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Topic: Folinic acid

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	Folinic acid - Wikipedia, the free encyclopedia
		Folinic acid is a 5-formyl derivative of tetrahydrofolic acid.
		In this case, folinic acid is not used for "rescue" purposes; rather, it enhances the effect of 5-fluorouracil on inhibiting thymidylate synthase.
		Folinic acid is also sometimes used to prevent toxic effects of high doses of antimicrobial dihydrofolate reductase inhibitors such as trimethoprim and pyrimethamine.
	en.wikipedia.org /wiki/Folinic_acid (275 words)

	Aidsmap \| Folinic acid (Site not responding. Last check: 2007-11-03)
		Folinic acid is an approved drug used to protect against the side-effects of folate antagonist drugs such as trimetrexate.
		Folinic acid needs to be continued for 72 hours after the last dose of trimetrexate to ensure adequate protection.
		Folinic acid may also be prescribed for people who are taking other drugs that can interfere with folate metabolism, such as intravenous co-trimoxazole.
	www.aidsmap.com /en/docs/FC48BD30-8673-432B-8480-46FDC2FFCE72.asp (180 words)

	MedlinePlus Herbs and Supplements: Folate (folic acid)
		Folic acid supplementation in doses higher than 0.8mg (800mcg) daily is categorized as FDA Pregnancy Category C. Breastfeeding: Folic acid is present in the breast milk and is likely safe to use during breastfeeding under the supervision of a qualified healthcare provider.
		Folinic acid may be used as an alternative to folic acid when indicated.
		The efficacy of folic acid and folinic acid in reducing methotrexate gastrointestinal toxicity in rheumatoid arthritis.
	www.nlm.nih.gov /medlineplus/druginfo/natural/patient-folate.html (5874 words)

	FOLINIC ACID
		Folinic acid is a B vitamin that is used to decrease the harmful effects of different drugs, such as pyrimethamine (Daraprim®) or trimetrexate (Neutrexin®). It is also used to treat certain types of anemias and cancers.
		Folinic acid comes as a 5 mg tablet that can be taken with or without food. It is also available as an injection for intravenous (through your veins) or intramuscular (through a muscle in an arm or buttock) administration.
		Folinic acid tablets should be stored in a cool (15-30°C) dry place, protected from light and well out of the reach of children.
	www.tthhivclinic.com /FactSheets/html/FOLINIC_ACID.html (456 words)

	Folate
		Folinic acid, also known as leucovorin, citrovorum factor and 5-formyltetrahydrofolate, is used as rescue therapy following high-dose methotrexate in the treatment of osteosarcoma.
		For example, 400 micrograms of folic acid taken on an empty stomach is equivalent to 470 micrograms of folic acid taken with food and is equivalent to 800 micrograms of food folate.
		Folic acid is indicated for the prevention of some birth defects and appears, as well, to confer significant protection against cardiovascular disease and some forms of cancer.
	www.pdrhealth.com /drug_info/nmdrugprofiles/nutsupdrugs/fol_0110.shtml (6413 words)

	Folinic Acid/Trimethylglcyine - Transdermal Cream (Site not responding. Last check: 2007-11-03)
		Transdermal Folinic Acid and Trimethylglycine Transdermal Cream is an interesting combination of two substances that have two completely different functions; however, the combination is formidable because of the co-dependency of their biochemistries.
		Folinic acid is a natural form of the folates found in foods, while folic acid is actually a synthetic form of the folates.
		Folinic acid also aids in the synthesis of the body’s genetic material and chromosomes, the DNA and the RNA, proteins, and in the appropriate functioning of iron in the body.
	www.springboard4health.com /store/more_hpl_folinic.html (985 words)

	Supplement News Blog — Folinic Acid: Adjunct Treatment for Colon Cancer? (Site not responding. Last check: 2007-11-03)
		Folinic acid is the active form of folate.
		Published in the August issue of Annals of Surgery, an investigative study assessed the efficacy of folinic acid or interferon alpha to modulate the toxicity of 5-flourouracil and levamisole for 12 months.
		Based on this research, folinic acid is a beneficial adjunctive treatment to chemopreventative therapy for colon cancer.
	www.supplementnews.org /blog/0603folinic_acid_adjunct_treatment.html (371 words)

	Refolinon
		Folinic acid is a derivative of tetrahydrofolic acid, so it is used to correct the deficiency.
		Folinic acid is a derivative of tetrahydrofolic acid and is usually given 24 hours after the methotrexate.
		Folinic acid tablets and injection (as calcium folinate) are also available without a brand name, ie as the generic medicine.
	www.netdoctor.co.uk /medicines/100003443.html (904 words)

	theSimonClinic - Psychiatry Without Drugs
		This is because ordinarily dietary folic acid must undergo a series of complicated vitamin and energy-dependent changes in the body from the intestine to the liver before it becomes activated to its coenzyme form methylfolate.
		Folinic acid available supplementally as oral calcium folinate skips this inefficient transport and streamlining of dietary folates and supplies a ready-made precursor to the brain where it is lacking for a no-nonsense conversion to the coenzyme form methylfolate.
		All this makes folinic acid a welcome addition to any psychiatrists tool box because its judicious use as an adjunct to drug therapies will directly increase levels of folate coenzyme where it is lacking and improve the outlook for those where it isn't.
	www.psychiatrywithoutdrugs.co.uk /folinic.htm (482 words)

	Folinic Acid, Leucovorin, Calcium Leucovorin, Citrovorum Factor Chemotherapy Drugs
		Folinic Acid is used in combination with other chemotherapy drugs to either enhance effectiveness, or as a "chemoprotectant." (For more detail, see "How this drug works" section below).
		Leucovorin is a compound similar to folic acid, which is a necessary vitamin.
		Methotrexate exerts its chemotherapeutic effect by being able to counteract and compete with folic acid in cancer cells resulting in folic acid deficiency in the cells and causing their death.
	www.chemocare.com /bio/folinic_acid.asp (880 words)

	Folinic Acid
		Folic acid undergoes a series of complicated vitamin and energy-dependent changes in your body, between your intestine and liver, before it is converted to its active form, methylfolate.
		Folinic acid, available supplementally as oral calcium folinate, supplies a ready-made precursor to areas of the brain where it is lacking, for rapid conversion to methylfolate.
		Folinic acid's antidepressant effect is due to its ability to regenerate a brain chemical called SAMe.
	www.thehealthierlife.co.uk /article/2844/folinic-acid.html (819 words)

	BodyBio - Folinic Acid
		Folinic acid, also known as 5-formyl tetrahydrofolate, is one active form in a group of vitamins known as folates.
		In contrast to folic acid, a synthetic form of folate, folinic acid is one of the forms of folate found naturally in foods.
		Folate deficiency is believed to be the most common vitamin deficiency in the world due to food processing, food selection, and intestinal disorders.
	www.bodybio.com /main/products/folinicacid.htm (65 words)

	Folic Acid
		It is not surprising that a folic acid deficiency has been implicated in a wide variety of disorders from Alzheimer's disease to atherosclerosis, heart attack, stroke, osteoporosis, cervical and colon cancer, depression, dementia, cleft lip and palate, hearing loss, and of course, neural tube defects.
		Folic acid supplementation is known to lower homocysteine levels and laws have recently been passed in the United States mandating folic acid fortification of bread and cereal.
		An inadequate intake of folic acid is firmly associated with an increased risk of vascular disease and, among women of childbearing age, with a significantly heightened risk of giving birth to a baby with neural tube defects.
	vvv.com /healthnews/folate.html (15573 words)

	Nutritional Wonders
		Folinic acid, also known as 5-formyl tetrahydrofolate, is an active form of a group of vitamins known as folates.
		In the body folinic acid may be converted into any of the other active forms of folate.
		When taking these drugs (and others as well) it is recommended that you take 800 mcg daily of folate, preferably as folinic acid.
	www.nutriwonders.com /Folinic.shtml (361 words)

	Product Abstract: Folic Acid
		Folic acid supplements in the range of 1 to 2 mg per day are generally innocuous, and usually are sufficient to reduce or normalize high homocysteine levels, even if the elevation is not due to inadequate folic acid supplementation.
		At present, 3 approaches to supplementation with folic acid exist: (i) consumption of a diet that is rich in folate and other vitamins; (ii) periconceptional supplementation; and (iii) fortification of food to ensure appropriate folic acid consumption for all women of childbearing age who are capable of becoming pregnant.
		Causes of mild increases in plasma homocysteine are usually dietetic deficiencies in folic acid, vitamin B6 or B12, or genetic by mutation of the methylene-tetrahydrofolate reductase.
	www.lef.org /prod_hp/abstracts/php-ab396.html (7425 words)

	Folate (folic acid) - MayoClinic.com
		Folic acid is well-tolerated in amounts found in fortified foods and supplements, in doses less than 1,000 micrograms per day.
		Doses of at least 400 micrograms folic acid per day from supplements or fortified food should be taken by women planning to become pregnant and continued through the first month of pregnancy.
		Folic acid supplementation in doses higher than 0.8 milligrams (800 micrograms) daily is categorized as FDA Pregnancy Category C. Based on human study, folic acid appears safe to use in pregnant women in a dose of 500-1,500 micrograms per day without lessening the protective effects of sulfadoxine/pyrimethamine as an intermittent preventative treatment for malaria.
	www.mayoclinic.com /health/folate/NS_patient-folate (3200 words)

	Folic acid and folinic acid for reducing side effects in patients receiving methotrexate for rheumatoid arthritis
		To assess the effects of folic acid and folinic acid in reducing the mucosal and gastrointestinal (GI) and haematologic side effects of low-dose of Methotrexate (MTX) in patients with Rheumatoid Arthritis (RA) and to determine whether or not folate supplementation alters MTX efficacy.
		No consistent differences in disease activity parameters were observed when comparing placebo and folic or folinic acid at low or high doses, although patients on high dose folinic acid had an increase in the number of tender joints, but not swollen joints.
		Therefore, for folinic acid to be considered cost-effective it must be found more effective than folic acid at reducing MTX side effects.
	www.cochrane.org /reviews/en/ab000951.html (640 words)

	Folic acid - Wikipedia, the free encyclopedia
		Folic acid and folate (the anion form) are forms of a water-soluble B vitamin.
		10.4 Folic acid and methotrexate for non-cancerous diseases
		Folinic acid is a form of folate that can help "rescue" or reverse the toxic effects of methotrexate.
	en.wikipedia.org /wiki/Folic_acid (3382 words)

	CiteULike: Effect of folic and folinic acid on cytopenia occurring during co-trimoxazole treatment of Pneumocystis ... (Site not responding. Last check: 2007-11-03)
		CiteULike: Effect of folic and folinic acid on cytopenia occurring during co-trimoxazole treatment of Pneumocystis carinii pneumonia.
		Effect of folic and folinic acid on cytopenia occurring during co-trimoxazole treatment of Pneumocystis carinii pneumonia.
		Folic acid is cheap and may be beneficial and should be prescribed.
	www.citeulike.org /user/blink/article/490067 (219 words)

	BioMed Central \| Full text \| Weekly oxaliplatin, 5-fluorouracil and folinic acid (OXALF) as first-line chemotherapy for ...
		The primary end point of this study was to determine the response rate and the toxicity of the weekly oxaliplatin, 5-fluorouracil and folinic acid (OXALF) regimen in elderly patients with advanced gastric cancer.
		We investigated in the present phase II study a weekly protocol with oxaliplatin, fluorouracil and folinic acid for treating elderly patients with advanced gastric cancer.
		More recently, Graziano et al [4] have reported the results of a phase II trial investigating the weekly combination of cisplatin, 5-fluorouracil and folinic acid (PLF) in a population advanced gastric cancer patients who were older than 65 year.
	www.biomedcentral.com /1471-2407/6/125 (3855 words)

	Folic or Folinic Acid Supplementation Reduces the Liver Toxicity of Mehotrexate Arthritis News Summary from Johns ... (Site not responding. Last check: 2007-11-03)
		Methotrexate is a folate antagonist and supplementation of MTX–treated patients with folate or folinic acid is believed to reduce MTX–associated toxicities.
		Patients who were naïve to MTX were begun on MTX 7.5 mg/wk and were randomized to folate 1 mg/day OR folinic acid 2.5 mg/wk OR placebo.
		Mean dosages of MTX at the end of the study were lower in the placebo group (14.5 mg/wk) than in the folic and folinic acid groups (18.0 and 16.4 mg/wk, respectively).
	www.hopkins-arthritis.som.jhmi.edu /news-archive/2001/folicacid.html (601 words)

	Reversal of hyperhomocyst(e)inaemia in chronic renal failure--is folic or folinic acid the answer? -- Massy 14 (12): ...
		Folic acid is a complex mixture of polyglutamate conjugate compounds
		folic acid is an indirect argument in favour of this hypothesis.
		Sustained reduction of hyperhomocysteinemia with folic acid in predialysis patients.
	ndt.oxfordjournals.org /cgi/content/full/14/12/2810 (1437 words)

	Hyperhomocysteinaemia therapy in haemodialysis patients: folinic versus folic acid in combination with vitamin B6 and ...
		Hyperhomocysteinaemia therapy in haemodialysis patients: folinic versus folic acid in combination with vitamin B6 and B12 -- Ducloux et al.
		-folinic acid versus folic acid for the treatment of hyperhomocysteinemia in hemodialysis patients.
		Efficacy of folinic versus folic acid for the correction of hyperhomocysteinemia in hemodialysis patients.
	ndt.oxfordjournals.org /cgi/content/full/17/5/865 (2502 words)

	Lederfolin
		Folinic acid injection can be used to reduce the side effects from high doses of the anticancer medicine methotrexate.
		It can also be used in combination with the anticancer medicine fluorouracil (5-FU), as it has been shown to boost the response rate to this anticancer medicine.
		Folinic acid is used in combination with 5-FU to increase the amount of tetrahydrofolate inside the cells and therefore boost the effect of the 5-FU.
	www.netdoctor.co.uk /medicines/100004925.html (847 words)

	Folixor: 1 and 5 mg Sublingual folic and folinic acid with B12, B6
		Folic Acid is B Vitamin and functions in a fashion similar to that of Vitamin B12.
		Folic Acid supplementation is essential for all women of child bearing age and individuals at risk for cardiovascular disease.
		Folic Acid may have additional applications for: women, cognition, oral hygiene.
	www.intensivenutrition.com /folixor.htm (376 words)

	Folic M: Folic and folinic acid with zinc for male fertility
		Folic M: Folic and folinic acid with zinc for male fertility
		This folic acid formula is especially designed for men and may help with family planning.
		Men who are concerned about their folic acid intake should consider FolicM®.
	www.intensivenutrition.com /folicm.htm (355 words)

	ASCO-GI: Radiation Therapy Plus Irinotecan, 5-Fluorouracil, and Folinic Acid Feasible, Effective in Advanced Rectal ...
		"In the adjuvant setting of high-risk rectal cancer, weekly irinotecan, 5-fluorouracil (5-FU), and folinic acid with concurrent pelvic radiation therapy is feasible and effective," said Nikolaos Ziras, MD, medical oncologist, Metaxa Memorial Cancer Hospital, Piraeus, Greece in his poster presentation.
		Of the 24 patients in the study, there was a 16.7% relapse rate -- 2 patients developed liver metastases and 2 patients experienced local recurrence of cancer.
		He said the chemoradiation treatment was associated with mild myelosuppression and mild to moderate gastrointestinal toxicity.
	www.docguide.com /dg.nsf/PrintPrint/4C79F341AD3FFDDD85256F9A0016A92C (600 words)

	Healthopedia.com Drugs Information - Leucovorin (Wellcovorin, citrovorum factor, folinic acid)
		Leucovorin (loo-koe-VOR-in) is used as an antidote to the harmful effects of methotrexate (a cancer medicine) that is given in high doses.
		Leucovorin acts the same way in the body as folic acid, which may be low in these patients.
		Other commonly used names are citrovorum factor and folinic acid.
	www.healthopedia.com /drugs/detailed/leucovorin (313 words)

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