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Topic: Galantamine

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	Galantamine articles and Alzheimer's research
		Galantamine is different from donepezil (Aricept®) and rivastigmine (Exelon®) in one very important way, galantamine has the unique ability to increase the receptiveness of nicotinic receptors to acetylcholine continue
		efficacy of galantamine in dementia and Alzheimer's disease
		Galantamine is an attractive option for patients with Alzheimer's disease who have not benefited from their current therapy.
	www.galantamine.cc (784 words)

	Galantamine - Wikipedia, the free encyclopedia
		Galantamine in its pure form is a white powder.
		Galantamine is a competitive and reversible cholinesterase inhibitor.
		Galantamine is indicated for mild to moderate dementia of the Alzheimer’s type.
	en.wikipedia.org /wiki/Galantamine (616 words)

	Life Enhancement:: Remember Galantamine? (How Could You Forget?)
		Galantamine is an alkaloid found in certain flowers, notably the common snowdrop, the daffodil, and the spider lily.
		Galantamine is used primarily in counteracting memory loss and other symptoms of age-related cognitive impairment, an insidious condition that eventually affects everyone to some degree.
		Because galantamine's efficacy is not limited by drug tolerance, it may retard the progress of dementia, in which case it may well extend the life of the patient.
	www.life-enhancement.com /article_template.asp?ID=692 (2732 words)

	Galantamine : by Ray Sahelian, M.D., galantamine for alzheimer's
		Galantamine offsets reductions in central cholinergic neurotransmission in Alzheimer's disease by specifically and reversibly inhibiting acetylcholinesterase.
		As galantamine is a modest acetylcholinesterase inhibitor in addition to being an allosteric modulator of nicotinic acetylcholine receptors, it is interesting to study the clinical effects of this compound in the light of its neurochemical properties to discern potential neuroprotective effects.
		Galantamine's safety profile is similar to that of other cholinesterase inhibitors with respect to cholinergically mediated gastrointestinal symptoms.
	www.raysahelian.com /galantamine.html (2488 words)

	Galantamine fights Alzheimer's article
		Galantamine helps preserve cholinergic function by effectively increasing the abundance of acetylcholine, which is required for proper memory function.
		In the second study, galantamine was again tested using a slow dose escalation, this time over a period of 8 weeks, in 978 patients with mild to moderate Alzheimer's disease.
		Moly (galantamine) is instrumental to the triumph of Odysseus, as it may be for you.
	www.smartnutrition.info /galantamine-alzheimers.htm (2902 words)

	Alzheimer's treatment Galantamine S
		Moreover, as the researchers found, galantamine does something else that none of the drugs or other herbs used to treat cholinergic decline do: it binds to acetylcholine receptors (proteins on the surface of the nerve cell that are activated by acetylcholine), thus directly stimulating neuronal function.
		Thus it is especially interesting to note that when galantamine was rediscovered by European scientists in the 1950s, it was found to be in folk-medicine use for neuromuscular relief, not for memory enhancement.
		Nevertheless, studies of galantamine in clinical usage indicate that it is one of the most extraordinary of these phytonutrients in terms of its scope.
	www.smartnutrition.info /galantamine4memory.htm (1346 words)

	Neuromedia - Our articles - Care & prescription drugs - Galantamine
		Galantamine stabilizes cognition and daily functioning for 12 months and may slow the decline of cognitive function for 36 months.
		Galantamine is contraindicated in patients with known hypersensitivity to galantamine.
		Galantamine may interact with anticholinergic drugs (that may oppose the effects of galantamine) or drugs that mimic acetylcholine (that may produce synergistic effects).
	www.neuromedia.ca /en/nos_articles/galantamine.asp (551 words)

	Reminyl (Galantamine) Offers Hope In Alzheimer's Disease (Site not responding. Last check: 2007-10-26)
		Galantamine is being developed by Janssen Pharmaceutica under an agreement with UK-based Shire Pharmaceuticals Group, plc.
		The groups that received 16 and 24 mg of galantamine were titrated up to their maximum doses over a course of up to eight weeks.
		Likewise, patients who received these doses of galantamine fared better as a group than those who took placebo in terms of both the frequency and severity of behavioral symptoms and their ability to perform activities of daily living (ADLs).
	www.pslgroup.com /dg/1D77EA.htm (978 words)

	Galantamine patient advice including side effects
		Galantamine should be taken twice a day, preferably with the morning and evening meals.
		Galantamine is not recommended for patients with severe liver disease or kidney disease.
		Galantamine is not usually prescribed for women of childbearing age.
	www.drugs.com /pdr/galantamine.html (908 words)

	Howstuffworks "Galantamine: A Profile of an Alzheimer's Drug"
		Galantamine will not cure Alzheimer's, but it may slow its progression, especially when used in the early stages of the disease.
		Cimetidine, erythromycin, ketoconazole, itraconazole, or paroxetine may increase the amount of galantamine in the body and increase its effects and toxicities.
		Taking galantamine with a nonsteroidal anti-inflammatory agent (such as ibuprofen) may increase stomach irritation and the risk of stomach ulcers.
	health.howstuffworks.com /define-galantamine.htm (707 words)

	GALANTAMINE
		Galantamine inhibits the break-down of acetylcholine, the brain’s primary messenger neurotransmitter
		Galantamine is the drug extract from a member of the snow-drop family.
		Galantamine is thought to work by boosting levels of the chemical messenger acetylcholine in the brain.
	www.antiaging-systems.com /a2z/reminyl.htm (177 words)

	Investigational Alzheimer’s Drug, Reminyl (Galantamine), Improves Memory And Behavior (Site not responding. Last check: 2007-10-26)
		Galantamine is being developed by Janssen Pharmaceutica under a co-development and licensing agreement with UK-based Shire Pharmaceuticals Group, plc.
		The scores that measure cognition and the frequency and severity of behavioral symptoms were improved in the galantamine group at the completion of the study, compared to when the patients began the trial.
		As with the shorter-term trial, side effects experienced by study participants who received galantamine were mostly GI in nature, transient and mild to moderate in intensity.
	www.pslgroup.com /dg/195B32.htm (1177 words)

	Effect of galantamine on patients with dementia American Family Physician - Find Articles
		Galantamine is an acetylcholinesterase inhibitor used for the treatment of Alzheimer's disease.
		Patients receiving galantamine were able to preserve independence in approximately one ADL over the five-month study compared with those receiving placebo.
		This greater benefit of galantamine in the severely demented can be explained by the fact that patients with more severe dementia tend to have more rapid declines than patients with mild disease.
	www.findarticles.com /p/articles/mi_m3225/is_11_71/ai_n14700229 (478 words)

	galantamine
		However, it is believed that galantamine prevents the breakdown of acetylcholine in the brain.
		Galantamine is used to improve thinking and memory in patients with Alzheimer's disease.
		Galantamine is in the FDA pregnancy category B. This means that it is unlikely to harm an unborn baby.
	hw.healthdialog.com /kbase/multum/d04750a1.htm (1050 words)

	Galantamine
		Galantamine is used to treat the symptoms of Alzheimer's disease (AD; a brain disease that slowly destroys the memory and the ability to think, learn, communicate and handle daily activities).
		Galantamine is in a class of medications called acetylcholinesterase inhibitors.
		Galantamine may improve the ability to think and remember or slow the loss of these abilities in people who have AD.
	www.safemedication.com /displaydrug.cfm?id=699058 (957 words)

	The Nicotinic Allosteric Potentiating Ligand Galantamine Facilitates Synaptic Transmission in the Mammalian Central ...
		The averaged amplitude of 60 events recorded in the absence of galantamine was taken as 1 and was used to normalize the averaged amplitude of events recorded at the same frequency for 5 min in the presence of the drug.
		The averaged amplitude of events recorded in the absence of galantamine was taken as 1 and was used to normalize the averaged amplitude of events recorded at the same frequency for 5 min in the presence of the drug.
		The frequency of ACh-induced IPSCs in the absence of galantamine was taken as 1 and was used to normalize the frequency of ACh-triggered IPSCs in the presence of galantamine or galantamine-plus-FK-1.
	molpharm.aspetjournals.org /cgi/content/full/61/5/1222 (8711 words)

	galantamine (Razadyne, Razadyne ER - formerly known as Reminyl) Drug Information by MedicineNet.com
		Galantamine is in a class of drugs called cholinesterase inhibitors that also includes tacrine (Cognex), donezepil (Aricept), and rivastigmine (Exelon).
		By blocking the enzyme that destroys acetylcholine, galantamine increases the concentration of acetylcholine in the brain, and this increase is believed to be responsible for the improvement in thinking seen with galantamine.
		Most often, galantamine therapy is started with the lowest dose, 4 mg twice daily, for several weeks, and then continued at 8 mg twice daily for a further several week period.
	www.medicinenet.com /galantamine/article.htm (635 words)

	Galantamine Activates Muscle-Type Nicotinic Acetylcholine Receptors without Binding to the Acetylcholine-Binding Site ...
		A, Galantamine is a low-efficacy agonist of the wild-type receptor.
		galantamine, two components were seen in the CT histogram (0.21 ± 0.04 and 8.3 ± 0.3 ms) and one component in the OT histogram (0.70 ± 0.17 ms).
		Galantamine does not reduce the initial rate of binding for I-, The reduction in the initial rate of I- BGT binding for wild-type adult receptors (expressed in QA-33 cells) by carbachol (open circles) and galantamine (filled squares).
	www.jneurosci.org /cgi/content/full/25/8/1992 (6487 words)

	Alzforum: Galantamine
		In trials of 3 to 6 months' duration, recipients of galantamine 16 or 24 mg/day achieved significant improvements in cognitive and global symptoms relative to placebo recipients.
		Galantamine also improved activities of daily living in these patients and significantly reduced the requirement for caregiver assistance with activities of daily living
		Galantamine: a review of its use in Alzheimer's disease.
	www.alzforum.org /dis/tre/drt/galantamine.asp (459 words)

	Galantamine (Systemic)
		Galantamine has not been studied in pregnant women.
		It is not known whether galantamine passes into breast milk.
		Studies on this medicine have been done only in adult patients, and there is no specific information comparing use of galantamine in children with use in other age groups.
	allnutritionals.com /drugs/g/galantamine-systemic.shtml (1038 words)

	MedlinePlus Drug Information: Galantamine
		Galantamine is used to treat the symptoms of Alzheimer's disease (AD; a brain disease that slowly destroys the memory and the ability to think, learn, communicate and handle daily activities).
		Galantamine may improve the ability to think and remember or slow the loss of these abilities in people who have AD.
		Galantamine may upset your stomach, especially at the beginning of your treatment.
	www.nlm.nih.gov /medlineplus/druginfo/medmaster/a699058.html (1106 words)

	RemedyFind: patient ratings of Razadyne (Galantamine) for Autism (Autistic Disorder)
		Razadyne (Galantamine), previously known by the brand name "Riminyl", is an acetylcholinesterase inhibitor medication approved (U.S. FDA February 2001) for the treatment of Alzheimer's disease.
		Razadyne (Galantamine) inhibits acetylcholinesterase, the enzyme responsible for the destruction of acetylcholine, a neurotransmitter.
		It may be that galantamine and rivastigmine match donepezil in tolerability if a careful and gradual titration routine over more than three months is used.
	www.remedyfind.com /treatments/45/107 (591 words)

	PhysicianFormulas.com: Galantamine
		As an acetylcholinesterase inhibitor, galantamine competitively blocks the breakdown of the natural neurotransmitter acetylcholine.
		Half or one capsule galantamine in the morning with breakfast.
		Galantamine was isolated from several plants, including daffodil bulbs, but is now synthesized.
	www.physicianformulas.com /store/scripts/prodview.asp?idproduct=63&idaff=18937 (342 words)

	Reminyl Online, Description, Chemistry, Ingredients - Galantamine Hydrobromide - RxList Monographs
		(galantamine hydrobromide) is a reversible, competitive acetylcholinesterase inhibitor.
		for oral use is available in circular biconvex film-coated tablets of 4 mg (off-white), 8 mg (pink), and 12mg (orange-brown).Each 4, 8, and 12 mg (base equivalent) tablet contains 5.126, 10.253, and 15.379 mg of galantamine hydrobromide, respectively.
		Inactive ingredients include colloidal silicon dioxide, crospovidone, hydroxypropyl methylcellulose, lactose monohydrate, magnesium stearate, microcrystalline cellulose, propylene glycol, talc, and titanium dioxide.The 4 mg tablets contain yellow ferric oxide.
	www.rxlist.com /cgi/generic/reminyl.htm (210 words)

	Mechanism of Action of Galantamine on N-Methyl-D-Aspartate Receptors in Rat Cortical Neurons -- Moriguchi et al. 310 ...
		Galantamine potentiation of NMDA currents in rat cortical neurons in primary culture.
		Galantamine at 1 µM does not shift the dose-response relationship for 7-ClKN inhibition of currents induced by 30 µM NMDA in multipolar neurons.
		Galantamine weakly inhibits acetylcholinesterase with an IC value of 600 to 800 nM.
	jpet.aspetjournals.org /cgi/content/full/310/3/933 (5450 words)

	Galantamine - Drugs & Vitamins - Drug Library - DrugDigest
		GALANTAMINE (Razadyne® ER) helps treat the symptoms associated with Alzheimer's disease.
		It is not a cure for Alzheimer's disease but offers improvement in memory, attention, reason, language, and the ability to perform tasks.
		If you are going to have surgery tell your prescriber or health care professional that you are taking galantamine.
	www.drugdigest.org /DD/DVH/Uses/0,3915,550105\|Galantamine,00.html (653 words)

	REMINYL® (Galantamine Hydrobromide) Reduces Rate of Alzheimer's Disease Progression By More Than 50 Percent ... (Site not responding. Last check: 2007-10-26)
		Experts believe the long-term efficacy of galantamine may be a result of its unique dual mechanism of action.
		Like other Alzheimer's disease treatments, galantamine enhances levels of the neurotransmitter acetylcholine (a chemical "messenger" responsible for sending signals between nerve cells in the brain), which is typically deficient in Alzheimer's disease.
		REMINYL® (galantamine) was developed by Johnson and Johnson Pharmaceutical Research and Development, L.L.C., under a co-development and licensing agreement with UK-based Shire Pharmaceuticals Group plc.
	www.jnj.com /news/jnj_news/20030902_112403.htm (905 words)

	Efficacy and safety of galantamine in patients with mild to moderate Alzheimer's disease: multicentre randomised ...
		Galantamine is a new drug that reversibly and competitively inhibits acetylcholinesterase
		Galantamine had a significantly better effect on daily functioning than placebo.
		This study shows that galantamine is an effective and well tolerated treatment for Alzheimer's disease.
	www.bmj.com /cgi/content/full/321/7274/1445 (4925 words)

	Effects of a flexible galantamine dose in Alzheimer's disease: a randomised, controlled trial -- Rockwood et al. 71 ...
		Galantamine is a novel agent that modulates nicotinic receptors
		Galantamine in AD A 6-month randomized, placebo-controlled trial with a 6-month extension.
		Efficacy and safety of galantamine in patients with mild to moderate Alzheimer's disease: a multicentre randomised controlled trial.
	jnnp.bmj.com /cgi/content/full/71/5/589 (4239 words)

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