroquinone in the Trimethylamine Dehydrogenase{middle ... Formation of W3A1 Electron-transferring Flavoprotein (ETF) Hydroquinone in the Trimethylamine Dehydrogenase{middle dot}ETF Protein Complex -- Jang et al. Electron-transferring Flavoprotein (ETF) Hydroquinone in the Trimethylamine Dehydrogenase·ETF Protein Complex The electron-transferring flavoprotein (ETF) from Methylophilus methylotrophus (sp. www.jbc.org /cgi/content/abstract/275/17/12546   (488 words)

Pfam 20.0 : Flavoprotein   (Site not responding. Last check: 2007-11-02) This family includes epidermin biosynthesis protein, EpiD P30197, which has been shown to be a flavoprotein that binds FMN [1]. This enzyme catalyses the removal of two reducing equivalents from the cysteine residue of the C-terminal meso-lanthionine of epidermin to form a --C==C-- double bond. This domain is found in diverse flavoprotein enzymes, including epidermin biosynthesis protein, EpiD, which has been shown to be a flavoprotein that binds FMN PUBMED:1644762. pfam.wustl.edu /cgi-bin/getdesc?name=Flavoprotein   (294 words)

The paper The NADPH and ATP formed by the light reactions provide the energy for the dark reactions of photosynthesis, known as the Calvin cycle or the photosynthetic carbon reduction cycle. Electron transfer from photosystem I to NADP+ requires ferredoxin, a small FeS protein, and ferredoxin-NADP oxidoreductase, a peripheral flavoprotein that operates on the outer surface of the photosynthetic membrane. Ferredoxin and NADP+ are water soluble and are found in the outer aqueous phase. www.life.uiuc.edu /govindjee/paper/gov.html   (12489 words)

Protein Kinase C Inhibitors Produce Mitochondrial Flavoprotein Oxidation in Cardiac Myocytes -- Kohro et al. 99 (5): ... Protein Kinase C Inhibitors Produce Mitochondrial Flavoprotein Oxidation in Cardiac Myocytes -- Kohro et al. Protein Kinase C Inhibitors Produce Mitochondrial Flavoprotein Oxidation in Cardiac Myocytes Copyright © 2004 by the International Anesthesia Research Society. www.anesthesia-analgesia.org /cgi/content/abstract/99/5/1316   (228 words)

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