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Topic: G6PD deficiency


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In the News (Tue 21 Oct 14)

  
 [No title]
G6PD deficiency is the lack of glucose-6-phosphate dehydrogenase, an enzyme present in red blood cells, which can cause a type of anemia known as hemolytic anemia.
G6PD deficiency is inherited as an X-linked, recessive condition, meaning that this condition usually occurs in boys.
Treating the symptoms associated with G6PD deficiency is usually as simple as removing the trigger - that is, treating your child's illness or infection or discontinuing the use of a certain drug.
www.utoronto.ca /kids/G6PD.htm   (457 words)

  
  G6PD Deficiency
G6PD deficiency is an inherited condition in which the body doesn't have enough of the enzyme glucose-6-phosphate dehydrogenase, or G6PD, which helps red blood cells (RBCs) function normally.
G6PD deficiency is passed along in genes from one or both parents to a child.
Treating the symptoms associated with G6PD deficiency is usually as simple as removing the trigger — that is, treating the illness or infection or stopping the use of a certain drug.
kidshealth.org /parent/general/aches/g6pd.html   (886 words)

  
 G6PD (Glucose-6-Phosphate Dehydrogenase) Deficiency
G6PD deficiency is the lack of glucose-6-phosphate dehydrogenase (an enzyme present in red blood cells) in the blood, which can cause a type of anemia known as hemolytic anemia.
G6PD deficiency is inherited by a gene on the X chromosome.
G6PD deficiency is inherited from females who carry one copy of the gene on one of their X chromosomes, to half of their sons.
www.healthsystem.virginia.edu /UVAHealth/adult_blood/glucose.cfm   (614 words)

  
 Hematology & Blood Disorders - G6PD (Glucose-6-Phosphate Dehydrogenase) Deficiency
G6PD deficiency is the lack of glucose-6-phosphate dehydrogenase (an enzyme present in red blood cells) in the blood, which can cause a type of anemia known as hemolytic anemia.
G6PD deficiency is inherited by a gene on the X chromosome.
G6PD deficiency is inherited from females who carry one copy of the gene on one of their X chromosomes, to half of their sons.
uuhsc.utah.edu /healthinfo/adult/Hemat/glucose.htm   (627 words)

  
 Glucose-6-Phosphate Dehydrogenase Deficiency | AHealthyMe.com
Glucose-6-phosphate dehydrogenase deficiency is an inherited condition caused by a defect or defects in the gene that codes for the enzyme, glucose-6-phosphate dehydrogenase (G6PD).
G6PD deficiency is the most common enzyme deficiency in the world, with about 400 million people living with it.
G6PD deficiency is caused by one copy of a defective G6PD gene in males or two copies of a defective G6PD gene in females.
www.ahealthyme.com /topic/topic100586877   (1118 words)

  
 The Henna Page - The Encyclopedia of Henna
G6PD deficiency is an inherited condition, and any infant who is diagnosed with this condition MUST NOT have henna.
G6PD deficiency is a recessive x-chromosome sex-linked inheritable trait.
Pediatricians in hospitals in Kuwait, Oman, and Arabia screen newborns for hyperbilirubinemia and G6PD deficiency, and warn parents to NOT henna their children if they are G6PD deficient, or are in a family carrying the deficiency.
www.hennapage.com /henna/encyclopedia/medical/g6pd.html   (728 words)

  
 G6PD Deficiency - Health and Medical Information produced by doctors - MedicineNet.com
G6PD deficiency leads to an abnormal rupture (breakage) of the red blood cells called hemolytic anemia (abnormally low red blood cell count).
G6PD deficiency is the most common known human enzyme disease, affecting 10% of the world's population.
There are different degress of G6PD deficiency, which vary according to the magnitude of the missing enzyme.
www.medicinenet.com /g6pd_deficiency/article.htm   (379 words)

  
 G6PD DEFICIENCY, DISTRIBUTION AND VARIANTS   (Site not responding. Last check: 2007-10-17)
Background: The first report of glucose-6-phosphate dehydrogenase (G6PD) deficiency in the Saudi population of the Eastern province paved the way for extensive investigations to determine the distribution and molecular pathogenesis of G6PD deficiency in Saudis in different parts of the country.
The G6PD gene is highly polymorphic, and over 300 variants resulting from single-point mutations are known to exist in the different populations of the world.
Of the total 13,796 males, 1249 were deficient and among the 13,613 females screened, 558 were deficient, giving a frequency of G6PD deficiency of 0.0905 and 0.041, respectively, in the males and females.
www.kfshrc.edu.sa /annals/213_214/01-036.htm   (1479 words)

  
 Glucose-6-phosphate dehydrogenase deficiency - The Doctors Lounge(TM)
Glucose-6-phosphate dehydrogenase (G6PD) is an enzyme in the pentose phosphate pathway (see image), a metabolic pathway that supplies energy to a number of cells (most notably erythrocytes), and maintains the level of the co-enzyme nicotinamide adenine dinucleotide phosphate (NADPH).
Deficiency of G6PD in the alternative pathway causes the build up of glucose and thus there is an increase of advanced glucosylating end products (AGE).
G6PD is said to be the most common enzyme deficiency disease in the world.
www.thedoctorslounge.net /hematology/diseases/g6pd.htm   (795 words)

  
 Glucose-6-Phosphate Dehydrogenase Deficiency
G6PD deficiency affects 400 million people around the world and is the most common genetic enzyme deficiency in man. Population and epidemiology information point to G6PD deficiency as providing some resistance to malaria.
Females with one G6PD deficiency mutation are carriers at a 50% risk to pass their G6PD deficiency X chromosome to a male child.
G6PD deficiency is found in populations from areas of the world where malaria is prevalent.
www.pediatrix.com /body_screening_menu.cfm?id=1593   (694 words)

  
 G6PD deficiency and adoption from Cambodia.
G6PD is just an enzyme in the red blood cells which is involved in metabolism of some drugs and other substances.
G6PD deficiency in Cambodian children is not the same as G6PD deficiency in African American children.
G6PD deficiency can be diagnosed easily by a blood test that measures the enzyme in the red blood cells.
www.comeunity.com /adoption/health/g6pd.html   (659 words)

  
 Bioline International Official Site (site up-dated regularly)
G6PD deficiency screening studies carried out in Aegean region indicates that the frequency of severe G6PD deficiency in population conforms to the screening criteria of WHO G6PD Deficiency Working Committee.
The high incidence of severe G6PD deficiency in the sampled Turkish population may be due to the geographic region with the history of malaria endemic and was surrounded by Gediz river and several waterlands.
In conclusion, this high incidence of severe G6PD deficiency implies that this inherited metabolite disorder is an important health problem in Manisa region and it is necessary to carry out large-scale screening in the whole population since severe G6PD deficiency related health problems are preventable.
www.bioline.org.br /request?gm06002   (2226 words)

  
 G6PD: The Test
G6PD activity testing may be ordered on children who had persistent jaundice as a newborn that was not due to another identified cause.
G6PD activity testing is primarily performed on patients who have had symptoms of anemia (such as fatigue, pallor, a rapid heart rate) and/or jaundice.
Genetic G6PD testing may sometimes be done within a family to help identify the relevant mutation in female carriers (such as the mother of an affected son or daughter of an affected father) when one or more male family member has a G6PD deficiency.
www.labtestsonline.org /understanding/analytes/g6pd/test.html   (912 words)

  
 G6PD Deficiency
G6PD deficiency is an inherited condition in which the body doesn't have enough of the enzyme glucose-6-phosphate dehydrogenase, or G6PD, which helps red blood cells (RBCs) function normally.
G6PD deficiency is passed along in genes from one or both parents to a child.
Treating the symptoms associated with G6PD deficiency is usually as simple as removing the trigger — that is, treating the illness or infection or stopping the use of a certain drug.
www.kidshealth.org /parent/general/aches/g6pd.html   (886 words)

  
 G6PD Deficiency - 2nd edition - Family factsheets - GOSH and ICH
G6PD deficiency is inherited which means it is passed from one or both parents to the child.
For example, G6PD deficiency is found in approximately 1 in 5 Africans, 1 in 5 Thais, 1 in 10 Afro-Caribbeans, 1 in 12 Cypriots, 1 in 15 Indians and 1 in 30 Chinese.
People with G6PD deficiency may have some protection against malaria but it is still important for them to take malaria tablets when in areas of the world where malaria occurs.
www.gosh.nhs.uk /factsheets/families/F040269/index.html   (925 words)

  
 Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency: A Review
G6PD in the active state consists of identical subunits of dimer and tetramer, the proportion of the two forms are pH dependent.
G6PD gene is located in the terminal region of the long arm of the X chromosome (Xq28), less than 2 centi-Morgan centrometric to the Factor VIII gene.
For example, in Hong Kong where the deficient gene frequency (q) is 5.5% in the males, the incidence of heterozygous female (2pq) is 2 0.945 x 0.055=10% and homozygote female (q2) is 0.055 x 0.055 =0.3%.
www.cchi.com.hk /specialtopic/case1/case1.htm   (3966 words)

  
 G6PD: Test Sample
G6PD deficiency is the most common enzyme deficiency in the world, affecting about 400 million people, according to the Nemours Foundation.
Since the G6PD gene is located on the X chromosome, of which males only have one, males will have a G6PD deficiency if their G6PD gene is affected.
Most people with G6PD deficiency can lead fairly normal lives, but they must be cautious to avoid certain medications, foods (such as fava beans), chemical substances (such as naphthalene, found in moth balls), and infections (bacterial and viral) that can cause oxidative stresses and lead to bouts of hemolytic anemia.
www.labtestsonline.org /understanding/analytes/g6pd/sample.html   (501 words)

  
 Glucose-6-Phosphate Dehydrogenase Deficiency | Caremark Health Resources
Glucose-6-phosphate dehydrogenase deficiency is an inherited condition caused by a defect or defects in the gene that codes for the enzyme, glucose-6-phosphate dehydrogenase (G6PD).
G6PD deficiency is the most common enzyme deficiency in the world, with about 400 million people living with it.
G6PD deficiency is caused by one copy of a defective G6PD gene in males or two copies of a defective G6PD gene in females.
healthresources.caremark.com /topic/topic100586877   (1075 words)

  
 Welcome to gulfMD.com - The world of Health, Progress and Hope
G6PD deficiency is often classified according to how severe a child's hemolytic reaction is, with classes 1 and 2 being the most severe, class 3 being mild, and class 4 not causing any symptoms at all.
G6PD deficiency is inherited, or passed along from one or both parents to a child in genes.
This explains why many more boys than girls have G6PD deficiency: Girls have two X chromosomes, so there's a good chance that if they inherit the mutated gene that leads to G6PD deficiency from one parent, they will not inherit it from the other, leaving one of their X chromosomes unaffected.
www.gulfmd.com /kids/G6PD_deficiency.asp   (868 words)

  
 Diagnosis and management of G6PD deficiency American Family Physician - Find Articles   (Site not responding. Last check: 2007-10-17)
G6PD deficiency occurs with increased frequency throughout Africa, Asia, the Mediterranean, and the Middle East.
Prevalence of the deficiency is correlated with the geographic distribution of malaria, which has led to the theory that carriers of G6PD deficiency may incur partial protection against malarial infection.
G6PD deficiency is one of a group of congenital hemolytic anemias, and its diagnosis should be considered in children with a family history of jaundice, anemia, splenomegaly, or cholelithiasis, especially in those of Mediterranean or African ancestry.
www.findarticles.com /p/articles/mi_m3225/is_7_72/ai_n15798257   (787 words)

  
 Re: What is the most common disease caused by an enzyme deficiency?
G6PD deficiency is also sometimes referred to as favism since some G6PD deficient individuals are also allergic to fava beans.
Individuals with reduced G6PD activity are at risk for several pathologies which can be potentially serious (even causing death) if they are not properly treated.The severity of the pathologies associated with G6PD deficiency has prompted researchers to study this condition.
In G6PD deficient red blood cells, an essential metabolite for the survival of the parasite is present in insufficient quantities.
www.madsci.org /posts/archives/feb2002/1014083446.Me.r.html   (1108 words)

  
 Glucose-6-phosphate dehydrogenase deficiency - The Doctors Lounge(TM)
Glucose-6-phosphate dehydrogenase (G6PD) is an enzyme in the pentose phosphate pathway (see image), a metabolic pathway that supplies energy to a number of cells (most notably erythrocytes), and maintains the level of the co-enzyme nicotinamide adenine dinucleotide phosphate (NADPH).
Deficiency of G6PD in the alternative pathway causes the build up of glucose and thus there is an increase of advanced glucosylating end products (AGE).
G6PD is said to be the most common enzyme deficiency disease in the world.
www.doctorslounge.com /hematology/diseases/g6pd.htm   (795 words)

  
 G6PD deficiency | DoctorNDTV: Health Information on G6PD deficiency
G6PD deficiency is a condition in which the red blood cells lack the enzyme glucose-6-phosphate dehydrogenase (G6PD).
G6PD found in the red blood cells, and protects these cells against strong oxygen compounds (oxidants) that may collect in case of a fever or when certain medicines are taken.
G6PD deficiency is inherited and is found in both males and females.
www.doctorndtv.com /topics/detailtopics.asp?id=274&heading=AllTopic   (560 words)

  
 Glucose-6-phosphate dehydrogenase deficiency - Wikipedia, the free encyclopedia
The hemoglobin is metabolized to bilirubin (causing jaundice at high concentrations) or excreted directly by the kidney (causing acute renal failure in severe cases).
The high prevalence of diabetes mellitus type 2 and hypertension in Afro-Caribbeans in the West could be directly related to G6PD deficiency.
Although female carriers can have a mild form of G6PD (dependent on the degree of inactivation of the unaffected X chromosome - see lyonization), homozygous females have been described; in these females there is co-incidence of a rare immune disorder termed chronic granulomatous disease (CGD).
en.wikipedia.org /wiki/Glucose-6-phosphate_dehydrogenase_deficiency   (956 words)

  
 CLINICAL ASPECTS OF G6PD DEFICIENCY   (Site not responding. Last check: 2007-10-17)
In order to prevent a severe reaction or even death, G6PD deficient individuals are prohibited from taking certain drugs; a list of drugs that are commonly reported in the literature as inducing hemolysis in G6PD deficient individuals appears in Table 2.
Since some G6PD deficient individuals are allergic to fava beans, the deficiency is therefore sometimes referred to as favism (THE FAVISM HOMEPAGE).
The compounds vicine and isouramil, abundant in fava beans, are hypothesized to be the causative agents of the hemolytic response (Beutler, 1994).
www.rialto.com /g6pd/clinical.htm   (883 words)

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