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Topic: FtsZ


  
  Prokaryotic cell division protein FtsZ
FtsZ localizes to a yet-to-be defined nucleation site (see schematic) at the mid-point of the cell soon after daughter cell formation and assembles as a ring (FtsZ- or simply Z-ring) that remains associated with the cytoplasmic membrane (17) (see FtsZ movie).
Early conclusions from sequence alignments between FtsZ and tubulin lead to a growing notion that these two proteins were homologous, at least over their GTP-binding domains.
FtsZ, a tubulin homologue in prokaryotic cell division.
www.umass.edu /microbio/chime/pipe/ftsz/present/index.htm   (1627 words)

  
  FtsZ - Wikipedia, the free encyclopedia
FtsZ is a protein encoded by the ftsZ gene that assembles into a ring at the future site of the septum of bacterial cell division.
During cell division, FtsZ is the first protein to move to the division site, and is essential for recruiting other proteins that produce a new cell wall between the dividing cells.
FtsZ's role in cell division is analogous to that of actin in eukaryotic cell division, but unlike the actin-myosin ring in eukaryotes, FtsZ is not thought to provide the mechanical force that physically divides the cell.
en.wikipedia.org /wiki/FtsZ   (389 words)

  
 Two Dictyostelium Orthologs of the Prokaryotic Cell Division Protein FtsZ Localize to Mitochondria and Are Required for ...
FtsZ, and the protein is absent from the mitochondria of fungi,
With the discovery of FtsZ in chloroplasts, it was proposed
Isolation of an ftsZ homolog from the archaebacterium Halobacterium salinarium: implications for the evolution of FtsZ and tubulin.
ec.asm.org /cgi/content/full/2/6/1315   (7607 words)

  
 Biochemistry 4103 Assignment--Septation and Cell Division
FtsZ was thus classified as an early acting gene because a mutation caused a 'lemon morphology', in which no septation occurred.
The cooperative polymerization of tubulin is catalyzed in vivo by vinblastine whereas ZipA catalyzes the coaligning of FtsZ polymers.
The inability of DivIB and DivIC to target to the septum in FtsZ depleted cells was found in Western Blot analysis not to be due to a decreased expression of the proteins (Katis et al, 2000).
www.ucs.mun.ca /~z83mmw/bioc4103/proteins.htm   (5570 words)

  
 Dynamic FtsZ polymerization is sensitive to the GTP to GDP ratio and can be maintained at steady state using a ...
A polymerization reaction with FtsZ at a concentration of 4·2 µM was performed in the absence (a) or presence (b) of acetyl phosphate (0·5 mM).
Bi, E. and Lutkenhaus, J. Isolation and characterization of ftsZ alleles that affect septal morphology.
Mukherjee, A. and Lutkenhaus, J. Analysis of FtsZ assembly by light scattering and determination of the role of divalent metal cations.
mic.sgmjournals.org /cgi/content/full/149/8/2235   (4133 words)

  
 Pfam 20.0 : Tubulin   (Site not responding. Last check: 2007-11-04)
FtsZ is the polymer-forming protein of bacterial cell division.
It is part of a ring in the middle of the dividing cell that is required for constriction of cell membrane and cell envelope to yield two daughter cells.
Tubulin is the major component of microtubules, while FtsZ is the polymer-forming protein of bacterial cell division, it is part of a ring in the middle of the dividing cell that is required for constriction of cell membrane and cell envelope to yield two daughter cells.
pfam.wustl.edu /cgi-bin/getdesc?name=Tubulin   (238 words)

  
 [No title]
In bacteria, FtsZ [1, 2, 3] is an essential cell division protein which appears to be involved in the initiation of this event.
FtsZ is a GTP binding protein PDOC00199 with a GTPase activity.
FtsZ is a protein of about 400 residues which is well conserved across bacterial species and which is also present in the chloroplast of plants [4] as well as in archaebacteria [5].
www.ebi.ac.uk /interpro/IEntry?ac=IPR000158   (691 words)

  
 William Margolin
FtsZ is an abundant protein that, in response to an unknown signal, polymerizes into a ring structure marking the division site and is essential for the initiation of cell division.
FtsZ is ubiquitous, with homologs in eubacteria, archaea and chloroplasts.
FtsZ and tubulin are the building blocks for the FtsZ division ring and microtubules, respectively, which are essential cytoskeletal structures in prokaryotes and eukaryotes.
mmg.uth.tmc.edu /webpages/faculty/wmargolin.html   (568 words)

  
 Tubulin and ftsZ:
Since tubulin is basic to eukarya and ftsZ is basic to bacteria, and since both eukarya and bacteria may have been among that consortium (or separated by two distinct seeding events), ID may be lurking in the background.
Polymerization of Ftsz, a bacterial homolog of tubulin.
FtsZ is a bacterial homolog of tubulin that is essential for prokaryotic cytokinesis.
www.idthink.net /biot/tub/index.html   (2438 words)

  
 Isolation of two plastid division ftsZ genes from Chlamydomonas reinhardtii and its evolutionary implication for the ...
Isolation of two plastid division ftsZ genes from Chlamydomonas reinhardtii and its evolutionary implication for the role of FtsZ in plastid division -- Wang et al.
ftsZ genes from Chlamydomonas reinhardtii and the phylogenetic
To prevent the artificial attraction from the unequal sequence lengths, the divergent N- and C-terminal sequences of FtsZs were deleted, and the protein core region of 317 amino acid positions in the alignment was used to reconstruct a phylogenetic tree.
jxb.oxfordjournals.org /cgi/content/full/54/384/1115   (1298 words)

  
 Chlamydiaceae evolution - Chlamydia & Chlamydophila - FtsZ - Cell division - Peptidoglycan
FtsZ is an indispensible participant in the cell division of most Bacteria, and in Archaea, only the kingdom Crenarchaeota is without it.
The three sequenced Mycoplasma genomes all have ftsZ but none of the genes of the peptidoglycan biosynthetis pathway and the organisms are not penicillin-sensitive (see Table 2 for references).
It is clear that loss of neither FtsZ nor peptidoglycan is prerequisite to obligate intracellular existence.
www.chlamydiae.com /docs/Chlamydiales/ev_ftsZ.asp   (1210 words)

  
 Genetic Classification and Differentiation of Bartonella Species Based on Comparison of Partial ftsZ Gene Sequences -- ...
PCR amplification and DNA sequencing of the portion of the ftsZ gene encoding the N-terminal region.
PCR amplification and DNA sequencing of the portion of the ftsZ gene encoding the C-terminal region.
The 75-kilodalton antigen of Bartonella bacilliformis is a structural homolog of the cell division protein ftsZ.
jcm.asm.org /cgi/content/full/40/10/3641   (3843 words)

  
 A Rapid Fluorescence Assay for FtsZ Assembly Indicates Cooperative Assembly with a Dimer Nucleus -- Chen et al. 88 (1): ...
FtsZ from Escherichia coli, Azotobacter vinelandii, and Thermotoga maritima—quantitation, GTP hydrolysis, and assembly.
Analysis of FtsZ assembly by light scattering and determination of the role of divalent metal cations.
Rate-limiting guanosine 5'-triphosphate hydrolysis during nucleotide turnover by FtsZ, a prokaryotic tubulin homologue involved in bacterial cell division.
www.biophysj.org /cgi/content/full/88/1/505   (5396 words)

  
 Dynamin and FtsZ: Missing Links in Mitochondrial and Bacterial Division -- Erickson 148 (6): 1103 -- The Journal of ...
The dynamin spirals are ~50-nm diameter, and FtsZ is ~23-nm diam.
Erickson, H.P. FtsZ, a tubulin homolog, in prokaryote cell division.
Lu, C.L., Reedy, M., Erickson, H.P. Straight and curved conformations of FtsZ are regulated by GTP hydrolysis.
www.jcb.org /cgi/content/full/148/6/1103   (2080 words)

  
 Activation of Cell Division Protein FtsZ. CONTROL OF SWITCH LOOP T3 CONFORMATION BY THE NUCLEOTIDE gamma -PHOSPHATE -- ...
FtsZ together with tubulin form a distinct group of GTPases (3-6), which form in turn structural polymers.
The structures of FtsZ and tubulin have a common fold and are remarkably similar (14, 15).
A, model of FtsZ association constructed as described by Löwe and Amos (48), using the crystal structure 1FSZ as monomer.
www.jbc.org /cgi/content/full/276/20/17307   (6602 words)

  
 Sequence Variation in the ftsZ Gene of Bartonella henselae Isolates and Clinical Samples -- Ehrenborg et al. 38 (2): ...
The use of the cell division protein FtsZ as a means of differentiating Bartonella species was recently described (13).
ftsZ genes in the region encoding the C-terminal region of the
I and II and variants Bh ftsZ 1 and 2 were identified in B.
jcm.asm.org /cgi/content/full/38/2/682   (3171 words)

  
 Visualization of a Cytoskeleton-like FtsZ Network in Chloroplasts -- Kiessling et al. 151 (4): 945 -- The Journal of ...
FtsZ that, therefore, most likely is located in mitochondria.
Erickson, H.P. FtsZ, a tubulin homologue in prokaryote cell division.
Löwe, J., and Amos, L.A. Crystal structure of the bacterial cell-division protein FtsZ.
www.jcb.org /cgi/content/full/151/4/945   (3362 words)

  
 [No title]
Tubulin is the major component of microtubules, while FtsZ is the polymer-forming protein of bacterial cell division, it is part of a ring in the middle of the dividing cell that is required for constriction of cell membrane and cell envelope to yield two daughter cells.
FtsZ and tubulin are GTPases, this entry is the GTPase domain.
FtsZ can polymerise into tubes, sheets, and rings in vitro and is ubiquitous in bacteria and archaea.
www.ebi.ac.uk /interpro/IEntry?ac=IPR003008   (339 words)

  
 Organelle Fission. Crossing the Evolutionary Divide -- Osteryoung 123 (4): 1213 -- PLANT PHYSIOLOGY
Although FtsZ is not involved in mitochondrial division in yeast or C.
During organelle evolution, FtsZ was recruited to function in constriction in the lineages leading to plants and algae, but not fungi or animals.
FtsZ2 in chloroplasts, and dynamin in yeast and animal mitochondria, are proposed to function on the cytosolic surface in organelle restriction, each perhaps having replaced the requirement for cell wall synthesis in division of the endosymbionts.
www.plantphysiol.org /cgi/content/full/123/4/1213   (2641 words)

  
 Use of the Cell Division Protein FtsZ as a Means of Differentiating among Bartonella Species -- Kelly et al. 5 (6): 766 ...
Alignment of the amino acid sequences of the FtsZ homologs of E.
The proper ratio of FtsZ to FtsA is required for cell division to occur in Escherichia coli.
FtsZ ring: the eubacterial division apparatus conserved in archaebacteria.
cdli.asm.org /cgi/content/full/5/6/766   (3612 words)

  
 Chloroplast Division in Higher Plants Requires Members of Two Functionally Divergent Gene Families with Homology to ...
FtsZs and the demonstration that it is localized in the chloroplast
PsFtsZ, a full-length FtsZ cDNA from pea (Pisum sativum), and
Margolin, W., Wang, R., and Kumar, M. (1996) Isolation of an ftsZ homolog from the archaebacterium Halobacterium salinarium: Implications for the evolution of FtsZ and tubulin.
www.plantcell.org /cgi/content/full/10/12/1991   (6970 words)

  
 Dynamic Trio: FtsZ, Plastid-Dividing, and Dynamin Rings Control Chloroplast Division -- Eckardt 15 (3): 577 -- THE ...
FtsZ and the formation of an FtsZ ring at the future division
FtsZ was identified as a cell division protein in Escherichia
Arimura, S., and Tsutsumi, N. A dynamin-like protein (ADL2b), rather than FtsZ, is involved in Arabidopsis mitochondrial division.
www.plantcell.org /cgi/content/full/15/3/577   (1648 words)

  
 Conditional expression of Mycobacterium smegmatis ftsZ, an essential cell division gene -- Dziadek et al. 149 (6): 1593 ...
FtsZ is an essential cell division protein in E.
Beall, B. and Lutkenhaus, J. FtsZ in Bacillus subtilis is required for vegetative septation and for asymmetric septation during sporulation.
Bi, E. and Lutkenhaus, J. FtsZ regulates frequency of cell division in Escherichia coli.
mic.sgmjournals.org /cgi/content/full/149/6/1593   (4221 words)

  
 IngentaConnect The division of pleomorphic plastids with multiple FtsZ rings in ...   (Site not responding. Last check: 2007-11-04)
In recent years, it was revealed that the bacterial cell division protein FtsZ is encoded in the nuclear genome of plant cells, and plays a major role in the plastid division process forming a ring along the center of plastids.
Although the best-characterized type of plastid division so far is the division with a single FtsZ ring at the plastid midpoint, it was recently reported that in some plant organs and tissues, plastids are pleomorphic and form multiple FtsZ rings.
Active DNA synthesis of pt nucleoids is induced by medium transfer, and the division and the distribution of pt nucleoids occur along with plastid elongation.
www.ingentaconnect.com /content/urban/251/2003/00000082/00000006/art00006   (489 words)

  
 BioMed Central | Full text | A canonical FtsZ protein in Verrucomicrobium spinosum, a member of the Bacterial phylum ...
Both FtsZ and tubulin are central to key cell biology processes – bacterial septation and cell division in the case of FtsZ and in the case of tubulins the function of microtubules necessary for mitosis and other key cytoskeleton-dependent processes in eukaryotes.
Both FtsZ and tubulin are significant for evolutionary cell biology since FtsZ is pivotal to cell division in most bacteria and tubulin is a cytoskeletal eukaryote signature protein [6]central to models for origins of eukaryote cell organization [7,8].
The distribution of genes for both tubulins and FtsZ must be determined in a wider selection of verrucomicrobia among all 5 subdivisions distinguished[25,26], e.g.
www.biomedcentral.com /1471-2148/7/37   (3976 words)

  
 Quantum Pharmaceuticals. R&D Program Drug Development in the areas of Psychiatric ...
People nearby may breathe in these bacteria and become infected.
FtsZ is a very promising target for new antimicrobial drugs because of its central role in bacterial cell division.
FtsZ, a tubulin-like GTPase, plays an essential role in bacterial cell division, and its homologs are present in almost all eubacteria and archaea.
www.q-pharm.com /home/contents/drug_d/in-house/Ftsz   (341 words)

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