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Topic: Functional genomics

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	Functional and Comparative Genomics: Human Genome Research in Progress
		Understanding the function of genes and other parts of the genome is known as functional genomics.
		The functions of human genes and other DNA regions often are revealed by studying their parallels in nonhumans.
		The availability of complete genome sequences generated both inside and outside the HGP is driving a major breakthrough in fundamental biology as scientists compare entire genomes to gain new insights into evolutionary, biochemical, genetic, metabolic, and physiological pathways.
	www.ornl.gov /sci/techresources/Human_Genome/research/function.shtml (560 words)

	What is Evolutionary and Ecological Functional Genomics Home Page
		Functional genomics, however, has now expanded beyond both this biomedical orientation and any technical restriction to standard model organisms, and is being practiced on a wide array of species of agricultural, ecological, and evolutionary significance.
		Again, the inclusion of 'function' (i.e., physiology, biochemistry, cell biology, neurosciences, developmental biology, etc.) is necessary to transform speculation about what particular genes or their variants might mean into sophisticated, rigorous, hypothesis-driven investigations of what particular genes and their variants do mean in terms of function at higher levels of biological integration.
		This is 'evolutionary and ecological functional genomics' (EEFG).
	pondside.uchicago.edu /~feder/EEFG/EEFGdef.html (2119 words)

	Functional Genomics
		With the genomes of many microorganisms completely sequenced, and new ones emerging almost every month, science is faced with the challenge of understanding the function of all the newly discovered genes.
		The field which is emerging to establish their role is known as functional genomics, and it differs from classical genetics both in the comprehensive and integrative nature of its analytical approach and the fact that it does not rely on a one-to-one relationship between gene and phenotype.
		The implicit functional genomics agenda, then, is that by comparison of the large-scale (co)expression of orphan genes with those of "known" genes, in different genetic backgrounds and under different environmental conditions, one may acquire clues as to the function of the orphans.
	dbkgroup.org /fungen.htm (476 words)

	Functional genomics - Wikipedia, the free encyclopedia
		Functional genomics is a field of molecular biology that attempts to make use of the vast wealth of data produced by genomic projects (such as genome sequencing projects) to describe gene (and protein!) functions and interactions.
		Unlike genomics and proteomics, functional genomics focus on the dynamic aspects such as gene transcription, translation, and protein-protein interactions, as opposed to the static aspects of the genomic information such as DNA sequence or structures.
		Functional genomics includes function-related aspects of the genome itself such as mutation and polymorphism (such as SNP) analysis, as well as measurement of molecular activities.
	en.wikipedia.org /wiki/Functional_genomics (266 words)

	Genomics - Wikipedia, the free encyclopedia
		Investigation of single genes, their functions and roles is something very common in today's medical and biological research, and can not be said to be genomics but rather the most typical feature of molecular biology.
		Genomics can be said to have appeared in the 1980s, and took off in the 1990s with the initiation of genome projects for several species.
		A major branch of genomics is still concerned with sequencing the genomes of various organisms, although the knowledge of full genomes have created the possibility for the field of functional genomics, mainly concerned with patterns of gene expression during various conditions.
	en.wikipedia.org /wiki/Genomics (913 words)

	NC State Genomic Sciences : Functional Genomics
		Students take a 15-credit Genomic Sciences core curriculum of courses that is common to both the Bioinformatics and Functional Genomics degree programs to ensure that all Genomic Science graduates receive a solid grounding in the basic elements of both areas.
		The advisor for a student minoring in Functional Genomics is not required to be a member of the Genomic Sciences Faculty.
		The Advisory Committee for students seeking an M.S. degree must be comprised of a minimum of three NCSU faculty: one Bioinformatics faculty member, one Functional Genomics member and one additional faculty member (not necessarily a Genomic Sciences faculty member).
	genomics.ncsu.edu /function.html (942 words)

	Functional and Comparative Genomics Fact Sheet
		Genome researchers look at many different features when comparing genomes: sequence similarity, gene location, the length and number of coding regions (called exons) within genes, the amount of noncoding DNA in each genome, and highly conserved regions maintained in organisms as simple as bacteria and as complex as humans.
		Genome size does not correlate with evolutionary status, nor is the number of genes proportionate with genome size.
		DOE Joint Genome Institute - Consortium of U.S. Department of Energy researchers developing and exploiting new technologies as a means for discovering and characterizing the basic principles and relationships underlying living systems.
	www.ornl.gov /sci/techresources/Human_Genome/faq/compgen.shtml (1915 words)

	Functional Genomics - Novartis.com
		The recently completed human genome sequence is yielding a plethora of potential new targets for intervention by novel therapeutic agents in a variety of diseases.
		In order to effectively and competitively exploit the genome data, an industrialized multidisciplinary and process-driven approach was instituted in the Functional Genomics Department for drug target identification and validation.
		This is feasible because functional conservation of genes, pathways and processes between fruit flies and humans allows the results obtained using this genetically tractable model organism to be applied to humans.
	www.nibr.novartis.com /ExpertisePlatforms/FunctionalGenomics (569 words)

	CHI presents Genomics On Target 2003 (Site not responding. Last check: 2007-10-08)
		The application of activity-based protein profiling to the functional characterization of enzyme activities that vary in human cancer specimens will be highlighted, as will be the use of this strategy as a screen to discover potent and selective reversible enzyme inhibitors.
		Along with the draft of the complete human genome, a number of innovative approaches have been added to the functional genomics toolbox: combinatorial nucleic acid and peptide libraries, RNAi, gene expression profiling, proteomics, etc. Integration of these approaches has greatly facilitated the identification, validation, and optimization of the drug discovery process.
		Genomics is the comprehensive analysis of the entire genetic content of an organism, and is rapidly becoming an essential drug discovery tool.
	www.genomicsontarget.com /fgn2003.asp (1537 words)

	Pharmaceutical Genomics glossary
		Genome scans for other complex diseases have met with limited success, in part because of the difficulty in detecting the small individual contribution to phenotype made by many different genes.
		As vertebrate genome sequences near completion and research re- focuses on their analysis, the issue of effective sequence display becomes critical: it is not helpful to have 3 billion letters of genomic DNA shown as plain text.
		Therefore, genomic data should not be used in lieu of traditional biochemistry, but as an initial guidelines to identify areas for deeper investigation and to see how those results fit in with the rest of the genome.
	www.genomicglossaries.com /content/genomics_glossary.asp (6108 words)

	Functional Genomics - The Institute for Genomic Research
		The Pathogen Functional Genomics Resource Center (PFGRC) at TIGR centralizes production, access, and training in the use of a variety of resources for exploring the roles of genes and gene products (including proteins) in a significant number of microbes known to cause disease.
		The goal of the Arabidopsis Array Project is to provide experimental validation for Arabidopsis thaliana gene predictions and to begin to assign functional roles to genes using DNA microarray technology as a key tool.
		Potato Functional Genomics Project provides links to the NSF-funded potato genome project at TIGR and includes sequence data, annotation, and links to the Solanum tuberosum Gene Index.
	www.tigr.org /microarray (317 words)

	Center for Medicago Genomics Research
		Investments in Medicago genomic and functional genomic resources have paid off handsomely in the past few years, especially in the area of symbiotic nitrogen fixation (SNF) research, where a number of genes involved in nodule development have been cloned for the first time (reviewed in (Oldroyd and Downie, 2004; Udvardi and Scheible, 2005)).
		Knowledge gained from genomics and functional genomics research on Medicago truncatula is being utilized to improve important forage and grain legumes.
		In fact, this process of translational genomics from model to crop species, especially cool-season forage legumes is one of the flagship enterprises that link numerous groups within all three divisions of the Noble Foundation.
	www.noble.org /medicago (970 words)

	bio0202-The Multinational Coordinated Arabidopsis thaliana Functional Genomics Project
		The Multinational Coordinated Arabidopsis Functional Genomics Project is an idea that developed from a workshop that was held in early 2000 entitled “Functional Genomics and the Virtual Plant: A blueprint for understanding how plants are built and how to improve them” (text available at http://www.arabidopsis.org/info/workshop2010.html).
		Some of the technologies that will be used in the new era of functional genomics research will be beyond the scope of individual labs and some will require sets of biological reagents that are not feasible for individual labs to produce, such as a complete cDNA library and complete protein and metabolite inventories.
		The structure of Genome Technology Centers, providing services and economies of scale for systems-based data generation, is not consistent with the traditional training of doctoral and post-doctoral researchers, and the traditional output measurement of publications.
	www.nsf.gov /pubs/2002/bio0202/functional.htm (2813 words)

	NYU > Biology > Center for Comparative Functional Genomics
		The genomic and bioinformatic faculty in our center are engaged in collaborative projects with scientists at NYU's Courant Institute of Math and Computer Sciences, The American Museum of Natural History (AMNH), The New York Botanical Garden (NYBG), and Cold Spring Harbor Laboratories (CSHL), as well as collaborators at Harvard and Rockefeller University.
		As part of a multi-year hiring plan, New York University's Center for Comparative Functional Genomics in the Department of Biology invites applications for multiple faculty positions (rank open) to begin September 1, 2007, or as negotiated, pending administrative approval.
		The Brown 7 genome labs approximately 8,000 Sq ft are the first to be completed and include "open plan" laboratories with space for 47 researchers (wet bench plus bioinformatics), plus rooms for common equipment, and a genome core facility.
	www.nyu.edu /fas/dept/biology/resources/ccfg.html (627 words)

	Biopharmaceutical Functional Genomics glossary (Site not responding. Last check: 2007-10-08)
		Functional annotation of the genome is primarily hampered by the lack of a unified transcript index.
		Functional genomics aims to discover the biological function of particular genes and to uncover how sets of genes and their products work together in health and disease.
		Other functional genomics goals include studies into gene expression and control, creation of mutations that cause loss or alteration of function in nonhuman organisms, and development of experimental and computational methods for protein analyses.
	www.genomicglossaries.com /content/functional_genomics_gloss.asp (3485 words)

	UCDavis Cotton Functional Genomics
		A major effort currently underway in functional genomics focuses on expression profiling of the fiber transcriptome in response to developmental, physiological, and environmental stimuli to generate a developmental model.
		This work is complemented by reverse genetic and other cotemporary approaches to determine the functional role of cotton fiber genes via ectopic expression that encompasses recent innovations in cotton regeneration and transformation methodology developed by our group suited for high-throughput studies.
		Genomic tools and resources developed by our group are made available through our Service Facility to the scientific community.
	cottongenomecenter.ucdavis.edu (429 words)

	2004 GRC on Structural, Functional & Evolutionary Genomics
		It will take a systematic approach to genomics, examining the evolution of proteins, protein functional sites, protein-protein interactions, regulatory networks, and metabolic networks.
		Emphasis will be placed on what we can learn from comparative genomics and entire genomes and proteomes.
		"Genomic analysis of the evolution of olfactory genes in vertebrates"
	www.grc.org /programs/2004/genomics.htm (260 words)

	CHI presents Genomics On Target 2002 (Site not responding. Last check: 2007-10-08)
		Now that we have the working draft of the human genome, the race is on to identify the genes and determine the functional significance of each gene, understand the complex functional networks and control mechanisms, and figure out the role that genotype and environment play in determining the phenotype.
		Genomics by itself cannot usually determine even the biochemical, much less the cellular or physiological functions of a protein.
		Functionally, knowledge is the human interpretation of data; connections are the currency of knowledge.
	www.genomicsontarget.com /fgn.asp (3198 words)

	nature insights: Functional genomics (Site not responding. Last check: 2007-10-08)
		Functional genomics has leapt from being a surrealistic, or at least futuristic, concept in the 1980s to an accepted (if not yet everyday) part of science in the year 2000.
		The next step in this biological revolution is 'functional genomics', not simply the assignation of function to the identified genes but the organization and control of genetic pathways that come together to make up the physiology of an organism.
		Scientists are scrambling to develop new technologies that exploit genome data to ask entirely new kinds of questions about the complex nature of living cells.
	www.nature.com /nature/insights/6788.html (395 words)

	Frontiers of Functional Genomics
		The new programme is supported by science and medical research councils and academies in 17 participating European countries and overseen by a steering committee consisting of a representative from each country.
		It will connect the most promising developments in functional genomics technologies with the expanding concept of systems biology, focusing particularly on applications in biomedicine, as well as the environment and implications for society at large.
		Our activities will bring together a wide range of functional genomics researchers in Europe through workshops, training courses, conferences and grants for short term inter-laboratory visits.
	www.functionalgenomics.org.uk /sections/programme/index.htm (165 words)

	Center For Evolutionary Functional Genomics
		The recent ability to obtain the complete DNA sequence information of any organism, or genome, has allowed us to map and explore the genetic blueprints necessary for life as well as their evolution.
		A recent publication by the Center for Evolutionary Functional Genomics is featured as an editor's choice in Science magazine, the world's leading journal of original scientific research, global news, and commentary.
		“The EFG is building a leading research program at the interface of genomics and bioinformatics that emphasizes the development of methods, technologies, and tools for analyzing genome sequence and functional genomics data.
	biodesign.asu.edu /centers/efg (323 words)

	Functional Genomics (Site not responding. Last check: 2007-10-08)
		Integration of large genomic datasets has been used to derive information on protein-protein interactions, with the aid of a new algorithm for detecting new relationships from expression profiles.
		We have also investigated the relationship of gene expression data to protein structure and function and protein abundance, primarily in the yeast genome.
		As a part of the Yale Center for Excellence in Genome Sciences and the Yale Center for Genomics and Proteomics, the lab is working on large-scale analyses of transcriptional activity and regulation, principally in the human and yeast genomes, in collaboration with a number of other labs.
	bioinfo.mbb.yale.edu /expression (184 words)

	Functional Genomics of Eukaryotes Program (Site not responding. Last check: 2007-10-08)
		More recently their research have derived into functional genomic approaches, namely transcriptomics.
		Common bean is the most important legume for human consumption in the world, it is highly produced in Mexico and it is the main source of protein in human diet.
		Research is focused in functional genomics of nodulation/symbiotic nitrogen fixation and responses to abiotic stresses.
	www.ccg.unam.mx /FunctionalGenomicsOfEukaryotes/FunctionalGenomicsOfEukaryotes.php (187 words)

	Microbial Functional Genomics
		Genomics: Toward a Genome-level Understanding of the Structure, Functions, and Evolution of Biological Systems (Jizhong Zhou, Dorothea K. Thompson, and James M. Tiedje).
		2.5 Diversity of Microbial Genomes and Whole-Genome Sequencing.
		Functional Genomic Analysis of Bacterial Pathogens and Environmentally Significant Microorganisms (Dorothea K. Thompson and Jizhong Zhou).
	www.cplbookshop.com /contents/C2299.htm (941 words)

	Functional Genomics and Proteomics Laboratories
		“I have been using the Birmingham Genomics Labs services for the past 3 years and have found the service to be both extremely quick and reliable.
		The Genomics Lab also offers the best value for money service that I have seen in the market place.
		Overall I would say that the Genomics Lab is probably the best sequencing service available currently within the UK and I would recommend it to anyone looking for a fast, efficient, friendly and cost-effective service.”
	www.genomics.bham.ac.uk (134 words)

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