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Detection of Galactomannan Antigenemia in Patients Receiving Piperacillin-Tazobactam and Correlations between In ...   (Site not responding. Last check: 2007-10-02) The galactomannan antigen reactivity observed in vitro with -mannitol and serum galactomannan as markers of infection. Efficacy of galactomannan antigen in the Platelia Aspergillus enzyme immunoassay for diagnosis of invasive aspergillosis in liver transplant recipients. jcm.asm.org /cgi/content/full/42/10/4744   (3037 words)

Patent 6,583,124 Galactomannan polymers are also readily available and have been used in food and personal care products such that the polymers are considered to be safe. Moreover, the galactomannans of the present invention (e.g., guar gum) demonstrate excellent gelling consistency and reproducibility, though the type or source of the galactomannan is varied. The types of galactomannans that may be used in the present invention are typically derived from guar gum, locust bean gum and tara gum. www.pharmcast.com /Patents/Yr2003/Jun2003/062403/6583124_Ophthalmic062403.htm   (2360 words)

Patent 6,413,494 In a preferred embodiment of the invention, the composition comprises (a) pectin or a derivative of pectin or a mixture thereof and (b) galactomannan. When pectin or galactomannan (such as guar gum or locust bean gum) is used alone as a drug carrier, e.g., coating material, the coating is easily dissolved and/or disintegrated in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF). Because both the pectin and galactomannan components of the composition of the present invention are specifically degraded in the colon, there is a burst of drug release in the colon due to the synergic effect of the colonic enzymatic activities. www.pharmcast.com /Patents/Yr2002/July2002/070202/6413494_Colonic070202.htm   (1860 words)

US Food & Drug Administration (FDA) approves the marketing of Platelia Aspergillus EIA kit in USA Galactomannan is a component of the fungal cell wall and an exoantigen of Aspergillus. Galactomannan antigen positivity can be detected 5-8 days (average) before clinical signs develop (in 65.2% of patients), findings on chest X-ray are visible (in 71.5% of patients) and culture results become positive (in 100% of patients) [ Among these, 31 patients had proven or probable IA. Galactomannan antigen was detected in 25 of these 31 patients with a resulting sensitivity of 80.7%. www.doctorfungus.org /news/aspergillosis_June03.htm   (986 words)

Research activity (text) The alkali-soluble fraction is mainly composed of a alpha1-3glucan and galactomannan. Galactomannan, chitin and beta1-3 glucan are the main components of the alkali-insoluble fraction. Galactomannan is composed of a core chain of alpha-mannose residues with a repeating mannose unit -[2Man alpha1-2Man alpha1-2Man alpha1-6Man-1]- and short side chains of beta1-5galactofuranose residues. www.pasteur.fr /recherche/unites/aspergillus/research2.htm   (2209 words)

[No title]   (Site not responding. Last check: 2007-10-02) The cationic galactomannan gum can be selected from the group consisting of cationic guar, locust bean and fenugreek gums, preferably the cationic galactomannan gum is cationic guar and cationic locust bean, and most preferably it is cationic guar gum. The composition of claim 2 wherein the cationic galactomannan gum is selected from the group consisting of guar, locust bean and fenugreek gum, the acid is water- soluble acid in particulate form, the ratio of cationic galactomannan gum to cationic starch is The composition of claim 18 wherein the cationic galactomannan gum is cationic guar gum, the acid is fumaric acid, and the ratio of cationic galactomannan gum to cationic starch is about 1: 10. www.wipo.int /cgi-pct/guest/getbykey5?KEY=00/31339.000602&ELEMENT_SET=DECL   (3261 words)

Aspergillosis Galactomannan antigen positivity is among the microbiological diagnostic criteria proposed by European Organization for Research and Treatment of Cancer (EUORTC) and Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group (MSG) for diagnosis of invasive aspergillosis [132]. Galactomannan antigen positivity can be detected 5-8 days (average) before clinical signs develop (in 65.2% of patients), findings on chest X-ray are visible (in 71.5% of patients) and culture results become positive (in 100% of patients) [2291]. It appears to be more frequent in children [1013, 1306] and may develop after translocation of galactomannan antigen found in various food stuff (bread, pasta, corn flakes, rice, cake, turkey, sausage, etc.) through the damaged intestinal mucosa [1306]. www.doctorfungus.org /mycoses/human/aspergillus/aspergillosis.htm   (2175 words)

Reactivity of Platelia Aspergillus Galactomannan Antigen with Piperacillin-Tazobactam: Clinical Implications Based on ... Galactomannan assay reactivity with antibiotic dilutions at achievable peak concentrations in serum and at a two-fold dilution above and at 2 dilutions below the peak Prospective assessment of Platelia Aspergillus galactomannan for the diagnosis of invasive aspergillosis in lung transplant recipients. Use of circulating galactomannan screening for early diagnosis of invasive aspergillosis in allogeneic stem cell transplant recipients. aac.asm.org /cgi/content/full/48/6/1989   (2137 words)

99 MLS Project-Jaime Wolansky   (Site not responding. Last check: 2007-10-02) The Aspergillus antigen galactomannan, or GM, is a major cell wall component and a major circulating antigen. Galactomannan Extraction: The initial weight of the freeze dried ethanol precipitate was 110.4 mg. The % yield of galactomannan from the ethanol precipitate is3.4 %. www.ualberta.ca /~medlabsc/wolansky.html   (903 words)

[No title]   (Site not responding. Last check: 2007-10-02) There is a relatively large number of galactomannans, which vary in composition depending on their origin. Galactomannan gums include guar gum, which is the pulverized endosperm of the seed of either of two leguminous plants (cyamposis tetragonalobus and psoraloids) and locust bean gum, which is found in the endosperm of the seeds of the carob tree (ceratonia The composition in accordance with claim 1 wherein said polymeric skin penetration enhancer is a polysaccharide gum selected from the group consisting of agar gum, alginate, carob gum, carrageen gum, ghatti gum, guar gum, karaya gum, kadaya gum, locust bean gum, rhamsan gum, xanthan gum, and a mixture thereof. www.wipo.int /cgi-pct/guest/getbykey5?KEY=99/22716.990514&ELEMENT_SET=DECL   (6081 words)

Title of Invention: Production of guar alpha-galact osidase by hosts transformed with recombinant DNA methods Galactomannans obtained from guar (Cyamopsis tetragonoloba), lucern (Medicago sativa) and fenugreek (Trigonella foenum-graecum) containing high proportions of galactose are mentioned as examples which can be used as starting materials in the process described in EP-A- 0 121 960. They yield galactomannans which have improved properties and can be used, for example as substitutes for locust bean (carob) gum, which has more favourable properties, such as gelling properties, in particular with other polysaccharides, than untreated guar gum has. (2) the use of a galactomannan with reduced galactose content in the preparation of foodstuffs, animal feedstuffs or cosmetics, which galactose-reduced galactomannan is obtained by treatment of a galactomannan having a higher galactose content with an alpha-galactosidase produced by a process according to the invention. www.nal.usda.gov /bic/Biotech_Patents/1994patents/05296365.html   (18772 words)

491. Carob bean gum (WHO Food Additives Series 15) A digestibility study in groups of five male and five female rats (Purdue strain) on a mannose-free diet showed that 85-100% of mannose fed as 1% carob bean gum in the diet for 18 hours was excreted in the faeces over a total of 30 hours. Some decrease in chain length of galactomannan may have occurred, probably through the action of the microflora as mammals are not known to possess mannosidase. The carbohydrate component of carob bean gum is considered to be a neutral galactomannan polymer consisting of a main chain of 1,4- linked D-mannose units with a side chain of D-galactose on every fourth or fifth unit, attached through 1,6-glycosidic linkages to the polymannose chain. www.inchem.org /documents/jecfa/jecmono/v15je06.htm   (2407 words)

Diagnosis of aspergillus peritonitis in a renal dialysis patient by PCR and galactomannan detection -- Scotter et al. ... Diagnosis of aspergillus peritonitis in a renal dialysis patient by PCR and galactomannan detection -- Scotter et al. Diagnosis of aspergillus peritonitis in a renal dialysis patient by PCR and galactomannan detection Autopsy-controlled prospective evaluation of serial screening for circulating galactomannan by a sandwich enzyme-linked immunosorbent assay for haematological patients at risk of invasive aspergillosis. jcp.bmjjournals.com /cgi/content/full/57/6/662   (1426 words)

Gelling compositions having a base of galactomannans and xanthan - Patent 4369125 In a method for obtaining aqueous gels based on galactomannan and xanthan, the xanthan employed has first been subjected to a treatment resulting in partial or total deacetylation before being introduced in the mixture in which the ratio of deacetylated xanthan to galactomannan is within the range of 15/85 to 90/10. A gelling composition consisting essentially of xanthan and a galactomannan gum selected from the group consisting of carob gum, tara gum, Espina Corona gum and mixtures thereof, wherein said xanthan has been subjected to a total or partial deacetylation treatment and wherein the ratio of deacetylated xanthan to galactomannan is from about 15/85 to 90/10. Gelling agents which are also known include those obtained from glucides such as the sugars as a result of the action of a micro-organism; this is the case of xanthan, which is a polysaccharide obtained as a result of the action of bacteria of the Xanthomonas type. www.freepatentsonline.com /4369125.html   (2163 words)

Effect of amphotericin B treatment on kinetics of cytokines and parameters of fungal load in neutropenic rats with ...  Galactomannan (GM) concentrations in the infected left lung (a) and serum (b) of rats with IPA. Quantitative galactomannan detection is superior to PCR in diagnosing and monitoring invasive pulmonary aspergillosis in an experimental rat model. Efficacy of unilamellar liposomal amphotericin B in treatment of pulmonary aspergillosis in persistently granulocytopenic rabbits: the potential role of bronchoalveolar D-mannitol and serum galactomannan as markers of infection. jac.oxfordjournals.org /cgi/content/full/52/3/428   (3952 words)

Project Preview   (Site not responding. Last check: 2007-10-02) The fenugreek galactomannan (hydrocolloid) can be used as a stabilizer and/or additive in a variety of foods, while with further development, the saponin fraction could also be employed as an effective emulsifier in cosmetics. Recently, physiological experiments carried out in animals and humans have shown that both galactomannan and saponin are effective in lowering cholesterol and glucose levels in the blood. The galactomannan has very good emulsification capabilities compared to other water soluble hydrocolloids and is a water soluble gum, having surprisingly unexpected surface activity. www.yissum.co.il /admin/project/project_preview.asp?ind=107   (488 words)

Publication Details - Philip A. Pizzo, M.D. - Stanford University School of Medicine A model of primary pulmonary aspergillosis in rabbits was developed to reproduce the persistent levels of profound granulocytopenia and the histopathologic features of bronchopneumonia, vascular invasion, and hemorrhagic infarction encountered in humans. D-mannitol was detectable in bronchoalveolar lavage fluid by gas-liquid chromatography/mass spectroscopy, and galactomannan was measurable in serum by latex agglutination immunoassay. Thus, D-mannitol in lavage fluid and galactomannan in serum may be useful markers of pulmonary aspergillosis, and liposomal amphotericin B was significantly more effective and safer than desoxycholate amphotericin B for treatment of pulmonary aspergillosis in profoundly granulocytopenic rabbits. www-med.stanford.edu /profiles/frdActionServlet?choiceId=showPublication&pubid=46272&fid=3843   (212 words)

Product Profile: Xanthan Gum & Cassia Tora Gum   (Site not responding. Last check: 2007-10-02) Galactomannans mixed with xanthan gum produce solutions that defy ordinary viscous blending laws. The synergism is a result of the interaction between the ordered region on the xanthan gum molecule and the unsubstituted "smooth" region of the galactomannan [2]. The synergism between xanthan gum and the galactomannan, carboxy methyl cassia tora gum, is profiled here. www.vilastic.com /PP3.html   (248 words)

Locust bean gum It encourages phase separation with skimmed milk powder showing synergistic viscosity with casein and becoming slightly thixotropic on forming a biphasic system containing casein micelles within a polysaccharide continuous network. Another galactomannan with lower substitution (with a mannose to galactose ratio of between about 5 - 7) is cassia gum, obtained from Cassia tora (also known as Cassia obtusifolia). Galactomannans may be engineered with lower substitution by the specific removal of some of their pendant galactose groups using certain www.lsbu.ac.uk /water/hyloc.html   (462 words)

CSIRO PUBLISHING - Australian Journal of Experimental Agriculture Seed galactomannans function as both an energy reserve and a water reservoir in germinating seed of many leguminous plants, and are used commercially as gelling agents, mainly in processed foods. The galactomannan content of 40 samples of C. The galactomannan content of whole seed was 33.7 ± 0.4% (mean and s.e.m. www.publish.csiro.au /nid/72/paper/EA01161.htm   (210 words)

VitaSprings.com - Promilin Fenugreek Seed Extract 500mg 60 tabs from Source Naturals One, a patent pending extract called Promilin, is standardized to contain 20% 4-hydroxyisoleucine; the other is rich in galactomannan fibers. Research suggests that both 4-hydroxyisoleucine and galactomannan fibers help support healthy blood sugar and insulin levels when used as part of your diet. One of the formula's fenugreek extracts is rich in galactomannan, a mucilaginous fiber that may benefit the bowel. www.vitasprings.com /promilin-source-naturals-print.html   (529 words)

European Society of Clinical Microbiology and Infectious Diseases   (Site not responding. Last check: 2007-10-02) Early diagnosis is important to achieve the best outcome for these patients; however, definite proof often is difficult to obtain due to counterindicated invasive procedures. Serum galactomannan detection is considered to be a useful test for early diagnosis and follow –up of invasive aspergillosis. No antigens were detected in the sera from one patient with confirmed IA. Latex agglutination assay of galactomannan was positive in both patients with probable IA. In patients without IA, 9 of 88 had positive antigenemia. www.blackwellpublishing.com /eccmid15/abstract.asp?id=37341   (377 words)

Forest Seeds ­ A Source of Gum   (Site not responding. Last check: 2007-10-02) The seeds of Cyamopsis tetragonolobus belonging the family Leguminosae is an event which has resulted in the emergence of one of the most important plants based industries of India and has contributed in its economic development. This galactomannan known as guar gum, has found varied uses in modern industries of mining, textiles, paper, pharmaceuticals, cosmetics, Oil-well drilling etc. throughout the world. The investigations carried out at this institute has shown that seeds of Leucaena leucocephala, Prospis cineraria and Cassia tora yield ~20­35 per cent galactomannan which is invariably present in the endosperm of the seeds and, therefore, easily separable by mechanical means. www.metla.fi /iufro/iufro95abs/d5pap104.htm   (227 words)

New Page 1 Researchers believe that the proven health benefits are related to the galactomannan which is the special hydrocolloid gum in the fenugreek. The special structure of the fenugreek galactomannan (substitution rate mannose: galactose of 1:1), is considered responsible for its superior potency over other dietary fibers. Unfortunately, a pungent odor and bitter taste have kept the fenugreek benefits from being widely enjoyed in western cultures until the most recent breakthrough by Adumim in 1998. www.fenupure.com /fenupure/fenupure.seedtoshelf.htm   (703 words)

Invasive Aspergillosis in Critically Ill Patients without Malignancy -- Meersseman et al. 170 (6): 621 -- American ...   (Site not responding. Last check: 2007-10-02) Galactomannan testing was performed in 51 of the 67 patients had serum galactomannan assays, but neither of them were positive. Maertens J, Verhaegen J, Lagrou K, Van Eldere J, Boogaerts M. Screening for circulating galactomannan as a noninvasive diagnostic tool for invasive aspergillosis in prolonged neutropenic patients and stem cell transplantation recipients: a prospective validation. ajrccm.atsjournals.org /cgi/content/full/170/6/621   (4071 words)

IngentaConnect Water-Soluble Galactomannan from the Seed of Ground Honeysuckle (... Water-Soluble Galactomannan from the Seed of Ground Honeysuckle (Lotus corniculatus L.): Structure and Properties Galactomannan, a water-soluble heteropolysaccharide, was isolated from the seed of a Far Eastern population of the ground honeysuckle Lotus corniculatus L. (yield, 1.65%). Analysis of this galactomannan showed that it consists of D-mannose and D-galactose residues (molar ratio, 1.22 : 1). www.ingentaconnect.com /content/maik/abim/2003/00000039/00000005/00474538   (213 words)

TAPPI -- leading technical association for the pulp, paper, and converting industry. Pulp strength loss during oxygen delignification is caused by cellulose depolymerization resulting from attack by radicals generated during delignification reactions. The objective was to investigate the use of radical-scavenging polymer additives that adsorb on cellulose surfaces where protection from radicals is needed. Increases in lignin–cellulose selectivity were observed for guar galactomannan as the adsorbed additive at charges as low as 0.3% on pulp. www.tappi.org /index.asp?pid=26028   (229 words)

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