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Topic: Frameshift

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	Frameshift mutation - Wikipedia, the free encyclopedia
		A frameshift mutation (also called a frameshift or a framing error) is a genetic mutation that inserts or deletes a number of nucleotides that is not evenly divisible by three from a DNA sequence.
		Frameshift mutations frequently result in severe genetic diseases.
		A frameshift mutation is responsible for the disabling of the CCR5 HIV receptor and some types of familial hypercholesterolemia (Lewis, 2005, p.
	en.wikipedia.org /wiki/Frameshift (158 words)

	[No title] (Site not responding. Last check: 2007-10-10)
		Frameshift mutations in microsatellites are usually due to DNA polymerase slippage and may be characterized by the type of the repeat.
		In one embodiment of the invention the fusion peptides may be constructed for enhanced detection or purification of the frameshift polypeptides, or of complexes of the frameshift polypeptides with the respective immunological entities according to the present invention.
		Preferred frameshift polypeptides according to the present invention occur in at least 25%, more preferred frameshift polypeptides in at least 30% and most preferred frameshift polypeptides in at least 33% of the cases of the particular condition to be treated by the method according to the present invention.
	www.wipo.int /cgi-pct/guest/getbykey5?KEY=03/87162.031023&ELEMENT_SET=DECL (11971 words)

	Efficiency of a programmed -1 ribosomal frameshift in the different subtypes of the human immunodeficiency virus type 1 ...
		G° (kcal/mole), of the frameshift stimulatory signal of the different mutants of subtype B is indicated.
		Secondary structure of the frameshift stimulatory signal of all of the subtypes of HIV-1 group M. The frameshift stimulatory region is folded according to the extended bulged stem–loop structure found for HIV-1 subtype B stimulator (Dulude et al.
		The mean value of the frameshift efficiency, calculated from the values obtained for all of the subtypes (1.9% in cultured cells and 6.0% in vitro), is arbitrarily set at 100%.
	www.rnajournal.org /cgi/content/full/9/10/1246 (4776 words)

	Spontaneous Frameshift Mutations in Saccharomyces cerevisiae: Accumulation During DNA Replication and Removal by ...
		Frameshift reversion spectra for a wild-type strain and for strains defective in proofreading and/or mismatch repair.
		Frameshift reversion spectra for strains deficient in the exonuclease activities of individual polymerases.
		of frameshift mutagenesis in yeast strains that are singly,
	www.genetics.org /cgi/content/full/159/1/65 (4891 words)

	Synthesis of a novel hepatitis C virus protein by ribosomal frameshift
		Besides ribosomal frameshift, it is also possible that the production of the F protein was caused by the deletion of one nucleotide or the insertion of two nucleotides at or near codon 11 during RNA synthesis by the T7 RNA polymerase.
		This 1−2% efficiency of ribosomal frameshift is not unusual as it is similar to that which was reported previously for a number of genes (Grentzmann et al., 1998; Ivanov et al., 2000).
		Although ribosomal frameshift for gene expression has been demonstrated for RNA viruses of several different families including retroviruses (Jacks and Varmus, 1985), coronaviruses (Brierley et al., 1989) and astroviruses (Marczinke et al., 1994), HCV is the first example that uses this mechanism to express a gene that is totally embedded in another coding sequence.
	www.nature.com /emboj/journal/v20/n14/full/7593881a.html (6065 words)

	Robert J. Sawyer: Frameshift (Site not responding. Last check: 2007-10-10)
		Frameshift is not the first novel in which Sawyer has done a good job of characterization.
		The main characters in Frameshift are Pierre Tardival, a French Canadian postdoctorate working in Berkeley who may have Huntington's Disease and Molly Bond, a psychologist "gifted" with the ability to read the minds of people in close proximity to her.
		Frameshift proves that Sawyer's writing and ambition continue to grow and keep pace with each other.
	www.sfsite.com /~silverag/frameshift.html (473 words)

	A reassessment of the response of the bacterial ribosome to the frameshift stimulatory signal of the human ...
		This frameshift stimulatory signal is a two-stem helix interrupted by a purine-rich bulge.
		The frameshift efficiencies were calculated from luciferase activities in the bacterial lysates as described in the text.
		The frameshift efficiencies are the means of three independent experiments, with the bars representing the standard error of the means.
	www.rnajournal.org /cgi/content/full/10/8/1225 (6518 words)

	Structural Analysis of the -1 Ribosomal Frameshift Elements in Giardiavirus mRNA -- Li et al. 75 (22): 10612 -- The ...
		1 ribosomal frameshift mediated by the 68-nt fragment in the ORF overlapping region of GLV mRNA.
		1 ribosomal frameshift relative to the wild-type frequency (100%) in the mutant transfectants are each shown at the corresponding position of the termination codon (see Table 1 for actual data).
		For the 68-nt frameshift region in GLV mRNA and the downstream 17-nt sequence of the luciferase mRNA, bases clearly modified by various chemicals are shown by large arrowheads.
	jvi.asm.org /cgi/content/full/75/22/10612 (5894 words)

	Base Composition of Mononucleotide Runs Affects DNA Polymerase Slippage and Removal of Frameshift Intermediates by ...
		Frameshift intermediates in homopolymer runs are removed efficiently by yeast mismatch repair proteins.
		Discrete in vivo roles for the MutL homologs Mlh2p and Mlh3p in the removal of frameshift intermediates in budding yeast.
		A novel frameshift mutation (+G) at codons 15/16 in a {beta}0 thalassaemia gene results in a significant reduction of {beta} globin mRNA values.
	mcb.asm.org /cgi/content/full/22/24/8756 (4143 words)

	Analysis of Natural Variants of the Human Immunodeficiency Virus Type 1 gag-pol Frameshift Stem-Loop Structure -- ...
		Frameshifting activity of the NL4-3 stem-loop and three wild-type stem-loop structures (white bars), 10 variant stem-loops (fl bars), and three artificial stem-loop mutants (gray bars) as determined by a yeast frameshift reporter assay.
		In vivo HIV-1 frameshift efficiency is directly related to the stability of the stem-loop stimulatory signal.
		Characterization of ribosomal frameshifting in HIV-1 gag-pol expression.
	jvi.asm.org /cgi/content/full/76/15/7868 (2470 words)

	Identification and analysis of the pseudoknot-containing gag-pro ribosomal frameshift signal of simian retrovirus-1.
		To investigate the requirements for frameshifting at the gag-pro overlap, we have inserted a stretch of 58 nucleotides containing the proposed frameshift signal into a plasmid that allows monitoring of translation in all three reading frames.
		In vitro translation of mRNAs derived from this plasmid indicated that the 58 nucleotides from the SRV-1 gag-pro overlap were sufficient to induce an efficient -1 shift in a heterologous context.
		The frameshift efficiency of the wild type sequence in rabbit reticulocyte lysate was 23%.
	www.aegis.com /aidsline/1994/oct/M94A0314.html (488 words)

	Identification of Putative Programmed -1 Ribosomal Frameshift Signals in Large DNA Databases -- Hammell et al. 9 (5): ...
		Structural and functional studies of retroviral RNA pseudoknots involved in ribosomal frameshifting: Nucleotides at the junction of the two stems are important for efficient ribosomal frameshifting.
		Frameshift autoregulation in the gene for Escherichia coli release factor 2: Partly functional mutants result in frameshift enhancement.
		Signals for ribosomal frameshifting in the Rous Sarcoma Virus gag-pol region.
	www.genome.org /cgi/content/full/9/5/417 (5445 words)

	Welcome to Mindawn - Frameshift - Unweaving the Rainbow
		Frameshift is an exciting new Progressive Rock project written and produced by Henning Pauly of Chain for James LaBrie, vocalist of the legendary progmetal band Dream Theater.
		Shortly before he started working on Frameshift he wrote a film score and suddenly it clicked.
		He did not want to limit the music on this album to what is possible with a rock band lineup, but to what is possible with the tools a film composer has at his disposal.
	www.mindawn.com /albums/34 (349 words)

	Amazon.co.uk: Frameshift: Books (Site not responding. Last check: 2007-10-10)
		A series of murders are traced to local neo-Nazis, someone is conducting an illegal experiment with Neanderthal DNA, and Department of Justice Agent Avi Meyer is hunting Ivan Marchenko, the concentration camp guard known as Ivan the Terrible, The Butcher of Treblinka.
		What makes Frameshift remarkable is the sympathetic and realistic portrayal of a progressively disabled hero, together with the interweaving into the story of the hunt for a real Nazi war criminal.
		He offers complex and imaginative scientific speculation, a thoughtful examination of the ethical implications of genetic testing, a slow-burning but dramatic thriller with a blockbuster climax, and a touching love story with a genuinely moving ending.
	www.amazon.co.uk /exec/obidos/ASIN/0006483208 (853 words)

	Amazon.com: Frameshift: Books (Site not responding. Last check: 2007-10-10)
		But a strange set of circumstances--including a knife attack, the in vitro fertilization of his wife, and an insurance company plot to use DNA samples to weed out clients predisposed to early deaths--draw Tardivel into a story that will ultimately involve the hunt for a Nazi death camp doctor.
		Frameshift shows why the New York Times calls Robert J. Sawyer "a writer of boundless confidence."--This text refers to an out of print or unavailable edition of this title.
		FRAMESHIFT was OK, but I would have liked it better if Sawyer hadn't cluttered it up with so many sub-plots.
	www.amazon.com /exec/obidos/tg/detail/-/0812571088?v=glance (1642 words)

	BLABBERMOUTH.NET - Former SKID ROW Singer SEBASTIAN BACH To Guest On New FRAMESHIFT CD
		The basic concept behind FRAMESHIFT's latest album, entitled "Human Grain", was initiated by Shawn Gordon, president of ProgRock Records, according to a posting on the project's official web site.
		FRAMESHIFT's "Human Grain" is scheduled for release in early 2005.
		The accuracy of the information contained herein is neither confirmed nor guaranteed by Roadrunner Records, and the views and opinions of authors expressed on these pages do not necessarily state or reflect those of Roadrunner Records or its employees.
	www.roadrunnerrecords.com /blabbermouth.net/news.aspx?mode=Article&newsitemID=30932 (509 words)

	Frameshift - "Unweaving the Rainbow" Review (Site not responding. Last check: 2007-10-10)
		Frameshift is basically a musical collaboration between multi-instrumentalist, Henning Pauly (Chain) and vocalist James LaBrie (Dream Theater).
		Here on Frameshifte, Henning built the project around James’ vocals and added insturmentation that fitted properly.
		To me this is the way it should be done if you have a frontman in any type of band.
	www.geocities.com /prognaut/reviews/frameshift.html (325 words)

	FRAMESHIFT An Absence Of Empathy reviews and MP3 (Site not responding. Last check: 2007-10-10)
		Like the first Frameshift cd this is not a concept album per se,with no storyline,but a series of songs revolving around the same topic.The topic here is human nature and violence.
		After several delays, the album was finally released, and for many Frameshift fans, the question waiting to be answered was "Can Sabastian Bach match James JaBrie's performance on Unweaving the Rainbow?" Sadly, he doesn't by any stretch of the imagination, but I never expected him to anyway.
		Frameshift is a first team band and do not waste time with boring nonsense melodies to fill the albums - like it has been happening to many good prog bands lastly (especially Dream Theater).
	www.progarchives.com /Progressive_rock_discography_CD.asp?cd_id=7627 (1547 words)

	ProgRock Records :: Products
		For listeners who like their music a bit heavier, there are songs like Nice Guys Finish First (mysterious, complex and filled with staccato guitar riffs) or Cultural Genetics, a song with some Dream Theater characteristics...
		Although there are influences, hints and references to other bands, it is very hard to compare Frameshift with any other band.
		I’m not going to give in to temptation and call Frameshift’s Unweaving the Rainbow, a new project with Dream Theater singer James LaBrie, the album LaBrie's main band should have released in lieu of the love-it-or-hate-it Train of Thought.
	www.progrockrecords.com /shop/view.php?id=23 (1676 words)

	Sequence Composition and Context Effects on the Generation and Repair of Frameshift Intermediates in Mononucleotide ...
		complex, binding to a frameshift intermediate in vitro was influenced
		and repair of frameshift intermediates that occur in repetitive
		Thus, the repair of a frameshift intermediate is not
	www.genetics.org /cgi/content/full/156/2/571 (4313 words)

	KNAC.COM - News - James LaBrie's Frameshift To Release Album (Site not responding. Last check: 2007-10-10)
		Frameshift, as a musical entity, is primarily Pauly and LaBrie.
		The origin of Frameshift goes back to spring 2002 when Pauly found old rehearsal tapes made with his group Chain, which had disbanded eight years before.
		Frameshift's Unweaving the Rainbow takes all the thematic depth and musical complexity of the finest progressive rock and gives it a fresh approach thanks to the skills of Pauly and LaBrie.
	www.knac.com /article.asp?ArticleID=2621&StartTime=1/1/2050 (1154 words)

	Characterization of the frameshift stimulatory signal controlling a programmed -1 ribosomal frameshift in the human ...
		Characterization of the frameshift stimulatory signal controlling a programmed -1 ribosomal frameshift in the human immunodeficiency virus type 1 -- Dulude et al.
		Characterization of the frameshift stimulatory signal controlling a programmed –1 ribosomal frameshift in the human immunodeficiency virus type 1
		V1 of an RNA fragment corresponding to the gag/pol frameshift
	nar.oxfordjournals.org /cgi/content/abstract/30/23/5094 (610 words)

	Frameshift - An Absence of Empathy CD Review!
		it was just different hearing such a new voice around the frameshift band.
		I really have to hand it to you btw, you have really inspired me to be a better musician.
		Tour...probably not...since I play pretty much all the instruments and the fact that there is a lot of production involved which is amlost impossible to do live, I don't think this stuff will ever get on stage.
	www.mikeportnoy.com /forum/printable.aspx?m=823009 (1911 words)

	Amino acid translation program for full-length cDNA sequences with frameshift errors -- FUKUNISHI and HAYASHIZAKI 5 ...
		The experimental frameshift error is expected to occur
		rates of frameshift corrections were 44% and 7%, respectively.
		is 9%, and 91% of the suggested frameshifts were true.
	physiolgenomics.physiology.org /cgi/content/full/5/2/81 (4187 words)

	BLABBERMOUTH.NET - FRAMESHIFT Mastermind To Guest On WRUW 91.1 FM
		Henning Pauly, the mastermind behind the FRAMESHIFT progressive rock project, will be calling into "The Metal Meltdown Show" on WRUW 91.1 FM Cleveland Friday afternoon at 5:15 p.m.
		Questions can be sent at www.metalmeltdown.com, and people can tune in live at www.wruw.org.
		FRAMESHIFT's recently released sophomore CD, "Absence of Empathy", features guest vocals by former SKID ROW singer Sebastian Bach.
	www.roadrunnerrecords.com /blabbermouth.net/news.aspx?mode=Article&newsitemID=38206 (324 words)

	ProgRock Records :: Products
		The basic concept of Frameshift’s Human Grain was conceived by progrockrecords president Shawn Gordon.
		James LaBrie (Dream Theater) was the vocalist on the previous cd of Frameshift, but because he could not find the time, Sebastian Bach was asked to do the singing.
		Well Frameshift’s An Absence of Empathy certainly has no shortage of the barrage of sound but thankfully there are many melodic moments as well.
	www.progrockrecords.com /shop/view.php?id=58 (2617 words)

	eBay - Book: Frameshift (ISBN: 0812571088) (Site not responding. Last check: 2007-10-10)
		This is the story of Pierre Tardivel, a scientist, and his complex battle against deadly illness, and ex-Nazi war criminal still hiding in the U.S., a crooked insurance company, and a plot to make him and his wife the victims of a bizarre genetic experiment.
		Frameshift is hard science fiction at its best, full of complications and neat surprises.
		Frameshift by Robert J. Sawyer (1998) 1st PB
	product.ebay.com /Frameshift_ISBN_0812571088_W0QQfvcsZ1388QQsoprZ214724 (239 words)

	Frameshift by Robert J. Sawyer : Booksamillion.com (031286325X, Hardcover)
		The two lines of investigation begin to converge in a sinister manner, while they worry about the possibility of bearing the child of an evil, sadistic killer...
		Nebula Award-winning science fiction author Robert J. Sawyer debuts his first hardcover thriller novel Frameshift (Tor, $23.95, 031286325X).
		Pierre Tardivel, who is working on the Human Genome Project, has a fifty-fifty chance of having the debilitating neurological Huntington's disease.
	www.booksamillion.com /ncom/books?pid=031286325X (349 words)

	Highly Frequent Frameshift DNA Synthesis by Human DNA Polymerase {micro} -- Zhang et al. 21 (23): 7995 -- Molecular and ...
		Highly Frequent Frameshift DNA Synthesis by Human DNA Polymerase {micro} -- Zhang et al.
		Polµ was largely dictated by the sequence context.
		Tippin, B., Kobayashi, S., Bertram, J. G., Goodman, M. To Slip or Skip, Visualizing Frameshift Mutation Dynamics for Error-prone DNA Polymerases.
	mcb.asm.org /cgi/content/abstract/21/23/7995 (765 words)

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