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Topic: Follicular lymphoma

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	UW Cytogenetic Services: Cancer: Lymphoma (Site not responding. Last check: 2007-10-13)
		Follicular lymphoma is a relatively common B-cell lymphoma composed of varying numbers of small-cleaved and large cells from follicle centers and occurs mainly in adults.
		A follicular lymphoma composed mainly of small cleaved cells is a low grade lymphoma and the leukemic form has been referred to as lymphosarcoma.
		Follicular lymphoma composed mainly of large cells is of intermediate grade.
	www.slh.wisc.edu /cytogenetics/cancer/lymphoma.php (411 words)

	[No title]
		Follicular lymphoma cells are characterized by how they look under the microscope; most cases are associated with a specific abnormality in the cell's DNA.
		In the case of follicular lymphoma, genetic material from chromosome 14 is moved to chromosome 18, which is called a translocation (t14:18).
		Lymphoma stage: In addition to the classifying follicular NHL by the cells involved, it is important that the stage of disease be determined.
	patient.cancerconsultants.com /nhl_cancer_treatment.aspx?id=849 (911 words)

	Pathology
		Malignant lymphomas (ML) are cohesive malignant proliferations of lymphocytes arising in lymph nodes and in lymphoid tissue of various organs (extranodal).
		In lymphoma, normal lymph node architecture is distorted or effaced by the proliferating malignant lymphoid cells.
		The physical presence of disease and the presence or absence of symptoms are the measures for the respective pathologic and clinical staging of lymphoma.
	www.med-ed.virginia.edu /courses/path/innes/wcd/lymphoma.cfm (974 words)

	UpToDate Patient information: Follicular lymphoma
		Follicular lymphoma is slightly more likely to be diagnosed in women than men, and is less commonly found in persons of Asian and fl ethnicity.
		— The diagnosis of follicular lymphoma is confirmed by removing all or part of an enlarged lymph node to examine its cells under a microscope, a procedure known as a biopsy.
		Although this is similar to the lower grades of lymphoma, the symptoms and growth pattern of follicular large cell lymphoma is similar to that seen in patients with diffuse large B-cell lymphoma.
	patients.uptodate.com /topic.asp?file=blod_dis/7201 (2652 words)

	Non-Hodgkin's Lymphoma - Types - oncologychannel
		Follicular lymphoma represents 70% of all the low-grade B-cell lymphomas.
		Mantle cell lymphoma is a tumor of the mantle cells that surround the germinal (reproducing) centers of the lymph nodes.
		Mantle cell lymphoma occurs Primarily in men (approximately 75%), and with an average patient age of 63, it rarely is seen in young patients.
	www.oncologychannel.com /nonhodgkins/types.shtml (1934 words)

	eMedicine - Lymphoma, Follicular : Article by César O Freytes, MD, FACP
		Microscopically, follicular lymphomas exhibit a follicular or nodular pattern of growth reminiscent of germinal centers.
		Despite the fact that most follicular lymphomas are advanced at the time of diagnosis, the median survival of patients with follicular lymphomas is approximately 8-10 years, and many patients may not require treatment for prolonged periods of time.
		Lymphomas cause detrimental effects by organ invasion and by obstruction of anatomical structures by a tumoral mass.
	www.emedicine.com /med/topic1362.htm (5851 words)

	Lymphoma Information Network - Follicular Lymphomas
		Follicular lymphomas (or more formally speaking, follicular center cell lymphomas with a follicular growth pattern) are one of the more common non-Hodgkin's lymphomas in North America.
		These lymphomas are the only intermediate grade follicular lymphomas - they are classified as indolent but their aggressive nature is noted by NCI.
		Large-cell follicular lymphoma is classified as an intermediate-grade lymphoma, and the patients may benefit from the inclusion of an anthracycline in their chemotherapy.
	www.lymphomainfo.net /nhl/follicular.html (737 words)

	Primary Cutaneous Follicular Center Cell Lymphoma
		Cases of primary cutaneous follicular lymphoma were characterized by the expression of classic markers of the germinal center, such as bcl6, CD10, and the presence of aggregates of follicular dendritic cells.
		Primary cutaneous B-cell lymphomas displaying a prominent follicular growth pattern are rare and remain poorly defined, particularly in terms of the frequency of detection of t(14;18) and whether or not, as a group, they represent an entity distinct from follicular lymphoma arising in lymph nodes.
		The morphologic, immunophenotypic, and clinical features of 16 cases of primary cutaneous follicular lymphoma, identified during a review of all PCBCL in the Scotland and Newcastle Lymphoma Group database, were studied and the number of cases harboring t(14;18) assessed by polymerase chain reaction using primers to the major breakpoint cluster region.
	www.thedoctorsdoctor.com /diseases/cbcl_fccl.htm (6239 words)

	New Non-Hodgkin's Lymphoma Drug Passes Hurdle
		Follicular lymphoma is the second most common form of non-Hodgkin's lymphoma and accounts for more than 20% of all cases.
		Follicular lymphoma is cancer of the lymph nodes, which are an important part of the immune system, the body's natural defense system against infection.
		The drug was approved by the FDA in 2003 for the treatment of follicular, non-Hodgkin's lymphoma in patients who have not responded to initial therapy with the drug Rituxan and who have relapsed following chemotherapy.
	www.webmd.com /content/article/100/105581 (260 words)

	Center News - 10/19/06 - Press Lab increases follicular lymphoma survival rates
		Patients in the study, with previously untreated, advanced-stage follicular lymphoma, showed a 23 percent increase in survival over patients treated with traditional chemotherapy alone.
		Every year, about 15,000 Americans are affected by follicular lymphoma, a slow-growing but determined cancer with a median survival rate of seven to 10 years after diagnosis.
		Follicular lymphoma is a type of non-Hodgkin's lymphoma, or cancer of the immune system, that affects B-cells, a type of white blood cell involved in the body's immune system.
	www.fhcrc.org /about/pubs/center_news/2006/oct19/art2.html (723 words)

	Follicular lymphoma - Wikipedia, the free encyclopedia
		Follicular lymphoma (FL) is the most common of the indolent non-Hodgkin's lymphomas.
		It is defined as a lymphoma of follicle center B-cells (centrocytes and centroblasts), which has at least a partially follicular pattern.
		The tumor is composed of follicle center cells, usually a mixture of centrocytes (cleaved follicle center cells, "small cells") and centroblasts (large noncleaved follicle center cells, "large cells").
	en.wikipedia.org /wiki/Follicular_lymphoma (284 words)

	eMedicine - Lymphoma, B-Cell : Article by Ajeet Gajra, MD
		Increased incidence of GI lymphomas is observed in patients with celiac sprue and inflammatory bowel disease.
		Follicular lymphoma is by far the most common of the indolent NHLs and represents almost 25% of all new cases of NHL; therefore, the treatment of follicular lymphoma serves as a paradigm for this group of diseases.
		Follicular lymphoma can be graded according to the percentage of blasts (grade I-III); follicular lymphoma grade III has a more aggressive course and is often treated similarly to diffuse large B-cell lymphoma.
	www.emedicine.com /med/topic1358.htm (10945 words)

	Primary follicular lymphoma of the testis in childhood: an entity with peculiar clinical and molecular characteristics ...
		Primary follicular lymphoma of the testis in childhood: an entity with peculiar clinical and molecular characteristics -- Pileri et al.
		Primary follicular lymphoma of the testis in childhood: an entity with peculiar clinical and molecular characteristics
		Primary follicular lymphoma of the testis in childhood.
	jcp.bmj.com /cgi/content/full/55/9/684 (2772 words)

	Can you tell me more about follicular lymphoma? : Cancerbackup (Site not responding. Last check: 2007-10-13)
		Follicular lymphoma is the second commonest form of NHL, accounting for about 40% of all cases.
		Sometimes the lymphoma only affects one or two groups of lymph glands in one part of the body but often glands in several different areas are involved.
		Sometimes the lymphoma cells may spread to involve various organs in the body, such as the bone marrow, liver or lungs, or the skin.
	www.cancerbackup.org.uk /QAs/Search/747 (734 words)

	ScienceDaily: NCI Scientists Create Model That Predicts Follicular Lymphoma Survival
		Lymphoma -- Lymphoma is a variety of cancer that originates in lymphocytes or, more rarely, of histiocytes.
		Hodgkin's lymphoma -- Hodgkin's lymphoma, formerly known as Hodgkin's disease, is a type of lymphoma first described by Thomas Hodgkin in 1832.
		Hodgkin's lymphoma is characterized clinically by the orderly spread of...
	www.sciencedaily.com /releases/2004/11/041118112802.htm (2038 words)

	Lymphoma Information Network - The Lymphoma Blog
		For older patients with follicular lymphoma, the addition of Rituxan (rituximab, MabThera) to standard CHOP chemotherapy boosted overall response rates, prolonged time to treatment failure, and improved overall survival, German researchers said at the ASH conference.
		Follicular lymphoma is an indolent lymphoma with an incidence that rises sharply with age, Dr. Buske noted.
		As expected, there is a number of significant lymphoma related releases coming from the American Society of Hematology (ASH) meeting in Florida this weekend.
	www.lymphomainfo.net /blog/index.cgi (944 words)

	lymphoma's Xanga Site
		The lymphoma is usually made up of T-lymphocytes, although in some cases the type of cell making up the lymphoma is unclear: this is known as null-cell type.
		The 'stage' of non-Hodgkin's lymphoma means how many groups of lymph nodes are affected, where they are in the body and whether other organs such as the bone marrow or liver are involved.
		Lymphoma is present in lymph nodes in both the upper and lower parts of the body (i.e.
	www.xanga.com /lymphoma (1790 words)

	Blood Test May Reveal Lymphoma Dangers
		But the survival time of people with follicular lymphoma varies greatly and may range from one year to more than 20 years after the cancer is diagnosed.
		The study showed that these genetic signatures accurately estimated follicular lymphoma survival times regardless of other traditional variables, such as the progression of the tumor.
		In addition, the results suggest that the aggressiveness of the follicular lymphoma is mainly determined by the environment in which the tumor occurs, rather than genetic differences within the tumor itself.
	www.webmd.com /content/article/97/104070.htm (451 words)

	Limited-Stage Follicular Lymphoma Might Be Curable: Presented at ICML
		Although radiotherapy is a widely accepted treatment for limited-stage follicular lymphoma, it has not been determined whether patients can be cured with this therapy.
		Of the 1455 patients identified with follicular lymphoma, 191 (median age, 63 years; range, 29-89 years; 46% male) had limited-stage disease that was treated with radiotherapy alone.
		The limited-stage definition for follicular lymphoma involved the clinical stages of IA or IIA, and a non-bulky lymphoma (< 10 cm) with fewer than 3 contiguous lymph node regions involved.
	www.docguide.com /dg.nsf/PrintPrint/CB189143A74EA81E8525701F005DB666 (630 words)

	Follicular Lymphoma Survival Model, November 18, 2004 Press Release - National Institutes of Health (NIH)
		Scientists at the National Cancer Institute (NCI), part of the National Institutes of Health, have created a model that predicts the survival of follicular lymphoma patients based on the molecular characteristics of their tumors at diagnosis.
		The model is based on two sets of genes — called survival-associated signatures — whose activity was found to be associated with good or poor prognosis for patients with the cancer.
		The scientists' results, to be published in the November 19, 2004, New England Journal of Medicine , suggest that immune cells infiltrating follicular* lymphoma tumors have an important impact on survival — both signatures came from such immune cells.
	www.nih.gov /news/pr/nov2004/nci-18.htm (763 words)

	Lymphoma - Wikipedia, the free encyclopedia
		Lymphoma is a variety of cancer that originates in lymphocytes or, more rarely, of histiocytes.
		Lymphomas are part of the broad group of diseases called hematological neoplasms.
		Traditionally, Lymphoma is classified as Hodgkin's lymphoma, discovered by Thomas Hodgkin in 1832, and non-Hodgkin's lymphoma (all other types of lymphoma).
	en.wikipedia.org /wiki/Lymphoma (686 words)

	FOLLICULAR LYMPHOMA (Site not responding. Last check: 2007-10-13)
		The t(14;18)(q32;q21) translocation characterizes approximately 60% of B-cell non-Hodgkins Lymphoma.
		It is seen in 85% of the indolent follicular lymphomas (FL) and 25% of diffuse aggressive large cell lymphomas (DLCL).
		It results in the juxtaposition of the BCL2 gene on chromosome 18 with the immunoglobulin heavy chain (IGH) gene on chromosome 14 resulting in overexpression of BCL2 and neoplastic proliferation of B-cells.
	cancergenetics.com /follicular.html (1301 words)

	Follicular lymphoma (FL)
		The lymphoma is composed of a mixture of centrocytes and centroblasts with a follicular and diffuse pattern.
		Lymphoma grading by the number of large cells/centroblasts is recommended: three grades are recognized with incresing number of centroblasts.
		Follicular lymphoma with a burkitt translocation--predictor of an aggressive clinical course: a case report and review of the literature.
	atlasgeneticsoncology.org /Anomalies/FollLymphomID2075.html (1181 words)

	UpToDate Clinical and pathologic features of follicular lymphoma
		The infiltrate in follicular lymphoma (FL) morphologically recapitulates normal germinal centers (GC) of secondary lymphoid follicles (show histology 2).
		The neoplastic follicles may be present throughout the tumor tissue, or only a portion, with a diffuse component occupying the rest of the tumor (show histology 3).
		Similar to normal GCs, T-cells and follicular dendritic cells are present in the malignant follicles; however, tingible body (debris-laden) macrophages are not typically observed [3].
	patients.uptodate.com /topic.asp?file=lymphoma/14191 (480 words)

	Follicular lymphoma
		While follicular lymphomas very often form outside of the lymph nodes, it is this follicular pattern of growth that gives it its name.
		Follicular lymphoma is a complicated type to discuss because it is a slow growing type of NHL which responds very well to treatment, but can rarely be cured.
		The reasoning behind this has always been that follicular lymphoma cannot be cured, and no matter what treatments you choose the life expectancy is the same.
	www.nhlcyberfamily.org /types/follicular.htm (892 words)

	Follicular Lymphoma Survival, Non-Hodgkins Lymphoma Cancer Treatment
		It's easy to find information about follicular lymphoma on the net and elsewhere, but the real challenge is to be able to understand it in becoming an informed, knowledgeable patient.
		Follicular lymphoma is a confusing and controversial disorder...often in the initial stages a benign-like condition, much different than what people may regard as "cancer".
		Although each case is different, the best chance for success comes from learning about follicular lymphoma, including treatments...what they can and cannot do...and combining that with the best in scientifically-based natural strategies targeted specifically to follicular lymphoma to help hold the lymphoma in check.
	www.lymphomasurvival.com (1169 words)

	Follicular lymphoma list
		CD5+ follicular lymphoma: a clinicopathologic study of three cases.
		CD2 is expressed by a subpopulation of normal B cells and is frequently present in mature B-cell neoplasms.
		Aberrant expression of T-cell-associated antigens on B-cell non-Hodgkin lymphomas.
	home.earthlink.net /~cfelten/fl_list.htm (120 words)

	BiovaxID™ Promising for Follicular Lymphoma
		NHL is categorized by the type of lymphocyte it involves and by the rate at which the cancer grows—both are determined by the cells’ appearance under a microscope.
		Follicular lymphoma is considered a low-grade or indolent lymphoma, which means that it is a slow-growing subset of NHL.
		Patients diagnosed with follicular lymphoma may wish to speak with their physician regarding their individual risks and benefits of participating in a clinical trial further evaluating BiovaxID or other novel therapeutic approaches.
	patient.cancerconsultants.com /news.aspx?id=35917 (505 words)

	Follicular Lymphoma International Prognostic Index -- Solal-Céligny et al. 104 (5): 1258 -- Blood
		Low-grade stage III-IV follicular lymphoma: multivariate analysis of prognostic factors in 484 patients: a study of the Groupe d'Etude des Lymphomes de l'Adulte.
		Prognosis of follicular lymphoma: a predictive model based on a retrospective analysis of 987 cases.
		Follicular lymphomas: assessment of prognostic factors in 127 patients followed for 10 years.
	www.bloodjournal.org /cgi/content/full/104/5/1258 (4210 words)

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