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Topic: Forskolin

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	Forskolin (Site not responding. Last check: 2007-08-17)
		Forskolin (7 beta-acetoxy-8, 13-epoxy-1 alpha,6 beta,9 alpha-trihydroxy-labd-14-ene-11-one) is the main active ingredient in the Ayurvedic herb Coleus forskohlii.
		Forskolin is an extract of an Ayurvedic herb that resensitizes cell receptors by activating the enzyme adenylcyclase and increasing the levels of cyclic AMP in cells.
		Forskolin relaxes the bronchial muscles and may dangerously increase the potency or action of certain asthma drugs, including albuterol, theophylline, and beclomethasone.
	www.greatvistachemicals.com /herb_extracts/forskolin.html (661 words)

	Forskolin : by Ray Sahelian, M.D., Coleus forskohli for sex, asthma, glaucoma, hypertension, forskolin
		Forskolin is a diterpene from the roots of the Indian plant Coleus forskohli which directly activates the adenylate cyclase and raises cyclic AMP levels in a variety of tissues.
		Forskolin is a widely used biochemical tool that activates adenyl cyclase, thereby increasing intracellular concentration of cAMP, and thus activating the PKA signal transduction pathway.
		Forskolin, a diterpene from the roots of an Indian plant, Coleus forskohlii, is a potent platelet aggregation inhibitor and has been examined for its effects on (a) tumor-induced human platelet aggregation and (b) pulmonary tumor colonization in mice.
	www.raysahelian.com /forskolin.html (2673 words)

	Supplement Update: Coleus Forskohlii
		Forskolin's basic mechanism of action is that it increases the amount of cyclic AMP (adenosine monophosphate) in cells by activating an enzyme called adenylate cyclase.
		Forskolin is actually patented by the Sabinsa corporation under US patent 5,804,596 for enhancing lean body mass which is what many athletes and weight trainers are trying to accomplish.
		Forskolin has been shown to be safe and effective and has a great amount of potential as a sports supplement.
	www.thinkmuscle.com /articles/jalali/forskolin.htm (526 words)

	Forskolin
		The decrease in PAF binding caused by forskolin was concomitant with a decrease in the physiological responses of platelets induced by PAF.
		Forskolin's ability to relax smooth muscle in bronchial asthma is most probably due to an increase in cAMP, although forskolin has other anti-allergic activities such as inhibiting the release of histamine and the synthesis of allergic compounds.
		Forskolin has also been shown to be a direct cerebral vasodialtor indicating that it may prove to be useful in cerebral bascular insufficiency and post-stroke recovery.
	www.netrition.com /forskolin_page.html (2557 words)

	:: ForsLean - Sabinsa Corporation ::
		Forskolin has also been shown to counteract the decreased response of fat cells to epinephrine, associated with aging.
		Forskolin is a known blood pressure lowering agent and is used in the management of hypertension, including ocular hypertension that leads to glaucoma4.
		Preliminary studies in humans have shown that forskolin increases the contractility of the heart muscle without increasing oxygen consumption and that it is a vasodilator4,8.
	www.forslean.com /Ephedrine.htm (791 words)

	Forskolin Supplement Profile
		Forskolin, along with a few select others (such as epinephrine), is the standard substance used in scientific studies when a lipolytic (fat burning) agent is needed (1-4).
		Lipolytic hormones such as epinephrine (adrenalin) activate adenylate cyclase as well, but forskolin does not have the same CNS effects, so it essentially bypasses the step that is associated with the unwanted side effects (nervousness, restlessness) we find with other fat loss agents that function by increasing lipolytic hormone levels.
		The typical dosage of forskolin is 25-60 mg per day divided between 2-3 doses, with 50-60 mg being the ideal range.
	www.1fast400.com /i6_Forskolin.html (973 words)

	Herbal Descriptions - Forskolin - Coleus forskohili (Site not responding. Last check: 2007-08-17)
		Forskolin is an important traditional Ayurvedic herb that has been a part of Indian medicine for centuries.
		The effects of Forskolin last for only a short period, and there are concerns that use may lead to possible cardiovascular complications.
		Forskolin would best be used under the supervision of a competent healthcare professional trained in its use.
	www.viable-herbal.com /herbdesc1/1forskol.htm (384 words)

	Brief Treatments with Forskolin Enhance S-Phase Entry in Balance Epithelia from the Ears of Rats -- Montcouquiol and ...
		The forskolin- and Br-cAMP-containing media were then replaced with a standard medium for the remainder of the 72 hr culture period.
		The forskolin was removed, and the pieces of epithelium were maintained in a standard medium containing KT5720 for 72 hr.
		Brief treatments with forskolin (15 min) or Br-cAMP (1 hr) could increase the density of RTK, such as ErbB receptors, inserted at the membrane surface, allowing the binding of GF such as GGF2.
	www.jneurosci.org /cgi/content/full/21/3/974 (6049 words)

	Forskolin Lowering High Cholesterol Levels Reducing Cardio Lower Reduce
		Forskolin may be helpful to control the underlying cause of glaucoma.
		The sometimes successful use of forskolin to reduce intraocular pressure may be due to its unique ability to stimulate adenylate cyclase activity and increase cyclic adenosine monophosphate (cAMP) which regulates and activates critical enzymes required for the cellular energy required to move fluid out of the eye.
		If you want to use forskolin to replace drugs that strengthen heart muscle contraction, extreme caution is also mandatory and physician cooperation essential.
	www.health-marketplace.com /Forskolin.htm (266 words)

	Forskolin-mediated G1 arrest in acute lymphoblastic leukaemia cells: phosphorylated pRB sequesters E2Fs -- Gützkow ... (Site not responding. Last check: 2007-08-17)
		Forskolin induces a transient inhibition of the cyclin-associated kinase activities.
		Effect of forskolin on the expression of G1 cyclin, CDK and CKI proteins.
		Effect of forskolin on the expression of p130 and p107.
	jcs.biologists.org /cgi/content/full/115/5/1073 (6358 words)

	cAMP-induced degradation of cyclin D3 through association with GSK-3{beta} -- Naderi et al. 117 (17): 3769 -- Journal ... (Site not responding. Last check: 2007-08-17)
		Forskolin was also found to induce degradation of cyclin D3 protein in normal human B lymphocytes (Fig.
		Cells were harvested at the indicated time points after addition of forskolin, lysates were prepared and equal amounts of protein were analyzed by immunoblotting with cyclin D3 and actin antibodies.
		Lower panel, the immunoblots were exposed, scanned and the intensity of the protein bands was quantified and plotted on a semi-log graph with the value obtained for cells not treated with cycloheximide set as 100%.
	jcs.biologists.org /cgi/content/full/117/17/3769 (9138 words)

	cAMP stimulates Na+ transport in rat fetal pneumocyte: involvement of a PTK- but not a PKA-dependent pathway -- Niisato ...
		Forskolin increased phosphorylation of tyrosine residues of ~70- to 80-, ~97-, and ~110- to 120-kDa proteins.
		TY23 was applied to rat FDLE cells 30 min before addition of forskolin and was also present in bathing solution after addition of forskolin.
		NPPB was applied to rat FDLE cells 5 min before addition of forskolin (5 µM) and was also present in bathing solution after addition of forskolin.
	ajplung.physiology.org /cgi/content/full/277/4/L727 (5480 words)

	cAMP-mediated Inhibition of DNA Replication and S Phase Progression: Involvement of Rb, p21Cip1, and PCNA -- Naderi et ...
		After synchronization, cells were treated with vehicle or forskolin for 2 or 4 h, and pulsed with BrdU for the final 30 min of treatment.
		After synchronization, cells were treated with vehicle or forskolin for 2 h and pulsed with BrdU for the final 30 min of treatment.
		Cells were released from Aph, cultured in drug-free medium in the absence or presence of 100 µM forskolin, and pulsed with BrdU for the final 30 min before harvesting at 2 h.
	www.molbiolcell.org /cgi/content/full/16/3/1527 (8529 words)

	Discount Health Supplements from DrugNatural.com: Forskolin Extract 60 cap
		Forskolin supports heart health and healthy blood pressure already within the normal range.
		By activating adenosin cyclase, cyclic adenosine monophosphate (cAMP) is increased in the cells.
		Forskolin Extract is analyzed and guaranteed to contain a minimum of 18% forskolin.
	www.drugnatural.com /p/157518 (245 words)

	Synergistic Regulation of Schwann Cell Proliferation by Heregulin and Forskolin -- Rahmatullah et al. 18 (11): 6245 -- ...
		Schwann cells were incubated for 24 h in serum-free medium and then stimulated with 2 µM forskolin (Fsk), 250 ng of heregulin peptide per ml, or heregulin plus 2 µM forskolin.
		Schwann cells were incubated for 24 h in serum-free medium and then stimulated with 2 µM forskolin (A), 250 ng of heregulin peptide per ml (B), or forskolin plus heregulin (C).
		by heregulin (in the absence of forskolin) was transient.
	mcb.asm.org /cgi/content/full/18/11/6245 (5108 words)

	Protein kinase-dependent and Ca2+-independent cAMP inhibition of ANP release in beating rabbit atria -- Cui et al. 282 ...
		4, inhibition by forskolin of myocytic ANP release
		Values are expressed as percent changes of the mean value of the 2 periods before the administration of forskolin or vehicle.
		Values are means of the last 2 periods after forskolin administration and also the corresponding periods for inhibitor-alone groups.
	ajpregu.physiology.org /cgi/content/full/282/5/R1477 (5444 words)

	PKA and PKC Enhance Excitatory Synaptic Transmission in Human Dentate Gyrus -- Chen and Roper 89 (5): 2482 -- Journal ...
		Addition of forskolin to the bath (dotted line) causes a gradual increase in mEPSC frequency over 20 min that then plateaus.
		Kamiya H, and Yamamoto C. Phorbol ester and forskolin suppress the presynaptic inhibitory action of group-II metabotropic glutamate receptor at rat hippocampal mossy fibre synapse.
		Forskolin: unique diterpene activator of adenylate cyclase in membranes and in intact cells.
	jn.physiology.org /cgi/content/full/89/5/2482 (5284 words)

	3',5'-Cyclic Adenosine Monophosphate Augments Intracellular Ca2+ Concentration and Gonadotropin-Releasing Hormone ...
		Forskolin was purchased from Wako Chemicals (Osaka, Japan).
		The cells were incubated with forskolin for 15 min at 37 C. Forskolin increased total cAMP levels in a concentration-dependent manner.
		Forskolin was applied for 5 min, as indicated by the horizontal bar.
	endo.endojournals.org /cgi/content/full/143/11/4210 (2880 words)

	Role of the Cyclic AMP Response Element Binding Complex and Activation of Mitogen-Activated Protein Kinases in ...
		Forskolin was purchased from Sigma (St. Louis, Mo.) and resuspended at a stock concentration of 1 mM in dimethyl sulfoxide
		Influence of EGF and forskolin on induction of the ERK pathway in JEG3 cells.
		Eighteen hours later, control solution (open bars) or forskolin (solid bars) was administered for a 6-h period as described in the legend to Fig.
	mcb.asm.org /cgi/content/full/20/10/3331 (8251 words)

	A Dominant Role for the Raf-MEK Pathway in Forskolin, 12-O-Tetradecanoyl-phorbol Acetate, and Platelet-Derived Growth ...
		forskolin (80% inhibition)- and TPA (50% reduction)-induced CREBGAL4
		forskolin, 50 ng/ml TPA, or 10 ng/ml PDGF for 3 h.
		forskolin were performed as described in the legend to Fig.
	mend.endojournals.org /cgi/content/full/13/7/1071 (6987 words)

	Targeted Protein Kinase A and PP-2B Regulate Insulin Secretion through Reversible Phosphorylation -- Lester et al. 142 ...
		C, Antiphosphoserine blot of RINm5F cell lysates treated with forskolin, FK506, the PKA anchoring inhibitor protein Ht31 or the PKA catalytic inhibitor, PKI.
		D, Forskolin stimulated PP-2B activity measured in lysates of RINm5F cells overexpressing the PKA anchoring inhibitor protein, Ht31.
		A, AKAP79 and the regulatory subunit (RII) of PKA are identified in RINm5F cells transfected with AKAP79 (79 OE RIN) or in wild-type, nontransfected RIN (RIN WT) using fluorescent tagged secondary antibodies to AKAP79 (Texas Red) and RII (FITC).
	endo.endojournals.org /cgi/content/full/142/3/1218 (5861 words)

	Bicarbonate and Chloride Secretion in Calu-3 Human Airway Epithelial Cells -- Devor et al. 113 (5): 743 -- The Journal ...
		Cells were stimulated with forskolin (2 µM) either before (A) or after (B) the addition of 30 mM Na-gluconate to the serosal solution.
		In addition, Na was required in the serosal bath to elicit a forskolin response.
		in response to forskolin and Cl in response to 1-EBIO.
	www.jgp.org /cgi/content/full/113/5/743 (6323 words)

	Forskolin Yohimbine,aminophylline, alternative-essentials.com (Site not responding. Last check: 2007-08-17)
		Topically applied products meant for localized fat loss of problem areas have been on the market for a few years now.
		overweight woman had ointment containing forskolin, yohimbine and aminophylline applied to the thigh five...
		placebo using forskolin, yohimbine or aminophylline in separate ointments...
	alternative-essentials.com /69/forskolin-yohimbine,aminophylline.html (223 words)

	forskolin extract - Find, Compare, and Buy at Shopping.com
		Forskolin Extract, 60 caps, PhytoPharmica Dietary ingredient to nutritionally support the increase of cyclic-AMP...
		Works to maintain healthy blood pressure levels Guaranteed to contain 18% forskolin Derived from an ancient Ayurvedic plant Read more at Amazon
		Works to maintain healthy blood pressure levels Guaranteed to contain 18% forskolin Derived from an ancient Ayurvedic plant Read more at Amazon Marketplace
	www.shopping.com /xGS-forskolin_extract (835 words)

	Amazon.com: Forskolin Extract capsules: Health & Personal Care (Site not responding. Last check: 2007-08-17)
		This item is not eligible for Amazon Prime, but over a million other items are.
		Forskolin extract has been used for centuries in Hindu and Ayurvedic traditional medicine, and over the years, there have been numerous health benefits linked to its use.
		These statements have not been evaluated by the Food and Drug Administration.
	www.amazon.com /exec/obidos/tg/detail/-/B0002H74Y6?v=glance (520 words)

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