
	Where results make sense

Topic: Fludarabine

In the News (Sat 22 Nov 08)

Lee Scott

Annika Sorenstam

Norm Coleman

Benji Madden

Freddie Mac

Puerto Rico

Vladimir Putin

Treasury Department

Mitt Romney

Giovanni Trapattoni

	Fludarabine (Systemic) - MayoClinic.com (Site not responding. Last check: 2007-11-03)
		Fludarabine interferes with the growth of cancer cells, which are eventually destroyed.
		Fludarabine is to be administered only by or under the immediate supervision of your doctor.
		Fludarabine may lower your body's resistance and there is a chance you might get the infection the immunization is meant to prevent.
	www.mayoclinic.com /health/drug-information/DR202630 (1499 words)

	Fludarabine - Wikipedia, the free encyclopedia
		Fludarabine inhibits DNA synthesis by interfering with ribonucleotide reductase and DNA polymerase.
		Fludarabine is associated with profound lymphopenia, and as a consequence, increases the risk of opportunistic infections significantly.
		Fludarabine is associated with the development of severe autoimmune hemolytic anemia in a proportion of patients.
	en.wikipedia.org /wiki/Fludarabine (371 words)

	Cancerquest: Fludarabine (Site not responding. Last check: 2007-11-03)
		Fludarabine (Fludara) is an antimetabolite that exerts its effects on cancer cells by preventing normal DNA replication.
		Fludarabine is used to treat chronic B-cell lymphocytic leukemia and is administered as an injection.
		Fludarabine should not be taken by women who are pregnant and patients should not become pregnant while using this drug, as it may have harmful affects on the developing fetus.
	www.cancerquest.org /printfriendly.cfm?printpage=1188 (102 words)

	Fludarabine Compared With Chlorambucil As Primary Therapy For Chronic Lymphocytic Leukemia (Site not responding. Last check: 2007-11-03)
		Fludarabine patients numbered 179, 193 were assigned to the chlorambucil group, and 137 patients received the combined fludarabine plus chlorambucil therapy.
		Fludarabine was also superior in high-risk and intermediate risk patients, although, the researchers caution, they cannot conclude that it is preferable to start fludarabine therapy in patients with intermediate-risk CLL.
		Fludarabine is superior in that it provides a complete response rate -- a surrogate measure of disease-free survival -- that is five times greater than with chlorambucil.
	www.pslgroup.com /dg/1F5436.htm (1533 words)

	Fludarabine
		Fludarabine is used in combination with other medications to treat chronic lymphocytic leukemia (CLL) and non-Hodgkin's lymphoma (NHL).
		Fludarabine is an effective treatment for chronic lymphocytic leukemia (CLL) that has not responded to other types of chemotherapy, such as chlorambucil or cyclophosphamide.
		Fludarabine should be administered only under the supervision of a medical oncologist or hematologist.
	www.webmd.com /cancer/Fludarabine (418 words)

	Long-term follow-up of a randomized trial of fludarabine-mitoxantrone, compared with cyclophosphamide, doxorubicin, ...
		Fludarabine is a purine analog, and mitoxantrone an anthracenedione,
		Fludarabine, mitoxantrone and dexamethasone in the treatment of indolent B- and T-cell lymphoid malignancies in Chinese patients.
		Fludarabine, mitoxantrone and dexamethasone as front-line therapy in elderly patients affected by newly-diagnosed, low-grade non-Hodgkin's lymphomas with unfavorable prognostic factors: results of a phase II study.
	annonc.oxfordjournals.org /cgi/content/full/16/3/466 (3341 words)

	Fludarabine Prolongs Leukemia Remission - National Cancer Institute
		Fludarabine used as the initial treatment for chronic lymphocytic leukemia (CLL) produces more and longer remissions than chlorambucil, according to the findings of a multicenter clinical trial for patients with high- and intermediate-risk CLL.
		Earlier trials have shown that fludarabine could be effective as second-line therapy, producing responses in patients who had not responded to chlorambucil.
		The median length of remission was 25 months for fludarabine and 14 months for chlorambucil, while the time before the disease progressed was 20 months for fludarabine and 14 months for chlorambucil.
	www.cancer.gov /clinicaltrials/results/fludarabine-prolongs-remission1200 (406 words)

	NGC - NGC Summary
		Fludarabine has been compared with the combination of cyclophosphamide, vincristine, and prednisone in a randomized trial reported in preliminary abstract form involving 309 previously untreated patients with diffuse small lymphocytic and follicular small cleaved or mixed cell lymphoma.
		Fludarabine has been compared with the combination of cyclophosphamide, vincristine, and prednisone in a randomized trial reported in preliminary abstract form involving 91 patients with low grade lymphoma who had previously received one to four treatment regimens.
		Fludarabine has been compared with the combination of cyclophosphamide, doxorubicin, and prednisone in a randomized trial reported in preliminary abstract form involving 92 patients with Waldenstrom's Macroglobulinemia who were either refractory to or relapsed from initial alkylator–based therapy.
	www.guideline.gov /summary/summary.aspx?ss=15&doc_id=4982&nbr=3528 (3597 words)

	Fludarabine – Fludara - Chemotherapy Drugs - Chemo
		The amount of fludarabine that you will receive depends on many factors, including your height and weight, your general health or other health problems, and the type of cancer or condition being treated.
		The side effects of fludarabine and their severity depend on how much of the drug is given.
		It is changed by the body so that it can pass into the cells then it is changed within the cell to its active form where it can interfere with the cancer cell's process of duplicating itself, and induces apoptosis (cell suicide).
	www.chemocare.com /bio/fludarabine.asp (1657 words)

	Fludarabine Results Positive in Treating Chronic Lymphocytic Leukemia (Site not responding. Last check: 2007-11-03)
		The overall response rate for complete and partial responses with fludarabine was 70% as compared to 43% with chlorambucil.
		Fludarabine patients had a median response duration of 33 months as compared to 17 months for those taking chlorambucil.
		Fludara(R) (fludarabine phosphate) was developed by Berlex in cooperation with the U.S. National Cancer Institute.
	www.pslgroup.com /dg/eefa.htm (711 words)

	Fludarabine Prolongs Leukemia Remission - National Cancer Institute
		Fludarabine used as the initial treatment for chronic lymphocytic leukemia (CLL) produces more and longer remissions than chlorambucil, according to the findings of a multicenter clinical trial for patients with high- and intermediate-risk CLL.
		Earlier trials have shown that fludarabine could be effective as second-line therapy, producing responses in patients who had not responded to chlorambucil.
		The median length of remission was 25 months for fludarabine and 14 months for chlorambucil, while the time before the disease progressed was 20 months for fludarabine and 14 months for chlorambucil.
	nci.nih.gov /clinicaltrials/results/fludarabine-prolongs-remission1200 (406 words)

	Addition of Cyclophosphamide to Fludarabine Improves Progression-Free Survival in Younger Patients with CLL
		Fludarabine and cyclophosphamide are commonly used agents in the treatment of CLL; either can be used alone as a single agent.
		Researchers from Germany recently conducted a clinical trial comparing the combination of fludarabine plus cyclophosphamide to fludarabine alone as initial treatment in patients with CLL who were under the age of 66 years.
		Fludarabine plus cyclophosphamide versus fludarabine alone in first-line therapy of younger patients with chronic lymphocytic leukemia.
	patient.cancerconsultants.com /news.aspx?id=36116 (620 words)

	ACS :: Cancer Drug Guide: fludarabine phosphate
		Fludarabine phosphate belongs to the general group of chemotherapy drugs known as antimetabolites.
		Fludarabine phosphate prevents cells from making DNA and RNA by interfering with the synthesis of nucleic acids, thus stopping the growth of cancer cells.
		Fludarabine phosphate is usually given as an injection in a vein over 30 minutes once a day for 5 days.
	www.cancer.org /docroot/CDG/content/CDG_fludarabine_phosphate.asp (636 words)

	Fludarabine : BC Cancer Agency
		Fludarabine phosphate is a synthetic fluorinated analog of the purine nucleoside antiviral agent vidarabine (ara-A).
		Fludarabine phosphate is a water-soluble prodrug that is rapidly dephosphorylated to 2-fluoro-vidarabine (2F-ara-A).
		Use fludarabine with caution in patients with severe impairment of bone marrow function, immunodeficiency, or a history of opportunistic infections.
	www.bccancer.bc.ca /HPI/DrugDatabase/DrugIndexPro/Fludarabine.htm (1907 words)

	Fludarabine (Fludara®) : Cancerbackup
		Fludarabine (pronounced flu-dar-a-been) is a chemotherapy drug that is given as a treatment for some types of cancer.
		It is most commonly used to treat a type of leukaemia known as chronic lymphocytic leukaemia.
		Fludarabine is a clear fluid after being dissolved from powder.
	www.cancerbackup.org.uk /Treatments/Chemotherapy/Individualdrugs/Fludarabine (1250 words)

	Fludarabine (Fludara®) : Cancerbackup (Site not responding. Last check: 2007-11-03)
		Fludarabine (pronounced flu-dar-a-been) is a chemotherapy drug that is given as a treatment for some types of cancer.
		It is most commonly used to treat a type of leukaemia known as chronic lymphocytic leukaemia.
		Fludarabine is a clear fluid after being dissolved from powder.
	www.cancerbacup.org.uk /info/fludarabine.htm (1227 words)

	NGC - NGC Summary
		A randomized trial comparing fludarabine, and the combination of fludarabine plus chlorambucil, with chlorambucil alone in patients with previously untreated intermediate- or high-risk chronic lymphocytic leukemia, was previously reported in abstract form and has now been updated in a full report.
		Fludarabine is associated with significant myelosuppression and immunosuppression, and an increased risk of opportunistic infection.
		A randomized trial comparing fludarabine, and the combination of fludarabine plus chlorambucil, with chlorambucil alone in patients with previously untreated intermediate- or high-risk chronic lymphocytic leukemia found that the risk of infection, particularly with herpes viruses, is greater in patients receiving fludarabine.
	www.guideline.gov /summary/summary.aspx?ss=15&doc_id=3283&nbr=2509 (3084 words)

	Reversible Neurologic Toxicity in Patients Treated with Standard-Dose Fludarabine Phosphate for Mycosis Fungoides and ...
		Fludarabine phosphate (NSC 312878) infusions for the treatment of acute leukemia: phase I and neuropathological study.
		Warrell RP Jr, Berman E. Phase I and II study of fludarabine phosphate in leukemia: therapeutic efficacy with delayed central nervous toxicity.
		Fludarabine: a new agent with marked cytoreductive activity in untreated chronic lymphocytic leukemia.
	www.annals.org /cgi/content/full/118/2/114 (1003 words)

	Fludarabine: Initial Treatment for Chronic Lymphocytic Leukemia?
		Fludarabine is a relatively new drug with proven efficacy in patients with CLL who have failed to respond to chlorambucil.
		The combination of fludarabine and chlorambucil caused toxic side effects in a large percentage of patients so this approach was discontinued before the end of the study.
		Side effects caused by fludarabine such as severe infections and low blood cell counts were much more prevalent in patients receiving fludarabine compared with chlorambucil.
	patient.cancerconsultants.com /leukemia_cancer_news.aspx?id=17909 (650 words)

	Leukemia Insights Newsletter-M.D. Anderson Cancer Center (Site not responding. Last check: 2007-11-03)
		Our studies demonstrated that fludarabine as a single agent was able to obtain a complete response rate of 65% and a partial response rate of 15% in previously untreated patients with CLL and in patients with Rai stage III and IV disease (54% and 19%).
		In our recent study with fludarabine and cyclophosphamide, all patients with relapsing disease who have not received fludarabine previously have responded to the combination of fludarabine and cyclophosphamide.
		This activity is based on fludarabine inhibiting DNA repair which is a mechanism of resistance to alkylating agents.
	www3.mdanderson.org /leukemia/insight/letter14.html (5032 words)

	Fludarabine
		Fludarabine is one of the newer chemotherapy drugs which has been around and in use for a few years.
		Fludarabine is a white powder and when prepared for use, it becomes a clear and colorless liquid and is given by intravenous route only.
		Fludarabine is normally given daily for 3-5 days and repeated every 4 weeks.
	www.tirgan.com /fludara.htm (147 words)

	Salvage Therapy for CLL and the Role of Stem Cell Transplantation -- Gribben 2005 (1): 292 -- Hematology
		Results of fludarabine and prednisone therapy in 264 patients with chronic lymphocytic leukemia with multivariate analysis-derived prognostic model for response to treatment.
		Fludarabine, cyclophosphamide and mitoxantrone in the treatment of resistant or relapsed chronic lymphocytic leukaemia.
		Chemoimmunotherapy with fludarabine, cyclophosphamide, and rituximab for relapsed and refractory chronic lymphocytic leukemia.
	www.asheducationbook.org /cgi/content/full/2005/1/292 (3578 words)

	MedlinePlus Drug Information: Fludarabine Phosphate
		Fludarabine can cause a decrease in the number of blood cells in your bone marrow.
		Fludarabine is in a class of drugs known as purine analogs; it slows or stops the growth of cancer cells in your body.
		you should know that fludarabine may interfere with the normal menstrual cycle (period) in women and may stop sperm production in men.
	www.nlm.nih.gov /medlineplus/druginfo/medmaster/a692003.html (495 words)

	NGC - NGC Summary
		Fludarabine in intermediate- and high-risk chronic lymphocytic leukemia.
		Autoimmune hemolytic anemia may be exacerbated or precipitated by fludarabine and is, therefore, considered by the manufacturer to be a contraindication to the use of this drug.
		The seventh full publication describes a randomized phase II trial comparing high-dose chlorambucil with fludarabine in previously untreated patients and the eighth publication is a trial of oral fludarabine.
	www.guideline.gov /summary/summary.aspx?doc_id=3283&mode=menu&ss=15 (1199 words)

	In Vitro Evaluation of Fludarabine in Combination With Cyclophosphamide and/or Mitoxantrone in B-Cell Chronic ... (Site not responding. Last check: 2007-11-03)
		in vitro, increased the cytotoxicity of fludarabine in all of
		Cell viability was determined by the MTT assay as described in Materials and Methods and is expressed as the percentage with respect to control cells at the beginning of the culture.
		The mechanism of the synergism between fludarabine and mafosfamide in B-CLL cells is not known.
	www.bloodjournal.org /cgi/content/full/94/8/2836 (5308 words)

	Leukaemia (lymphocytic) - fludarabine
		NICE has recommended that people with B-cell chronic lymphocytic leukaemia (CLL) who have had to stop their first chemotherapy treatment (for example, because it was causing side effects or their disease had progressed), may be treated with fludarabine tablets.
		Fludarabine may be introduced at the stage where people with CLL might have previously been offered one of the following combination treatments:
		People with CLL should only be given fludarabine by a drip when their condition is such that they are unable to take the tablets.
	www.nice.org.uk /cat.asp?c=22177 (190 words)

	Fludarabine-Related Pulmonary Toxicity* : A Distinct Clinical Entity in Chronic Lymphoproliferative Syndromes -- Helman ...
		We hypothesized that pulmonary toxicity from fludarabine is
		Byrd, JC, Hargis, JB, Kester, KE, et al Opportunistic pulmonary infections with fludarabine in previously treated patients with low-grade lymphoid malignancies: a role for Pneumocystis carinii pneumonia prophylaxis.
		Grever, MR Fludarabine monophosphate in chronic lymphocytic leukemia [letter].
	www.chestjournal.org /cgi/content/full/122/3/785 (2832 words)

	Lymphocyte depletion with fludarabine in patients with psoriatic arthritis: clinical and immunological effects -- ...
		Lymphocyte depletion with fludarabine in patients with psoriatic arthritis: clinical and immunological effects -- Takada et al.
		Lymphocyte depletion with fludarabine in patients with psoriatic arthritis: clinical and immunological effects
		efficacy of fludarabine in PsA and analyse its immunomodulatory
	ard.bmjjournals.com /cgi/content/full/62/11/1112 (1711 words)

	Fludarabine and Transformation? (Site not responding. Last check: 2007-11-03)
		And in the process he provided a broader perspective on the question of fludarabine and how it may or may not increase the risk of transformation.
		This includes a 938 patient, prospective randomized study that was comparing fludarabine, CAP, and CHOP in previously untreated stage B and C CLL patients.
		This study is cited as having looked at the transformation issue and did not find a relationship between fludarabine and transformation.
	www.lymphomation.org /fludarabine-transf.htm (558 words)

	Fludarabine Drug Information
		Pregnancy-There is a chance that this medicine may cause birth defects if either the male or female is taking it at the time of conception or if it is taken during pregnancy.
		Children-There is no specific information comparing use of fludarabine in children with use in other age groups.
		Kidney disease-Effects of fludarabine may be increased because of slower removal from the body
	www.drugs.com /cons/Fludarabine.html (1739 words)

Try your search on: Qwika (all wikis)