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Topic: Folate


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In the News (Sat 25 May 19)

  
 Folic acid - Wikipedia, the free encyclopedia
Folate deficiency can result in the formation of large red blood cells that do not contain adequate hemoglobin, the substance in red blood cells that carries oxygen to your body's cells.
Folate is involved in the synthesis, repair, and functioning of DNA, our genetic map, and a deficiency of folate may result in damage to DNA that may lead to cancer.
Folate intake and carcinogenesis of the colon and rectum.
en.wikipedia.org /wiki/Folate   (4195 words)

  
 nutrition.org -- Nutritent Information   (Site not responding. Last check: 2007-10-08)
The folates found in nature contain the core chemical structure of pteroylglutamic acid but vary in their state of reduction, the single carbon moiety they bear and/or the length of the glutamate chain attached.
The metabolic role of folate is as an acceptor and donor of one-carbon units in a variety of reactions involved in amino acid and nucleotide metabolism.
Deficiencies: Given the role that folate coenzymes play in the synthesis of RNA, DNA and protein, it is not surprising that the folate requirement and, consequently, the risk of deficiency is elevated during periods of rapid growth and/or enhanced metabolic activity (e.g.
www.nutrition.org /nutinfo/content/fola.shtml   (828 words)

  
 Foods rich in folate may reduce risk of stroke
Folate is a B-vitamin found in citrus fruits; tomatoes; leafy green vegetables such as spinach and romaine lettuce; pinto, navy, and kidney beans; and grain products.
Folate is thought to have beneficial effects on the cardiovascular system by decreasing levels of homocysteine, an amino acid that is linked to a higher risk of atherosclerosis.
Specific dietary intake of folate was not available in the first database, but researchers later matched the recorded foods and portions to foods listed in a database to estimate the amount of folate ingested by patients in a 24-hour period.
www.americanheart.org /presenter.jhtml?identifier=3002589   (875 words)

  
 How Folate Can Help Prevent Birth Defects
Folate is a B vitamin found in a variety of foods and added to many vitamin and mineral supplements as folic acid, a synthetic form of folate.
Folate is needed both before and in the first weeks of pregnancy and can help reduce the risk of certain serious and common birth defects called neural tube defects, which affect the brain and spinal cord.
Folate occurs naturally in a variety of foods, including liver; dark-green leafy vegetables such as collards, turnip greens, and Romaine lettuce; broccoli and asparagus; citrus fruits and juices; whole-grain products; wheat germ; and dried beans and peas, such as pinto, navy and lima beans, and chickpeas and fl-eyed peas.
www.fda.gov /fdac/features/796_fol.html   (1673 words)

  
 Folate
Folate, a member of the B-vitamin family, is a collective term for a number of chemical forms which are structurally related and which have similar biological activity to folic acid.
Folates are also involved in reactions leading to de novo purine nucleotide synthesis, interconversion of serine and glycine, generation and utilization of formate, the metabolism of L-histidine to L-glutamic acid, the metabolism of dimethylglycine to sarcosine and the metabolism of sarcosine to glycine.
Folate plays a central role in the formation of nucleic acid precursors, such as thymidylic acid and purine nucleotides, which are essential for nucleic acid synthesis and cell division.
www.pdrhealth.com /drug_info/nmdrugprofiles/nutsupdrugs/fol_0110.shtml   (6413 words)

  
 Vitamin B9 ( Folic acid / Folate )
The classic symptoms of a folate deficiency anemia are weakness, inflamed and sore tongue, numbness or tingling in the hands and feet, indigestion, diarrhea, depression, irritability, pallor, drowsiness, and slow, weakened pulse.
Oral contraceptives increase the removal of folate from the blood plasma; methotrexate, a medication used for immunosuppression in cancer and psoriasis, is a folate antagonist.
Folate absorption from the intestine is impaired in a zinc deficiency.
www.herbs2000.com /vitamins/v_b9.htm   (1197 words)

  
 Health Benefits of Folate
Folate (or folic acid) is a vitamin that is an essential nutrient for growth and good health.
Folate is necessary for the formation and development of new and normal tissue.
Care should be taken to keep total daily folate consumption under 1 milligram because the effects of high intake are not well known and may complicate the diagnosis of vitamin B-12 deficiency.
www.pea-lentil.com /folate.html   (439 words)

  
 Dietary Supplement Fact Sheet: Folate
Folate is a water-soluble B vitamin that occurs naturally in food.
A deficiency of folate can occur when an increased need for folate is not matched by an increased intake, when dietary folate intake does not meet recommended needs, and when folate excretion increases.
Folate is involved in the synthesis, repair, and function of DNA, our genetic map, and there is some evidence that a deficiency of folate can cause damage to DNA that may lead to cancer [52].
ods.od.nih.gov /factsheets/folate.asp#ref   (4652 words)

  
 Folate   (Site not responding. Last check: 2007-10-08)
Folate supplements may also help prevent other types of birth defects, such as defects of the heart, palate, and urinary tract; conversely, drugs that impair folate action may increase risk of birth defects.
High-dose folate (10 mg daily) might be helpful for normalizing abnormalities in the appearance of the cervix (as seen under a microscope) in women taking oral contraceptives, but it does not appear to reverse actual cervical dysplasia.
Aspirin and folate binding: in vivo and in vitro studies of serum binding and urinary excretion of endogenous folate.
www.al-hikmah.org /folate.asp   (3443 words)

  
 MedlinePlus Medical Encyclopedia: Folate-deficiency anemia
Folate, also called folic acid, is necessary for red blood cell formation and growth.
Because folate is not stored in the body in large amounts, a continual dietary supply of this vitamin is needed.
In a pregnant woman, folate deficiency has been associated with neural tube or spinal defects (such as spina bifida) in the infant.
www.nlm.nih.gov /medlineplus/ency/article/000551.htm   (542 words)

  
 Membrane and tissue distribution of folate binding protein in pig -- Villanueva et al. 275 (5): 1503 -- AJP - ...
Folate absorption in alcoholic pigs: in vitro hydrolysis and transport at the intestinal brush border membrane.
Folate transport in isolated brush-border membrane vesicles from rat intestine.
Folate binding protein: molecular characterization and transcript distribution in pig liver, kidney and jejunum.
ajpregu.physiology.org /cgi/content/full/275/5/R1503   (4635 words)

  
 Consumer Information Center: How Folate Can Help Prevent Birth Defects
Folate's potential to reduce the risk of neural tube defects is so important that the Food and Drug Administration is requiring that by 1998, food manufacturers fortify enriched grain products with folic acid.
Some labels may claim that the product is "high in folate or folic acid," which means a serving of the food provides 20 percent or more of the Daily Value for folic acid.
Any one or a combination of these options for ensuring adequate folate can help assure women of childbearing age that, if they become pregnant, their babies will be off to a healthy start.
www.pueblo.gsa.gov /cic_text/health/folate/796_fol.html   (1655 words)

  
 Folate (Folacin, Folic Acid)
The U.S. RDA for folate is the amount of the vitamin used as a standard in nutrition labeling of foods.
The 1989 RDA for folate has been set at 180 micrograms per day for women 19 to 50 years of age and 200 micrograms for men 19 to 50 years of age.
Folate, a water-soluble vitamin, helps the body form red blood cells and aids in the formation of genetic material within every body cell.
ohioline.osu.edu /hyg-fact/5000/5553.html   (850 words)

  
 Translational upregulation of folate receptors is mediated by homocysteine via RNA-heterogeneous nuclear ...
Folates are critical for the perpetuation of one-carbon metabolism
Henderson, G.B., Tsuji, J.M., and Kumar, H.P. Mediated uptake of folate by a high-affinity binding protein in sublines of L1210 cells adapted to nanomolar concentrations of folate.
Expression of folate receptors and heterogeneous nuclear ribonucleoprotein-E1 in women with human papillomavirus-mediated transformation of cervical tissue to cancer.
www.jci.org /cgi/content/full/113/2/285   (9324 words)

  
 Folate Synthesis and Metabolism in Plants and Prospects For Biofortification -- Basset et al. 45 (2): 449 -- Crop ...
Folate Synthesis and Metabolism in Plants and Prospects For Biofortification -- Basset et al.
Folate Synthesis and Metabolism in Plants and Prospects For Biofortification
Folates are essential cofactors for one-carbon transfer reactions
crop.scijournals.org /cgi/content/abstract/45/2/449   (236 words)

  
 Membrane and tissue distribution of folate binding protein in pig -- Villanueva et al. 275 (5): 1503 -- AJP - ...
Membrane and tissue distribution of folate binding protein in pig -- Villanueva et al.
Folate binding protein may participate in folate homeostasis by regulating monoglutamyl folate transport across relevant cell
Folate binding protein transcripts were present in threefold greater
ajpregu.physiology.org /cgi/content/abstract/275/5/R1503   (224 words)

  
 Folate: A Key to Optimizing Health and Reducing Disease Risk in the Elderly -- Rampersaud et al. 22 (1): 1 -- Journal ...
Folate serves as a coenzyme in the remethylation of homocysteine
Kwasniewska A, Tukendorf A, Semczuk M: Folate deficiency and cervical intraepithelial neoplasia.Eur J Gynaec Oncol18 :526 –530,1997.
Lindenbaum J, Healton EB, Savage DG, Brust JCM, Garrett TJ, Podell ER, Marcell PD, Stabler SP, Allen RH: Neuropsychiatric disorders caused by cobalamin deficiency in the absence of anemia or macrocytosis.N Engl J Med318 :1720 –1728,1988.
www.jacn.org /cgi/content/full/22/1/1   (5235 words)

  
 Differential Expression of Folate Receptor in Pituitary Adenomas -- Evans et al. 63 (14): 4218 -- Cancer Research
to tumors by facilitating the acquisition of folate is unclear.
Orr R. B., Kreisler A. R., Kamen B. Similarity of folate receptor expression in UMSCC 38 cells to squamous cell carcinoma differentiation markers.
Antony A. The biological chemistry of folate receptors.
cancerres.aacrjournals.org /cgi/content/full/63/14/4218   (5773 words)

  
 JAMA -- Abstract: Folate Intake and the Risk of Incident Hypertension Among US Women, January 19, 2005, Forman et al. ...
JAMA -- Abstract: Folate Intake and the Risk of Incident Hypertension Among US Women, January 19, 2005, Forman et al.
folate intake of 400 µg/d or more was not significantly
Conclusion  Higher total folate intake was associated with
jama.ama-assn.org /cgi/content/abstract/293/3/320   (360 words)

  
 Folate: A Key to Optimizing Health and Reducing Disease Risk in the Elderly -- Rampersaud et al. 22 (1): 1 -- Journal ...
Folate: A Key to Optimizing Health and Reducing Disease Risk in the Elderly -- Rampersaud et al.
Folate: A Key to Optimizing Health and Reducing Disease Risk in the Elderly
Inadequate folate status is associated with an increased risk
www.jacn.org /cgi/content/abstract/22/1/1   (349 words)

  
 Reduced folate transport to the CNS in female Rett patients -- Ramaekers et al. 61 (4): 506 -- Neurology
Reduced folate transport to the CNS in female Rett patients -- Ramaekers et al.
Reduced folate transport to the CNS in female Rett patients
folate binding capacity of FBP is not explained by a defect
www.neurology.org /cgi/content/abstract/61/4/506   (497 words)

  
 Large doses of folate might help keep high blood pressure under control
Folic acid is one of the more essential B vitamins, especially for women of childbearing age, and a little bit--100 micrograms a day--goes a long way toward preventing spina bifida and other birth defects.
The report, part of the ongoing Nurses' Health Study, tracked the folate intake of nearly 94,000 women ages 27 to 44 over eight years and found that those who consumed at least 1,000 micrograms a day had a 46% lower risk of high blood pressure than women who took less than 200 a day.
But since 65 million Americans suffer from high blood pressure, and there isn't any known downside to taking folate, it might not be a bad idea for all adults to take the current recommended dose of 400 micrograms a day.
www.newstarget.com /004127.html   (1248 words)

  
 Role of Folate in Colon Cancer Development and Progression -- Kim 133 (11): 3731 -- Journal of Nutrition   (Site not responding. Last check: 2007-10-08)
Folate, a water-soluble B vitamin and important cofactor in
dietary folate intake compared with those with the lowest intake.
Dietary Folate Intake and Incidence of Ovarian Cancer: The Swedish Mammography Cohort
nutrition.org /cgi/content/abstract/133/11/3731S   (429 words)

  
 Nat'l Academies Press: (DRI) Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin ...
For each nutrient the book presents what is known about how the nutrient functions in the human body, what the best method is to determine its requirements, which factors (caffeine or exercise, for example) may affect how it works, and how the nutrient may be related to chronic disease.
This volume of the series presents information about thiamin, riboflavin, niacin, vitamin B6, folate, vitamin B12, pantothenic acid, biotin, and choline.
Based on analysis of nutrient metabolism in humans and data on intakes in the U.S. population, the committee recommends intakes for each age group--from the first days of life through childhood, sexual maturity, midlife, and the later years.
www.nap.edu /catalog/6015.html   (504 words)

  
 Holistic Health Encyclopedia - R   (Site not responding. Last check: 2007-10-08)
Rose hips are one of the most natural and abundant sources of vitamin C. Once the petals have fallen off a rose all that remains attached to the stem is the rose hip, also known as the dried fruit of the rose.
Besides being a major supplier of vitamin C, rose hips also contain vitamin E, vitamin K, riboflavin, and folate.
Rose hips help the body defend itself against infections, especially colds and flus, by stimulating the immune system.
www.findhealer.com /glossary/R.php3   (2578 words)

  
 ConsumerLab.com - B Vitamins (including Thiamin, Niacin, B-6, B-12, Riboflavin and Folate) review
Just click SUBSCRIBE or, if you already are a subscriber, LOG-IN now.
Listed below are just 26 of the 42 supplements covered in the full, 12-page report.
To view this article in its entirety, including the names of the products that failed testing and those that passed testing, please click below on the "Log In" button if you are already a subscriber or the "Subscribe" button to learn how to subscribe.
www.consumerlab.com /results/vitaminb.asp   (1003 words)

  
 AllRefer Health - Folic Acid (Folate) (Diet - Folic Acid, Folate, Pteroylglutamic Acid, Vitamin B9)
AllRefer Health - Folic Acid (Folate) (Diet - Folic Acid, Folate, Pteroylglutamic Acid, Vitamin B9)
You are here : AllRefer.com > Health > Diet and Nutrition > Folic Acid (Folate)
Alternate Names : Diet - Folic Acid, Folate, Pteroylglutamic Acid, Vitamin B9 Definition
health.allrefer.com /health/folic-acid-folate-info.html   (398 words)

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