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| | Antiresorptive therapy, anabolic therapy, and exercise effects on bone mass, structure, and strength assessed in a rat ... |
 | | However, structural abnormalities or mineralization defects in the bone formed during fluoride administration have been demonstrated in several studies, thus indicating that the increase in bone mass is not necessarily paralleled by an improved bone quality. |
 | | The purpose of the present investigation was to evaluate the effect on bone biomechanical competence of current therapies (fluoride and estrogen) or potential therapies (PTH, bisphosphonates, PTH co-therapy with an antiresorptive agent, and exercise) in treatment or prophylaxis of osteoporosis, assessed in either rat femoral neck and rat femoral body, or both. |
 | | Therefore this study provides further evidence for a possible detrimental effect of fluoride on bone quality, and as such agrees with previous investigations recommending discontinuance of the general use of fluoride in treatment of osteoporosis until further clinical trials, using fracture rate as an end-point, have been performed. |
| www.fluoride-journal.com /97-30-2/302-119.htm (1189 words) |
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