| | Diabetes: Oxidative stress affects synaptosomal [gamma]-a... @ HighBeam Research |
 | | These effects of oxidative stress on amino acid accumulation may be due to membrane lipoperoxidation, which may impair the GABA transporter, leading to a decrease of GABA accumulation (42), and/or it may increase the release and extracellular accumulation of aspartate and glutamate (38,40). |
 | | (14), insulin dose-dependently stimulates synaptosomal amino acid uptake, and 1 [micro]mol/l was the lowest insulin concentration that increased glutamate uptake by cortical synaptosomes, by an effect maintained during 1-20 min of in vitro incubation. |
 | | The ascorbate/ [Fe.sup.2+]-induced increase in thiobarbituric acid reactive substances (TBARSs) was similar in Wistar and GK rats and was hot reverted by insulin (1 [micro]mol/l), suggesting that other mechanisms, rather than a direct effect in membrane lipid peroxidation, may mediate insulin neuroprotection. |
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