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Topic: Fucose

  Why Fucose?
Fucose is a rare sugar, one of the eight known bioactive sugars essential for proper cell to cell communication.
Fucose is also excreted in breast milk and may play a part in the transfer of immunity to the newborn.
Fucose is a rare sugar not commonly consumed in most people's diets, at least not to a level that is beneficial to the body.
www.webmyweb.info /why_fucose.php   (825 words)

 Fucose   (Site not responding. Last check: 2007-10-11)
Fucose should not be confused with Fructose, which is a monosaccharide found in fruits and honey.
During the latter stages of pregnancy, excretion of Fucose in the urine is markedly increased, which is consistent with fetal development and the transfer of immunity to the newborn.
Fucose is readily found in several medicinal mushrooms, such seaweeds as kelp and wakame, and beer yeast.
www.innvista.com /health/nutrition/essensug/fucose.htm   (1115 words)

Fucose is one of the eight essential sugars the body requires for optimal function of cell-to-cell communication.
Fucose is particularly active in inflammatory diseases and has the ability to suppress such allergic skin reactions as contact dermatitis.
Some studies have concluded that Fucose and Mannose appeared to be the most effective of the essential sugars when it came to slowing the growth of cancer cells.
www.glyconutrients-center.org /fucose.php   (1247 words)

 Nutratose™ - New Scientific Breakthrough! For The First Time All Eight Essential Glyconutrients All-In-One ...
Currently, more than 2,000 clinical studies world-wide, prove the positive health benefits of glyconutrition.
An independent carbohydrate analytical laboratory has run High Performance Liquid Chromatography on a hydrolyzed sample of our glyconutrient polymer and qualitatively demonstrated that the essential monosaccharides, Mannose, Fucose, Xylose, Glucose, Galactose, N-Acetylneuraminic Acid, N-Acetylgalactosamine and N-Acetylglucosamine are all present along with Arabinose, another beneficial sugar.
The lab was able to quantify the result so that several samples run on the same lot are within the 95% confidence level.
www.micronutra.com /nutratose.html   (3444 words)

  Detection of Root Mucilage Using an Anti-fucose Antibody -- SINHA ROY et al. 89 (3): 293 -- Annals of Botany
ELISA (enzyme-linked immunosorbent assay) for fucose in sequential dilution of anti-fucose antibody.
A and B, Detection of fucose in exuded root mucilage and outer cell walls of the epidermis in maize (A) and wheat (B) root tips.
H fucose into the cell-wall polysaccharides of the cap and epidermis of corn roots.
aob.oxfordjournals.org /cgi/content/full/89/3/293   (2898 words)

 NAP: Fucus (Bladderwrack)
The core region (or backbone) of fucoidan is composed primarily of a repeating chain of fucose sugars.
Fucose is also attached to this backbone, forming branch points at every 2-3 fucose residues within the chain.
Since bladderwrack is such excellent food source of fucose and fucose containing sugar chains, it can actually bind many of the more problematic blood type O lectins, bacteria, and microorganisms.
www.dadamo.com /napharm/store3/template2/fucus.htm   (1835 words)

 Dr. Thomas Wiese
Fucose is a monosaccharide normally present in the serum and is the only levorotatory sugar synthesized and utilized by mammalian systems (30).
In my hands, a large amount of the fucose fed to rats is excreted in the urine in a concentration-dependent fashion (Wiese and Yorek, unpublished observations), although the amount of free and bound fucose increases in the serum of fucose-fed rats (32,33).
Whereas fucose is usually thought of as a terminal sugar residue, one recent report states that a tetrasaccharide containing Gal, Fuc, GlcNAc and NeuAc is bound to serine 61 of human factor IX, with fucose being the reducing sugar (28).
www.fhsu.edu /chemistry/twiese/researchbackground.htm   (1831 words)

 [No title]   (Site not responding. Last check: 2007-10-11)
Background of the Invention Fucose is found widely distributed in the complex carbohydrates and glycoconjugates of bacteria, plants, and animals.
Fucose is added to these glycoconjugates by specific transferases that use GDP-fucose as the sugar donor.
Biological implications Fucose is found in the glycoconjugates of bacteria, plants and animals where it plays roles in maintaining structural integrity as well as in molecular recognition.
www.wipo.int /cgi-pct/guest/getbykey5?KEY=00/09744.000525&ELEMENT_SET=DECL   (6723 words)

 Fucose expression in skeletal muscle: a lectin histochemical study.   (Site not responding. Last check: 2007-10-11)
Binding sites for three fucose specific lectins, Aleuria aurantia agglutinin (AAA), Lotus tetragonolobus agglutinin (LTA) and Ulex europeus I agglutinin (UEA I), were investigated in sections from normal human and rat muscles, in muscle from patients with Duchenne muscular dystrophy (DMD) and in denervated and devascularized rat muscle.
In normal human muscle addition of fucose to the AAA incubation medium or treatment of the sections with formaldehyde followed by periodic oxidation before lectin incubation strongly inhibited the staining at all sites other than endothelial cells.
The AAA-positive fucose residues in the sarcolemma of normal muscle fibres that were resistant to periodic acid oxidation could not be shown by AAA in denervated muscle.
plab.ku.dk /tcbh/abstract/146.htm   (571 words)

 Fucose: biosynthesis and biological function in mammals -- Becker and Lowe 13 (7): 41R -- Glycobiology
The salvage pathway utilizes fucose that is transported into the cytosol from an extracellular origin or fucose that is liberated from catabolism of fucosylated glycans in the lysosome and then transported into the cytosol.
that fucose is catabolized in mammals by a pathway analogous
Moloney, D.J. and Haltiwanger, R.S. (1999) The O-linked fucose glycosylation pathway: identification and characterization of a uridine diphosphoglucose: fucose-beta1,3-glucosyltransferase activity from Chinese hamster ovary cells.
glycob.oxfordjournals.org /cgi/content/full/13/7/41R   (6784 words)

 Sweet solution: sugars to the rescue -- Freeze 158 (4): 615 -- The Journal of Cell Biology   (Site not responding. Last check: 2007-10-11)
Fucose (blue triangle) is activated to GDP-Fucose in two ways.
Knocking out this pathway forces cells to rely on the other pathway where fucose enters the cell through a putative plasma membrane transporter, is converted to Fuc-1-P, and then to GDP-Fuc in the cytosol.
Metabolism of L-fucose-1-14C and of fucose glycoproteins in the rat.
www.jcb.org /cgi/content/full/158/4/615   (1206 words)

 Conditional control of selectin ligand expression and global fucosylation events in mice with a targeted mutation at ...   (Site not responding. Last check: 2007-10-11)
The wall of the colon in FX(-/-) mice reared in the absence of fucose is roughly twice the normal thickness, necessitating separate panels that display the basal (bottom left) and lumenal (bottom right) aspects of the fucose-deficient FX(-/-) colon wall.
Axillary lymph nodes were isolated from WT mice fed standard laboratory chow (WT, off fucose), FX(-/-) mice fed standard laboratory chow (FX[-/-] off fucose), or FX(-/-) mice fed standard laboratory chow, and then supplied with 100 mM fucose in their drinking water 3 d before sacrifice (FX[-/-], on fucose).
FX(-/-) mice reared from weaning until 8 wk of age on chow that included 5% wt/wt fucose were placed in cages containing standard chow, and peripheral blood was collected from the retroorbital plexus 1, 3, 5, 8, and 12 d later.
www.jcb.org /cgi/content/full/158/4/801   (7690 words)

 The Eight Essential Sugars - Low Carb
Fucose is easy to remember, it's mostly found in fungus.
A few mushrooms that include fucose are reishi mushrooms and orange peel mushrooms.
Fucose is also found in kelp and bladderwrack.
www.bellaonline.com /articles/art16104.asp   (613 words)

 Science News: Sugar coated: molecular dress-up may disguise gut bacteria
Making fucose from the sugar mannose is common in bacteria, including B. fragilis.
Mammalian cells, in contrast, convert fucose from their surroundings into a form called guanosine diphosphate-fucose (GDP-fucose), which they attach to their surface proteins.
Comstock's team created a strain of B. fragilis lacking the gene that directs the conversion of mannose to fucose, then the researchers grew the bacteria on a nutrient-rich medium containing both sugars.
www.findarticles.com /p/articles/mi_m1200/is_12_167/ai_n13596296   (555 words)

“Fucose also reduced collagen production in cultured cerebral microvessel endothelial cells obtained from animals ingesting a diet composed of 20% fucose.40 Although this level of fucose is much higher than the level that would be expected in a normal diet, this finding suggests that fucose may be a factor in the regulation of collagen production.”
It appears that elevated fucose in inflammation is a response that tends to regulate (perhaps diminish) the extent of inflammation.
In contrast, a complete glyconutritional complex that includes glucosamine is typically taken at around 500 mg per day, but it includes all 8 necessary sugars, and thus in typical dose contains only a fraction of the glucosamine now consumed in the widely used GC supplements.
www.avantrex.com /resources/dupuytren.html   (1072 words)

 Scientists dissect bacterial crosstalk
But when fucose is available, it no longer can bind to that spot on the DNA.
Those that were unable to make fucose isomerase, the first enzyme in the fucose-metabolizing pathway, couldn't tell the mice to give them fucose.
And the mutant that lacked fucose isomerase signaled once more if the fucose transporter was removed.
www.eurekalert.org /pub_releases/1999-08/WUSo-Sdbc-200899.php   (778 words)

 A novel fucose recognition fold involved in innate immunity - Nature Structural & Molecular Biology
Humoral and cell-associated carbohydrate-binding proteins from the host are responsible for the initial recognition step in the first line of internal defense, which leads to agglutination, endocytosis by phagocytic cells and the activation of protease cascades, resulting in clotting, melanization or complement-mediated killing of the pathogen.
A network of hydrogen bonds maintains this triad of residues in optimal positions to provide all the polar interactions to the carbohydrate: His 144 interacts with Arg 86, the main chain oxygen of Ser 53 interacts with His 52 and Asp 81 interacts with Arg 79 to form a salt bridge (Fig.
The positions of residues participating in polar interactions with the fucose are marked with a red star; residues that coordinate the cation are marked with green triangles.
www.nature.com /nsmb/journal/v9/n8/full/nsb817.html   (5739 words)

 O-fucosyltransferase 1/neurotic
Notch and its ligands are modified by a protein O-fucosyltransferase (O-fut1, also known as Neurotic or Ofut1) that attaches fucose to a serine or threonine within EGF domains.
It is speculated that the amount of Nti endogenously expressed in S2 cells saturates the ability of fucose alone to promote the ligand binding.
The substrate of Fringe is EGF-O-fucose and the transfer of fucose to Notch by protein O-fucosyltransferase 1 is necessary for Fringe to function.
www.sdbonline.org /fly/hjmuller/neurotic1.htm   (3554 words)

 Fucose supplementation in leukocyte adhesion deficiency type II -- Etzioni et al. 95 (11): 3641 -- Blood
Urine fucose levels in the patient while on therapy were 10 times higher (1.2 µmol/L) than in control (25-110 µmol/L).
After a month, the dose of fucose was decreased to 1 g/d and was continued for up to 12 months.
The letter reports that a loading dose of 5 grams of fucose was followed by hypoglycemia.
www.bloodjournal.org /cgi/content/full/95/11/3641   (2196 words)

 Role of terminal fucose residues in clearance of human glycosylated alpha-amylase -- Tollefsen and Rosenblum 255 (3): ...   (Site not responding. Last check: 2007-10-11)
Role of terminal fucose residues in clearance of human glycosylated alpha-amylase -- Tollefsen and Rosenblum 255 (3): 374 -- AJP - Gastrointestinal and Liver Physiology
To examine the role of terminal fucose in the clearance of
therefore that terminal fucose is the recognition marker that effects the
ajpgi.physiology.org /cgi/content/abstract/255/3/G374   (272 words)

 Re: Agglutinate to the fucose in your diet not your system.
I understand this to mean that adding the sugars fucose and mannose to your diet give the bad lectins in your diet a chance to agglutinate to them instead of the sugars in your digestive tract.
The hope would be that all the lectins agglutinate to these free-floating sugars before they reach the sugars that are part of your digestive tract.
I know that everyone has some fucose in their digestive tract, with Os having the most.
www.dadamo.com /forum/archive8/config.pl?read=40250   (326 words)

 Characterization of a Novel Fucose-Regulated Promoter (PfcsK) Suitable for Gene Essentiality and Antibacterial ...
operon, is induced by fucose and repressed by glucose or sucrose.
pneumoniae R6 cells grown in a semidefined medium in the presence of 0.2% glucose and 1% fucose) was denatured together with 5 pmol of fcsKpe primer and reverse transcribed to cDNA.
fucose from 0.01 to 1% in 0.3% sucrose (Fig.
jb.asm.org /cgi/content/full/185/6/2051   (3845 words)

 Insights into leukocyte adhesion deficiency type 2 from a novel mutation in the GDP-fucose transporter gene -- Hidalgo ...   (Site not responding. Last check: 2007-10-11)
Effect of fucose administration on circulating neutrophil counts in the LADII patient.
The possible induction by fucose therapy of fucosylated antigens on the surfaces of erythrocytes was also a major clinical
Leukocyte adhesion deficiency type II is a generalized defect of de novo GDP-fucose biosynthesis: endothelial cell fucosylation is not required for neutrophil rolling on human nonlymphoid endothelium.
www.bloodjournal.org /cgi/content/full/101/5/1705   (5737 words)

 KickAS: Fucose, fucans, Sea Kelp and Inflammtion. Bowel et
However, I did some digging on Fucose after reading a report on it being discovered that is hides some good bowel bugsd from the immune system and is actually secreted by the gut...This got my interest....
There are heaps of sea weeds etc in the health shops, some are green it;s the brown one which are richer in the fucose, but even so the nori normal available sea weed seems ok.
Some papers say it is involved in inhibiting some adhesion molecules ICAM etc which are the targets of the next generation drugs in MS, chrons colitis etc....curent on trials...
www.kickas.org /ubbthreads/showflat.php?Cat=0&Number=193828   (839 words)

 Daniel Moloney's research
  O-linked fucose consists of the sugar, fucose, directly attached to protein through the hydroxyl group of either serine or threonine.
  Although the actual number of proteins identified with the O-linked fucose modification is small, a database search reveals that numerous secreted and cell-surface proteins from nematodes to insects to humans contain the consensus sequence for the addition of the sugar, O-linked fucose, meaning that this sugar modification appears to be conserved through evolution.
  Moloney, D.J. and Haltiwanger, R.S. (1999) The O-linked fucose glycosylation pathway: Identification and characterization of a uridine diphosphoglucose: fucose-beta-1,3 glucosyltransferase activtity from Chinese hamster ovary cells.
www.sinc.sunysb.edu /Stu/dmoloney/dresearch.html   (627 words)

 A molecular sensor that allows a gut commensal to control its nutrient foundation in a competitive ecosystem -- Hooper ...   (Site not responding. Last check: 2007-10-11)
Fucose Binds to FucR and Blocks Its Ability to Bind Target DNA Sequences.
P-labeled DNA fragment, corresponding to the 283 bp of sequence 5' to the initiator Met codon of fucR, was incubated with 30 ng of purified FucR and 1 mM of
A further prediction from the model is that abolishing fucose
www.pnas.org /cgi/content/full/96/17/9833   (4770 words)

 Golgi nucleotide sugar transport and leukocyte adhesion deficiency II -- Hirschberg 108 (1): 3 -- Journal of Clinical ...
GDP-fucose is synthesized in the cytosol from either GDP-mannose (probably the major pathway) or from free fucose.
The nucleotide sugar is then transported via the GDP-fucose transporter into the lumen of the Golgi apparatus, where specific fucosyltransferases add fucose to a variety of glycoproteins and glycolipids.
Impairment of the golgi gdp-l-fucose transport and unresponsiveness to fucose replacement therapy in lad II patients.
www.jci.org /cgi/content/full/108/1/3   (2798 words)

 Enhancement of Glutamate Release by L-Fucose Changes Effects of Glutamate Receptor Antagonists on Long-Term ...
Fucose and fucose-containing sugar epitopes enhanced hippocampal long-term potentiation in the freely moving rats.
Fucose and fucosyllactose enhance in-vitro hippocampal long-term potentiation.
Identification of fucose a(1-2) galactose epitope-containing glycoproteins from rat hippocampus.
www.learnmem.org /cgi/content/full/7/4/227   (3269 words)

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