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Topic: Flunitrazepam

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	DEA Resources, For Law Enforcement Officers, Intelligence Reports, Rohypnol
		Flunitrazepam is a benzodiazepine that is used in the short-term treatment of insomnia and as a sedative hypnotic and preanesthetic medication.
		Flunitrazepam is touted as an effective “parachute” or remedy for the depression that follows a stimulant high.
		Flunitrazepam is reported to be readily available in the Miami area, and epidemiologists from that area have stated that it is South Florida’s fastest growing drug problem.
	www.usdoj.gov /dea/pubs/rohypnol/rohypnol.htm (1020 words)

	Flunitrazepam - Wikipedia, the free encyclopedia
		Flunitrazepam (formerly marketed under the trade name Rohypnol in North America, pronounced ˌfluːnaɪˈtræzəpæm) is a drug which is a benzodiazepine derivative.
		Flunitrazepam is usually consumed orally, and is often combined with alcohol.
		Flunitrazepam is currently a Schedule III drug under the international Convention on Psychotropic Substances of 1971 [5]; in the United States, it is on Schedule IV
	en.wikipedia.org /wiki/Flunitrazepam (6504 words)

	California Coalition on Sexual Offending
		Flunitrazepam became a Schedule IV Controlled Substance in California on January 1, 1997; and, the good news is, a substantial drop in its availability, at least in the streets of Los Angeles, has been noted since that date.
		Flunitrazepam is also Schedule IV federally, though effort is being made to upgrade it to Schedule I. NOTE: Possession of flunitrazepam (trade name Rohypnol) is now covered by 11377 of the Health and Safety Code, and possession for sale and sales are covered by 11378/11379 HandS.
		Flunitrazepam is a hypnotic sedative prescribed legally in at least 64 countries outside the United States for diminishing anxiety, skeletal and muscle relaxation and sleep depravation.
	www.ccoso.org /newsletter/roofies.html (2681 words)

	'date Rape' Drug Gaining Popularity
		Flunitrazepam, a sedative 10 times more potent than Valium, is known on the street as "rophies, R-2, or roaches." According to the report, the drug "causes a euphoric, drunken-like high and heightens the effect of alcohol and other drugs."
		Flunitrazepam has gained media attention in recent years due to its use as a 'date rape' drug.
		The authors say that "it is difficult to speculate whether the use of flunitrazepam is a passing fad or will become an epidemic." They point out that the drug is cheaper than alcohol (less than $1 per pill), and difficult to detect on standard drug urine tests.
	www.personalmd.com /news/a1999010511.shtml (516 words)

	GDCADA \| Rohypnol - Facts and Statistics
		Flunitrazepam has never been approved for medical use in the U.S., therefore, doctors cannot prescribe it and pharmacists cannot dispense it.
		Flunitrazepam causes partial amnesia — individuals are unable to remember certain events that they experienced while under the influence of the drug.
		This effect is particularly dangerous when flunitrazepam is used to aid in the commission of sexual assault — victims may not be able to clearly recall the assault, assailant, or events surrounding the assault.
	www.gdcada.org /statistics/rohypnol.htm (414 words)

	What are Ruffies?
		Flunitrazepam is a benzodiazepine similar to many on the US market (eg, diazepam, triazolam) that is only available legally in other countries.
		Flunitrazepam is commonly abused in Europe, Asia, South America, especially Chile, where it is available without a prescription.
		Flunitrazepam's increase in popularity in the US may be due to its easy access from foreign countries and to exposure in media such as Internet news groups and radio talk shows.
	earthops.org /rohypnol5.html (394 words)

	Rohypnol: "Roofies", "Rophies", the "Date Rape" Drug- Health Hazards and ...
		Flunitrazepam is marketed under the trade name Rohypnol- and is manufactured worldwide, particularly in Europe and Latin America, in 1- and 2-milligram tablets by Hoffman-La Roche, Inc., a large pharmaceutical manufacturer.
		Rohypnol (Flunitrazepam), commonly known as "Roofies," "Rophies," "Rope," and the "Forget Pill," is increasingly being used by youth -- in many cases as a date rape drug because of its ability to affect willpower.
		Two common misperceptions about flunitrazepam may explain the drug's popularity among young people: first, many erroneously believe that the drug is unadulterated—and therefore "safe"—because it comes in pre-sealed bubble packs; second, many mistakenly think its use cannot be detected by urinalysis testing.
	www.ohsinc.com /rohypnol_roofies_rophies__rope_date_rape_pill.htm (1160 words)

	Flunitrazepam ( Rohypnol ) : the date rape drug ? (Site not responding. Last check: 2007-10-08)
		Flunitrazepam does not seem to be involved in medical emergencies more often than other benzodiazepines, and there is no indication that flunitrazepam is more toxic than other benzodiazepines when taken in overdose by drug abusers or other individuals.
		Survey research among typical patient populations suggests that flunitrazepam is characteristic of benzodiazepines in that it is used appropriately and conservatively, with low liability for abuse.
		Thus the reported preference for flunitrazepam among opioid abusers seems to be the only way in which flunitrazepam is distinguished from other benzodiazepines; it is unclear what characteristics of the drug may be responsible for this reported preference.
	www.biopsychiatry.com /flunit.htm (329 words)

	[No title]
		Therefore, although there is an age-dependent reduction of flunitrazepam binding in cerebral membranes, the increased sensitivity requires less flunitrazepam binding to achieve the same effects.
		Reports indicate that flunitrazepam is used by drug addicts in Spain and Malaysia to alleviate withdrawal symptoms and to gain a state of oblivion.
		The conjuctional use of flunitrazepam with other drugs such as alcohol or heroine is popular because of the intensified effects of the combination.
	sulcus.berkeley.edu /mcb/165_001/papers/manuscripts/_523.html (2303 words)

	Flunitrazepam - Buy Online Cheap, Generics and Brand !
		Flunitrazepam (Rohypnol©) is a benzodiazepine that is marketed and licensed for use in Europe, Asia, and Latin America for the short term treatment of insomnia and as a sedative-hypnotic and preanesthetic medication.
		Flunitrazepam / Rohypnol tablets are white and contain the name "Roche" and an encircled 1 or 2 on one side (indicating 1mg or 2mg tablets).
		Flunitrazepam / Rohypnol can also contribute to the toxicity of ethanol such that concentrations of Flunitrazepam / Rohypnol and ethanol are individually less than those required for fatal toxicity when used alone.(10) Tolerance and dependence do occur with the use of benzodiazepines.
	www.findrxonline.com /flunitrazepam.htm (1448 words)

	rohypnol drug information, rohypnol side effects
		Rohypnol (flunitrazepam), most commonly known as a date-rape drug, continues to be abused among teenagers...
		Rohypnol (flunitrazepam), also known as roofies, is a sedative in the same recreational drug family...
		Flunitrazepam, trade name Rohypnol, is a central nervous system depressant in a class of drugs called...
	www.drugs.com /sch/rohypnol (523 words)

	Rohypnol - MOTM
		Flunitrazepam is a benzodiazepine (central nervous system depressant), similar to valium, but 10 times stronger.
		Chemically, Flunitrazepam, temazepam, triazolam and diazepam (valium) are all structurally related benzodiazepines, with the same mechanism of action.
		Flunitrazepam has a long half-life (18-26 hours) and it also has an active metabolite (like valium) that lasts 36-200 hours.
	www.chm.bris.ac.uk /motm/rohypnol/rohypnolh.htm (573 words)

	Canada Gazette
		Flunitrazepam is, however, marketed in a number of other countries for the treatment of insomnia.
		Flunitrazepam was listed in Schedule IV to the CDSA but was exempted from the application of the CDSA by the Regulations Exempting Certain Precursors and Controlled Substances from the Application of the Controlled Drugs and Substances Act.
		Also, if in the future flunitrazepam or GHB receive approval for sale in Canada under the FDAR, they may be added to a schedule to the regulations under the CDSA to permit their distribution and possession under strict controls.
	canadagazette.gc.ca /partII/1998/19980401/html/sor173-e.html (1128 words)

	Rohypnol Alert - DEA Highlights-1995
		Flunitrazepam (marketed under the trade name Rohypnol) is manufactured worldwide, particularly in Europe and Latin America, in 1- and 2-milligram tablets by Hoffman-La Roche, Inc., a large pharmaceutical manufacturer.
		Two common misperceptions about flunitrazepam may explain the drug's popularity among young people: first, many erroneously believe that the drug is unadulterated (and therefore "safe") because it comes in presealed bubble packs; second, many mistakenly think its use cannot be detected by urinalysis testing.
		In March 1995, flunitrazepam was moved to Schedule III by the World Health Organization, requiring more thorough record keeping on its licit distribution, the first benzodiazepine to require more rigid controls.
	earthops.org /rohypnol2.html (1092 words)

	Prescription Drugs: Abuse, Addiction, and Treatment
		The illicit use of flunitrazepam is characterized by its combined use with other drugs, although it may be used alone, too.
		The abuse of flunitrazepam in the U.S. was first reported from south Florida at the June 1993 CEWG meeting.
		Flunitrazepam use appears to be spreading in the U.S. among high school and college youth.
	www.drug-rehabcenter.com /prescription_drugs3.htm (1345 words)

	Flunitrazepam (Rohypnol) \| CESAR
		Flunitrazepam, trade name Rohypnol, is a central nervous system depressant in a class of drugs called benzodiazepines.
		Benzodiazepines are sedative-hypnotics used to treat anxiety, insomnia and sleep disorders, and seizure disorders; they are also used as skeletal-muscle relaxants.
		Though not approved for use in the United States, Rohypnol (flunitrazepam) is currently scheduled with other benzodiazepines as a Schedule IV controlled substance.
	www.cesar.umd.edu /cesar/drugs/rohypnol.asp (1162 words)

	EMedHome.com
		Subsequent to the Drug-Induced Rape Prevention Act of 1996, the DEA was instructed by Congress to re-schedule flunitrazepam from IV to I. Today, abuse continues, primarily in Florida, Texas and California, where the drug is smuggled into the country by international mail, courier service or commercial airlines.
		Flunitrazepam is typically combined with alcohol or other drugs.
		Flunitrazepam and its involvement in date or acquaintance rape.
	www.emedhome.com /features_printfriendly.cfm?FID=10 (1346 words)

	Drugs information - Flunitrazepam (Rohypnol (roofies))
		flunitrazepam (trade name Rohypnol) is a type of tranquilliser.
		as a medicine, flunitrazepam is a tablet used to treat sleeplessness (insomnia), and for its calming and anaesthetic properties.
		It is always wise to use caution and common sense when accepting drinks from other people, as it is possible to “spike” drinks with other substances.
	www.thamesvalley.police.uk /news_info/drugs/Rohypnol.htm (274 words)

	Rohypnol (Flunitrazepam) Information (via CobWeb/3.1 planet03.csc.ncsu.edu) (Site not responding. Last check: 2007-10-08)
		Rohypnol (flunitrazepam) manufactured by the pharmaceutical company Hoffmann-La Roche Inc, is the brand name of a sleeping pill prescribed for insomnia in Mexico, South America, Europe and Asia.
		The illicit use of flunitrazepam is characterized by its use with other drugs, although it may be used alone.
		After patients have received their initial phenobarbital doses, a benzodiazpine, such as chlordiazepoxide or diazepam, can be administered as needed to alleviate emerging alcohol withdrawal signs and symptoms (e.g., rising pulse and blood pressure, tremulousness, diaphoresis) and prevent withdrawal seizures.
	www.a1b2c3.com.cob-web.org:8888 /drugs/roof_01.htm (1925 words)

	Drug InfoNet Doctors' Answers to Frequently Asked Questions - Flunitrazepam (Site not responding. Last check: 2007-10-08)
		The patient consumed flunitrazepam (rohypnol) and alcohol (champagne) and went into a comatose state for approximately 20 minutes.
		The patient was, at the time, a suspected heroin addict, and his spouse was present during the incident.
		It appears that this is an exaggeration, because 50 pills would seem to be a lethal dose, even for a flunitrazepam addict taking 6 mg daily.
	www.druginfonet.com /faq/faqfluz.htm (423 words)

	Zinc and Flunitrazepam Modulation of GABA-Mediated Currents in Rat Suprachiasmatic Neurons -- Strecker et al. 81 (1): ...
		The effect of flunitrazepam on currents evoked by pressure application of GABA was examined.
		Flunitrazepam had little effect on sIPSC amplitudes, in contrast to a strong potentiation of responses to pressure application of GABA.
		Flunitrazepam significantly potentiated the responses to pressure-applied GABA in all 13 SCN neurons from mature rats.
	jn.physiology.org /cgi/content/full/81/1/184 (5130 words)

	Rophies - Rohypnol (Site not responding. Last check: 2007-10-08)
		Flunitrazepam is a sleeping pill manufactured by Hoffmann-LaRoche under the brand name Rohypnol.
		While flunitrazepam is an approved prescription medication in much of the world, it is not approved for sale in the United States.
		The illegal flunitrazepam sold in the United States is typically diverted from legal sources in Mexico and South America.
	www.well.com /user/woa/fsrophie.htm (339 words)

	Regional Differences in the Inhibition of Mouse In Vivo [3H]Ro 15-1788 Binding Reflect Selectivity for 1 versus 2 and 3 ... (Site not responding. Last check: 2007-10-08)
		Thus, the nonselective compounds flunitrazepam, diazepam, and DMCM all produced a similar inhibition of binding in cerebellum and spinal cord (respective ID values of 0.2 to 0.3 mg/kg, 2 mg/kg, and 10 mg/kg IP); whereas, the
		H]Ro 15-1788 was estimated by measuring the membrane-bound radioactivity in mice pretreated for 30 min with 30 mg/kg flunitrazepam.
		Moreover, the ID for flunitrazepam of 0.2 to 0.3 mg/kg is in good agreement with previous published values of 0.17 mg/kg (Benavides et al.
	www.nature.com /npp/journal/v20/n3/full/1395235a.html (3381 words)

	AAP News Release - Study Reports on Voluntary Use of "Rape Drug" (Site not responding. Last check: 2007-10-08)
		CHICAGO-A new study reports that voluntary use of the drug flunitrazepam, also known as “rophies, R-2 or roaches,” is becoming a health concern among some young women.
		Flunitrazepam is an inexpensive, small, white pill that dissolves easily in liquids and is odorless, colorless and tasteless.
		The drug causes a euphoric, drunken-like high and is often taken with alcohol or other drugs because it heightens their effects.
	www.aap.org /advocacy/archives/janrdrg.htm (370 words)

	Postsynaptic Receptor Occupancy During Evoked Transmission at Striatal GABAergic Synapses In Vitro -- Rumpel and ...
		In cells where flunitrazepam enhanced IPSC amplitudes (n = 18), the mean increase in peak amplitude was by 26.0 ± 5.3%.
		In 500 nM flunitrazepam, mIPSC peak amplitudes increased
		Flunitrazepam increases the amplitude and decay time constant of mIPSCs without affecting their rise time.
	jn.physiology.org /cgi/content/full/84/2/771 (5990 words)

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