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Topic: Ganciclovir


In the News (Tue 29 Jul 14)

  
  BioMed Central | Full text | Dexamethasone inhibits the HSV-tk/ ganciclovir bystander effect in malignant glioma cells
The effects of dexamethasone on cell proliferation and sensitivity to ganciclovir were assessed with a thymidine incorporation assay and a MTT test.
Ganciclovir monophosphate is subsequently bis and tri-phosphorylated by cellular kinases and is then incorporated in the DNA of replicating cells, blocking the cell cycle and inducing apoptosis [1,4,5].
The reasons why ganciclovir failed to enhance the toxicity of sFAS-L on U87-TK cells remain unknown and are beyond the scope of the present work, as is the thorough assessment of the effects of dexamethasone on HSV-TK/GCV-induced apoptosis.
www.biomedcentral.com /1471-2407/5/32   (4996 words)

  
 Definition of ganciclovir - NCI Dictionary of Cancer Terms
Definition of ganciclovir - NCI Dictionary of Cancer Terms
An antiviral agent used to prevent or treat cytomegalovirus infections that may occur when the body's immune system is suppressed.
In gene therapy, ganciclovir is used with an altered herpes simplex virus-1 gene to kill advanced melanoma cells and brain tumor cells.
www.cancer.gov /Templates/db_alpha.aspx?CdrID=45303   (70 words)

  
  (STEP) Ganciclovir for Cytomegalovirus (CMV Retinitis)
Ganciclovir's main toxicity is suppression of the bone marrow, while foscarnet often causes damage to the kidney and disruption of electrolyte balance.
Most clinicians have recommended initiation of therapy with ganciclovir, although there was some question of this after a trial comparing the two agents was halted early due to a survival advantage seen in people that were given foscarnet (12.6 months with foscarnet; 8.5 months with ganciclovir).
Advantages of local therapy of CMV retinitis with ganciclovir included achieving much higher concentrations of the drug in the eye where it is needed (4.1 mcg/ml with implant, 0.93 mcg/ml with intravenous), avoiding exposure of the body to the toxic effects of the drug, and avoiding use of an indwelling catheter.
www.aegis.com /pubs/step/1995/STEP7202.html   (2043 words)

  
 Consumer Reports Medical Guide - Ganciclovir Injection
Giving ganciclovir too quickly may increase the side effects of this medication.The manufacturer states that this medication should not be prescribed for other uses.
Ganciclovir injection is used to treat cytomegalovirus (CMV) retinitis (eye infection) that can cause blindness in people whose immune system is not working normally, including people with acquired immune deficiency syndrome (AIDS).
Ganciclovir is also used to prevent cytomegalovirus (CMV) disease in people who have received an organ transplant and who are at risk of getting CMV disease.
www.consumerreports.org /mg/drug-reports/ganciclovir-injection.htm?view=Print   (1391 words)

  
  Drug Information
GANCICLOVIR (Vitrasert(R)) is used to treat cytomegalovirus (CMV) retinitis (viral eye infection).
Ganciclovir implants are placed in position by a surgical procedure that requires a high level of surgical skill.
Ganciclovir is not a cure, and repeat courses of the medication are commonly needed to prevent or treat reactivation of the virus.
www.muschealth.com /cds/CPDrugInfo.details.aspx?cpnum=272&gname=&id=347   (412 words)

  
 Medical Update: Intravitreal Ganciclovir for CMV Retinitis
Ganciclovir is one of two drugs that are used to treat sight-threatening CMV retinitis (the other is foscarnet).
Ganciclovir is commonly administered intravenously and requires the patient to have a PICC line installed.
Intravitreal ganciclovir means that, instead of the drug being injected into a vein, the drug is injected directly into the vitreous humor of the eye.
www.aegis.com /pubs/bala/1994/BA940305.html   (433 words)

  
 Ganciclovir - Learn about Ganciclovir Side Effects and Precautions   (Site not responding. Last check: )
The pharmacology action of Ganciclovir is that it inhibits cytomegalovirus (CMV) and other virus replication by competitive inhibition of viral DNA polymerases and direct incorporation into viral DNA.
Ganciclovir is used in treatment of CMV retinitis in immunocompromised patients, including patients with AIDS; prevention of CMV disease in organ transplant patients at risk for CMV.
Ganciclovir levels may be decreased when administered 2 hr after didanosine but not when given simultaneously.
www.health-care-clinic.com /drugs/g/ganciclovir.htm   (371 words)

  
 MedlinePlus Drug Information: Ganciclovir Injection
Ganciclovir may lower the number of all types of cells in your blood, causing serious and life-threatening problems.
The manufacturer warns that ganciclovir should only be used for treatment of patients with certain diseases because the medication may cause severe side effects and there currently is not enough information to support safety and effectiveness in other groups of patients.
Ganciclovir works by preventing the spread of CMV disease or slowing the growth of CMV.
www.nlm.nih.gov /medlineplus/druginfo/medmaster/a689014.html   (1360 words)

  
 GANCICLOVIR
Ganciclovir is used to treat complications from AIDS-associated cytomegalovirus infections.
IVIG plus ganciclovir is beneficial in treating CMV pneumonia in patients who are not ventilator dependent.
Antiviral drugs, such as ganciclovir and acyclovir, are used to reduce viral load or prevent infection in immune-compromised people.
www.websters-online-dictionary.org /definition/english/Ga/Ganciclovir.html   (374 words)

  
 MedlinePlus Drug Information: Ganciclovir
Ganciclovir capsules are used to treat CMV retinitis after the condition has been controlled by intravenous (injected into a vein) ganciclovir.
Ganciclovir is also used to prevent cytomegalovirus (CMV) disease in people who have acquired immunodeficiency syndrome (AIDS) or who have received an organ transplant and are at risk of CMV disease.
Ganciclovir is in a class of medications called antivirals.
www.nlm.nih.gov /medlineplus/druginfo/medmaster/a605011.html   (1314 words)

  
 Ganciclovir (Systemic) - MayoClinic.com   (Site not responding. Last check: )
Ganciclovir is used to treat the symptoms of cytomegalovirus (CMV) infection of the eyes in people whose immune system is not working fully.
Ganciclovir may be used for other serious CMV infections as determined by your doctor.
Ganciclovir is to be administered only by or under the supervision of your doctor.
www.mayoclinic.com /health/drug-information/DR202255   (1586 words)

  
 Simple Facts Sheets: oral ganciclovir
Ganciclovir (trade name Cytovene), foscarnet (Foscavir) and cidofovir (Vistide) are the approved drugs for treating CMV retinitis.
Ganciclovir and foscarnet are usually given by intravenous infusion, which means directly into a vein, twice daily.
Oral ganciclovir was approved for CMV prevention because the results of one study showed that prophylaxis can delay the onset of CMV disease in people with low T4 cell counts.
www.atdn.org /simple/cytovene.html   (788 words)

  
 Cecil Textbook of Medicine : />
Ganciclovir, also known as dihydroxy propoxymethyl guanine (DHPG), is an acyclic nucleoside analogue of acyclovir that has increased in vitro activity against all herpesviruses compared with acyclovir, including 8 to 20 times greater antiviral activity against CMV.
The mode of action of ganciclovir against CMV and EBV (which do not produce virus-specific TK) is not entirely known, but it has been suggested that these viruses may induce a cellular TK or viral kinase that efficiently promotes the obligatory initial phosphorylation of ganciclovir to its monophosphate.
Ganciclovir has been licensed by the U.S. Food and Drug Administration for treating CMV retinitis and life-threatening CMV diseases in patients with acquired immunodeficiency syndrome (AIDS) and other immunocompromised patients.
www.merckmedicus.com /ppdocs/us/common/cecils/chapters/358_006.htm   (358 words)

  
 Aidsmap | Options for treating ganciclovir-resistant CMV discussed at IDSA conference
This is of significant concern as CMV can become resistant to the current standard-of-care medications, ganciclovir and valganciclovir, leaving few treatment options.
Valganciclovir, an oral ‘pro-drug’ of ganciclovir (GCV), is converted to GCV in the body.
Ganciclovir and valganciclovir, the preferred maintenance treatments, are therefore essentially the same from the standpoint of resistance.
www.aidsmap.com /en/news/759A0DEF-178A-4ED3-9B64-6D437C0D0B27.asp   (745 words)

  
 Impact of Prophylactic Immediate Posttransplant Ganciclovir on Development of Transplant Atherosclerosis : A Post Hoc ...
ganciclovir was also shown to decrease the incidence of fungal infections,
ganciclovir was 20% compared with 80% in the placebo group.
incidence of death or retransplantation at follow-up in ganciclovir
circ.ahajournals.org /cgi/content/full/100/1/61   (4497 words)

  
 Ganciclovir Roche : Laboratoires Roche
Cymevan (Ganciclovir) est un traitement d’entretien des rétinites à cytomégalovirus.
Surveillance hematologique, chez les patients recevant du ganciclovir par voie orale, il est recommande de surveiller la numeration formule sanguine, principalement les neutrophiles et la numeration plaquettaire toutes les deux semaines.
Ganciclovir Roche Chez les patients ayant deja presente une leucopenie sous ganciclovir ou chez qui les neutrophiles sont inferieurs a 1 000 mm3 en debut de traitement, le nombre de neutrophiles doit etre evalue une fois par semaine, surveillance renale.
www.roche.fr /traitement-sida/ganciclovir-roche.htm   (306 words)

  
 NEJM -- Oral Ganciclovir as Maintenance Treatment for Cytomegalovirus Retinitis in Patients with AIDS
ganciclovir at a dose of 3000 mg daily.
Oral Ganciclovir for Patients with Cytomegalovirus Retinitis Treated with a Ganciclovir Implant.
Oral Ganciclovir for the Prevention of Cytomegalovirus Disease in Persons with AIDS.
content.nejm.org /cgi/content/short/333/10/615?query=prevarrow&ck=nck   (1172 words)

  
 GANCICLOVIR a Commonly Used Medication
ZDV may potentiate ganciclovir's bone marrow toxicity; nephrotoxic and bone marrow depressant drugs should be administered with caution due to possible additive effects.
Imipenerm-cilastatin + DHPG may result in seizures, and should not be used together unless benefit clearly outweighs risk.
Monitor for visual disturbances which may indicate progression of retinal CMV; regular opthalmology F/U is essential for early detection of disease reactivation.
www.hivdent.org /drugs/GANCICLOVIR.htm   (212 words)

  
 Mesothelioma Drug Ganciclovir - ELSS
Recent studies have demonstrated the utility of exposing tumor cells to cells transduced to express the Herpes simplex virus gene for thymidine kinase (HSV-TK).
By virtue of their expression of HSV-TK, the transduced cells are rendered susceptible to the antiviral drug, ganciclovir (GCV).
The hope is that administration of ganciclovir will result in killing of the transduced ovarian cancer cells as well as the nearby malignant mesothelioma cells.
www.mesothelioma.com /gt_lsu_study.htm   (373 words)

  
 Clinical Trial: Ganciclovir Plus Arginine Butyrate in Treating Patients With Cancer or Lymphoproliferative Disorders ...
Ganciclovir is an antiviral drug that acts against the Epstein Barr virus.
PURPOSE: Phase I trial to study the effectiveness of arginine butyrate plus ganciclovir in treating patients who have cancer or lymphoproliferative disorders that are associated with the Epstein Barr virus.
Arginine butyrate-induced susceptibility to ganciclovir in an Epstein-Barr-virus-associated lymphoma.
www.clinicaltrials.gov /ct/show/NCT00006340   (593 words)

  
 Clinical Trial: A Pharmacokinetic and Tolerance Study of Oral Ganciclovir in HIV-Infected Children With Asymptomatic ...
PRIMARY: To determine the pharmacokinetics, MTD, and long-term safety and tolerance of oral ganciclovir in HIV-infected infants, children, and adolescents.
Maintenance treatment with intravenous (IV) ganciclovir for cytomegalovirus retinitis in AIDS patients is now standard therapy, but daily IV therapy can be complicated by catheter infections and thrombosis.
An oral regimen of ganciclovir has been administered safely in adult AIDS patients and may be of significant benefit to children and infants as well.
www.clinicaltrials.gov /ct/show/NCT00000805?order=31   (841 words)

  
 AdvHSV-tk gene therapy with intravenous ganciclovir improves survival in human malignant glioma: a randomised, ...
AdvHSV-tk gene therapy with intravenous ganciclovir improves survival in human malignant glioma: a randomised, controlled study.
Seventeen patients were randomized to receive AdvHSV-tk gene therapy (3 x 10(10) pfu) by local injection into the wound bed after tumor resection, followed by intravenous ganciclovir (GCV), 5 mg/kg twice daily for 14 days.
The control group of 19 patients received standard care consisting of radical excision followed by radiotherapy in those patients with primary tumors.
braintumors.researchtoday.net /archive/1/3/1284.htm   (330 words)

  
 GANCICLOVIR - ORAL CAPSULE
WARNING: Ganciclovir capsules are used only to prevent CMV infection in HIV patients or organ transplant patients; or for people who have CMV eye infection and weak immune systems.
Using oral ganciclovir instead of the injectable form may increase the risk of developing a more severe infection.
Caution is advised if this drug is used in the elderly, as they may have decreased kidney function which can cause ganciclovir to build up in their bloodstream.
www.personalmd.com /drgdb/4069.htm   (659 words)

  
 Plasma Cytomegalovirus (CMV) DNA Load Predicts CMV Disease and Survival in AIDS Patients -- Spector et al. 101 (2): 497 ...
The original study consisted of 725 participants randomized in a 2:1 ratio to receive ganciclovir or placebo, respectively.
Although a benefit of ganciclovir was also observed for patients PCR positive at baseline, there was an increase in the number
ganciclovir still had a 26% incidence of CMV disease at 12 mo.
www.jci.org /cgi/content/full/101/2/497   (4121 words)

  
 Qualitative Plasma PCR Assay (AMPLICOR CMV Test) versus pp65 Antigenemia Assay for Monitoring Cytomegalovirus Viremia ...   (Site not responding. Last check: )
Qualitative Plasma PCR Assay (AMPLICOR CMV Test) versus pp65 Antigenemia Assay for Monitoring Cytomegalovirus Viremia and Guiding Preemptive Ganciclovir Therapy in Allogeneic Stem Cell Transplantation -- Solano et al.
ganciclovir therapy occurred a median of 7.5 days earlier than
Oral valganciclovir leads to higher exposure to ganciclovir than intravenous ganciclovir in patients following allogeneic stem cell transplantation.
jcm.asm.org /cgi/content/abstract/39/11/3938   (497 words)

  
 Ganciclovir   (Site not responding. Last check: )
Ganciclovir is a derivative of acyclovir that was developed to treat human cytomegalovirus (CMV) infection.
Initial formulations were given intravenously and were quite toxic.
Please visit Thomas Chi's Antiviral Drug Page for more detailed information
www.stanford.edu /group/virus/rhabdo/2000/ganciclovir.html   (90 words)

  
 Link Directory - Ganciclovir
Home » Pharmacy » Drugs and Medications » G » Ganciclovir
Information on dosage, usage, side effects, interactions, and drug comparisons including generics when available.
A special implant that is put directly into an infected eye.(Vitrasert)
www.jmbsoft.com /software/linkx/demo/Pharmacy/Drugs_and_Medications/G/Ganciclovir   (36 words)

  
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