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Topic: GLUT4

In the News (Fri 17 Feb 12)

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	The Endosomal Compartment Is an Insulin-Sensitive Recruitment Site for GLUT4 and GLUT1 Glucose Transporters in Cardiac ...
		GLUT4 vesicle populations in cardiomyocytes in response to insulin
		Immunotitration of GLUT4, GLUT1, and SCAMPs in intracellular membranes from nonstimulated cardiomyocytes.
		GLUT4 and GLUT1 in the plasma membrane; Fig.
	endo.endojournals.org /cgi/content/full/142/12/5267 (6050 words)

	Characterization of Two Distinct Intracellular GLUT4 Membrane Populations in Muscle Fiber. Differential Protein ...
		The abundance of GLUT4 was assayed in 1) surface membrane fraction 23F1 enriched in sarcolemmal markers and in membrane fraction 23F2 enriched in sarcolemmal markers and in T-tubule markers; and 2) in intracellular membranes 26F1, 29F1, 35F1, 26F2, 29F2, and 35F2 from control and insulin-stimulated muscles.
		The abundance of GLUT4 and cellubrevin was assayed in plasma membranes (PM) and intracellular membrane fractions (LDM) from unstimulated and insulin-treated cardiomyocytes (A).
		that cellubrevin and VAMP2 colocalize with GLUT4 in intracellular
	endo.endojournals.org /cgi/content/full/138/7/3006 (6601 words)

	GLUT4 and Transferrin Receptor Are Differentially Sorted Along the Endocytic Pathway in CHO Cells -- Wei et al. 140 ...
		GLUT4 and Transferrin Receptor Are Differentially Sorted Along the Endocytic Pathway in CHO Cells -- Wei et al.
		The trafficking of GLUT4, a facilitative glucose transporter, is examined in transfected CHO cells.
		of GLUT4 and GLUT1 subcellular trafficking in basal and insulin-stimulated
	www.jcb.org /cgi/content/full/140/3/565 (6829 words)

	Aberrant insulin-induced GLUT4 translocation predicts glucose intolerance in the offspring of a diabetic mother -- ...
		Aberrant insulin-induced GLUT4 translocation predicts glucose intolerance in the offspring of a diabetic mother -- Thamotharan et al.
		Representative Western blots (top) depict GLUT4 in sarcolemmal/plasma membrane (PM) and low-density microsomal (LDM) subcellular fractions in 1-day-old rats born to control mothers that were treated with either vehicle (0 U/kg at 0 min) or insulin at 8 or 40 U/kg at 10, 20, and 40 min before analysis.
		Representative Western blots demonstrate GLUT4 in PM and LDM subcellular fractions in 1-day-old rats born to CP and DP mothers that were treated with vehicle (0 min) or with 8 U/kg (low dose) or 40 U/kg (high dose) of insulin 20 min before analysis.
	ajpendo.physiology.org /cgi/content/full/284/5/E901 (7109 words)

	Separation of Insulin Signaling into Distinct GLUT4 Translocation and Activation Steps -- Funaki et al. 24 (17): 7567 ...
		GLUT4 translocated to the plasma membrane by PBP10 treatment was exposed to the extracellular surface.
		GLUT4 to the plasma membrane in spite of the PI 3-kinase inhibitor,
		Dissociation of insulin-stimulated glucose uptake and GLUT4 translocation.
	mcb.asm.org /cgi/content/full/24/17/7567 (6874 words)

	Insulin Increases Cell Surface GLUT4 Levels by Dose Dependently Discharging GLUT4 into a Cell Surface Recycling Pathway ...
		that a significant proportion of GLUT4 is clustered in the TGN
		of wild-type GLUT4 and GLUT4 Tail in fibroblasts and adipocytes
		of GLUT4 Tail in adipocytes and that of GLUT4 in fibroblasts.
	mcb.asm.org /cgi/content/full/24/14/6456 (6557 words)

	Muscle-specific Transgenic Complementation of GLUT4-deficient Mice . Effects on Glucose But Not Lipid Metabolism -- ...
		GLUT4 in the etiology of the GLUT4-null phenotype.
		of the impairment in the expression or the translocation of GLUT4
		to the GLUT4 carboxy terminus (16, 17) and subsequently a
	www.jci.org /cgi/content/full/100/3/671 (4536 words)

	GLUT4
		Moderately reduced glycemias in the fasted state and increased glycemias in the fed state of male mice
		Cardiac and adipose tissue abnormalities but not diabetes in mice deficient in GLUT4
		The murine GLUT4 (glucose transporter-4) gene and promoter were cloned by plaque hybridization to the rat GLUT4 complementary DNA from a genomic 129/Sv lambda library.
	www.bioscience.org /knockout/glut4.htm (151 words)

	New protein provides clue to diabetes
		While most glucose transporters reside at the cell surface, GLUT4 is usually deep inside the cell, only moving to the surface when insulin sends a signal.
		When insulin reaches the cell surface, it signals TUG to release GLUT4, which then moves to the cell surface to allow glucose absorption.
		Lodish proposes that discovering this key component of the GLUT4 pathway is a significant clue for possibly identifying a diabetes drug target.
	www.eurekalert.org /pub_releases/2003-10/wifb-npp101503.php (843 words)

	And Then There Was GLUT4: Tackling Diabetes At The Molecular Level
		Thus it could be seen that GLUT4 is an especially key component of the body’s metabolic network; not only is it responsible for glucose intake in individual tissues, but it also affects the activity of organs in which it is not even found.
		Second, it serves to remind us that the body is not merely an amalgam of individual systems, each isolated to their own specific tasks, but instead it is a complex network of dazzling interactions—it is a universe that continually reveals new surprises, applications, and challenges.
		Essentially, the mice missing one or both copies of the GLUT4 gene suffered from insulin resistance—a condition that is well-recognized as a symptom of type II diabetes.
	student.biology.arizona.edu /honors2005/group05/glucose.html (920 words)

	Altered Hepatic and Muscle Substrate Utilization Provoked by GLUT4 Ablation -- Ranalletta et al. 54 (4): 935 -- Diabetes
		Increased activation of the pentose phosphate pathway in GLUT4 null liver.
		representation of the adaptations in GLUT4 null liver and skeletal
		GLUT4 null mice have an enhanced ability to clear serum TGs, suggesting increased peripheral TG utilization in the absence of GLUT4.
	diabetes.diabetesjournals.org /cgi/content/full/54/4/935 (5345 words)

	Turning Signals On and Off: GLUT4 Traffic in the Insulin-Signaling Highway -- Thong et al. 20 (4): 271 -- Physiology
		GLUT4 translocation (58, 87, 130) and fusion with the membrane
		GLUT4 translocation, expression of a CA Akt1 fused to the NH terminus of GLUT4 was without effect on IRAP translocation (29).
		Inhibition of the translocation of GLUT1 and GLUT4 in 3T3-L1 cells by the phosphatidylinositol 3-kinase inhibitor, wortmannin.
	physiologyonline.physiology.org /cgi/content/full/20/4/271 (7481 words)

	GLUT4 glucose transporter deficiency increases hepatic lipid production and peripheral lipid utilization -- Kotani et ...
		Impact of absence of GLUT4 in adipose tissue and muscle on glucose tolerance, insulin tolerance, and plasma insulin levels.
		Effect of GLUT4 KO in both adipose tissue and skeletal muscle compared with single-tissue GLUT4 knockout mice.
		Impact of decreasing GLUT4 in adipose tissue and muscle on in vivo glucose metabolism.
	www.jci.org /cgi/content/full/114/11/1666 (6941 words)

	Recycling of the Insulin-sensitive Glucose Transporter GLUT4. ACCESS OF SURFACE INTERNALIZED GLUT4 MOLECULES TO THE ...
		The insulin-sensitive glucose transporter GLUT4 is translocated to the plasma membrane in response to insulin and recycled
		Recycling of endocytosed GLUT4 was studied by comparing the cellular
		Entry of Newly Synthesized GLUT4 into the Insulin-responsive Storage Compartment Is Dependent upon Both the Amino Terminus and the Large Cytoplasmic Loop
	www.jbc.org /cgi/content/abstract/276/5/3371 (619 words)

	Reduced glucose uptake precedes insulin signaling defects in adipocytes from heterozygous GLUT4 knockout mice -- LI et ...
		Reduced glucose uptake precedes insulin signaling defects in adipocytes from heterozygous GLUT4 knockout mice -- LI et al.
		Expression of GLUT4 protein in controls was set to 100% in each group.
		The reduction of GLUT4 expression was similar among N/N, N/H, and H/H adipocytes of GLUT4(+/-) mice (Fig.
	www.fasebj.org /cgi/content/full/14/9/1117 (4545 words)

	Metabolic adaptations in skeletal muscle overexpressing GLUT4: effects on muscle and physical activity -- TSAO et al. ...
		Metabolic adaptations in skeletal muscle overexpressing GLUT4: effects on muscle and physical activity -- TSAO et al.
		GLUT4 is important in both the regulation of glucose
		GLUT4 is expressed at high levels in skeletal muscles that predominantly
	www.fasebj.org /cgi/content/full/15/6/958 (6865 words)

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