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Topic: Fluoroacetate

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	Fluoroacetate (Site not responding. Last check: 2007-10-29)
		Fluoroacetate is also a metabolite of many other fluorinated pesticides and other organic fluoride compounds, such as those used in anesthetics (i.e.
		It is commonly thought that the toxicity of fluoroacetate is the result of its conversion into fluorocitrate which is a potent inhibitor of enzymes in the tricarboxylic-acid-cycle (i.e.
		Regarding the liver and fluoroacetate, it should be noted that the liver is the organ with the highest fluoroacetate-defluorination ability (Soiefer and Kostyniak, 1983).
	www.bruha.com /science/html/fluoroacetate.html (2505 words)

	Sodium fluoroacetate (PDS)
		Baits of sodium fluoroacetate should be removed and the area thoroughly cleaned up after the necessary purpose has been fulfilled.
		General">4.1.1 General: sodium fluoroacetate is a water soluble salt of very high toxicity which is used mainly as a rodenticide.
		The presence of the compound in blood and tissues is indicative of absorption.
	www.inchem.org /documents/pds/pds/pest16_e.htm (0 words)

	Dorlands Medical Dictionary
		Carnivores are affected when they eat small animals that have died from fluoroacetate rodenticides, and ruminants are affected when they eat fluoroacetate-containing plants such as Acacia georginae or species of Dichapetalum, Gastrolobium, Oxylobium, or Palicourea.
		Poisoning in humans is usually caused by ingestion of rodenticides.
		Fluoroacetate blocks one of the steps in the tricarboxylic acid cycle, causing symptoms that are often fatal such as neurological problems ranging from ataxia and agitation to convulsions, and heart problems such as severe tachycardia and cardiomyopathy.
	www.mercksource.com /pp/us/cns/cns_hl_dorlands.jspzQzpgzEzzSzppdocszSzuszSzcommonzSzdorlandszSzdorlandzSzdmd_p_26zPzhtm (0 words)

	Sodium fluoroacetate (62-74-8). Index from Fluoride Action Network Pesticide Project.
		Inhalation exposure to unspecified levels of sodium fluoroacetate caused salivation, loss of speech, violent convulsions, and coma in a male worker.
		Sodium fluoroacetate (1080), is a fluorinated carboxylic acid ester with high to very high toxicity to birds and mammals.
		EPA denied request from Texas Department of Agriculture for the use of sodium fluoroacetate on certain mammalian vectors to control gray fox rabies.
	www.flouridealert.com /pesticides/sodium.fluoroacetate-page.htm (0 words)

	Sodium fluoroacetate (62-74-8). Index from Fluoride Action Network Pesticide Project.
		Inhalation exposure to unspecified levels of sodium fluoroacetate caused salivation, loss of speech, violent convulsions, and coma in a male worker.
		Sodium fluoroacetate (1080), is a fluorinated carboxylic acid ester with high to very high toxicity to birds and mammals.
		EPA denied request from Texas Department of Agriculture for the use of sodium fluoroacetate on certain mammalian vectors to control gray fox rabies.
	www.fluorideaction.org /pesticides/sodium.fluoroacetate-page.htm (1720 words)

	Sodium fluoroacetate (CASRN 62-74-8) \| IRIS \| US EPA
		Fluoroacetate is converted to fluorocitrate in vivo which in turn inhibits the enzyme aconitase of the tricarboxylic acid (TcA or Krebs) cycle.
		Although administration of fluoroacetate following a single intravenous injection results in substantial bone accumulation indicative of defluorination of the molecule (Sykes et al., 1986), the acute and subchronic toxicological effects of fluoroacetate are clearly due to aconitase inhibition.
		The symptoms exhibited in human poisoning by fluoroacetate are consistent with the effects of fluorocitrate inhibition of aconitase in the cat, pig and rhesus monkey.
	www.epa.gov /iris/subst/0469.htm (1575 words)

	SODIUM FLUOROACETATE (PIM 494)
		In the United Kingdom fluoroacetate is formulated as a 5% solid concentrate and a 0.375% bait for dilution to 0.25% with water.
		Sodium fluoroacetate is rapidly absorbed from the gastrointestinal tract.
		Mead RJ, Moulden DL and Twigg LE (1985) Significance of sulfhydryl compounds in the manifestation of fluoroacetate toxicity to the rat, brush-tailed possum, woylie and western grey kangaroo.
	www.intox.org /databank/documents/chemical/sodfluor/pim494.htm (4081 words)

	Biosafety
		Absorption of fluoroacetate occurs relatively early in the tract (stomach or small intestine), and the toxin is absorbed before it reaches the intestinal tract microbes (Diagram).
		The fluoroacetate detoxification project was initiated by a group of animal producers from Queensland and the Northern Territory who were losing significant numbers of cattle every year from fluoroacetate poisoning.
		Natural fluoroacetate resistance in Australian native animals has been shown conclusively to be a feature of the animals' own biochemistry, and not of their digestive tract microbes, even though the microbes have co-existed with detoxifying soil bacteria for millions of years.
	wwwscience.murdoch.edu.au /centres/rumen/biosafety.html (3635 words)

	Journal of Cerebral Blood Flow & Metabolism - Trafficking of Amino Acids Between Neurons and Glia In Vivo. Effects ...
		Fluoroacetate was used to selectively inhibit glial TCA cycle activity to allow further differentiation between the glial and neuronal formation of amino acids.
		Sodium fluoroacetate (Sigma) was dissolved in 30 mmol/L NaCl to a concentration of 12 mg/mL (120 mmol/L), and pH was adjusted to 7.4.
		Treatment with fluoroacetate led to an increase in the level of citrate in agreement with conversion of fluoroacetate into fluorocitrate, which is an inhibitor of aconitase (Peters, 1957).
	www.nature.com /jcbfm/journal/v17/n11/full/9590313a.html (5516 words)

	Fluoroacetate (Steve Harris) (Site not responding. Last check: 2007-10-29)
		Once >ingested, fluoroacetate (by analogy to acetate) is converted to >fluoroacetyl CoA which then enters the citric acid cycle.
		Sodium fluoroacetate is indeed to use to poison coyotes, since it tastes like salt (blood) so there is no way the animal can tell the bait has something funny in it.
		Fluoroacetic acid is one of the more deadly chemicals to manufacture outside of the nerve agents.
	www.yarchive.net /med/fluoroacetate.html (195 words)

	Sodium Fluoroacetate. TOXNET profile from Hazardous Substances Data Bank.
		The rate of defluorination of fluoroacetate in erythrocytes and in extracts of liver acetone powders of Tiliqua rugosa was 8- and 4.5-fold greater, respectively, than that found in similar preparations from Rattus norvegicus.
		Fluoroacetate administered ip to rats and mice is defluorinated to give fluoride ion evident in urine and kidney by (19)F NMR.
		Sodium fluoroacetate in all solutions and dry baits are restricted for all uses based on acute oral toxicity, hazard to nontarget avian species, use and accident history.
	www.fluoridealert.org /pesticides/sodium.fluoroacetate.toxnet.htm (8691 words)

	Isolation of an Aldehyde Dehydrogenase Involved in the Oxidation of Fluoroacetaldehyde to Fluoroacetate in Streptomyces ... (Site not responding. Last check: 2007-10-29)
		Isolation of an Aldehyde Dehydrogenase Involved in the Oxidation of Fluoroacetaldehyde to Fluoroacetate in Streptomyces cattleya -- Murphy et al.
		Isolation of an Aldehyde Dehydrogenase Involved in the Oxidation of Fluoroacetaldehyde to Fluoroacetate in Streptomyces cattleya
		Streptomyces cattleya is unusual in that it produces fluoroacetate and 4-fluorothreonine as secondary metabolites.
	aem.asm.org /cgi/content/full/67/10/4919 (1631 words)

	Release Proposal
		Toxicity effects of fluoroacetate will be tested by continuing to administer the toxin in a familiar feed, to a total dose of 0.35 mg/kg body weight for sheep and cattle, and 0.65 mg/kg for goats.
		The failure of this type of gene to be established naturally in rumen bacteria, when ruminants are exposed to both fluoroacetate and to natural detoxifying bacteria, is a strong indication that such transfer is not favoured in nature.
		Fluoroacetate is used as a pesticide to control feral monogastric animals such as rabbits, feral cats, foxes, and rodents.
	wwwscience.murdoch.edu.au /centres/rumen/GMAC.html (11859 words)

	1080
		Inhalation: no information Cumulation of compound: cumulation of sodium fluoroacetate occurs to some extent and some tolerance can be demonstrated in the mouse and rat and possibly in the rhesus monkey.
		treatment for sodium fluoroacetate poisoning is mainly symptomatic.
		The use of sodium fluoroacetate should be restricted to sewers, ships and other structures where the operator can completely control the rodenticide and the environment.
	www.the-piedpiper.co.uk /th15(j).htm (762 words)

	EWG Report \|\| Canaries in the Kitchen \|\| Teflon Toxicosis (Site not responding. Last check: 2007-10-29)
		Sodium fluoroacetate was previously used as a powerful rodent killer (rodenticide).
		In the body, it breaks down into sodium and fluoroacetate, which is responsible for the toxicity.
		Sodium fluoroacetate kills rodents, and other animals, by inhibiting the tricarboxylic acid (TCA) cycle which transforms energy found in food to energy the body uses.
	www.ewg.org /reports/toxicteflon/teflonoffgas.php (2877 words)

	Citizens for Responsible Wildlife Management v. State
		A citizen groups filed a declaratory judgment action against the State of Washington seeking a determination that the 2000 initiative 713 barring use of body-gripping traps, sodium fluoroacetate, or sodium cyanide to trap or kill mammals was unconstitutional.
		The official ballot title reads: "Shall it be a gross misdemeanor to capture an animal with certain body-gripping traps, or to poison an animal with sodium fluoroacetate or sodium cyanide?" State of Washington Voters Pamphlet, General Election 8 (Nov. 7, 2000).
		It is unlawful to poison or attempt to poison any animal using sodium fluoroacetate, also known as compound 1080, or sodium cyanide.
	www.animallaw.info /cases/causwa71p3d644.htm (6125 words)

	Sodium Fluoroacetate (1080) - Guidelines for the Safe Use of
		Sodium Fluoroacetate (1080) - Guidelines for the Safe Use of
		The major purpose of these guidelines is to provide advice on the safe occupational use of sodium monofluoroacetate (1080) in its various formulations.
		The primary intention is to provide practical guidelines for assisting users to develop working practices of a standard consistent with the requirements of the Health and Safety in Employment Act (HSE Act) 1992 and the Hazardous Substances and New Organisms Act (HSNO Act) 1996.
	www.osh.dol.govt.nz /order/catalogue/400.shtml (0 words)

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