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Romazicon (Flumazenil) drug warnings and precautions - prescription drugs and medications at RxList The administration of flumazenil can precipitate benzodiazepine withdrawal in animals and man. This has been seen in healthy volunteers treated with therapeutic doses of oral lorazepam for up to 2 weeks who exhibited effects such as hot flushes, agitation and tremor when treated with cumulative doses of up to 3 mg doses of flumazenil. Flumazenil caused a slight increase in unscheduled DNA synthesis in rat hepatocyte culture at concentrations which were also cytotoxic; no increase in DNA repair was observed in male mouse germ cells in an in vivo DNA repair assay. Pup survival was decreased during the lactating period, pup liver weight at weaning was increased for the high-dose group (125 mg/kg/day) and incisor eruption and ear opening in the offspring were delayed; the delay in ear opening was associated with a delay in the appearance of the auditory startle response. www.rxlist.com /cgi/generic3/flumazenil_wcp.htm   (2526 words)

Flumanazil | Poison Control Center - Children's Hospital of Philadelphia The pharmacologic profile of flumazenil is unaltered in the presence of benzodiazepine agonists and the kinetics profiles of those benzodiazepines are unaltered by flumazenil. Flumazenil may be considered for the reversal of benzodiazepine sedation in cases where general anesthesia has been induced and/or maintained with benzodiazepines; where sedation has been produced by benzodiazepines for diagnostic and therapeutic procedures; in therapeutic misadventures and for the management of benzodiazepine overdose in patients who are not at risk for seizures. Flumazenil is a benzodiazepine antagonist with clinical utility in the reversal of sedation and CNS depression due to benzodiazepines. www.chop.edu /consumer/jsp/division/generic.jsp?id=72619   (1412 words)

Virtual Hospital: Rx Update   (Site not responding. Last check: 2007-10-17) Flumazenil (Romazicon[R]) is FDA-labeled for the complete or partial reversal of the sedative effects of benzodiazepines used for diagnostic and therapeutic procedures or for general anesthesia. Flumazenil is not an antidote for narcotic overdose or for respiratory depression. The use of flumazenil is contraindicated in patients exhibiting signs of cyclic antidepressant overdose and in patients who have been given benzodiazepines to control life-threatening conditions such as status epilepticus or increased cranial pressure. www.healthcare.uiowa.edu /pharmacy/RxUpdate/1998/05.RXU.html   (579 words)

Isolation and Pharmacological Characterization of Microsomal Human Liver Flumazenil, Carboxylesterase A carboxylesterase that hydrolyzes flumazenil to flumazenil acid and catalyzes the methyl transesterification of flumazenil with methanol to form flumazenil methyl ester was isolated from human liver microsomes by a five-step purification procedure. PMSF an inhibitor of serine proteases and mammalian acetylcholinesterase inhibited the metabolism of flumazenil to flumazenil acid and flumazenil methylester. Recently we investigated the metabolism of flumazenil in human liver microsomes and suggested that a carboxylesterase from human liver microsomes is involved in the degradation and metabolism of flumazenil (11, 12). www.ualberta.ca /~csps/JPPS1(1)/G.Geisslinger/isolationresearch.htm   (3763 words)

Naloxone, Flumazenil and Dantrolene as Antidotes Flumazenil (1 to 15 mg/kg) was administered intragastrically to rats that had been pretreated with daily diazepam doses of 113 mg/kg for about 6 months. The diagnostic use of flumazenil in such cases can be justified by its high therapeutic index and the fact that this may limit the use of other diagnostic procedures such as cerebral CT scan, clinical chemistry analyses and even lumbar puncture. Burkhart KK & Kulig KW (1990) The diagnostic utility of flumazenil in coma of unknown etiology. www.inchem.org /documents/antidote/antidote/ant01.htm   (14737 words)

MedicineHouse.com The administration of flumazenil to patients given agonists is remarkably free of cardiovascular effects unlike opioid reversal with naloxone. Flumazenil does not affect the central nervous system effects of drugs affecting GABA-ergic neurons by means other than the benzodiazepine receptor (including ethanol, barbiturates, or general anesthetics) and does not reverse the effects of opioids. Flumazenil produces withdrawal symptoms (seizures, emergent confusion and agitation) in the presence of physical dependence. www.medicinehouse.com /cgi-bin/drug1.php?drug=flumazenil   (960 words)

Clinical Trial: Effects of Flumazenil on Brain Excitability Flumazenil is commonly used in hospitals to reverse the effects of a group of drugs called benzodiazepines, one of which is Valium. Flumazenil will be infused through a catheter (thin plastic tube) attached to a needle placed in an arm vein. The purpose of this study is to investigate the effects of flumazenil on cortical excitability in healthy human volunteers. www.clinicaltrials.gov /ct/show/NCT00015678   (556 words)

Romazicon( flumazenil ) data sheet The pharmacokinetic profile of flumazenil is unaltered in the presence of benzodiazepine agonists and the kinetic profiles of those benzodiazepines are unaltered by flumazenil. The pharmacokinetics of benzodiazepines are unaltered in the presence of flumazenil. Flumazenil caused a slight increase in unscheduled DNA synthesis in rat hepatocyte culture at concentrations which were also cytotoxic; no increase in DNA repair was observed in male mouse germ cells in an in vivo DNA repair assay. psyweb.com /Drughtm/jsp/romaz.jsp   (6689 words)

Complete Flumazenil information from Drugs.com Flumazenil may cause benzodiazepine withdrawal symptoms in individuals who have been taking benzodiazepines long enough to have some degree of tolerance or physical dependence. Use of flumazenil to diagnose benzodiazepine-induced sedation in the ICU is not recommended because of the risk of adverse reactions. Flumazenil is intended as an adjunct to, not a substitute for, proper management of overdose patients (eg, airway maintenance, decontamination). www.drugs.com /ppa/flumazenil.html   (735 words)

University of Iowa Anesthesia Publications   (Site not responding. Last check: 2007-10-17) The behavioral effects of flumazenil by itself, and the acute reversal of benzodiazepine effects, are also controversial. Flumazenil reversed both the sedative and the memory effects of the benzodiazepine. Flumazenil reverses both the sedative and memory effects of the drug. www.anesth.uiowa.edu /readabstract.asp?PMID=8267193   (293 words)

Flumazenil [ANTIDOTE] - Evanston Northwestern Healthcare   (Site not responding. Last check: 2007-10-17) Flumazenil (50 mg I.V.) has been utilized to reverse carbamazepine-induced coma (serum level 27.8 mg/L), but it should not be utilized in any patient with an underlying seizure disorder; since carbamazepine can be epileptogenic, it should not be used routinely for this overdose. Flumazenil should be used with caution in the intensive care unit because of increased risk of unrecognized benzodiazepine dependence in such settings. Flumazenil may produce severe withdrawal reactions in patients physically dependent on benzodiazepines. www.enh.org /healthandwellness/bioterrorism/hf054925.aspx?lid=1093   (697 words)

Response to Flumazenil in Women With Premenstrual Dysphoric Disorder -- Le Mellédo et al. 157 (5): 821 -- Am J ... Response to Flumazenil in Women With Premenstrual Dysphoric Disorder -- Le Mellédo et al. Flumazenil (2 mg) or normal saline placebo were Behavioral responses to flumazenil were assessed with the Panic ajp.psychiatryonline.org /cgi/content/full/157/5/821   (1369 words)

Flumazenil Dosage, Interactions, Side Effects, How to Use The duration of reversal is related to the plasma levels of the benzodiazepine and the dose of flumazenil. The reversal of benzodiazepine effects may be associated with the onset of seizures in certain high-risk clients (e.g., concurrent major sedative-hypnotic drug withdrawal, recent therapy with repeated doses of parenteral benzodiazepines, myoclonic jerking or seizure activity prior to administration of flumazenil in cases of overdose, and concurrent cyclic antidepressant overdosage). Flumazenil may precipitate a withdrawal syndrome if the client is dependent on benzodiazepines. www.healthdigest.org /drug-prescribing-database/flumazenil-1721.htm   (795 words)

Benzodiazepine receptor antagonists for hepatic encephalopathy Flumazenil had a significant beneficial effect on improvement of hepatic encephalopathy at the end of treatment (RD 0.28; 95% CI 0.20 to 0.37, eight trials). Flumazenil may be associated with adverse events, but trial results were heterogeneous. Flumazenil had a significant beneficial effect on short-term improvement of hepatic encephalopathy in patients with cirrhosis and a highly favourable prognosis. www.cochrane.org /reviews/en/ab002798.html   (523 words)

flumazenil   (Site not responding. Last check: 2007-10-17) Flumazenil antagonizes the actions of benzodiazepines on the central nervous system. Flumazenil does not antagonize CNS effects of ethanol, barbiturates or opioids. Flumazenil may precipitate withdrawal syndromes in patients who are dependent on benzodizepines. www.templejc.edu /dept/ems/drugs/flumazenil.html   (154 words)

BestBETs: Flumazenil and suspected benzodiazepine overdose... You suspect an overdose and wonder whether flumazenil should be given to ascertain whether benzodiazepines are involved. The sensitivity of a single dose of flumazenil is high enough to allow failure to respond to be used as a SnNout for benzodiazepine overdose. The possibility of mixed overdose is a relative contraindication to using flumazenil. www.bestbets.org /cgi-bin/bets.pl?record=00147   (396 words)

BioCarta - Charting Pathways of Life It is used clinically to reverse theeffects of benzodiazepines in conscious sedation, general anesthesia, and management of suspected benzo-diazepine overdose. Kochs and colleagues reported that flumazenil might be beneficial in protecting against cerebral ischemia. The study by Zhang and Yao indicates that flumazenil mimics preconditioning in cardiomyocytes via the generation of H2O2 as the reactive oxygen species (ROS). www.biocarta.com /pathfiles/h_flumazenilPathway.asp   (382 words)

Flumazenil preconditions cardiomyocytes via oxygen radicals and KATP channels -- Zhang and Yao 279 (4): 1858 -- AJP - ... Kochs and colleagues (19) reported that flumazenil might be beneficial in protecting against cerebral ischemia. The sources and intracellular regulation of ROS signals by flumazenil are unknown. Cardiorespiratory effects of antagonism of diazepam sedation with flumazenil in patients with cardiac disease. ajpheart.physiology.org /cgi/content/full/279/4/H1858   (3686 words)

eMedicine - Toxicity, Sedative-Hypnotics : Article by Jeffrey S Cooper, MD The use of flumazenil for suspected benzodiazepine overdoses is controversial. Some sources would go so far as to suggest that flumazenil has no role in the routine treatment of a coma unless the patient is known not to be benzodiazepine dependent and the overdose is known to result only from benzodiazepines. Use of flumazenil in intentional drug overdose of unknown etiology is not cost effective or particularly prudent and is not encouraged. www.emedicine.com /emerg/topic525.htm   (1944 words)

Flumazenil improves cognitive and neuromotor emergence and attenuates shivering after halothane-, enflurane- and ... Flumazenil improves cognitive and neuromotor emergence and attenuates shivering after halothane-, enflurane- and isoflurane-based anesthesia : [Le flumazenil ameliore le retour de l'activite cognitive et neuromotrice et attenue les frissons apres une anesthesie a base d'halothane, d'enflurane ou d'isoflurane] -- Weinbroum and Geller 48 (10): 963 -- Canadian Journal of Anesthesia Flumazenil reduces the duration of thiopentone but not of propofol anaesthesia in humans. The effect of benzodiazepine receptor antagonism by flumazenil on the MAC of halothane in the rat. www.cja-jca.org /cgi/content/full/48/10/963   (3809 words)

Flumazenil - Wikipedia, the free encyclopedia Flumazenil (flumazepil, Ro 15-1788, Anexate®, Lanexat®, Mazicon®, Romazicon®) is a benzodiazepine antagonist, used as an antidote in the treatment of benzodiazepine overdose. Therefore, repeat doses of flumazenil may be required to prevent recurrent symptoms of overdosage once the initial dose of flumazenil wears off. Subjects who are physically dependent on benzodiazepines may suffer benzodiazepine withdrawal symptoms, including seizure, upon administration of flumazenil. en.wikipedia.org /wiki/Flumazenil   (195 words)

Web Posters Flumazenil PET will be shown to alter the decision-making processes in patients with medically intractable epilepsy. The introduction of Flumazenil PET findings will provide information that will either alter surgical strategies or expand the population eligible for invasive monitoring. Patients who are found to be multifocal will also be studied to determine the ability of flumazenil to identify patients who are not good candidates for resective surgery. www.dana.org /webposters/poster.cfm?displayrec=45   (186 words)

Flumazenil - Drugs & Vitamins - Drug Library - DrugDigest FLUMAZENIL (Romazicon®) helps to reverse the sedative (drowsiness and relaxation) effects of benzodiazepine drugs (e.g., diazepam) following surgery or drug overdose. Some side effects are not caused by flumazenil, but by reversal of the effects of benzodiazepines or other medicines taken. If you have been given flumazenil because of an overdose of benzodiazepines, ask your prescriber or health care professional for written instructions about how to take your medicines. www.drugdigest.org /DD/DVH/Uses/0,3915,6115|Flumazenil,00.html   (450 words)

University of Iowa Anesthesia Publications   (Site not responding. Last check: 2007-10-17) Flumazenil may attenuate some subjective effects of nitrous oxide in humans: a preliminary report. Two double-blind, randomized, crossover trials were conducted to study whether the benzodiazepine antagonist, flumazenil, would interact with the subjective and psychomotor effects of nitrous oxide in healthy volunteers. Experiment 1 tested a range of flumazenil doses used clinically (0, 0.25, 0.5, and 1.0 mg/70 kg) whereas Experiment 2 tested a supraclinical flumazenil dose (0 and 5.0 mg/70 kg). www.anesth.uiowa.edu /readabstract.asp?PMID=7675863   (152 words)

Flumazenil - Drugs & Vitamins - Drug Library - DrugDigest Flumazenil is for injection or infusion into a vein. It is given by a health-care professional in a hospital or clinic setting. Flumazenil can affect mental processes, such as memory or judgment. www.drugdigest.org /DD/PrintablePages/Monograph/0,7765,6115|Flumazenil|,00.html   (372 words)

A comparison of intramuscular ketamine with high dose intramuscular midazolam with and without intranasal flumazenil in ... Difficulty in administration of the intranasal flumazenil was Geller E, Niv D. The use of flumazenil in the treatment of 34 intoxicated patients. Antagonism of the hypnotic effect of midazolam in children: a randomised, double-blind study of placebo and flumazenil administered after midazolam-induced anaesthesia. emj.bmjjournals.com /cgi/content/full/18/1/34   (2794 words)

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