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Topic: GFAP

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	GFAP definition - Medical Dictionary definitions of popular medical terms
		The degenerative brain condition called Alexander disease is caused by mutation in GFAP (glial fibrillary acidic protein).
		The altered GFAP protein may block the normal assembly of intermediate filaments and other proteins that contribute to the structure of astrocytes.
		The gene for GFAP is on chromosome 17 in band 17q21.
	www.medterms.com /script/main/art.asp?articlekey=33140 (441 words)

	Effects of microgravity and bone morphogenetic protein II on GFAP in rat brain -- Day et al. 85 (2): 716 -- Journal of ...
		The GFAP content in the remaining brain halves was assessed by using a sandwich ELISA (56).
		GFAP mRNA was quantified in the sm and slm of the hippocampus (Fig.
		The decrease in GFAP mRNA was accompanied by a 56% increase in the adrenal glucocorticoid Cort.
	jap.physiology.org /cgi/content/full/85/2/716 (3896 words)

	Differential expression of GFAP in early v late AMD: a quantitative analysis -- Wu et al. 87 (9): 1159 -- British ...
		Significantly increased GFAP immunoreactivity was noted in both astrocytes (that is, inner retinal expression; in NFL) and Müller cells (that is, outer retinal expression, aberrant, Ab) in all GA specimens, compared with the normal control.
		The predominant expression of GFAP in astrocytes and relative paucity of expression in Müller cell end feet is illustrated in (D).
		The significance of GFAP upregulation in retinal pathology,
	bjo.bmj.com /cgi/content/full/87/9/1159 (4228 words)

	NIOSH Update / Further Evidence of GFAP as a Useful Marker is Offered in New Study by NIOSH, Partner Researchers
		NIOSH researchers and their partners have been investigating the question of whether various occupational exposures are associated with a risk of neurological disease, using a study population of Japanese-American men who were born between 1900 and 1919.
		In this study, levels of GFAP, a sensitive marker of neural damage, were measured in brain tissue samples of deceased men who had been diagnosed with dementia, and of deceased men who had not been diagnosed with dementia.
		Further, the researchers showed that higher GFAP levels were associated with a lower performance on a test of cognitive function.
	www.cdc.gov /niosh/updates/upd-01-06-05.html (403 words)

	GFAP table
		GFAP in astrocytic cells; 55 kDa in WB.
		GFAP in astrocytes and microglia in the brain and in peripheral nerves; cytoplasmic
		GFAP; astrocytes in the brain, follicular-stellate cells of the pituitary gland, Schwann cells, and enteric glia cells; cytoplasmic
	www.alzforum.org /res/com/ant/GFAP/GFAP-tableC.html (1384 words)

	Edward T. Browning
		Vimentin is the intermediate filament protein that is expressed early in astrocytic development, GFAP is expressed as astrocytes mature.
		The thrust of recent research has been to identify the specific amino acid residues that are phosphorylated in GFAP and vimentin so that the phosphorylation of each may be studied independently.
		To accomplish this goal a double knockout of the GFAP gene is required in these diploid cells.
	www2.umdnj.edu /pharmweb/Faculty/ebrowning/ebrowning.htm (767 words)

	Sex Steroids and Synaptic Plasticity in Aging
		Transcriptional regulation of GFAP in astrocytes and of genes expressed in neurons that show modulation by estradiol using in vitro cell models for response to estradiol, corticosterone and injury.
		GFAP promoter regions were identified that mediate responses to wounding and interactions with E2 (Rozovsky et al., submitted).
		Reproductive aging and the regulation of GFAP in hypothalamic astrocytes in the female rat: dissociations of GFAP induction from the induced LH-surge, submitted.
	geroweb.usc.edu /epp/Project1.asp (663 words)

	ExactAntigen gfap -- reagents, researchers, and patents (Site not responding. Last check: 2007-10-10)
		(2002) Identification of GFAP gene mutation in hereditary adult-onset Alexander's disease Ann Neurol 52:779-85.
		(2004) The intermediate filament GFAP is important for the control of experimental murine Staphylococcus aureus-induced brain abscess and Toxoplasma encephalitis J Neuropathol Exp Neurol 63:631-40.
		(2004) Effects of 1alpha,25 dihydroxyvitamin D3 on the expression of HO-1 and GFAP in glial cells of the photothrombotically lesioned cerebral cortex J Chem Neuroanat 28:225-38.
	www.exactantigen.com /gene/gag/gfap.html (624 words)

	LIF and BMP signaling generate separate and discrete types of GFAP-expressing cells -- Bonaguidi et al. 132 (24): 5503 ...
		Sorted cells were plated in a neurosphere-forming assay to assess self-renewal and subsequent spheres were plated for differentiation to assess the ability to form neurons (red), astrocytes (purple) and oligodendrocytes (blue).
		EGFP fluorescence was exhibited by 29.4±3.3% of the GFAP
		the co-localization of Ki67 and GFAP in the SGZ (Fig.
	dev.biologists.org /cgi/content/full/132/24/5503 (6289 words)

	Imaging Endogenous Gene Expression in Brain Cancer In Vivo with 111In-Peptide Nucleic Acid Antisense ...
		The GFAP Northern autoradiogram for lanes 1–5 was developed overnight and for lanes 6–8 was developed for 10 d; despite this overexposure of the film, the signal representing the GFAP transcript expressed in C6 glioma cells in tissue culture is not detectable (B, lane 6).
		GFAP mRNA is not detectable in either RG2 cells (Fig.
		GFAP transcript was found in cultured C6 cells (Fig.
	jnm.snmjournals.org /cgi/content/full/45/10/1766 (5464 words)

	AANS.org \| Education and Meetings \| AANS Scientific Journals \| Neurosurgical Focus
		This GFAP is a 50-kD intracytoplasmic filamentous protein that constitutes a portion of, and is specific for, the cytoskeleton of the astrocyte.
		It is known that early in neuroembryogenesis, astrocytes may synthesize vimentin instead of GFAP as their primary IF.[7,109] The switch to GFAP predominance occurs prenatally in human astrocytes and is caused by factors that have yet to be elucidated.
		Because GFAP is a cytoskeletal element that appears to play an important role in astrocytic differentiation and because it is the most specific marker for cells of astrocytic lineage, several groups have studied how the modulation of GFAP expression might affect astrocytoma growth and differentiation.
	www.aans.org /education/journal/neurosurgical/july97/3-1-p2.asp (6822 words)

	Novel Molecular Method for Detection of Bovine-Specific Central Nervous System Tissues as Bovine Spongiform ...
		A segment of bovine, ovine, caprine, and porcine GFAP gene was
		Sequencing of the amplified subunits of bovine, ovine, caprine,
		Real-time GFAP RT-PCR amplification curves of undiluted and 10-, 100-, 1000-, 10,000-, and 100,000-fold dilutions of bovine cDNA.
	jmd.amjpathol.org /cgi/content/full/7/3/368 (4092 words)

	Proinflammatory cytokines increase glial fibrillary acidic protein expression in enteric glia -- von Boyen et al. 53 ...
		Lane 1: glial fibrillary acidic protein (GFAP) immunoreactivity of unstimulated cultures; lane 2: with 100 ng/ml interleukin (IL)-1ß and 20 µg/ml anti-IL-1ß; lane 3: with 5 ng/ml IL-1ß; lane 4: with 10 ng/ml IL-1ß; lane 5: with 20 ng/ml IL-1ß; lane 6: with 80 ng/ml IL-1ß; and lane 7: with 100 ng/ml IL-1ß.
		Lane 1: GFAP amount of unstimulated cultures; lane 2: GFAP amount with demecolcine; lane 3: cultures stimulated with IL-1ß (80 ng/ml); and lane 4: cultures after stimulation with IL-1ß (80 ng/ml) and demecolcine.
		is caused by an increase in GFAP expression in GFAP- enteric
	gut.bmj.com /cgi/content/full/53/2/222 (4081 words)

	The Predominant Neural Stem Cell Isolated from Postnatal and Adult Forebrain But Not Early Embryonic Forebrain ...
		NSCs or induce GFAP expression in all NSCs.
		GFAP immunoreactivity is intense in intracellular filaments located in cell processes and that sometimes traverse the cell body but is weak in somatic cytoplasm.
		GFAP is an intermediate filament protein, as are nestin and vimentin (Lendahl et al., 1990
	www.jneurosci.org /cgi/content/full/23/7/2824 (7551 words)

	Bidirectional Transcription Regulation of Glial Fibrillary Acidic Protein by Estradiol in Vivo and in Vitro -- Stone et ...
		In the arcuate nucleus of the hypothalamus, GFAP expression
		GFAP intron 1 in situ hybridization signal in the arcuate nucleus of the hypothalamus (A and B) and in the outer molecular layer of the dentate gyrus (C and D) during the rat estrous cycle.
		In situ hybridization analysis of GFAP intron 1 (A, C, and E) and GFAP mRNA (B, D, and F) levels in the arcuate nucleus of the hypothalamus (A and B), the outer molecular layer of the dentate gyrus (C and D), and the hilus (E and F) during the rat estrous cycle.
	endo.endojournals.org /cgi/content/full/139/7/3202 (4166 words)

	GFAP Is Expressed as a Major Soluble Pool Associated with Glucagon Secretory Granules in A-cells of Mouse Pancreas -- ...
		GFAP Is Expressed as a Major Soluble Pool Associated with Glucagon Secretory Granules in A-cells of Mouse Pancreas -- Bertelli et al.
		GFAP Is Expressed as a Major Soluble Pool Associated with Glucagon Secretory Granules in A-cells of Mouse Pancreas
		The association of GFAP with the periphery of secretory granules
	www.jhc.org /cgi/content/full/48/9/1233 (4829 words)

	Laser photocoagulation alters the pattern of staining for neurotrophin-4, GFAP, and CD68 in human retina -- Ghazi-Nouri ...
		The expression of GFAP and the macrophage marker
		Intense staining for GFAP was observed throughout all the retinal
		It is notable that an increased immunoreactivity for GFAP
	bjo.bmj.com /cgi/content/full/87/4/488 (2793 words)

	Glial Fibrillary Acidic Protein (GFAP)-like Immunoreactivity in Rat Endocrine Pancreas -- Regoli et al. 48 (2): 259 -- ...
		GFAP has been reported to be specifically expressed in mature
		cell GFAP is involved in the secretory machinery.
		Gard AL, White FP, Dutton GR (1985) Extraneural glial fibrillary acidic protein (GFAP) immunoreactivity in perisinusoidal stellate cells of rat liver.
	www.jhc.org /cgi/content/full/48/2/259 (3080 words)

	bosnia ch5
		The General Framework Agreement for Peace (GFAP) in Bosnia and Herzegovina authorized the establishment of IFOR to ensure compliance with the provisions of the GFAP.
		The implementation of the civil aspects of the GFAP was essential to IFOR's exit strategy and the return to normalcy for the people of Bosnia and Herzegovina.
		The primary and supporting military objectives outlined in the GFAP that had civil or political implications were translated into a comprehensive CIMIC Campaign Plan, which was to guide civil-military activities during the IFOR deployment.
	www.fas.org /irp/ops/smo/docs/ifor/bosch05.htm (4834 words)

	Clinicopathological study of cellular proliferation and invasion in gliomatosis cerebri: important role of neural cell ...
		Cells in the gemistocytic astrocytoma were (B) positive for GFAP but (E) were only weakly positive for L1.
		We categorised the neoplastic GC cells as type A (GFAP and L1 positive gemistocytic cells) and type B (small, GFAP and L1 negative or weakly positive, spindle shaped cells).
		A, in which GFAP and L1 positive gemistocytic cells are abundant.
	jcp.bmj.com /cgi/content/full/58/2/166 (2886 words)

	BordeyPublications
		The expression of GFAP in SVZ stem cells has lead investigators to call them astrocytes, a generic term for glia expressing GFAP.
		These GFAP-expressing cells express several features in common with astrocytes; these include the presence of glycogen granules, close contacts with blood vessels, ensheathment of neuronal elements (neuroblasts in the SVZ and synapses elsewhere in the brain), and glutamate transporters.
		Furthermore, ependymal cells, which are not astrocytes, express GFAP and derive from radial glia but are postmitotic.
	info.med.yale.edu /neurosur/research/bordey/Bordeyneurogenesis.html (1768 words)

	Cayman Chemical \| GFAP (human) EIA Kit \| Description
		Glial fibrillary acidic protein (GFAP) is a 40 - 53 kDa monomeric molecule found only in adult glial cells of the central nervous system (CNS) and represents the major part of the cytoskeleton of astrocytes.
		Traumatic injury to the adult CNS results in a rapid inflammatory response by the resident astrocytes, characterized mainly by hypertrophy, proliferation (of astrocytes), and increased GFAP expression, resulting in astrogliosis.
		Thus, GFAP is considered to be a reliable cell-specific biomarker for monitoring neuronal activity under developmental and pathological conditions, such as brain injury, and retinal stress.
	www.caymanchem.com /promo/chembuyersguide/catalog/10007621.html (194 words)

	Regulation of neural markers nestin and GFAP expression by cultivated bone marrow stromal cells -- Wislet-Gendebien et ...
		Regulation of neural markers nestin and GFAP expression by cultivated bone marrow stromal cells -- Wislet-Gendebien et al.
		Regulation of neural markers nestin and GFAP expression by cultivated bone marrow stromal cells
		GFAP (red) is expressed by a large fraction of cells (A), of which some also contained green fluorescent protein (B), and thus originate from mNSC.
	jcs.biologists.org /cgi/content/full/116/16/3295 (5034 words)

	RedOrbit - Science - Growth Hormone Overexpression in the Central Nervous System Results in Hyperphagia-Induced Obesity ... (Site not responding. Last check: 2007-10-10)
		Pancreatic sections from GFAP- bGH transgenic mice and littermate controls were examined by immunohistochemistry with proinsulin and glucagon antibodies.
		A marked islet hyperplasia was observed in the pancreas from GFAP-bGH mice, and the islet architecture was disturbed with an α-cell disorganization (Fig.
		In Table 3, the difference in gene expression between GFAP- bGH transgenic mice and littermate controls is given with respect to genes involved in metabolism as well as genes dependent on the sexually dimorphic secretory pattern of growth hormone (55-58).
	www.redorbit.com /news/display/?id=121755 (8340 words)

	Dysregulation of Signal Transduction Pathways as a Potential Mechanism of Nervous System Alterations in HIV-1 gp120 ...
		A riboprobe spanning the junction of GFAP exons
		Increased GFAP immunoreactivity in brains of humans with HIVE and tg mice with cerebral expression of HIV-1 gp120.
		increases in PKC and GFAP immunoreactivities in gp120- and PMA-stimulated
	www.jci.org /cgi/content/full/97/3/789 (7103 words)

	Oligodendrogliomas Result from the Expression of an Activated Mutant Epidermal Growth Factor Receptor in a RAS ...
		GFAP and APC IHC was used to identify differentiated astrocytes
		A–C, majority of the double transgenics were oligodendrogliomas with HandE staining (A) showing the typical fried egg appearance with homogenous round nuclei and condensed chromatin and GFAP (B) and Nestin (C) immunonegativity.
		D–F, a minority of the double transgenics showed oligoastrocytoma features with transformed appearing astrocytes with irregular nuclei (HandE, A) which were GFAP (E) and Nestin (F) positive, among the predominant oligodendroglioma cells.
	cancerres.aacrjournals.org /cgi/content/full/63/5/1106 (4228 words)

	GFAP table (Site not responding. Last check: 2007-10-10)
		IH(P) cell membrane GFAP in astrocytes, ependymal cells and corresponding tumors; no cross react with other intermediate filaments
		GFAP in astrocytic cells; no cross with other neurospecific proteins
		GFAP phospho T7; no cross with unphospho GFAP or with other phospho intermediate filament proteins
	www.alzforum.org /res/com/ant/GFAP/GFAP-tableNEW.shtml (1512 words)

	IngentaConnect Olig2 expression, GFAP, p53 and 1p loss analysis contribute to gl... (Site not responding. Last check: 2007-10-10)
		The expression of Olig2, a basic helix–loop–helix (bHLH) transcription factor involved in oligodendroglial specification, was investigated by immunohistochemistry in a series of 146 tumours and control samples.
		Double labelling was performed on a subset of the most typical tumours, according to the WHO classification.
		Combined testing of Olig2, 1p status, GFAP and p53 expression may therefore be helpful in refining current classification and providing more homogeneous sets of gliomas for clinical studies.
	www.ingentaconnect.com /content/bsc/nan/2005/00000031/00000001/art00007 (369 words)

	GFAP Promoter Drives Muller Cell-Specific Expression in Transgenic Mice -- Kuzmanovic et al. 44 (8): 3606 -- ...
		GFAP Promoter Drives Muller Cell-Specific Expression in Transgenic Mice -- Kuzmanovic et al.
		transgene and the endogenous GFAP gene was examined by injecting
		sequences of the GFAP gene are sufficient to direct high-level
	www.iovs.org /cgi/content/abstract/44/8/3606 (364 words)

	NATO/SFOR Informer: From GFAP to EU
		NATO/SFOR Informer: From GFAP to EU From GFAP to EU By Mr.
		On a regional level, "Bosnia and Herzegovina has to be seen in the wider regional context, and there Croatia and the FRY are now supporting the General Framework Agreement for Peace (GFAP) and are respecting the sovereignty of Bosnia and Herzegovina.
		These two countries have actually become Bosnia and Herzegovina's competitors for international funds, and they are also in the race to move ever closer to the EU.
	www.nato.int /sfor/indexinf/121/p15a/t0115a.htm (1308 words)

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