
	Where results make sense

Topic: Gamma glutamyl transpeptidase

Related Topics

Aspartate transaminase

Viral hepatitis

EC number

Liver

Alcohol

Enzyme

Blood plasma

Hepatitis C

Acetaminophen

Acquired Immunodeficiency Syndrome

Autoimmune disease

Alkaline phosphatase

Gallstone

Regeneration (biology)

Hepatitis B

	GGT1 - gamma-glutamyltransferase 1
		GGT activity was highest in cultures from cauda epididymis, both in conditioned media and cell fractions, while GST activity did not show regional differences in conditioned media, but exhibited higher activity in cell homogenates from cauda cultures than those obtained from corpus and caput epididymis.
		Normal GGT activity was observed in all nine amniotic fluid samples from pregnancies with fetuses affected with different forms of inborn errors of metabolism diseases, in the two pregnancies with hemophilia A and in the pregnancy with a male fetus with fragile X syndrome.
		GGT is present in embryonic yolk sac and its activity increases with gestational age, suggesting that the developing embryo might be at risk from maternal exposure to glutathione conjugates or compounds which are shown to form glutathione conjugates.
	www.ihop-net.org /UniPub/iHOP/gi/88608.html (6888 words)

	MedlinePlus Medical Encyclopedia: Gamma-glutamyl transpeptidase
		This test is used to detect diseases of the liver, bile ducts, and kidney; and to differentiate liver or bile duct (hepatobiliary) disorders from bone disease.
		GGT participates in the transfer of amino acids across the cellular membrane and in glutathione metabolism.
		In particular, ALP is increased in hepatobiliary disease and bone disease.
	www.nlm.nih.gov /medlineplus/ency/article/003458.htm (679 words)

	GGT (Gamma-glutamyltransferase)
		The clinical usefulness of serum gamma-glutamyl transpeptidase (gamma GT) assay for the diagnosis of liver disease in children was assessed retrospectively in 398 children investigated from 1981 to 1986, in whom diagnosis was ascertained according to currently accepted criteria including liver histology in each case.
		Serum gamma GT was raised in all children with biliary atresia, sclerosing cholangitis, paucity of interlobular bile ducts, and alpha 1-antitrypsin deficiency with jaundice.
		Serum gamma GT was normal in spite of patent clinical signs of cholestasis in 3 patients with benign recurrent intrahepatic cholestasis, 1 infant with post-hemolytic neonatal cholestasis, and in 22 of 28 patients with progressive idiopathic cholestasis akin to Byler disease.
	www.thedoctorsdoctor.com /labtests/ggt.htm (2795 words)

	Gamma Glutamyl Transpeptidase (GGT)
		GGT is a biliary excretory enzyme which is more specific for hepatic disease than is alkaline phosphatase.
		When GGT and alkaline phosphatase are both high, but one is disproportionately elevated, suspect the possibility of drug-induced cholestasis (including alcoholism if it is GGT which is much higher).
		GGT is normal in normal children, adolescents, and in pregnant women.
	www.labcorp.com /datasets/labcorp/html/chapter/mono/pr004400.htm (764 words)

	Identity of maleate-stimulated glutaminase with gamma-glutamyl transpeptidase in rat kidney. (Site not responding. Last check: 2007-11-03)
		Gamma-Glutamyl transpeptidase was purified from rat kidney by a procedure involving Lubrol extraction, acetone precipitation, ammonium sulfate fractionation, treatment with bromelain, and column chromatography on DEAE-cellulose and Sephadex G-100.
		The purified transpeptidase (enzyme III) is similar to the phosphate-independent maleate-stimulated glutaminase preparation obtained from rat kidney by Katunuma and colleagues with respect to amino acid and carbohydrate content, apparent molecular weight, and relative transpeptidase and maleate-stimulated "glutaminase" activities.
		The studies on the ontogeny of gamma-glutamyl transpeptidase and other data are considered in relation to the proposal that this enzyme is involved in amino acid and peptide transport.
	www.arclab.org /medlineupdates/abstract_237905.html (431 words)

	How should a patient with an isolated GGT elevation be evaluated?
		GGT is found in highest concentrations in the liver (particularly in biliary tubular epithelium), but also in the kidneys, seminal vesicles, pancreas, spleen, heart, and brain.
		GGT measurement is often used to determine if elevations in other enzymes (especially alkaline phosphatase) come from the liver or a nonhepatic source such as the bones or placenta.
		Gamma-glutamyl transpeptidase in diseases of the liver and bone.
	www.clevelandclinicmeded.com /ccjm/may2000/ccjmoneminutemay.htm (759 words)

	GGT: The Test
		GGT is increased in most diseases that cause acute damage to the liver or bile ducts, but is usually not helpful in distinguishing between different causes of liver damage.
		GGT levels fall after meals, so it is best to be tested when you have not eaten for at least 8 hours.
		Levels of GGT increase with age in women, but not in men, and are always somewhat higher in men than in women.
	www.labtestsonline.org /understanding/analytes/ggt/test.html (538 words)

	Diagnostic Handbook (Site not responding. Last check: 2007-11-03)
		GGT is found almost entirely in the liver.
		GGT is the enzyme most reliably raised by excessive alcohol, typically in the range 60-200 but occasionally >1000.
		If the cause of an elevated GGT is uncertain, total abstinence from alcohol with weekly GGT estimations over a 4-week period may provide the answer.
	www.dml.co.nz /hbook/5a79c58.htm (82 words)

	Gamma glutamyl transpeptidase - TheBestLinks.com - GGT, Alcohol, Enzyme, Liver, ... (Site not responding. Last check: 2007-11-03)
		Gamma glutamyl transpeptidase - TheBestLinks.com - GGT, Alcohol, Enzyme, Liver,...
		Gamma glutamyl transpeptidase (GGT) is a liver enzyme.
		Its level in the blood may be tested for, as an elevated level may indicate an abnormality in the liver, though this can be caused by a number of conditions.
	www.thebestlinks.com /GGT.html (103 words)

	gamma glutamyl transpeptidase - General Practice Notebook
		Gamma-glytamyl transpeptidase is an enzyme which is found in hepatocytes and biliary epithelial cells.
		GGT serum measurement provides a very sensitive indicator of the presence or absence of hepatobiliary disease.
		However the usefulness of measurement of serum GGT is limited by its lack of specificity.
	www.gpnotebook.co.uk /simplepage.cfm?ID=-40239026 (896 words)

	JIAS:Volume 7/2 (Site not responding. Last check: 2007-11-03)
		Serum gamma-glutamyl transpeptidase concentrations were significantly increased in both extract groups while serum alkaline phosphatase concentrations did not have a significant effect in both treatment groups after 7 and 14 days.
		Serum gamma-glutamyl transpeptidase and alkaline phosphatase are membrane-bound enzymes and are released unequally depending on the pathological phenomenon.
		Elevation of serum gamma-glutamyl transpeptidase concentration is generally regarded as one of the most sensitive indices of hepatic damage (19).
	www.medicaljournal-ias.org /7_2/Daly.htm (2949 words)

	Gamma glutamyl transpeptidase and mean corpuscular volume: their usefulness in the assessment of in-patient alcoholics ... (Site not responding. Last check: 2007-11-03)
		Gamma glutamyl transpeptidase and mean corpuscular volume: their usefulness in the assessment of in-patient alcoholics -- Latcham 149 (3): 353 -- The British Journal of Psychiatry
		Gamma glutamyl transpeptidase and mean corpuscular volume: their usefulness in the assessment of in-patient alcoholics
		Gamma glutamyl transpeptidase and mean corpuscular volume are shown to be
	bjp.rcpsych.org /cgi/content/abstract/149/3/353 (100 words)

	Inhibition of gamma -Glutamyl Transpeptidase or Cysteine S-Conjugate beta -Lyase Activity Blocks the Nephrotoxicity of ... (Site not responding. Last check: 2007-11-03)
		GGT was inhibited by pretreating the mice with acivicin.
		deCeaurriz J and Ban M (1990) Role of gamma-glutamyl transpeptidase and beta-lyase in the nephrotoxicity of hexachloro-1,3-butadiene and methyl mercury in mice.
		Hanigan MH, Gallagher BC, Townsend DM and Gabarra V (1999) Gamma-glutamyl transpeptidase accelerates tumor growth and increases the resistance of tumors to cisplatin in vivo.
	jpet.aspetjournals.org /cgi/content/full/300/1/142 (4374 words)

	Differential Expression of the Rat {gamma}-Glutamyl Transpeptidase Gene Promoters along with Differentiation of ... (Site not responding. Last check: 2007-11-03)
		GGT mRNA IV labeling occurs in all cells at E14, is absent at PN1, and reappears at PN3 in biliary CK19-positive cells.
		GGT mRNA V accumulation is detected at E14 in all cells; it decreases at E16 and is not detected at E18.
		In the control liver (A), GGT staining appears only in biliary cells around bile ducts (arrow); at day 2 (B), GGT staining is seen in bile ducts (arrow) and in oval cells (arrowheads) adjacent to bile ducts in the portal area and radiating into the disorganized liver parenchyma.
	ajp.amjpathol.org /cgi/content/full/157/2/537 (5508 words)

	Avishay-Abraham Stark, Associate Professor
		A good example for such an enzyme is -glutamyl transpeptidase (GGT) which is induced to high levels in the very early stages of liver and skin cancer.
		GGT participates in a metabolic pathway which detoxifies and excretes carcinogens, thus allowing GGT-rich pre-cancerous cells to survive in a carcinogen-induced toxic environment, whereas GGT-poor cells cease to proliferate or die out.
		GGT may participate in the elevation of glutathione concentration within cells, thus increasing their resistance to acute toxicity and facilitating their proliferation.
	www.tau.ac.il /lifesci/biochemistry/members/stark.html (894 words)

	Synthesis and metabolism of leukotrienes in {gamma}-glutamyl transpeptidase deficiency -- Mayatepek et al. 45 (5): 900 ... (Site not responding. Last check: 2007-11-03)
		Synthesis and metabolism of leukotrienes in {gamma}-glutamyl transpeptidase deficiency -- Mayatepek et al.
		Recently, mice deficient in GGT were developed and used in LT metabolism studies (10–12).
		Recently, mice deficient in GGT have been developed (11, 12).
	www.jlr.org /cgi/content/full/45/5/900 (1947 words)

	Medical Encyclopedia: Gamma-glutamyl transpeptidase (Print Version)
		Blood is drawn from a vein on the inside of the elbow or the back of the hand.
		GGT is elevated in hepatobiliary disease, but not in bone disease.
		So, a patient with an elevated ALP and a normal GGT probably has bone disease, not hepatobiliary disease.
	www.nlm.nih.gov /medlineplus/print/ency/article/003458.htm (621 words)

	Tyrphostins reduce chemotherapy-induced intestinal injury in mice: assessment by a biochemical assay
		The assay is based on the determination of the enzymatic activity of gamma-glutamyl transpeptidase, a marker of the brush border epithelium of the small intestine.
		The assay is based on the determination of the enzymatic activity of gamma-glutamyl transpeptidase (GGT), a marker of the brush border epithelium of the small intestine (Tate and Meister, 1981; Ferraris et al, 1992).
		In this context, it should be noted that GGT in different cell types is subject to phenotypic alterations induced by different agents (Novogrodsky et al, 1976; Wasserman et al, 1987; Sidi et al, 1988).
	www.nature.com /bjc/journal/v92/n2/full/6602324a.html (2010 words)

	Quinones increase gamma -glutamyl transpeptidase expression by multiple mechanisms in rat lung epithelial cells -- Liu ...
		In the lung, the expression of GGT mRNAs is
		GGT mRNA content was increased by 102, 206, and 183% when the cells were treated with 5 µM DMNQ for 6, 12, or 24 h, respectively.
		We conclude that the superinduction of GGT by cycloheximide in
	ajplung.physiology.org /cgi/content/full/274/3/L330 (4425 words)

	Marie H. Hanigan's Publications (Site not responding. Last check: 2007-11-03)
		Hanigan, M.H. (1996) Gamma-Glutamyl Transpeptidase, A Glutathionase: Its Expression in Carcinogenesis.
		Townsend, D.M. and Hanigan, M.H. (2000) In vivo Metabolism of Cisplatin to a Nephrotoxin by Gamma-Glutamyl Transpeptidase and Beta-Lyase.
		Townsend, D.M., Marto, J.A., Macdonald, T.L. and Hanigan, M.H. (2001) Characterization of a Glutathione Conjugate of Cisplatin that is Metabolized by Gamma-Glutamyl Transpeptidase to a Nephrotoxin.
	w3.ouhsc.edu /cell_biology/faculty/haniganpubs.html (1775 words)

	{gamma}-Glutamyl Transpeptidase-Deficient Mice Are Resistant to the Nephrotoxic Effects of Cisplatin -- Hanigan et al. ... (Site not responding. Last check: 2007-11-03)
		GGT is expressed on the luminal surface of the proximal tubule
		to cysteinyl-glycine-conjugates by GGT on the surface of the
		Townsend DM, Hanigan MH: In vivo metabolism of cisplatin to a nephrotoxin by gamma-glutamyl transpeptidase and beta-lyase.
	ajp.amjpathol.org /cgi/content/full/159/5/1889 (3030 words)

	glutamyl transpeptidase, Primary Sclerosing Cholangitis Literature
		Chida K 1990 Histochemical and immunohistochemical study on the expression of alkaline phosphatase, gamma-glutamyl transpeptidase and alpha-fetoprotein during the process of rat hepatocyte proliferation.
		Kampa IS, Jarzabek J, Clain J 1976 The use of gamma-glutamyl transpeptidase in differentiating liver from bone isoenzymes of alkaline phosphatase.
		Selinger MJ, Matloff DS, Kaplan MM 1982 gamma-Glutamyl transpeptidase activity in liver disease: serum elevation is independent of hepatic GGTP activity.
	www.psc-literature.org /ggt.htm (11077 words)

	GGT (Gamma Glutamyl Transpeptidase) articles, support groups, and resources
		GGT in the 240 range (Gastroenterology and Liver Diseases Forum)
		GGT of 253 in a asymptomatic female (Gastroenterology and Liver Diseases Forum)
		High level of GGT (Gamma Glutamyl Transferase) (Gastroenterology and Liver Diseases Forum)
	www.medhelp.org /HealthTopics/GGT.html (634 words)

	{gamma}-Glutamyl transpeptidase and glutathione biosynthesis in non-tumorigenic and tumorigenic rat liver oval cell ... (Site not responding. Last check: 2007-11-03)
		GGT, and was purified from ascitic fluid of mice injected with
		Selvaraj,P., Balasubramanian,K.A. and Hill,P.G. (1981) Isolation of gamma-glutamyl transpeptidase from human primary hepatoma and comparison of its kinetic and catalytic properties with the enzyme from normal adult and fetal liver.
		Taniguchi,N., Tsukada,Y. and Takatuwa,E. -Glutamyl transpeptidase from azo-dye induced hepatoma and fetal rat liver.
	carcin.oxfordjournals.org /cgi/content/full/23/4/669 (4634 words)

	Distribution of gamma-glutamyl transpeptidase in human salivary glands: immunohistochemical study using a monoclonal ...
		Distribution of gamma-glutamyl transpeptidase in human salivary glands: immunohistochemical study using a monoclonal antibody -- Shiozawa et al.
		Articles by Shiozawa, M. Articles by Aiso, S. Distribution of gamma-glutamyl transpeptidase in human salivary glands: immunohistochemical study using a monoclonal antibody
		transpeptidase (gamma-GT) in human salivary glands using a monoclonal
	www.jhc.org /cgi/content/abstract/41/2/205 (190 words)

	Reproductive Defects in {gamma}-Glutamyl Transpeptidase-Deficient Mice -- Kumar et al. 141 (11): 4270 -- Endocrinology (Site not responding. Last check: 2007-11-03)
		GGT is primarily the result of an intraovarian defect, because
		-glutamyl transpeptidase messenger ribonucleic acid are expressed in the adult rat testis and epididymis.
		-Glutamyl transpeptidase of rat seminal vesicles; effect of orchidectomy and hormone administration on the transpeptidase in relation to its possible role in secretory activity.
	endo.endojournals.org /cgi/content/full/141/11/4270 (4751 words)

	Involvement of Polyomavirus Enhancer Activator 3 in the Regulation of Expression of Gamma-Glutamyl Transpeptidase ...
		Regulation of gamma-glutamyl transpeptidase catalytic activity and protein level in the initial segment of the rat epididymis by testicular factors: role of basic fibroblast growth factor.
		Multiple forms of gamma-glutamyl transpeptidase messenger ribonucleic acid are expressed in the adult rat testis and epididymis.
		Expression of multiple gamma-glutamyl transpeptidase messenger ribonucleic acid transcripts in the adult rat epididymis is differentially regulated by androgens and testicular factors in a region-specific manner.
	www.biolreprod.org /cgi/content/full/60/3/664 (7371 words)

	{gamma}-Glutamyl Transpeptidase Inhibition Suppresses Milk Protein Synthesis in Isolated Ovine Mammary Cells -- ... (Site not responding. Last check: 2007-11-03)
		-Glutamyl transpeptidase in lactating mammary secretory tissue of cow and rat.
		Hanigan, M. -Glutamyl transpeptidase, a glutathionase: Its expression and function in carcinogenesis.
		Lack of relationship between gamma-glutamyl transpeptidase and tyrosine transport in cultured bovine adrenal chromaffin cells.
	www.dairy-science.org /cgi/content/full/87/2/321 (4122 words)

Try your search on: Qwika (all wikis)